scholarly journals Effects of Laser Acupuncture on Longitudinal Bone Growth in Adolescent Rats

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Mijung Yeom ◽  
Sung-Hun Kim ◽  
Bina Lee ◽  
Xiuyu Zhang ◽  
Hyangsook Lee ◽  
...  
Keyword(s):  
Growth Rate ◽  
Growth Plate ◽  
Bone Growth ◽  
Growth Potential ◽  
Male Rats ◽  
Adolescent Male ◽  
Laser Acupuncture ◽  
Longitudinal Bone Growth ◽  
Level Laser ◽  
Adolescent Rats

Longitudinal bone growth is the results of chondrocyte proliferation and hypertrophy and subsequent endochondral ossification in the growth plate. Recently, laser acupuncture (LA), an intervention to stimulate acupoint with low-level laser irradiation, has been suggested as an intervention to improve the longitudinal bone growth. This study investigated the effects of laser acupuncture on growth, particularly longitudinal bone growth in adolescent male rats. Laser acupuncture was performed once every other day for a total of 9 treatments over 18 days to adolescent male rats. Morphometry of the growth plate, longitudinal bone growth rate, and the protein expression of BMP-2 and IGF-1 in growth plate were observed. The bone growth rate and the heights of growth plates were significantly increased by laser acupuncture. BMP-2 but not IGF-1 immunostaining in growth plate was increased as well. In conclusion, LA promotes longitudinal bone growth in adolescent rats, suggesting that laser acupuncture may be a promising intervention for improving the growth potential for children and adolescents.

scholarly journals Comparison of the Effect of Velvet Antler from Different Sections on Longitudinal Bone Growth of Adolescent Rats

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Hye Kyung Kim ◽  
Myung-Gyou Kim ◽  
Kang-Hyun Leem
Keyword(s):  
Growth Plate ◽  
Bone Growth ◽  
In Vitro Study ◽  
Vitro Study ◽  
Longitudinal Bone Growth ◽  
Growing Rats ◽  
Velvet Antler ◽  
Adolescent Rats

The aim of this study was to compare the effectiveness of velvet antler (VA) from different sections for promoting longitudinal bone growth in growing rats. VA was divided into upper (VAU), middle (VAM), and basal sections (VAB). An in vivo study was performed to examine the effect on longitudinal bone growth in adolescent rats. In addition, in vitro osteogenic activities were examined using osteoblastic MG-63 cells. VA promoted longitudinal bone growth and height of the growth plate in adolescent rats. Bone morphogenetic protein-2 (BMP-2) in growth plate of VA group was highly expressed compared with control. The anabolic effect of VA on bone was further supported by in vitro study. VA enhanced the proliferation, differentiation, and mineralization of MG-63 cells. The mRNA expressions of osteogenic genes such as collagen, alkaline phosphatase, and osteocalcin were increased by VA treatment. These effects of in vivo and in vitro study were decreased from upper to basal sections of VA. In conclusion, VA treatment promotes longitudinal bone growth in growing rats through enhanced BMP-2 expression, osteogenic activities, and bone matrix gene expressions. In addition, present study provides evidence for the regional differences in the effectiveness of velvet antler for longitudinal bone growth.

scholarly journals Effects of Egg Yolk Proteins on the Longitudinal Bone Growth of Adolescent Male Rats

2004 ◽  
Vol 68 (11) ◽  
pp. 2388-2390 ◽  
Author(s):  
Kang-Hyun LEEM ◽  
Myung-Gyou KIM ◽  
Hyun-Mi KIM ◽  
Mujo KIM ◽  
Young-Ja LEE ◽  
...  
Keyword(s):  
Bone Growth ◽  
Egg Yolk ◽  
Male Rats ◽  
Adolescent Male ◽  
Yolk Proteins ◽  
Longitudinal Bone Growth

Effects of Jaoga-Yukmiwon®, a Korean herbal medicine, on chondrocyte proliferation and longitudinal bone growth in adolescent male rats

2003 ◽  
Vol 17 (9) ◽  
pp. 1113-1116 ◽  
Author(s):  
K. Leem ◽  
S. Y. Park ◽  
D. H. Lee ◽  
Y. M. Boo ◽  
K. H. Cho ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Bone Growth ◽  
Male Rats ◽  
Adolescent Male ◽  
Chondrocyte Proliferation ◽  
Longitudinal Bone Growth

Effects of Amomum villosum on longitudinal bone growth in adolescent rats

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
JY Kim ◽  
SH Lee ◽  
J Park ◽  
MY Kim ◽  
GT Chang ◽  
...  
Keyword(s):  
Bone Growth ◽  
Longitudinal Bone Growth ◽  
Adolescent Rats ◽  
Amomum Villosum

scholarly journals Catch-Up Growth after Hypothyroidism Is Caused by Delayed Growth Plate Senescence

Endocrinology ◽  
2008 ◽  
Vol 149 (4) ◽  
pp. 1820-1828 ◽  
Author(s):  
Rose Marino ◽  
Anita Hegde ◽  
Kevin M. Barnes ◽  
Lenneke Schrier ◽  
Joyce A. Emons ◽  
...  
Keyword(s):  
Growth Rate ◽  
Growth Inhibition ◽  
Growth Plate ◽  
Bone Growth ◽  
Structural Characteristics ◽  
Linear Growth Rate ◽  
Growth Plate Chondrocytes ◽  
Growth Plates ◽  
Catch Up ◽  
Growth Inhibiting

Catch-up growth is defined as a linear growth rate greater than expected for age after a period of growth inhibition. We hypothesized that catch-up growth occurs because growth-inhibiting conditions conserve the limited proliferative capacity of growth plate chondrocytes, thus slowing the normal process of growth plate senescence. When the growth-inhibiting condition resolves, the growth plates are less senescent and therefore grow more rapidly than normal for age. To test this hypothesis, we administered propylthiouracil to newborn rats for 8 wk to induce hypothyroidism and then stopped the propylthiouracil to allow catch-up growth. In untreated controls, the growth plates underwent progressive, senescent changes in multiple functional and structural characteristics. We also identified genes that showed large changes in mRNA expression in growth plate and used these changes as molecular markers of senescence. In treated animals, after stopping propylthiouracil, these functional, structural, and molecular senescent changes were delayed, compared with controls. This delayed senescence included a delayed decline in longitudinal growth rate, resulting in catch-up growth. The findings demonstrate that growth inhibition due to hypothyroidism slows the developmental program of growth plate senescence, including the normal decline in the rate of longitudinal bone growth, thus accounting for catch-up growth.

Sites of action of testosterone and estradiol on longitudinal bone growth

1983 ◽  
Vol 244 (2) ◽  
pp. E135-E140 ◽  
Author(s):  
J. O. Jansson ◽  
S. Eden ◽  
O. Isaksson
Keyword(s):  
Replacement Therapy ◽  
Bone Growth ◽  
Body Weight Gain ◽  
Inhibitory Effect ◽  
Body Growth ◽  
Female Rats ◽  
Male Rats ◽  
Longitudinal Bone Growth ◽  
Sites Of Action ◽  
Different Doses

In this study the mechanisms by which sex steroids influence body growth were investigated. The effect of different doses of testosterone propionate on longitudinal bone growth and body weight gain was studied in a) gonadectomized male rats, b) gonadohypophysectomized male rats, and c) gonadohypophysectomized male rats given replacement therapy with bovine growth hormone (bGH). The effect of different doses of estradiol benzoate on the same growth parameters was studied in female rats divided into the same experimental groups as the males. Accumulated longitudinal bone growth was determined using oxytetracycline as an intravital marker. Testosterone caused a dose-dependent increase in longitudinal bone growth in gonadectomized male rats. In contrast, testosterone exerted no significant increase in longitudinal bone growth in gonadohypophysectomized male rats with and without bGH replacement therapy. Treatment with estrogen inhibited longitudinal bone growth and body weight gain. The inhibitory effect of estradiol was approximately the same in gonadohypophysectomized female rats given bGH replacement therapy as in gonadectomized female rats. The results suggest that testosterone exerts its stimulatory effect on body growth mainly by modulating hypothalamopituitary functions, e.g., by altering the secretory pattern of GH. On the other hand, it seems that changes in the hypothalamopituitary functions are less significant for the inhibitory effect of estradiol on body growth. It is concluded from this study that the sites of action for estrogen and testosterone in modulating body growth in the rat are different.

Fluoride Inhibits Longitudinal Bone Growth by Acting Directly at the Growth Plate in Cultured Neonatal Rat Metatarsal Bones

2019 ◽  
Vol 197 (2) ◽  
pp. 522-532 ◽  
Author(s):  
Rui Ma ◽  
Shuang Liu ◽  
Tingting Qiao ◽  
Demin Li ◽  
Ruixue Zhang ◽  
...  
Keyword(s):  
Growth Plate ◽  
Bone Growth ◽  
Neonatal Rat ◽  
Longitudinal Bone Growth ◽  
Metatarsal Bones
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