scholarly journals Giant Cell Arteritis Presenting as Choroidal Infarction

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Nikolaos Kopsachilis ◽  
Maria Pefkianaki ◽  
Anca Marinescu ◽  
Sobha Sivaprasad
Keyword(s):  
Giant Cell Arteritis ◽  
Giant Cell ◽  
Vision Loss ◽  
Retinal Vessel ◽  
Interesting Case ◽  
Vessel Occlusion ◽  
Systemic Complications ◽  
Ocular Manifestations ◽  
Granulomatous Vasculitis ◽  
Choroidal Infarction

Background. Giant cell arteritis (GCA) is a systemic granulomatous vasculitis that affects large- and medium-sized arteries of the head and neck. Ocular manifestations of GCA usually are anterior ischaemic optic neuropathy (AION) or retinal vessel occlusion.Case Report. We report an interesting case of a 70-year-old man who presented with sudden vision loss and choroidal infarction in his left eye. Thorough clinical and paraclinical evaluation revealed an underlying GCA, the treatment of which prevented further vision loss and systemic complications.Conclusion. This is an unusual presentation of choroidal infarction associated with CGA and emphasizes the need of thorough systemic evaluation in patients with choroidal infarction.

scholarly journals Vision Loss in Patients with Giant Cell Arteritis Treated with Tocilizumab

2020 ◽  
Author(s):  
Jennifer Amsler ◽  
Iveta Kysela ◽  
Christoph Tappeiner ◽  
Luca Seitz ◽  
Lisa Christ ◽  
...  
Keyword(s):  
Giant Cell Arteritis ◽  
Giant Cell ◽  
Structural Changes ◽  
Vision Loss ◽  
Treated Patient ◽  
Laboratory Data ◽  
Reactive Protein ◽  
American College Of Rheumatology ◽  
Low Incidence ◽  
Initiation Of Therapy

Abstract Objectives: Giant cell arteritis (GCA) may lead to vision loss. To what extent tocilizumab (TCZ) is able to prevent vision loss is unknown. The aim was to analyze the occurrence of vision loss in a large GCA cohort treated with TCZ.Methods: In this observational monocentric study, GCA patients treated with TCZ between the years 2010 and 2018 were studied. Demographic, clinical and laboratory data were analyzed. Results: A total of 186 patients were included (62% female); 109 (59%) fulfilled the American College of Rheumatology (ACR) criteria, in 123 (66%) patients, large vessel vasculitis was diagnosed in magnetic resonance-angiography (MRA). Cumulative duration of TCZ treatment was 224 years, median treatment duration was 11.1 (IQR 5.6-17.9) months. Glucocorticoids (GC) were tapered over a median of 5.8 (IQR 3.0-8.5) months. At baseline, visual symptoms were present in 70 (38%) and vision loss in 21 (11%) patients. Patients with vision loss at baseline were older (p=0.032), had a lower C-reactive protein (p=0.002), more often cranial symptoms (p<0.001) or jaw claudication (p=0.031) and showed a negative association with MRA of the aorta (p=0.006). Two patients (1.1%) developed vision loss, both at initiation of TCZ treatment.Conclusion: Our data show a very low incidence of vision loss in TCZ-treated patient. The two cases of AION occurred at initiation of therapy, they support the hypothesis that advanced, and established structural changes of arteries are key factors for this accident. Whether shorter duration of concomitant GC treatment is risky regarding vision loss needs to be studied.

Vision Loss From Giant Cell Arteritis in Patients With Other Ocular Diagnoses

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Prem Nichani ◽  
Valérie Biousse ◽  
Nancy J. Newman ◽  
Jonathan A. Micieli
Keyword(s):  
Giant Cell Arteritis ◽  
Giant Cell ◽  
Vision Loss

scholarly journals Evaluating the Incidence of Arteritic Ischemic Optic Neuropathy and Other Causes of Vision Loss from Giant Cell Arteritis

Ophthalmology ◽  
2016 ◽  
Vol 123 (9) ◽  
pp. 1999-2003 ◽  
Author(s):  
John J. Chen ◽  
Jacqueline A. Leavitt ◽  
Chengbo Fang ◽  
Cynthia S. Crowson ◽  
Eric L. Matteson ◽  
...  
Keyword(s):  
Giant Cell Arteritis ◽  
Giant Cell ◽  
Optic Neuropathy ◽  
Vision Loss ◽  
Ischemic Optic Neuropathy

Immunology and ocular manifestations of giant cell arteritis

1997 ◽  
Vol 5 (2) ◽  
pp. 141-146 ◽  
Author(s):  
William T. Barchuk ◽  
Ligaya Centeno ◽  
Larry Frohman ◽  
Leonard Bielory
Keyword(s):  
Giant Cell Arteritis ◽  
Giant Cell ◽  
Ocular Manifestations

scholarly journals Giant Cell Arteritis: From Neurologist’s Perspective

2021 ◽  
Author(s):  
Ravish Rajiv Keni ◽  
M. Sowmya ◽  
Sreekanta Swamy
Keyword(s):  
Giant Cell Arteritis ◽  
Giant Cell ◽  
Visual Loss ◽  
Multidisciplinary Care ◽  
The Elderly ◽  
External Carotid Artery ◽  
Laboratory Evaluation ◽  
High Dose ◽  
Granulomatous Vasculitis ◽  
Dose Corticosteroid

Giant cell arteritis (GCA) is a granulomatous vasculitis affecting large- and medium-sized arteries in the elderly and potentially causes visual loss. In an elderly patient presenting with acute pain in the distribution of the external carotid artery (e.g., headache, scalp tenderness); polymyalgia rhematica; or acute/transient visual loss or diplopia; a possibility of GCA should be considered in one of the differential diagnosis. Urgent laboratory evaluation (e.g., ESR, CRP, platelet count), followed immediately by empiric high-dose corticosteroid therapy is warranted in patients suspected of having GCA. Although ultrasound techniques are sensitive for the diagnosis of GCA, TAB remains the best confirmatory test. Patients with GCA often require long durations of steroid therapy and steroid-related complications are common. Multidisciplinary care and the use of steroid-sparing regimens are warranted in case of relapse.

scholarly journals A typical case of giant cell arteritis with vision loss due to delayed diagnosis

2018 ◽  
Vol 19 (4) ◽  
pp. 139-140
Author(s):  
Ami Watanabe ◽  
Hiroki Isono ◽  
Kaoru Shimada ◽  
Yusuke Chino
Keyword(s):  
Giant Cell Arteritis ◽  
Giant Cell ◽  
Vision Loss ◽  
Delayed Diagnosis ◽  
Typical Case

Treatment of Vision Loss in Giant Cell Arteritis

2011 ◽  
Vol 14 (1) ◽  
pp. 84-92 ◽  
Author(s):  
Ryan A. Scheurer ◽  
Andrew R. Harrison ◽  
Michael S. Lee
Keyword(s):  
Giant Cell Arteritis ◽  
Giant Cell ◽  
Vision Loss

scholarly journals Lyme carditis mimicking giant cell arteritis

2015 ◽  
Vol 7 (1) ◽  
Author(s):  
Krati Chauhan
Keyword(s):  
Giant Cell Arteritis ◽  
Giant Cell ◽  
Temporal Artery ◽  
Interesting Case ◽  
Temporal Artery Biopsy ◽  
Laboratory Findings ◽  
Reactive Protein ◽  
System Disease ◽  
Lyme Carditis

Presenting an interesting case of a patient who complained of myalgias, fatigue, headache, jaw claudication and scalp tenderness. Patient’s physical examination was unremarkable. Laboratory findings showed elevated erythrocyte sedimentation rate and C-reactive protein, bilateral temporal artery biopsy results were negative and first degree atrioventricular block was seen on electrocardiogram. Serology for <em>Borrelia burgdorferi</em> was positive; patient was diagnosed with Lyme carditis and treated with doxycycline. Lyme is a tick-borne, multi-system disease and occasionally its presentation may mimic giant cell arteritis. On follow-up there was complete resolution of symptoms and electrocardiogram findings.

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