scholarly journals A Simple and Green Protocol for 2H-Indazolo[2,1-b]phthalazine-triones Using Grinding Method

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Xiao-chuan Jia ◽  
Jing Li ◽  
Yu Ding ◽  
Bin Zhang ◽  
Na Wang ◽  
...  
Keyword(s):  
Reaction Time ◽  
Sulfonic Acid ◽  
Catalytic Amount ◽  
Solvent Free ◽  
Short Reaction Time ◽  
Green Protocol ◽  
Simple Operation ◽  
Grinding Method ◽  
Toluene Sulfonic Acid ◽  
High Yields

A robust, facile, and solvent-free route for the three-component synthesis of 2H-indazolo[2,1-b]phthalazine-triones in the presence of a catalytic amount ofp-toluene sulfonic acid utilizing grinding has been developed. Short reaction time, simple operation, and high yields are the advantages of this protocol.

Rapid synthesis of homoallylic alcohol from aldehyde with allyltributylstannane under solvent-free conditions

2012 ◽  
Vol 90 (2) ◽  
pp. 167-172 ◽  
Author(s):  
Pranjal P. Bora ◽  
H. Atoholi Sema ◽  
Barisha Wahlang ◽  
Ghanashyam Bez
Keyword(s):  
Reaction Time ◽  
Phosphotungstic Acid ◽  
Catalytic Amount ◽  
Solvent Free ◽  
Reaction Conditions ◽  
Rapid Synthesis ◽  
Short Reaction Time ◽  
Solvent Free Conditions ◽  
Solvent Free Reaction

A catalytic amount (2 mol %) of phosphotungstic acid (PTA) is sufficient to synthesize homoallylic alcohol in excellent yields from aldehyde with allyltributylstannane upon grinding under solvent-free reaction conditions. Easy handling, very short reaction time, solvent-free reaction conditions, and aqueous workup free isolation protocol may make our method very useful for synthetic chemists.

Multi-component synthesis of highly substituted imidazoles catalyzed by nanorod vanadatesulfuric acid

2015 ◽  
Vol 69 (11) ◽  
Author(s):  
Masoud Nasr-Esfahani ◽  
Morteza Montazerozohori ◽  
Tooba Abdizadeh
Keyword(s):  
Reaction Time ◽  
High Purity ◽  
Ammonium Acetate ◽  
Chlorosulfonic Acid ◽  
Solvent Free ◽  
One Pot ◽  
Short Reaction Time ◽  
Solvent Free Conditions ◽  
High Yields ◽  
Tetrasubstituted Imidazoles

AbstractNanorod vanadatesulfuric acid (VSA NRs), as a recyclable and eco-benign catalyst, was used for one-pot synthesis of 2,4,5-trisubstituted imidazoles and 1,2,4,5-tetrasubstituted imidazoles using aldehydes, benzil, benzoin or 9,10-phenanthrenequinone and ammonium acetate or aniline under solvent-free conditions providing high to excellent yields. VSA is easily prepared by a simple reaction of chlorosulfonic acid and sodium metavanadate in high purity. As compared with the conventional procedures, the present protocol offers several advantages such as simplicity of procedure, short reaction time, high yields, easy workup, recoverability and reusability of the catalyst and simple purification of the products.

A Study on the Sulfonation of Aromatic Amines with Sulfuric Acid under Microwave Irradiation

2003 ◽  
Vol 2003 (8) ◽  
pp. 493-494 ◽  
Author(s):  
Hui-Zhang Li ◽  
Li-Wei Xiao ◽  
Hong-Ya Li ◽  
Kai-Fang Wang ◽  
Xu Li
Keyword(s):  
Sulfuric Acid ◽  
Reaction Time ◽  
Microwave Irradiation ◽  
Aromatic Amines ◽  
Solvent Free ◽  
Short Reaction Time ◽  
Solvent Free Conditions ◽  
High Yields

The sulfonation of aromatic amines with high yields, simple operations and short reaction time has been studied under microwave irradiation in solvent-free conditions.

The preparation and photolysis of (E)-1-Aryl-3-methyl-3-phenylbut-1-enes

1983 ◽  
Vol 36 (3) ◽  
pp. 565 ◽  
Author(s):  
JW Blunt ◽  
JM Coxon ◽  
WT Robinson ◽  
HA Schuyt
Keyword(s):  
Reaction Time ◽  
Benzyl Alcohol ◽  
Sulfonic Acid ◽  
Reaction Times ◽  
Grignard Reaction ◽  
Aryl Substituent ◽  
Reaction Conditions ◽  
Careful Choice ◽  
Short Reaction Time ◽  
Toluene Sulfonic Acid

Reaction of 2-methyl-2-phenylpropylmagnesium chloride with benzaldehyde in tetrahydrofuran gave 2,7-dimethyl-2,4,5,7-tetraphenyloctane-4,5-diol as a 1 : 2 mixture of clear transparent crystalline plates (meso) and needles (�), 3-methyl-1,3-diphenylbutan-1-one, benzyl alcohol, 2-methyl-2-phenylpropaneand a low yield of 3-methyl-1,3-diphenylbutan-1-ol. The distinction between the meso and the (+)- diols was unequivocal because the unique space group of the former requires thedimeric molecules to lie about a crystallographic centre of symmetry. The mechanism involved in the formation of the products of the Grignard reaction is examined. By careful choice of reaction conditions a series of I-aryl-3-methyl-3-phenylbutan-1-ols were prepared. Dehydration of the 1-aryl-3-methyl-3-phenylbutan-1-ols with p-toluene sulfonic acid and a short reaction time gives(E)-1-aryl-3-methyl-3-phenylbut-1-enes but longer reaction times afford 3-aryl-1,1-dimethylindanes.Photolysis of the (E)-1-aryl-3-methyl-3-phenylbut-1-enes affords (Z)-1-aryl-3-methyl-3-phenylbut-1-enes and trans-1-aryl-3,3-dimethyl-2-phenylcyclopropanes. Extended photolysis gives 4-aryl-2-methyl-3-phenylbut-1-enes via trans-1-aryl-3,3-dimethyl-2-phenylcyclopropane by rupture of the cyclopropyl bond adjacent to the aryl substituent.

scholarly journals Study of the Three-Component Reactions of 2-Alkynylbenzaldehydes, Aniline, and Dialkyl Phosphites—The Significance of the Catalyst System

Materials ◽  
2021 ◽  
Vol 14 (20) ◽  
pp. 6015
Author(s):  
Nóra Popovics-Tóth ◽  
Kármen Emőke Szabó ◽  
Erika Bálint
Keyword(s):  
Reaction Time ◽  
Chromatographic Separation ◽  
Crucial Role ◽  
Catalyst System ◽  
Short Reaction Time ◽  
Simple Operation ◽  
Dialkyl Phosphites ◽  
Simple Extraction ◽  
High Yields

New, practical approaches for the synthesis of α-amino (2-alkynylphenyl)-methylphosphonates and 1,2-dihydroisoquinolin-1-ylphosphonates were developed. By the propylphosphonic anhydride (T3P®)-mediated Kabachnik–Fields reaction of 2-alkynylbenzaldehydes, aniline, and dialkyl phosphites, α-amino (2-alkynylphenyl)-methylphosphonates were obtained selectively in high yields. The method developed is a simple operation and did not require a chromatographic separation since the products could be isolated from the reaction mixture by a simple extraction. At the same time, 2,3-disubstituted-1,2-dihydroisoquinolin-1-ylphosphonates could be prepared effectively from the same kinds of starting materials (2-alkynylbenzaldehydes, aniline, and dialkyl phosphites) at 60 °C in a short reaction time by changing the catalyst for CuCl. Therefore, it was proved that the catalyst system applied played a crucial role with respect to the reaction outcome.

Green Protocol for Synthesis of Bis-indolylmethanes and Bis-indolylglycoconjugates in the Presence of Iron(III) Fluoride as a Heterogeneous, Reusable, and Eco-Friendly Catalyst

2006 ◽  
Vol 59 (11) ◽  
pp. 837 ◽  
Author(s):  
Vinod T. Kamble ◽  
Babasaheb P. Bandgar ◽  
Satish B. Suryawanshi ◽  
Sudhir N. Bavikar
Keyword(s):  
Efficient Method ◽  
Carbonyl Compounds ◽  
Catalytic Amount ◽  
Solvent Free ◽  
Environmentally Benign ◽  
Good Activity ◽  
Green Protocol ◽  
Solvent Free Conditions ◽  
High Yields

An efficient method for the preparation of bis-indolylmethanes and bis-indolylglycoconjugates from carbonyl compounds with indoles in the presence of a catalytic amount of iron(iii) fluoride under solvent-free conditions is reported. The desired products were obtained in high yields with a simple and environmentally benign procedure. The use of iron(iii) fluoride is feasible because of its stability, easy handling, easy recovery, reusability, and good activity.

scholarly journals Iodination of industrially important aromatic compounds using N-iodosuccinimide by grinding method

2018 ◽  
Vol 7 (6) ◽  
pp. 477-486
Author(s):  
Vivek Sharma ◽  
Priyanka Srivastava ◽  
Santosh Kumar Bhardwaj ◽  
D.D. Agarwal
Keyword(s):  
Gas Chromatography ◽  
Reaction Time ◽  
Solid State ◽  
Aromatic Compounds ◽  
Room Temperature ◽  
High Yield ◽  
Short Reaction Time ◽  
Grinding Method ◽  
High Yields ◽  
Work Up

Abstract Iodination of various industrially and pharmaceutically important substituted aromatics has been achieved using N-iodosuccinimide (NIS) in solid state by grinding at room temperature. This method provides several advantages such as short reaction time (5–8 min), high yields (94–99%), and nonhazardous and simple work-up procedure. High gas chromatography (GC) purity (95–99.9%) suggests that the reaction is highly selective. Substrates which are sensitive to oxidation, viz aniline and phenols are iodinated smoothly in high yield.

One-Pot, Regioselective Synthesis of Homopropargyl Alcohols using Propargyl Bromide and Carbonyl Compound by the Mg-mediated Reaction under Solvent-free Conditions

2020 ◽  
Vol 17 (6) ◽  
pp. 438-442
Author(s):  
Xiaofang Ma ◽  
Shunxi Li ◽  
Samrat Devaramani ◽  
Guohu Zhao ◽  
Daqian Xu
Keyword(s):  
Reaction Time ◽  
Organic Synthesis ◽  
Carbonyl Compounds ◽  
Solvent Free ◽  
Propargyl Bromide ◽  
Important Goal ◽  
One Pot ◽  
Short Reaction Time ◽  
Solvent Free Conditions ◽  
Volatile Organic

The elimination of volatile organic solvents in organic synthesis is the most important goal in “Green” chemistry. We report a simple, efficient and facile method for the addition of progargyl bromide to carbonyl compounds using Mg metal as a mediator under solvent-free conditions which could regioselectively generate homopropargyl alcohols efficiently in good to excellent yields. The procedure has advantages such as short reaction time, operationally simple, excellent product yields, high regioselectivity and organic solvent-free.

Visible Light Assisted Hantzsch Reaction: Synthesis of Polycyclic Dihydropyridines

2019 ◽  
Vol 16 (8) ◽  
pp. 676-682
Author(s):  
Ankusab Noorahmadsab Nadaf ◽  
Kalegowda Shivashankar
Keyword(s):  
Reaction Time ◽  
Light Intensity ◽  
Ammonium Acetate ◽  
Low Cost ◽  
Aromatic Aldehydes ◽  
Light Irradiation ◽  
High Yield ◽  
Short Reaction Time ◽  
Green Protocol ◽  
Dihydropyridine Derivatives

The polycyclic dihydropyridine nucleus represents the heterocyclic system of invaluable core motifs with wide applications in chemical, biological and physical properties. Although this kind of compounds have been extensively synthesized by other groups, the synthesis of these compounds under CFL light intensity were not explored. The synthesis of polycyclic dihydropyridine derivatives were achieved through the reaction of 4-hydroxycoumarin, aromatic aldehydes and ammonium acetate under CFL light irradiation conditions. A series of polycyclic dihydropyridine derivatives were prepared under CFL light irradiation conditions with high yield, short reaction time, ambient condition and without the use of catalyst. The results displayed an efficient method for the synthesis of polycyclic dihydropyridine derivatives. Clean profile, short reaction time, low cost and use of CFL light intensity instead of catalyst making it a genuinely green protocol.

Design, Synthesis, Antimicrobial Evaluation and Molecular Modeling Study of New 2-mercaptoimidazoles (Series-III)

2019 ◽  
Vol 16 (5) ◽  
pp. 512-521 ◽  
Author(s):  
Nidhi Rani ◽  
Randhir Singh
Keyword(s):  
Sulfonic Acid ◽  
Docking Study ◽  
Molecular Docking Study ◽  
One Pot ◽  
Design Synthesis ◽  
Toluene Sulfonic Acid ◽  
Antimicrobial Evaluation ◽  
Bacteria And Fungi ◽  
High Yields ◽  
Antimicrobial Potency

Background: A series of novel substituted 2-mercaptoimidazoles was synthesised efficiently and in high yields using one-pot synthesis from m-hydroxyacetophenones. Methods: The structures of the newly synthesized compounds were established, their molecular activity was investigated against some bacteria and fungi were further validated using molecular docking study. Results: Reaction of o-hydroxyphenacylbromide (2) with substituted aniline and KSCN, in the presence of catalyst p-toluene sulfonic acid afforded 4(a-r) in good yield. The structure of compounds (4a-r) was confirmed by IR, NMR and MS. Conclusion: The compounds exhibited excellent antimicrobial potency against the tested microorganism.

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