scholarly journals Human Polyomavirus Reactivation: Disease Pathogenesis and Treatment Approaches

2013 ◽  
Vol 2013 ◽  
pp. 1-27 ◽  
Author(s):  
Cillian F. De Gascun ◽  
Michael J. Carr
Keyword(s):  
Immunocompromised Patient ◽  
Immunocompromised Host ◽  
Therapeutic Options ◽  
Human Polyomavirus ◽  
Host Immune System ◽  
New Members ◽  
Disease Aetiology ◽  
The Relationship ◽  
Over 40 Years ◽  
Human Polyomaviruses

JC and BK polyomaviruses were discovered over 40 years ago and have become increasingly prevalent causes of morbidity and mortality in a variety of distinct, immunocompromised patient cohorts. The recent discoveries of eight new members of thePolyomaviridaefamily that are capable of infecting humans suggest that there are more to be discovered and raise the possibility that they may play a more significant role in human disease than previously understood. In spite of this, there remains a dearth of specific therapeutic options for human polyomavirus infections and an incomplete understanding of the relationship between the virus and the host immune system. This review summarises the human polyomaviruses with particular emphasis on pathogenesis in those directly implicated in disease aetiology and the therapeutic options available for treatment in the immunocompromised host.

scholarly journals Review on the Relationship between Human Polyomaviruses-Associated Tumors and Host Immune System

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Serena Delbue ◽  
Manola Comar ◽  
Pasquale Ferrante
Keyword(s):  
Immune Response ◽  
Immune System ◽  
Human Population ◽  
Host Immune System ◽  
Dna Viruses ◽  
Human Host ◽  
Immunosuppressed Patients ◽  
The Relationship ◽  
Associated Tumors ◽  
Human Polyomaviruses

The polyomaviruses are small DNA viruses that can establish latency in the human host. The name polyomavirus is derived from the Greek rootspoly-, which means “many,” and -oma, which means “tumours.” These viruses were originally isolated in mouse (mPyV) and in monkey (SV40). In 1971, the first human polyomaviruses BK and JC were isolated and subsequently demonstrated to be ubiquitous in the human population. To date, at least nine members of thePolyomaviridaefamily have been identified, some of them playing an etiological role in malignancies in immunosuppressed patients. Here, we describe the biology of human polyomaviruses, their nonmalignant and malignant potentials ability, and their relationship with the host immune response.

Organizational Conditions Affecting Withdrawal Intentions and Decisions as Moderated by Work Experience

1980 ◽  
Vol 46 (3_suppl) ◽  
pp. 1223-1231 ◽  
Author(s):  
James M. La Rocco ◽  
Allan P. Jones
Keyword(s):  
Work Experience ◽  
Active Duty ◽  
New Members ◽  
Organizational Conditions ◽  
Situational Characteristics ◽  
Initial Expectation ◽  
Withdrawal Decision ◽  
One Year ◽  
The Impact ◽  
The Relationship

Numerous studies of withdrawal from work organizations have considered demographic and other personal history characteristics of leavers. Relatively few of these studies have incorporated dynamic situational characteristics in their designs. In the present effort, the relationship between perceived characteristics of the work environment and stated intentions to reenlist were examined for two groups of first-term Navy enlistees: 198 with less than one year of active duty and less than six months of sea duty, and 516 personnel with more than one year of active duty and more than six months of sea time. It was hypothesized that: (a) the relationship between organizational conditions and intent to reenlist would be weaker for new members than for experienced men, (b) that new personnel would be most likely to change their intentions over time, and (c) that new personnel would quickly assimilate the beliefs, values, and perspectives of their more experienced co-workers. Hypothesis 1 was not supported although the pattern of relationships was in the predicted direction. Hypotheses 2 and 3 were supported. The authors discuss the need for research which emphasizes the impact of initial expectation and organizational socialization on the withdrawal decision process.

scholarly journals Characterization of T Antigens, Including Middle T and Alternative T, Expressed by the Human Polyomavirus Associated with Trichodysplasia Spinulosa

2015 ◽  
Vol 89 (18) ◽  
pp. 9427-9439 ◽  
Author(s):  
Els van der Meijden ◽  
Siamaque Kazem ◽  
Christina A. Dargel ◽  
Nick van Vuren ◽  
Paul J. Hensbergen ◽  
...  
Keyword(s):  
Expression Pattern ◽  
T Antigen ◽  
Productive Infection ◽  
Human Polyomavirus ◽  
T Antigens ◽  
Viral Oncoprotein ◽  
Early Region ◽  
Alternative Mrna Splicing ◽  
Donor And Acceptor ◽  
Human Polyomaviruses

ABSTRACTThe polyomavirus tumor (T) antigens play crucial roles in viral replication, transcription, and cellular transformation. They are encoded by partially overlapping open reading frames (ORFs) located in the early region through alternative mRNA splicing. The T expression pattern of the trichodysplasia spinulosa-associated polyomavirus (TSPyV) has not been established yet, hampering further study of its pathogenic mechanisms and taxonomic relationship. Here, we characterized TSPyV T antigen expression in human cell lines transfected with the TSPyV early region. Sequencing of T antigen-encoded reverse transcription-PCR (RT-PCR) products revealed three splice donor and acceptor sites creating six mRNA splice products that potentially encode the antigens small T (ST), middle T (MT), large T (LT), tiny T, 21kT, and alternative T (ALTO). Except for 21kT, these splice products were also detected in skin of TSPyV-infected patients. At least three splice products were confirmed by Northern blotting, likely encoding LT, MT, ST, 21kT, and ALTO. Protein expression was demonstrated for LT, ALTO, and possibly MT, with LT detected in the nucleus and ALTO in the cytoplasm of transfected cells. Splice site and start codon mutations indicated that ALTO is encoded by the same splice product that encodes LT and uses internal start codons for initiation. The genuineness of ALTO was indicated by the identification of acetylated N-terminal ALTO peptides by mass spectrometry. Summarizing, TSPyV exhibits an expression pattern characterized by both MT and ALTO expression, combining features of rodent and human polyomaviruses. This unique expression pattern provides important leads for further study of polyomavirus-related disease and for an understanding of polyomavirus evolution.IMPORTANCEThe human trichodysplasia spinulosa-associated polyomavirus (TSPyV) is distinguished among polyomaviruses for combining productive infection with cell-transforming properties. In the research presented here, we further substantiate this unique position by indicating expression of both middle T antigen (MT) and alternative T antigen (ALTO) in TSPyV. So far, none of the human polyomaviruses was shown to express MT, which is considered the most important viral oncoprotein of rodent polyomaviruses. Coexpression of ALTO and MT, which involves a conserved, recently recognized overlapping ORF subject to positive selection, has not been observed before for any polyomavirus. As a result of our findings, this study provides valuable new insights into polyomavirus T gene use and expression. Obviously, these insights will be instrumental in further study and gaining an understanding of TSPyV pathogenicity. More importantly, however, they provide important leads with regard to the interrelationship, functionality, and evolution of polyomaviruses as a whole, indicating that TSPyV is a suitable model virus to study these entities further.

Spiritual Well-Being and Marital Adjustment

1988 ◽  
Vol 16 (2) ◽  
pp. 153-158 ◽  
Author(s):  
Patricia D. Roth
Keyword(s):  
Religious Orientation ◽  
Marital Adjustment ◽  
Well Being ◽  
Dyadic Adjustment ◽  
Scale Scores ◽  
Spiritual Well Being ◽  
Married Individuals ◽  
Relationship Of ◽  
The Relationship ◽  
Over 40 Years

This pilot study investigated the relationship of spiritual well-being (defined here as a well-integrated internal religious orientation) to marital adjustment. The subscale dimensions of satisfaction, cohesion, consensus, and affectual expression were used as indicators of adjustment as measured by Spanier's (1976) Dyadic Adjustment Scale. These scale scores were correlated with the religious, existential, and spiritual well-being scores from Paloutzian & Ellison's (1982) Spiritual Well-Being Scale. Subjects were 147 married individuals from churches in Southern California. Responses indicated that spiritual well-being correlated significantly to marital adjustment, with significant differences for years married: Those married 10–40 years showed a higher correlation than those married over 40 years. Existential well-being scores correlated highly with marital adjustment scores at most marital stages. This provides some support for the hypothesis that lived-out spirituality is an important factor in perception of marital happiness.

scholarly journals Nicholas John Seymour Mackintosh. 9 July 1935—8 February 2015

2018 ◽  
Vol 64 ◽  
pp. 299-316 ◽  
Author(s):  
John M. Pearce
Keyword(s):  
Formal Theory ◽  
Human Intelligence ◽  
Theoretical Context ◽  
Experimental Psychologist ◽  
Wide Range ◽  
To Come ◽  
Learning And Cognition ◽  
The Relationship ◽  
Over 40 Years

Nicholas Mackintosh was an experimental psychologist whose principal goal was to understand the basic mechanisms of learning and cognition, largely through research with animals. The two textbooks that he wrote on this topic synthesized a vast body of research and set it within a theoretical context of association formation that has remained dominant for over 40 years. He developed a formal theory of the relationship between attention and learning that had an immediate impact and can be expected to be the foremost theory of its kind for many years to come. He was also a prolific experimenter, whose ingenious experiments were remarkable for the theoretical insights they offered into the mechanisms of learning in a wide range of species. Towards the end of his career, he developed an interest in the measurement of human intelligence. The textbook that followed from this interest is one of the most authoritative ever written on the topic.

scholarly journals Age-Specific Seroprevalences of Merkel Cell Polyomavirus, Human Polyomaviruses 6, 7, and 9, and Trichodysplasia Spinulosa-Associated Polyomavirus

2013 ◽  
Vol 20 (3) ◽  
pp. 363-368 ◽  
Author(s):  
Jérôme T. J. Nicol ◽  
Rémy Robinot ◽  
Audrey Carpentier ◽  
Giovanni Carandina ◽  
Elisa Mazzoni ◽  
...  
Keyword(s):  
Merkel Cell Polyomavirus ◽  
Human Polyomavirus ◽  
Merkel Cell ◽  
High Antibody ◽  
Specific Antibodies ◽  
Virus Like Particle ◽  
Antibody Titers ◽  
Immunosorbent Assays ◽  
Human Polyomaviruses

ABSTRACTSix new human polyomaviruses have been identified since 2008 (Merkel cell polyomavirus [MCPyV], human polyomavirus 6 [HPyV6], HPyV7, HPyV9, trichodysplasia spinulosa polyomavirus [TSPyV], and Malawi polyomavirus [MWPyV]). The presence of specific antibodies against MCPyV, HPyV6, HPyV7, HPyV9, and TSPyV in 828 Italian subjects aged 1 to 100 years was investigated by virus-like particle-based enzyme-linked immunosorbent assays (ELISAs). The findings indicate that all of these new polyomaviruses circulate widely in humans, with seroprevalences in adulthood ranging from 39.4% for HPyV9 to 87.1% for MCPyV, and that primary exposure is most intense in childhood, with the exception of HPyV7 and HPyV9, for which the seroprevalence increased throughout life. The proportion of subjects with high antibody titers was found to increase with age for MCPyV and to decrease with age for TSPyV.

Antimicrobial stewardship in the immunocompromised patient

2016 ◽  
Author(s):  
Haifa Lyster
Keyword(s):  
Antimicrobial Stewardship ◽  
Antimicrobial Agents ◽  
Immunocompromised Patient ◽  
Immunocompromised Host ◽  
Mechanisms Of Action ◽  
Antimicrobial Use ◽  
Risk Of Infection ◽  
Invasive Procedures ◽  
Diagnostic Uncertainty ◽  
Hospital Environments

Immunocompromised patients are at a high risk of infection with resistant organisms due to their increased exposure to hospital environments, including the intensive care unit, their frequent need for invasive procedures, and increased antimicrobial use. To limit this growing trend, and due to the paucity of development of new antimicrobial agents with novel mechanisms of action, the judicious use of the agents currently available should be encouraged. A broad spectrum of possible infections combined with the diagnostic uncertainty, clinical condition, and the specialist teams’ perceptions make antimicrobial stewardship very difficult. However, evidence presented in this chapter illustrates how stewardship in the immunocompromised host may be achieved.

Liberal hospitality

The Athenaeum ◽  
2020 ◽  
pp. 133-156
Author(s):  
Michael Wheeler
Keyword(s):  
Public Life ◽  
The Political ◽  
Science Literature ◽  
Religion And Science ◽  
New Members ◽  
The Public ◽  
The Arts ◽  
Wide Range ◽  
The Relationship ◽  
Social Backgrounds

This chapter assesses the Athenæum's 'hospitality' towards a wide range of ideologies and social backgrounds among candidates and members. Non-partisan politically, it accommodated both sides in the Reform debates of the 1830s, with members engaging in pamphlet wars rather than calling for resignations, as happened at the political clubs. Similarly, the pattern of early Rule II elections indicates a willingness to introduce new members of outstanding ability in science, literature, and the arts who were known to be the chief antagonists of equally prominent existing members. The chapter looks at some of the flashpoints in the club's history between 1860 and 1890, when liberal opinion in politics, religion, and science assumed the ascendancy in Britain, and the Athenæum strove to maintain its tradition of tolerance and balance. It is at these flashpoints, and at times when conservative sexual mores influenced public life, that the relationship between national developments and the life of the club, conducted on the margins between the private and the public, is most revealing.

Sign in / Sign up

Export Citation Format

Share Document