A Facile Synthesis of Fluorine-Containing 1,7-Phenanthrolines by the Cyclization of N-Propargyl-6,8-bis(trifluoroacetyl)quinolin-5-amine with Various Active Methylene Compounds

Heterocycles ◽  
2010 ◽  
Vol 82 (1) ◽  
pp. 803 ◽  
Author(s):  
Etsuji Okada ◽  
Dai Shibata ◽  
Ayaka Sakai ◽  
Mizuki Hatakenaka ◽  
Shohei Saikawa ◽  
...  
Keyword(s):  
Facile Synthesis ◽  
Active Methylene Compounds ◽  
Active Methylene

Amino Acid Derivatives in Organic Synthesis, Part 4 [1]: Facile Synthesis of Heterocycles Containing a Glycine Residue

2000 ◽  
Vol 55 (1) ◽  
pp. 104-108 ◽  
Author(s):  
Laila M. Chabaka ◽  
Yehia A. Allam ◽  
Galal A. M. Nawwar
Keyword(s):  
Amino Acid ◽  
Organic Synthesis ◽  
Acid Group ◽  
The Other ◽  
Amino Acid Derivatives ◽  
Carboxylic Acid Group ◽  
Facile Synthesis ◽  
Peptide Linkage ◽  
Active Methylene Compounds ◽  
Active Methylene

Pyridines, thiazolopyridines and pyrazolopyrans containing glycinate residue were prepared by reacting N-cyanoacryloglycinate ylidenes with active methylene compounds via a Michael addition - intracyclization synthetic pathway.Simple routes for the synthesis of heterocycles with an amino acid residue were previously reported [1-3] as the incorportation of these residues improves the pharmacokinetics and toxicity of active compounds [4,5]. However, trials to deesterify these residues for coupling purposes were unsuccessful. So, we tried herein new approaches for synthesizing heterocyles carrying one or two glycine moieties with free carboxylic acid group to facilitate further peptide linkage [6] on one hand and on the other one could be able to form metal chelates, a property having a significant output on the toxicological behaviour [7]

scholarly journals A new and facile synthetic approach to substituted 2-thioxoquinazolin-4-ones by the annulation of a pyrimidine derivative

2010 ◽  
Vol 6 ◽  
pp. 1056-1060 ◽  
Author(s):  
Nimalini Devi Moirangthem ◽  
Warjeet Singh Laitonjam
Keyword(s):  
Ethyl Cyanoacetate ◽  
Pyrimidine Derivative ◽  
Synthetic Approach ◽  
Facile Synthesis ◽  
Benzenoid System ◽  
Active Methylene Compounds ◽  
Pyrimidine Moiety ◽  
Derivatives Of ◽  
Active Methylene

A new and facile synthesis of 2-thioxoquinazolin-4-ones by introducing a benzenoid system in the pyrimidine moiety by reacting ethoxymethylene derivatives of 1,3-diarylthiobarbituric acids (DTBA) with active methylene compounds, such as malononitrile and ethyl cyanoacetate, in presence of ZnCl2 has been developed.

A solvent free approach for Knoevenagel condensation: facile synthesis of 3-cyano and 3-carbethoxycoumarins

2014 ◽  
Vol 3 (3) ◽  
Author(s):  
Suresh Kumar
Keyword(s):  
Knoevenagel Condensation ◽  
Aromatic Aldehydes ◽  
Solvent Free ◽  
Efficient Synthesis ◽  
Facile Synthesis ◽  
Basic Alumina ◽  
Active Methylene Compounds ◽  
Active Methylene

AbstractA simple, efficient and solvent free approach for the Knoevenagel condensation has been developed which involves grinding of active methylene compounds with aromatic aldehydes over basic alumina. Using this solvent free Knoevenagel approach, a facile and efficient synthesis of 3-cyano and 3-carbethoxycoumarins has also been developed, which involves the grinding of 2-hydroxybenzaldehydes with malononitrile or ethylcyanoacetate respectively over basic alumina followed by grinding with p-toluenesulphonic acid (PTSA) in the same mortar.

A γ-Fluoro β-Acetoxypropyl Sulfonium Salt as an Equivalent of a (Fluoromethyl)vinyl Sulfonium Salt: Reagent for the Facile Synthesis of Monofluoromethylated Cyclopropanes or Aziridines

Synlett ◽  
2018 ◽  
Vol 29 (18) ◽  
pp. 2372-2376 ◽  
Author(s):  
Takeshi Hanamoto ◽  
Yuuri Fujiwara ◽  
Ryuhei Muta ◽  
Keiichi Sato ◽  
Hiroaki Haramura ◽  
...  
Keyword(s):  
Organic Compounds ◽  
Easy Access ◽  
Facile Synthesis ◽  
Sulfonium Salt ◽  
Active Methylene Compounds ◽  
Active Methylene

A β-monofluoromethylated vinyl sulfonium salt, prepared in situ from a precursor γ-fluoro β-acetoxypropyl sulfonium salt under mild basic conditions, reacted with a lvariety of active methylene compounds or a primary sulfone amide under basic conditions to provide the corresponding monofluoromethylated three-membered rings in good-to-excellent yields. This new sulfonium reagent should permit easy access to a variety of important monofluoromethylated organic compounds.

A Facile Synthesis of 3H-Benzo[1,2]Dithiole-3-Thiones and Their Condensation with Active Methylene Compounds

2011 ◽  
Vol 186 (12) ◽  
pp. 2341-2349 ◽  
Author(s):  
Hongwei Jin ◽  
Dong Jiang ◽  
Jianrong Gao ◽  
Genrong Qiang ◽  
Yuan Gong
Keyword(s):  
Facile Synthesis ◽  
Active Methylene Compounds ◽  
Active Methylene
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