scholarly journals LXXXVII.—Preparation of secondary amines from carboxylic acids. Part II. Preparation of the heptadecyl and pentadecyl derivatives of α- and β-naphthylamine

1911 ◽  
Vol 99 (0) ◽  
pp. 827-833
Author(s):  
Henry Rondel Le Sueur
Keyword(s):  
Carboxylic Acids ◽  
Secondary Amines ◽  
Derivatives Of

scholarly journals Synthesis and Biological Activity of 2,5-Bisubstituted Derivatives of 1,3,4-Thiadiazol-2,5-dithiol

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
T. S. Zhivotova ◽  
R. E. Bakirova ◽  
S. D. Fazylov ◽  
S. K. Kabieva ◽  
T. V. Kryazheva
Keyword(s):  
Biological Activity ◽  
Acrylic Acid ◽  
Carboxylic Acids ◽  
Biological Properties ◽  
Secondary Amines ◽  
Derivatives Of

By reaction of 1,3,4-thiadiazol-2,5-dithiol with different organohalogens, chlorides of carboxylic acids, acrylic acid derivatives, alkaloids, and secondary amines, various derivatives of 2,5-bi-substituted 1,3,4-thiadiazole were synthesized, and biological properties of some of them were studied.

Some 1-substitution derivatives of 4-aryl-2,3-dihalogeno-1-naphthols

1984 ◽  
Vol 49 (1) ◽  
pp. 110-121 ◽  
Author(s):  
Jiří Křepelka ◽  
Drahuše Vlčková ◽  
Milan Mělka
Keyword(s):  
Thionyl Chloride ◽  
Oxirane Ring ◽  
Secondary Amines ◽  
Two Phase ◽  
Lytic Effect ◽  
Primary And Secondary Amines ◽  
Phase Medium ◽  
Chloro Derivatives ◽  
Derivatives Of

Alkylation of derivatives of 4-aryl-1-naphthols (I-V) by 2,3-epoxypropyl chloride in methanolic sodium hydroxide gave epoxy derivatives VI, VIII, IX, XI and XII, apart from products of cleavage of the oxirane ring, VII and X. Analogous alkylation of compounds I, IV and V by 2-(N,N-diethylamino)ethyl chloride hydrochloride in a two-phase medium afforded basic ethers XIII to XV. The cleavage of the oxirane ring in compound VI by the action of primary and secondary amines, piperidine and substituted piperazines led to compounds XVI-XXIV. Reaction of thionyl chloride with compounds XXI, XXII and XXIV gave chloro derivatives XXV-XXVII.Exposure of compound XXII to 4-methylbenzenesulfonyl chloride produced compound XXVIII, retaining the secondary alcoholic group. In an antineoplastic screening in vivo none of the compounds prepared had an appreciable activity. Compound XVII, being an analogue of propranolol, was used in the test of isoproterenolic tachycardia, and showed a beta-lytic effect comparable with that of propranol.

Direct amidation of carboxylic acids with amines under microwave irradiation using silica gel as a solid support

2015 ◽  
Vol 17 (5) ◽  
pp. 3157-3163 ◽  
Author(s):  
Andrea Ojeda-Porras ◽  
Alejandra Hernández-Santana ◽  
Diego Gamba-Sánchez
Keyword(s):  
Fatty Acids ◽  
Microwave Irradiation ◽  
Carboxylic Acids ◽  
Silica Gel ◽  
Solid Support ◽  
Secondary Amines ◽  
Primary And Secondary Amines ◽  
Direct Amidation

A highly improved methodology for the direct amidation of carboxylic acids with amines using silica gel as a solid support and catalyst is described. Several examples using aliphatic, aromatic, unsaturated and fatty acids combined with primary and secondary amines are shown.

ChemInform Abstract: Heterocyclic Analogues of 5,12-Naphthacenequinone. Part 12. Synthesis of 2-Substituted Derivatives of 4,11-Dimethoxy-5,10-dioxoanthra[2,3-b]furan-3-carboxylic Acids.

ChemInform ◽  
2014 ◽  
Vol 45 (44) ◽  
pp. no-no
Author(s):  
A. S. Tikhomirov ◽  
A. E. Shchekotikhin ◽  
Yu. N. Luzikov ◽  
A. M. Korolev ◽  
M. N. Preobrazhenskaya
Keyword(s):  
Carboxylic Acids ◽  
Derivatives Of

Heterocyclic Analogs of 5,12-Naphthacene-Quinone. 12. Synthesis of 2-Substituted Derivatives of 4,11-Dimethoxy-5,10-Dioxo-Anthra[2,3-b]Furan-3-Carboxylic Acids

2014 ◽  
Vol 50 (2) ◽  
pp. 271-280 ◽  
Author(s):  
A. S. Tikhomirov ◽  
A. E. Shchekotikhin ◽  
Yu. N. Luzikov ◽  
A. M. Korolev ◽  
M. N. Preobrazhenskaya
Keyword(s):  
Carboxylic Acids ◽  
Derivatives Of
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