scholarly journals A Facile Synthesis of Pyrido[2′,3′:3,4]pyrazolo[1,5-a]pyrimidine and Pyrido[2′,3′:3,4]pyrazolo[5,1-c][1,2,4]triazine Bearing a Thiophene Moiety

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Tilal Elsaman ◽  
Mohamed Fares ◽  
Hatem A. Abdel-Aziz ◽  
Mohamed I. Attia ◽  
Hazem A. Ghabbour ◽  
...  
Keyword(s):  
Hydrazine Hydrate ◽  
Diazonium Salt ◽  
Facile Synthesis ◽  
Amine Derivative ◽  
Thiophene Moiety ◽  
Active Methylene

Pyridinone derivative8was synthesized and transformed into the respective chloropyridine9, which was allowed to react with hydrazine hydrate to afford pyrazolo[3,4-b]pyridin-3-amine derivative11. Compound11was used as a key intermediate for a facile synthesis of the title compounds14,15,17,21a,b, and24a–cwhere the reaction of11with some 1,3-dielecrophiles resulted in the formation of pyrido[2′,3′:3,4]pyrazolo[1,5-a]pyrimidines14,15, and17, whereas diazotization of compound11gave the respective diazonium salt18which was coupled with some active methylene-containing compounds to give the corresponding hydrazones19a,band22a–c. Cyclization of the latter hydrazones yielded the pyrido[2′,3′:3,4]pyrazolo[5,1-c][1,2,4]triazines21a,band24a–c, respectively.

Synthesis of some new pyrazolo[1,5-a]pyrimidine and pyrazolo[1,5-c]-as-triazine derivatives

1986 ◽  
Vol 51 (10) ◽  
pp. 2193-2198 ◽  
Author(s):  
Abdel Ghani A. Elagamey ◽  
Fathy M. A. El-Taweel ◽  
F. A. Amer
Keyword(s):  
Hydrazine Hydrate ◽  
Diazonium Salt ◽  
Triazine Derivatives ◽  
Active Methylene

Several new pyrazolo[1,5-a]pyrimidine and pyrazolo[1,5-c]-as-triazine derivatives were synthesized via the reaction of 3-antipyrinyl-5-aminopyrazole or its diazonium salt with enaminonitriles, enaminoesters and active methylene reagents. The action of hydrazine hydrate on the obtained polyfunctional products was also studied.

Amino Acid Derivatives in Organic Synthesis, Part 4 [1]: Facile Synthesis of Heterocycles Containing a Glycine Residue

2000 ◽  
Vol 55 (1) ◽  
pp. 104-108 ◽  
Author(s):  
Laila M. Chabaka ◽  
Yehia A. Allam ◽  
Galal A. M. Nawwar
Keyword(s):  
Amino Acid ◽  
Organic Synthesis ◽  
Acid Group ◽  
The Other ◽  
Amino Acid Derivatives ◽  
Carboxylic Acid Group ◽  
Facile Synthesis ◽  
Peptide Linkage ◽  
Active Methylene Compounds ◽  
Active Methylene

Pyridines, thiazolopyridines and pyrazolopyrans containing glycinate residue were prepared by reacting N-cyanoacryloglycinate ylidenes with active methylene compounds via a Michael addition - intracyclization synthetic pathway.Simple routes for the synthesis of heterocycles with an amino acid residue were previously reported [1-3] as the incorportation of these residues improves the pharmacokinetics and toxicity of active compounds [4,5]. However, trials to deesterify these residues for coupling purposes were unsuccessful. So, we tried herein new approaches for synthesizing heterocyles carrying one or two glycine moieties with free carboxylic acid group to facilitate further peptide linkage [6] on one hand and on the other one could be able to form metal chelates, a property having a significant output on the toxicological behaviour [7]

Facile synthesis of tremelliform Co0.85Se nanosheets: An efficient catalyst for the decomposition of hydrazine hydrate

2012 ◽  
Vol 119-120 ◽  
pp. 139-145 ◽  
Author(s):  
Cheng-Cheng Liu ◽  
Ji-Ming Song ◽  
Jing-Feng Zhao ◽  
Hua-Jun Li ◽  
Hai-Sheng Qian ◽  
...  
Keyword(s):  
Hydrazine Hydrate ◽  
Facile Synthesis ◽  
Efficient Catalyst

A Facile Synthesis of Fluorine-Containing 1,7-Phenanthrolines by the Cyclization of N-Propargyl-6,8-bis(trifluoroacetyl)quinolin-5-amine with Various Active Methylene Compounds

Heterocycles ◽  
2010 ◽  
Vol 82 (1) ◽  
pp. 803 ◽  
Author(s):  
Etsuji Okada ◽  
Dai Shibata ◽  
Ayaka Sakai ◽  
Mizuki Hatakenaka ◽  
Shohei Saikawa ◽  
...  
Keyword(s):  
Facile Synthesis ◽  
Active Methylene Compounds ◽  
Active Methylene

Facile synthesis of graphene sheets from fluorinated graphite

RSC Advances ◽  
2015 ◽  
Vol 5 (50) ◽  
pp. 40148-40153 ◽  
Author(s):  
Li Chen ◽  
Jiaojiao Lei ◽  
Fuhui Wang ◽  
Guochao Wang ◽  
Huixia Feng
Keyword(s):  
Hydrazine Hydrate ◽  
Graphene Sheets ◽  
Facile Synthesis ◽  
Fluorinated Graphite ◽  
Chemical Exfoliation

The chemical exfoliation of FGi by hydrazine hydrate to create graphene sheets.

A Facile Synthesis and Reactions of Some Novel Pyrazole-based Heterocycles

2019 ◽  
Vol 16 (3) ◽  
pp. 405-412 ◽  
Author(s):  
Ahmed A.O. Abeed ◽  
Talaat I. El-Emary ◽  
Mohamed S.K. Youssef
Keyword(s):  
1H Nmr ◽  
High Performance ◽  
Nmr Spectra ◽  
Melting Points ◽  
Facile Synthesis ◽  
Direct Titration ◽  
Elemental Analyses ◽  
Ft Ir ◽  
Active Methylene ◽  
Pyrazoline Derivative

<p>Aim and Objective: This work presents the synthetic capability and the exploitation of 1,3-diphenyl- 1H-pyrazole-4-carboxladehyde 1 and 5-diphenyl pyrazolyl-2-pyrazoline analogue 8 to serve as excellent precursors for the synthesis of substituted indol-2,3-dione, trizolo[3,4-a]benzazoles, thiazolo[2,3- a]benzimidazole-3-one, substituted 2-pyrazoline and pyrazole-substituted-pyrazolines using various reagents. </P><P> Materials and Methods: Using chemicals from Aldrich, Fluka, or Merck, and pure solvents, we apply the synthetic procedures for the synthesis of novel heterocycles. The melting points of these compounds were determined using APP. Digital ST 15 melting point apparatus. SP3-100 spectrophotometer recorded FT-IR spectra (KBr) (cm-1). NMR spectra (&#948;, ppm) were recorded on 400 MHz AVANCE-III High-Performance FT-NMR Spectrometer BRUCKER (Switzerland) and some 1H NMR spectra were recorded on Varian EM-360L NMR Spectrophotometer (90 MHz) (USA) in CDCl3 or DMSO-d6 as a solvent. Elemental analyses were carried out at a Vario EL C, H, N, and S Analyzer. Bromine was determined using direct titration method after carius combustion. </P><P> Results: The structures of the compounds were confirmed by IR, 1H NMR, 13C NMR, and elemental analyses. </P><P> Conclusion: 1,3-Diphenyl-1H-pyrazole-4-carboxladehyde 1 and 2-pyrazoline derivative 9 confirmed their importance in the synthetic organic chemistry. Depending on the formyl group of aldehyde 1 and active methylene of pyrazoline 8, we synthesized new series of heterocycles; indol-2,3-dione, trizolo[3,4-a]benzazole, thiazolo[2,3-a]benzimidazole-3-one and pyrazolyl-pyrazoline derivatives expecting their pharmacological applications. The targeted compounds were substantiated from its spectral data.</p>

Reactions of ferrocenyl chalcones with hydrazines and active methylene compounds

2016 ◽  
Vol 22 (2) ◽  
pp. 69-77 ◽  
Author(s):  
Marwa El-Hussieny ◽  
Hisham Abdallah A. Yosef ◽  
Mohamed R.H. Mahran ◽  
Nabila M. Ibrahim
Keyword(s):  
Hydrazine Hydrate ◽  
Reaction Mechanisms ◽  
Ethyl Acetoacetate ◽  
New Products ◽  
Ethyl Cyanoacetate ◽  
Spectroscopic Methods ◽  
Phenyl Hydrazine ◽  
Active Methylene Compounds ◽  
Ferrocenyl Chalcones ◽  
Active Methylene

AbstractClaisen-Schmidt condensation of ferrocenecarboxaldehyde (2b) with 2-acetylfuran (4) yielded (E)-3-ferrocenyl-1-(2-furyl)prop-2-en-1-one (E-5) together with 1,5-di(2-furyl)-3-ferrocenylpentane-1,5-dione (6). Reactions of the ferrocenyl chalcones 3a,b and 5 with hydrazine hydrate, phenyl hydrazine, ethyl acetoacetate, ethyl cyanoacetate and malononitrile, were also studied. Possible reaction mechanisms were discussed and structures of the new products were unambiguously characterized by common analytical and spectroscopic methods.

scholarly journals A new and facile synthetic approach to substituted 2-thioxoquinazolin-4-ones by the annulation of a pyrimidine derivative

2010 ◽  
Vol 6 ◽  
pp. 1056-1060 ◽  
Author(s):  
Nimalini Devi Moirangthem ◽  
Warjeet Singh Laitonjam
Keyword(s):  
Ethyl Cyanoacetate ◽  
Pyrimidine Derivative ◽  
Synthetic Approach ◽  
Facile Synthesis ◽  
Benzenoid System ◽  
Active Methylene Compounds ◽  
Pyrimidine Moiety ◽  
Derivatives Of ◽  
Active Methylene

A new and facile synthesis of 2-thioxoquinazolin-4-ones by introducing a benzenoid system in the pyrimidine moiety by reacting ethoxymethylene derivatives of 1,3-diarylthiobarbituric acids (DTBA) with active methylene compounds, such as malononitrile and ethyl cyanoacetate, in presence of ZnCl2 has been developed.

Sign in / Sign up

Export Citation Format

Share Document