scholarly journals Chromoendoscopy to Detect Early Synchronous Second Primary Esophageal Carcinoma in Patients with Squamous Cell Carcinomas of the Head and Neck?

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Pavel Komínek ◽  
Petr Vítek ◽  
Ondřej Urban ◽  
Karol Zeleník ◽  
Magdaléna Halamka ◽  
...  
Keyword(s):  
Esophageal Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Second Primary ◽  
Esophageal Mucosa ◽  
Intense Staining ◽  
Primary Tumors ◽  
Flexible Esophagoscopy ◽  
Esophageal Carcinomas

Objective. To evaluate the use of flexible esophagoscopy and chromoendoscopy with Lugol’s solution in the detection of early esophageal carcinomas (second primary carcinomas) in patients with squamous cell carcinoma of the head and neck (HNSCC).Methods. All patients with newly diagnosed HNSCC underwent office-based Lugol's chromoendoscopy. After flexible esophagoscopy with white light, 3.0% Lugol's iodine solution was sprayed over the entire esophageal mucosa. Areas with less-intense staining (LVLs) were evaluated and biopsies taken.Results. 132 patients with HNSCC were enrolled in this study. The most frequent primary tumors were oropharyngeal (49/132), tumors of the oral cavity (36/132), and larynx (35/132). The majority of subjects (107/132 patients, 81.1%) had advanced HNSCC carcinomas (stages III and IV). Multiple LVLs were discovered in 24 subjects (18.2%) and no LVLs in 108 (81.8%) subjects. Fifty-five LVL biopsy specimens were obtained and assessed. Squamous cell carcinomas were detected in two patients, peptic esophagitis in 11 patients, gastric heterotopic mucosa in two patients, hyperplasia in two patients, and low- and high-grade dysplasia in three patients.Conclusion. Although only two patients with synchronous primary carcinomas were found among the patients, esophagoscopy should be recommended after detection of HNSCC to exclude secondary esophageal carcinoma or dysplasia.

scholarly journals Genetic profile of second primary tumors and recurrences in head and neck squamous cell carcinomas

Head & Neck ◽  
2011 ◽  
Vol 34 (6) ◽  
pp. 830-839 ◽  
Author(s):  
Virginia Franco Gutiérrez ◽  
César Álvarez Marcos ◽  
José Luis Llorente ◽  
Marta Alonso Guervós ◽  
Francisco Domínguez Iglesias ◽  
...  
Keyword(s):  
Head And Neck ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Second Primary ◽  
Genetic Profile ◽  
Primary Tumors ◽  
Second Primary Tumors

scholarly journals Treatment and outcomes of second primary tumors in patients with head and neck squamous cell carcinoma

2017 ◽  
Vol 28 ◽  
pp. x106
Author(s):  
T. Siripoon ◽  
P. Pattaranutaporn ◽  
C. Jiarpinitnun ◽  
J. Juengsamarn ◽  
S. Bunbanjerdsuk ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Second Primary ◽  
Primary Tumors ◽  
Second Primary Tumors

scholarly journals Prognostic and Therapeutic Potential of Nuclear Receptors in Head and Neck Squamous Cell Carcinomas

2009 ◽  
Vol 2009 ◽  
pp. 1-10 ◽  
Author(s):  
Shirley K. Knauer
Keyword(s):  
Head And Neck ◽  
Nuclear Receptors ◽  
Squamous Cell ◽  
Therapeutic Potential ◽  
Treatment Options ◽  
Survival Rates ◽  
Squamous Cell Carcinomas ◽  
High Rate ◽  
Second Primary ◽  
Tumor Entity

Head and neck squamous cell carcinomas are among the most common neoplasms worldwide and characterized by local tumor aggressiveness, high rate of early recurrences, development of metastasis, and second primary cancers. Despite modern therapeutic strategies and sophisticated surgical management, overall survival-rates remained largely unchanged over the last decades. Thus, the need for novel treatment options for this tumor entity is undeniable. A key event in carcinogenesis is the uncontrolled modulation of genetic programs. Nuclear receptors belong to a large superfamily of transcription factors implicated in a broad spectrum of physiological and pathophysiological processes, including cancer. Several nuclear receptors have also been associated with head and neck cancer. This review will summarize their mode of action, prognostic/therapeutic relevance, as well as preclinical and clinical studies currently targeting nuclear receptors in this tumor entity.

scholarly journals Second primary tumors in patients with head and neck squamous cell carcinoma

Cancer ◽  
1995 ◽  
Vol 75 (6) ◽  
pp. 1343-1353 ◽  
Author(s):  
Andrew S. Jones ◽  
Pradeep Morar ◽  
David E. Phillips ◽  
John K. Field ◽  
David Husband ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Second Primary ◽  
Primary Tumors ◽  
Second Primary Tumors

Expression of matrix metalloproteinases and tissue inhibitor of metalloproteinases in laryngeal and pharyngeal squamous cell carcinoma: A quantitative analysis

2000 ◽  
Vol 122 (5) ◽  
pp. 712-716
Author(s):  
Steven P. Magary ◽  
Matthew W. Ryan ◽  
R. W. Tarnuzzer ◽  
Lori Kornberg
Keyword(s):  
Head And Neck ◽  
Squamous Cell ◽  
Normal Tissue ◽  
Squamous Cell Carcinomas ◽  
Chain Reaction ◽  
Primary Tumors ◽  
Qrt Pcr ◽  
Specific Mrnas ◽  
Polymerase Chain ◽  
Pharyngeal Squamous Cell Carcinoma

Squamous cell carcinomas of the head and neck are known for their aggressive growth and propensity to metastasize. Invasion is facilitated by matrix metalloproteineases (MMPs). Tissue inhibitors of MMPs (TIMPs) negatively regulate MMP activity. MMP and TIMP expression in head and neck squamous cell carcinomas was determined by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR). qRT-PCR allows measurement of several mRNAs from as little as 4 μg of total cellular RNA. We measured MMP-1, MMP-2, MMP-9, and TIMP-1 expression in 8 specimens of primary tumors and adjacent normal tissue. MMP-1 was overexpressed in 6 of 8 tumors, and MMP-9 was over-expressed in 4 of 7 tumors. MMP-2 was expressed in 3 of 8 tumors and 3 of 8 normal samples. TIMP-1 was expressed in all specimens. This work demonstrates that qRT-PCR can be used to examine expression of specific mRNAs in clinical specimens. Therefore this method provides another tool for the molecular analysis of tumors.

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