scholarly journals Appraisal of theDeqiConcept among Contemporary Chinese Acupuncturists

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Sheng Chen ◽  
Shengnan Guo ◽  
Federico Marmori ◽  
Yanping Wang ◽  
Qi Zhao ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Clinical Research ◽  
Therapeutic Effect ◽  
Traditional Theory ◽  
Acupuncture And Moxibustion ◽  
Depth Analysis ◽  
Key Factor ◽  
Acupuncture Research ◽  
Contemporary Chinese

Deqi, an important component of the traditional theory of acupuncture and moxibustion, is the key factor in determining clinical therapeutic effect of acupuncture. In this paper, based on the digging up, arrangement, and in-depth analysis of the famous contemporary Chinese acupuncturists' perspectives ofdeqi, the authors summarize the concept and manifestation, as well as the properties ofdeqi, and correlativity ofdeqiwith acupuncture manipulation through reviewing modern clinical research. Proposals for more scientific and standardized acupuncture research are introduced to reexamine and restore the implication ofdeqiin combination with the clinical practice.

scholarly journals In Pursuit of an Effective Treatment: the Past, Present and Future of Clinical Trials in Inclusion Body Myositis

2021 ◽  
Author(s):  
A. M. Snedden ◽  
J. B. Lilleker ◽  
H. Chinoy
Keyword(s):  
Clinical Practice ◽  
Effective Treatment ◽  
Inclusion Body ◽  
Therapeutic Effect ◽  
Outcome Measures ◽  
Inclusion Body Myositis ◽  
Cytotoxic T Cells ◽  
Treatment Options ◽  
Trial Methodology ◽  
Short Treatment

Abstract Purpose of review No clinical trial in sporadic inclusion body myositis (IBM) thus far has shown a clear and sustained therapeutic effect. We review previous trial methodology, explore why results have not translated into clinical practice, and suggest improvements for future IBM trials. Recent findings Early trials primarily assessed immunosuppressive medications, with no significant clinical responses observed. Many of these studies had methodological issues, including small participant numbers, nonspecific diagnostic criteria, short treatment and/or assessment periods and insensitive outcome measures. Most recent IBM trials have instead focused on nonimmunosuppressive therapies, but there is mounting evidence supporting a primary autoimmune aetiology, including the discovery of immunosuppression-resistant clones of cytotoxic T cells and anti-CN-1A autoantibodies which could potentially be used to stratify patients into different cohorts. The latest trials have had mixed results. For example, bimagrumab, a myostatin blocker, did not affect the 6-min timed walk distance, whereas sirolimus, a promotor of autophagy, did. Larger studies are planned to evaluate the efficacy of sirolimus and arimoclomol. Summary Thus far, no treatment for IBM has demonstrated a definite therapeutic effect, and effective treatment options in clinical practice are lacking. Trial design and ineffective therapies are likely to have contributed to these failures. Identification of potential therapeutic targets should be followed by future studies using a stratified approach and sensitive and relevant outcome measures.

scholarly journals Construction of the National Brain Tumor Registry of China for better management and more efficient use of data: a protocol

BMJ Open ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. e040055
Author(s):  
Liwei Zhang ◽  
Wang Jia ◽  
Nan Ji ◽  
Deling Li ◽  
Dan Xiao ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Clinical Research ◽  
Brain Tumour ◽  
Brain Tumours ◽  
Benefit Sharing ◽  
Data Quality Control ◽  
Clinical Trial Registry ◽  
Discharge Data ◽  
Tumor Registry ◽  
Depth Analysis

IntroductionBrain tumours encompass a complex group of intracranial tumours that mostly affect young adults and children, with a high incidence rate and poor prognosis. It remains impossible to systematically collect data on patients with brain tumours in China and difficult to perform in-depth analysis on the status of brain tumours, medical outcomes or other important medical issues through a multicentre clinical study. This study describes the first nation-wide data platform including the entire spectrum of brain tumour entities, which will allow better management and more efficient application of patient data in China.Methods and analysisThe National Brain Tumor Registry of China (NBTRC) is a registry of real-word clinical data on brain tumours. It is established and managed by the China National Clinical Research Center for Neurological Diseases and administered by its scientific and executive committees. The 54 participating hospitals of the NBTRC are located in 27 provinces/municipalities, performing more than 40 000 brain tumour surgeries per year. The data consist of in-hospital medical records, images and follow-up information after discharge. Data can be uploaded in three ways: the web portal, remote physical servers and offline software. The data quality control scheme is seven-dimensional. Each participating hospital could focus on a single pathology subtype and public subtypes of brain tumour for which they expect to conduct related multicentre clinical research. The standardised workflow to conduct clinical research is based on the benefit-sharing mechanism. Data collection will be conducted continuously from 1 February 2019 to 31 January 2024.Ethics and disseminationInformed consent will be obtained from all participants. Consent for the adolescents’ participation will be also obtained from their guardians via written consent. The results will be published in professional journals, in both Chinese and English.Trial registration numberChinese Clinical Trial Registry (ChiCTR1900021096).

Confirming neuropathic pain in cancer patients: Applying the NeuPSIG grading system in clinical practice and clinical research

Pain ◽  
2014 ◽  
Vol 155 (5) ◽  
pp. 859-863 ◽  
Author(s):  
Matthew R. Mulvey ◽  
Roman Rolke ◽  
Pål Klepstad ◽  
Augusto Caraceni ◽  
Marie Fallon ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Clinical Practice ◽  
Clinical Research ◽  
Cancer Patients ◽  
Grading System

Exploration of factors leading to successful mediation

2017 ◽  
Vol 28 (1) ◽  
pp. 24-49 ◽  
Author(s):  
Yafei Zhang ◽  
Li Chen
Keyword(s):  
Data Analysis ◽  
Design Methodology ◽  
Information Dissemination ◽  
Gold Medal ◽  
Chinese Society ◽  
Content Type ◽  
Effective Factors ◽  
Key Factor ◽  
Contemporary Chinese

Purpose The purpose of this study is to explore possible factors leading to a successful mediation in Chinese mediation shows. In China, media always play an indispensable role in information dissemination, morality advocacy and policy explanation. Design/methodology/approach This paper employed content analysis of 166 episodes of one representative mediation show, Gold Medal Mediation, and regression technique in data analysis. Findings Results of ordinal regression suggested that “secret talking”, rather than transparency, between disputants had significant influence on successful mediation. Function of mediators is limited in reaching full mediation. The effective factors leading to full mediation include compromise of rights, secret talking, attitude of the observer cohort. It suggests that the role of mediator is limited, rather than being over-exaggerated, in successful mediation. The successful mediation is largely dependent on disputants’ motivations. Additionally, “compromise of rights” by disputants is a key factor in solving disputes. Research limitations/implications Findings of this study revealed the role of Chinese mediation shows in propagating mediation in contemporary Chinese society and supporting upheld morality values. Due to the nature of the chosen mediation show, some disputes take more than one episode to solve. However, this study looks at each episode without considering the integrity of the dispute. That is, if the disputes take two episodes, the coder codes the two episodes as two separate disputes instead of looking at it as one dispute. Originality/value By exploring various aspects of mediations shows, including the role of mediators, disputants and a cohort of observers, this study can both explicitly show predicted factors to successful mediations on the shows, and can implicitly examine the power and perceived justification of mediation in contemporary China via media.

Collaborative Research: Once More Into the Breach

PEDIATRICS ◽  
1988 ◽  
Vol 82 (3) ◽  
pp. 510-511
Author(s):  
EVAN CHARNEY
Keyword(s):  
Clinical Practice ◽  
Clinical Research ◽  
Collaborative Research ◽  
Molecular Level ◽  
Organ System ◽  
Biomedical Science ◽  
Memorial Hospital ◽  
Narrow Focus ◽  
Higher Power ◽  
Practice Based Research

In this issue, Christoffel and associates1 described a new program of practice-based research involving community pediatricians and the Department of Pediatrics at Children's Memorial Hospital in Chicago. In one sense, all clinical research is practice based and has a long and honorable history in medicine. What has changed is that the gap between those who conduct research and those in clinical practice has widened. As the pathophysiology of diseases is better understood, the frontier of biomedical science has moved from the whole patient to the organ system, the cell, and, now, the molecular level. It is as if each generation of researchers has snapped a progressively higher power lens under the microscope, with a deeper but more narrow focus.

Dolutegravir monotherapy: when should clinical practice be clinical research?

2016 ◽  
Vol 22 (2) ◽  
pp. 93-95 ◽  
Author(s):  
Joel Gallant ◽  
Jeremy Sugarman
Keyword(s):  
Clinical Practice ◽  
Clinical Research
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