scholarly journals Dealing with the Surgical and Medical Challenges of Penetrating Brain Injuries

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Nikolaos Syrmos ◽  
Mario Ganau ◽  
Antonella De Carlo ◽  
Lara Prisco ◽  
Laura Ganau ◽  
...  
Keyword(s):  
Brain Injuries ◽  
Medical Literature ◽  
High Energy ◽  
Point Of View ◽  
Construction Site ◽  
Inappropriate Treatment ◽  
English Medical Literature ◽  
Flow Charts ◽  
Work Accidents ◽  
Clinical Conditions

Peacetime has reduced the overall incidence of penetrating brain injuries (PBI), and those related to missile penetration are not common anymore at least in western countries. Nevertheless, PBI still occur, and car crashes or work accidents are their main causes. The management of such cases is characterized by many challenges, not only from a surgical and medical point of view, but also for the different and sometimes bizarre dynamics by which they present. Herein we report an unusual deep penetrating brain injury, due to a high-energy crash against a metallic rod in a construction site, with a good surgical outcome despite dramatic clinical conditions on admission. A discussion of the surgical results and functional outcome related to PBI, as found in the English medical literature, is provided. Moreover the most common postoperative complications along with the diagnostic flow charts and therapeutic options useful to prevent inappropriate treatment are highlighted.

scholarly journals Twin-to-Twin Transfusion Syndrome: Definition, Staging, and Ultrasound Assessment

2016 ◽  
Vol 19 (3) ◽  
pp. 175-183 ◽  
Author(s):  
Eftichia Kontopoulos ◽  
Ramen H. Chmait ◽  
Ruben A. Quintero
Keyword(s):  
English Language ◽  
Medical Literature ◽  
Staging System ◽  
Cervical Length ◽  
Point Of View ◽  
Ultrasound Evaluation ◽  
Comprehensive Examination ◽  
English Medical Literature ◽  
Ultrasound Assessment ◽  
Definition Of

Objective: The purpose of this article is to review the definition of twin-to-twin transfusion syndrome (TTTS) and the sonographic diagnostic assessment of these cases prior to therapy.Materials and Methods: The article addresses the terminology used to refer to the condition and describes the systematic ultrasound assessment of the condition, including the ultrasound diagnosis, the staging of the disease, cervical assessment and pre-operative mapping.Results: From an etymologic and medical point of view, the term ‘fetofetal transfusion’ is more appropriate than ‘TTTS’. However, as the latter, and its attendant acronym TTTS, have been widely adopted in the English language, it is impractical to change at this point. TTTS is defined sonographically in the combined presence of a maximum vertical pocket (MVP) of 8 cm or greater in one sac and 2 cm or less in the other sac, regardless of the gestational age at diagnosis. Staging of the condition using the Quintero staging system is practical, reproducible, and accepted. Transvaginal cervical length assessment should be an integral part of the ultrasound evaluation. Pre-operative mapping to anticipate the location of the placental vascular anastomoses and avoid injuring the dividing membrane is also discussed.Conclusions: The term ‘TTTS’ can continue to be used in the English medical literature. The condition can be diagnosed and assessed following a systematic ultrasound methodology. The use of such ultrasound methodology breaks the examination into a distinct set of components, assuring a comprehensive examination and proper communication among caregivers.

In situ TEM studies of irradiation effects for materials improvement

1991 ◽  
Vol 49 ◽  
pp. 452-453
Author(s):  
Charles W. Allen
Keyword(s):  
Nuclear Reactor ◽  
Austenitic Stainless Steels ◽  
High Energy ◽  
Point Of View ◽  
In Situ Tem ◽  
Irradiation Effects ◽  
Tem Analysis ◽  
Radiation Induced ◽  
Analytical Tools

Irradiation effects studies employing TEMs as analytical tools have been conducted for almost as many years as materials people have done TEM, motivated largely by materials needs for nuclear reactor development. Such studies have focussed on the behavior both of nuclear fuels and of materials for other reactor components which are subjected to radiation-induced degradation. Especially in the 1950s and 60s, post-irradiation TEM analysis may have been coupled to in situ (in reactor or in pile) experiments (e.g., irradiation-induced creep experiments of austenitic stainless steels). Although necessary from a technological point of view, such experiments are difficult to instrument (measure strain dynamically, e.g.) and control (temperature, e.g.) and require months or even years to perform in a nuclear reactor or in a spallation neutron source. Consequently, methods were sought for simulation of neutroninduced radiation damage of materials, the simulations employing other forms of radiation; in the case of metals and alloys, high energy electrons and high energy ions.

scholarly journals Insulin Receptor Isoforms in Cancer

2018 ◽  
Vol 19 (11) ◽  
pp. 3615 ◽  
Author(s):  
Veronica Vella ◽  
Agostino Milluzzo ◽  
Nunzio Scalisi ◽  
Paolo Vigneri ◽  
Laura Sciacca
Keyword(s):  
Insulin Receptor ◽  
Cancer Cells ◽  
Predictive Biomarker ◽  
Point Of View ◽  
Receptor Isoforms ◽  
Insulin Receptor Isoforms ◽  
Target Therapies ◽  
Isoform Expression ◽  
Exon 11 ◽  
Clinical Conditions

The insulin receptor (IR) mediates both metabolic and mitogenic effects especially when overexpressed or in clinical conditions with compensatory hyperinsulinemia, due to the metabolic pathway resistance, as obesity diabetes. In many cancers, IR is overexpressed preferentially as IR-A isoform, derived by alternative splicing of exon 11. The IR-A overexpression, and the increased IR-A:IR-B ratio, are mechanisms that promote the mitogenic response of cancer cells to insulin and IGF-2, which is produced locally by both epithelial and stromal cancer cells. In cancer IR-A, isoform predominance may occur for dysregulation at both mRNA transcription and post-transcription levels, including splicing factors, non-coding RNAs and protein degradation. The mechanisms that regulate IR isoform expression are complex and not fully understood. The IR isoform overexpression may play a role in cancer cell stemness, in tumor progression and in resistance to target therapies. From a clinical point of view, the IR-A overexpression in cancer may be a determinant factor for the resistance to IGF-1R target therapies for this issue. IR isoform expression in cancers may have the meaning of a predictive biomarker and co-targeting IGF-1R and IR-A may represent a new more efficacious treatment strategy.

scholarly journals Theoretical Research on the Gas Phase Density Change in Processes Occurring During Work of the Transport Module Intended for Transport From the Seabed

2018 ◽  
Vol 1 (1) ◽  
pp. 597-604
Author(s):  
Wiktor Filipek ◽  
Krzysztof Broda
Keyword(s):  
Gas Phase ◽  
High Energy ◽  
Point Of View ◽  
Theoretical Research ◽  
Reduced Form ◽  
Phase Density ◽  
Marine Deposits ◽  
Polymetallic Nodules ◽  
Degree Equation ◽  
Seafloor Massive Sulphides

Abstract In recent years, we have observed a great interest in the exploitation of marine deposits by various methods of mining and transport to the surface. However, obtaining natural resources deposited at greater depths such as polymetallic nodules and seafloor massive sulphides – SMS creates a lot of challenges for both scientists and engineers. The solutions developed so far, unfortunately, have so far been characterized by high energy consumption. For several years the authors have been conducting theoretical and experimental research on new concepts of seabed to surface transport. The results of them have been presented in previous publications. This publication presents the results of the continuation of research on the concept of construction and operation of an autonomous transport module (submitted for printing). It focuses on a theoretical analysis of the change in gas phase density in the processes occurring during operation of the transport module intended for transport from the seabed. For this purpose, a reduced form of the van der Waals equation was used in the form of a third-degree equation for parameters interested from the point of view of the transport module.

scholarly journals Back to the Future: Very High-Energy Electrons (VHEEs) and Their Potential Application in Radiation Therapy

Cancers ◽  
2021 ◽  
Vol 13 (19) ◽  
pp. 4942
Author(s):  
Maria Grazia Ronga ◽  
Marco Cavallone ◽  
Annalisa Patriarca ◽  
Amelia Maia Leite ◽  
Pierre Loap ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Current Knowledge ◽  
High Energy ◽  
High Dose Rate ◽  
Point Of View ◽  
High Dose ◽  
Dose Rates ◽  
High Energy Electrons ◽  
Very High Energy ◽  
Very High

The development of innovative approaches that would reduce the sensitivity of healthy tissues to irradiation while maintaining the efficacy of the treatment on the tumor is of crucial importance for the progress of the efficacy of radiotherapy. Recent methodological developments and innovations, such as scanned beams, ultra-high dose rates, and very high-energy electrons, which may be simultaneously available on new accelerators, would allow for possible radiobiological advantages of very short pulses of ultra-high dose rate (FLASH) therapy for radiation therapy to be considered. In particular, very high-energy electron (VHEE) radiotherapy, in the energy range of 100 to 250 MeV, first proposed in the 2000s, would be particularly interesting both from a ballistic and biological point of view for the establishment of this new type of irradiation technique. In this review, we examine and summarize the current knowledge on VHEE radiotherapy and provide a synthesis of the studies that have been published on various experimental and simulation works. We will also consider the potential for VHEE therapy to be translated into clinical contexts.

scholarly journals Use of Steel and Polyolefin Fibres in the La Canda Tunnels: Applying MIVES for Assessing Sustainability Evaluation

2018 ◽  
Author(s):  
Marcos G. Alberti ◽  
Jaime C. Gálvez ◽  
Alejandro Enfedaque ◽  
Ana Carmona ◽  
Cristina Valverde ◽  
...  
Keyword(s):  
Value Function ◽  
Raw Materials ◽  
High Energy ◽  
Point Of View ◽  
Concrete Slabs ◽  
Function Concept ◽  
Sustainability Evaluation ◽  
Value Model ◽  
The Value Function ◽  
High Energy Consumption

Construction involves the use of significant quantities of raw materials and entails high-energy consumption. For the sake of choosing the most appropriate solution that considers environmental and sustainable concepts, tools such as the integrated value model for sustainable assessment (Modelo Integrado de Valor para una Evaluación Sostenible, MIVES) used in Spain, plays a key role in obtaining the best solution. MIVES is a multi-criteria decision-making method based on the value function concept and the seminars delivered by experts. Such tools, in order to show how they may work, require application to case studies. In this paper, two concrete slabs manufactured with differing reinforcement during the construction of the La Canda Tunnels are compared by means of MIVES. The two concrete slabs were reinforced with a conventional steel-mesh and with polyolefin fibres. The results showed that from the point of view of sustainability, the use of polyolefin fibres provided a significant advantage mainly due to the lower maintenance required.

scholarly journals A Comparative Analytical Study Of Shukra Dosha With Semen Analysis

2021 ◽  
Vol 9 (02) ◽  
Author(s):  
Shivanand F Kawane
Keyword(s):  
Comparative Research ◽  
Analytical Study ◽  
Research Study ◽  
Semen Analysis ◽  
Medical Science ◽  
Modern Science ◽  
Point Of View ◽  
Laboratory Examination ◽  
Different Types ◽  
Clinical Conditions

As we know Shukra dhatu is a most essential end product of the rest of all 6 dhatus of sharira. So, an analytical comparative research study has been made on infertility(bandhatva) patients. In this study, we explain tenets of shukra dhatu and different types of shukra doshas according to Acharya Charaka and Sushruta. According to doshas 8 types of Shukra doshas explaind by acharya and 9 types of semen abnormality by modern science. An attempt has been made to correlate these shukra doshas with an abnormality of semen according to modern medical science, on the basis of clinical features, physical appearance, and laboratory examination of semen. For the study 20 patient suffering from any kind of infertility has been selected from O.P.D. of Shalya Tantra department of Arogyashala rugnalaya, Nashik. On observation, the result showed out of 20 patients , 10 patients suffering from vatapittaj, 6 from shukra kshaya, 2 from vataj and 2 from pittaj shukra dosha according to ayurvedic point of view. Simultaneously we correlate it with different clinical conditions of semen and we found Out of 20 patients, 8 suffering from Oligoasthenospermia, 6 from Oligospermia, 2 from Asthenozoospermia, 2 from Tetratazospermia, 2 from Infective semen.  

Wilfred Harris' Early Description of Cluster Headache

Cephalalgia ◽  
2002 ◽  
Vol 22 (4) ◽  
pp. 320-326 ◽  
Author(s):  
CJ Boes ◽  
DJ Capobianco ◽  
MS Matharu ◽  
PJ Goadsby
Keyword(s):  
Cluster Headache ◽  
Medical Literature ◽  
Significant Interest ◽  
Early Description ◽  
English Medical Literature ◽  
Acute Attacks ◽  
Cluster Phenomenon

Wilfred Harris was a London neurologist with a significant interest in the treatment of neuralgia. Harris' descriptions of what he called migrainous neuralgia were the first recorded of cluster headache in the English medical literature. He was probably one of the first to describe the cluster phenomenon itself and the effectiveness of ergotamine in treating acute attacks of cluster headache. His seminal contributions to the clinical and therapeutic spectrum of cluster headache are reviewed.

scholarly journals Alveolar soft-part sarcoma of the oral cavity: A review of literature

Rare Tumors ◽  
2018 ◽  
Vol 10 ◽  
pp. 203636131881090 ◽  
Author(s):  
Pankaj Shelke ◽  
Gargi Sachin Sarode ◽  
Sachin Chakradhar Sarode ◽  
Rahul Anand ◽  
Ghevaram Prajapati ◽  
...  
Keyword(s):  
Soft Tissues ◽  
Medical Literature ◽  
Soft Part ◽  
Case Reports ◽  
Correct Diagnosis ◽  
Treatment Strategies ◽  
Malignant Neoplasm ◽  
Alveolar Soft Part Sarcoma ◽  
Prognostic Features ◽  
English Medical Literature

An alveolar soft-part sarcoma is a malignant neoplasm primarily affecting the soft tissues of head and neck. The aim of the present review is to systematically present the demographic and clinico-pathological data of articles published in the English medical literature. A comprehensive search of the databases (PubMed, Medline, SCOPUS, Web of Science, and Google Scholar) along with cross references to the published articles on alveolar soft-part sarcoma for eligible studies/case reports published since 1957 till date was done to retrieve the data. A total of 74 cases were identified and analyzed from 42 papers published in the English medical literature. All the clinical, radiographic, and prognostic features were analyzed and presented along with the treatment strategies. Alveolar soft-part sarcoma is a rare and aggressive malignancy of uncertain histologic origin with a propensity for vascular invasion and distant metastasis. This neoplasm requires careful clinical, radiographic, and histopathologic evaluation to reach to the correct diagnosis.

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