scholarly journals Low-Fat Nondairy Minidrink Containing Plant Stanol Ester Effectively Reduces LDL Cholesterol in Subjects with Mild to Moderate Hypercholesterolemia as Part of a Western Diet

Cholesterol ◽  
2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Maarit Hallikainen ◽  
Johan Olsson ◽  
Helena Gylling
Keyword(s):  
Intervention Group ◽  
Hdl Cholesterol ◽  
Western Diet ◽  
Control Group ◽  
Low Fat ◽  
Cholesterol Lowering ◽  
Plant Stanol Ester ◽  
Plant Stanols ◽  
Plant Stanol ◽  
Stanol Ester

The cholesterol-lowering efficacy of plant stanol ester (STAEST) added to fat- or milk-based products is well documented. However, their efficacy when added to nondairy liquid drinks is less certain. Therefore, we have investigated the cholesterol-lowering efficacy of STAEST added to a soymilk-based minidrink in the hypercholesterolemic subjects. In a randomized, double-blind, placebo-controlled parallel study, the intervention group (n=27) consumed 2.7 g/d of plant stanols as the ester in soymilk-based minidrink (65 mL/d) with the control group (n=29) receiving the same drink without added plant stanols once a day with a meal for 4 weeks. Serum total, LDL, and non-HDL cholesterol concentrations were reduced by 8.0, 11.1, and 10.2% compared with controls (P<0.05 for all). Serum plant sterol concentrations and their ratios to cholesterol declined by 12–25% from baseline in the STAEST group while the ratio of campesterol to cholesterol was increased by 10% in the controls (P<0.05 for all). Serum precursors of cholesterol remained unchanged in both groups. In conclusion, STAEST-containing soymilk-based low-fat minidrink consumed once a day with a meal lowered LDL and non-HDL cholesterol concentrations without evoking any side effects in subjects consuming normal Western diet. The clinical trial registration number is NCT01716390.

scholarly journals Cereal-Based Snack Bar with Added Plant Stanol Ester (Benecol®) Consumed between Meals Lowers Serum Total and LDL Cholesterol Effectively in Mildly to Moderately Hypercholesterolemic Subjects

Cholesterol ◽  
2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Essi Sarkkinen ◽  
Mari Lyyra ◽  
Sakari Nieminen ◽  
Päivi Kuusisto ◽  
Ingmar Wester
Keyword(s):  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Double Blind ◽  
Cholesterol Lowering ◽  
Plant Stanol Ester ◽  
Parallel Design ◽  
Plant Stanol ◽  
Habitual Diet ◽  
Stanol Ester ◽  
Hypercholesterolemic Subjects

The cholesterol-lowering effect of foods with added plant sterols or stanols consumed as snacks might be compromised. The purpose of this study was to confirm the cholesterol-lowering efficacy of a specially formulated cereal-based snack bar with added plant stanol ester (1.6 g plant stanols/day) when consumed between meals twice a day. In a double-blind, placebo-controlled, 4-week parallel-design study, 71 mildly to moderately hypercholesterolemic subjects were randomized into one of two groups, stanol or placebo group. Subjects were advised to replace their ordinary snacks with test products in an isocaloric manner and otherwise keep their habitual diet unchanged. The study showed that a snack bar product with added plant stanol ester lowered LDL and non-HDL cholesterol by 8.6% and 9.2% (mean%-change), respectively, as compared to the placebo product. The change in LDL cholesterol was statistically significantly different (P=0.001) between the groups while the change in HDL cholesterol or triglycerides did not differ between the groups. In conclusion, the cereal-based snack bar with added plant stanol ester ingested without a meal reduced LDL cholesterol significantly without affecting HDL cholesterol or triglyceride concentrations in mildly hypercholesterolemic men and women. The study is registered as NCT03284918.

Abstract 15438: Serum Proprotein Convertase Subtilisin/Kexin Type 9 Levels Are Not Increased by Plant Stanol Ester Consumption

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Piia Simonen ◽  
Ulf-Håkan Stenman ◽  
Helena Gylling
Keyword(s):  
Cholesterol Metabolism ◽  
Critical Role ◽  
Cholesterol Absorption ◽  
Control Group ◽  
Proprotein Convertase ◽  
Baseline Serum ◽  
Plant Stanol Ester ◽  
Plant Stanols ◽  
Plant Stanol ◽  
Stanol Ester

Introduction: Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a critical role in regulating cholesterol metabolism mainly by binding to LDL receptors targeting them for degradation. Statins, inhibitors of cholesterol synthesis, increase the serum PCSK9 concentration limiting the potential of statins to reduce LDL cholesterol (C) concentration, whereas ezetimibe, an inhibitor of cholesterol absorption, has ambiguous effects on circulating PCSK9 levels. Plant stanols lower LDL-C by inhibiting cholesterol absorption, but their effect on serum PCSK9 concentration is not known. Hypothesis: We assessed the hypothesis that consumption of plant stanol esters lowers LDL-C without increasing circulating PCSK9 levels. Methods: Ninety-two normo- and mildly hypercholesterolemic subjects, 35 men and 57 women (mean age 50.8±1.0 (SE) years) were randomly divided into plant stanol ester (STANOL) (n=46) and control (n=46) groups. They consumed spread enriched with (STANOL group) and without (control group) plant stanol (3g /d) ester in a double-blind intervention for six months. Serum lipids and lipoproteins were analysed enzymatically and serum PCSK9 concentration was quantitated with Quantikine Elisa Immunoassay at baseline and after the intervention. Results: At baseline, serum PCSK9 levels correlated positively with LDL-C in the whole study population. Serum total, LDL-C and non-HDL-C concentrations, similar between the study groups at baseline, declined by 7%,10%, and 11% at the end of the intervention in the STANOL group compared with the control group (p< 0.001, for all). The baseline serum PCSK9 concentrations were similar between the groups (STANOL 284±16 ng/ml, controls 273±16 ng/ml, ns). At the end of the intervention, serum PCSK9 concentrations were unchanged from baseline in both groups and did not differ between the groups (STANOL 293 ±15 ng/ml, controls 309±16 ng/ml, ns). Conclusion: In conclusion, plant stanol ester consumption does not affect the circulating PCSK9 concentration. Thus, plant stanols provide an efficient dietary means to lower LDL-C concentration without interfering with the LDL receptor-mediated cellular cholesterol uptake and removal.

scholarly journals Cholesterol Lowering Effect of Plant Stanol Ester Yoghurt Drinks with Added Camelina Oil

Cholesterol ◽  
2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Pia Salo ◽  
Päivi Kuusisto
Keyword(s):  
Ldl Cholesterol ◽  
Double Blind ◽  
Cholesterol Lowering ◽  
Plant Stanol Ester ◽  
Camelina Oil ◽  
Plant Stanols ◽  
Lowering Effect ◽  
Plant Stanol ◽  
Stanol Ester ◽  
Cholesterol Lowering Effect

The aim of this study was to investigate the effects of yoghurt minidrinks containing two doses of plant stanol ester either with or without added camelina oil on the serum cholesterol levels in moderately hypercholesterolemic subjects. In this randomised, double-blind, parallel group study, 143 subjects consumed a 65 mL minidrink together with a meal daily for four weeks. The minidrink contained 1.6 or 2.0 grams of plant stanols with or without 2 grams of alpha-linolenic acid-rich camelina oil. The placebo minidrink did not contain plant stanols or camelina oil. All plant stanol treated groups showed statistically significant total, LDL, and non-HDL cholesterol lowering relative to baseline and relative to placebo. Compared to placebo, LDL cholesterol was lowered by 9.4% (p<0.01) and 8.1% (p<0.01) with 1.6 g and 2 g plant stanols, respectively. With addition of Camelina oil, 1.6 g plant stanols resulted in 11.0% (p<0.01) and 2 g plant stanols in 8.4% (p<0.01) reduction in LDL cholesterol compared to placebo. In conclusion, yoghurt minidrinks with plant stanol ester reduced serum LDL cholesterol significantly and addition of a small amount of camelina oil did not significantly enhance the cholesterol lowering effect. This trial was registered with ClinicalTrials.gov NCT02628990.

scholarly journals Optimal Use of Plant Stanol Ester in the Management of Hypercholesterolemia

Cholesterol ◽  
2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Susanna Rosin ◽  
Ilkka Ojansivu ◽  
Aino Kopu ◽  
Malin Keto-Tokoi ◽  
Helena Gylling
Keyword(s):  
Functional Foods ◽  
Ldl Cholesterol ◽  
Daily Intake ◽  
Full Potential ◽  
Cholesterol Reduction ◽  
Cholesterol Lowering ◽  
Plant Stanol Ester ◽  
Plant Stanol ◽  
Reduce Serum Cholesterol ◽  
Stanol Ester

Plant stanol ester is a natural compound which is used as a cholesterol-lowering ingredient in functional foods and food supplements. The safety and efficacy of plant stanol ester have been confirmed in more than 70 published clinical studies and the ingredient is a well-established and widely recommended dietary measure to reduce serum cholesterol. Daily intake of 2 g plant stanols as plant stanol ester lowers LDL-cholesterol by 10%, on average. In Europe, foods with added plant stanol ester have been on the market for 20 years, and today such products are also available in many Asian and American countries. Despite the well-documented efficacy, the full potential in cholesterol reduction may not be reached if plant stanol ester is not used according to recommendations. This review therefore concentrates on the optimal use of plant stanol ester as part of dietary management of hypercholesterolemia. For optimal cholesterol lowering aiming at a lower risk of cardiovascular disease, plant stanol ester should be used daily, in sufficient amounts, with a meal and in combination with other recommended dietary changes.

Plant Stanol Ester as a Cholesterol-Lowering Ingredient of Benecol® Foods

2005 ◽  
Author(s):  
Pia Salo ◽  
Anu Hopia ◽  
Jari Ekblom ◽  
Ritva Lahtinen ◽  
Päivi Laakso
Keyword(s):  
Cholesterol Lowering ◽  
Plant Stanol Ester ◽  
Plant Stanol ◽  
Stanol Ester

Plant Stanol Ester as a Cholesterol-Lowering Ingredient of Benecol® Foods

2019 ◽  
pp. 699-730
Author(s):  
Pia Salo ◽  
Anu Hopia ◽  
Jari Ekblom ◽  
Ritva Lahtinen ◽  
Päivi Laakso
Keyword(s):  
Cholesterol Lowering ◽  
Plant Stanol Ester ◽  
Plant Stanol ◽  
Stanol Ester

scholarly journals Alterations in mood after changing to a low-fat diet

1998 ◽  
Vol 79 (1) ◽  
pp. 23-30 ◽  
Author(s):  
Anita S. Wells ◽  
Nicholas W. Read ◽  
Jonathan D. E. Laugharne ◽  
N. S. Ahluwalia
Keyword(s):  
Dietary Fat ◽  
Plasma Cholesterol ◽  
Intervention Group ◽  
Hdl Cholesterol ◽  
Diet Group ◽  
Total Serum ◽  
Control Group ◽  
Total Serum Cholesterol ◽  
Low Fat ◽  
Low Fat Diet

The effects on mood of reducing dietary fat while keeping the energy constant were examined in ten male and ten female healthy volunteers aged between 20 and 37 years. Each volunteer consumed a diet containing 41% energy as fat for 1 month. For the second month half of the subjects changed to a low-fat diet (25% energy from fat) and the remainder continued to eat the diet containing 41% energy from fat. Changes in mood and blood lipid concentrations were assessed before, during and at the end of the study. Profile of mood states (POMS) ratings of anger–hostility significantly increased in the intervention group after 1 month on the low-fat diet, while during the same period there was a slight decline in anger–hostility in the control subjects (group F 6.72; df 1,14; P = 0.021). Tension–anxiety ratings declined in the control group consuming the higher fat diet but did not change in the group consuming the low-fat diet (group F 6.34; df 1,14; P = 0.025). There was a decline in fasting concentrations of HDL-cholesterol after the low-fat diet and a small increase in subjects consuming the medium-fat diet (group F 4.96; df 1,12; P = 0.046), but no significant changes in concentrations of total serum cholesterol, LDL-cholesterol or triacylglycerol were observed. The results suggest that a change in dietary fat content from 41 to 25% energy may have adverse effects on mood. The alterations in mood appear to be unrelated to changes in fasting plasma cholesterol concentrations.

scholarly journals Plant stanol ester spreads as components of a balanced diet for pregnant and breast-feeding women: evaluation of clinical safety

2008 ◽  
Vol 101 (12) ◽  
pp. 1797-1804 ◽  
Author(s):  
K. Laitinen ◽  
E. Isolauri ◽  
L. Kaipiainen ◽  
H. Gylling ◽  
T.A. Miettinen
Keyword(s):  
Breast Milk ◽  
Cholesterol Synthesis ◽  
Intervention Group ◽  
Clinical Safety ◽  
Plant Stanol Ester ◽  
Balanced Diet ◽  
Plant Stanol ◽  
The Impact ◽  
Stanol Ester ◽  
Β Carotene

Clinical safety of consuming plant stanol ester spreads during pregnancy and lactation, the impact on maternal and infant serum and breast-milk cholesterol and the ratios (μmol/mmol of cholesterol) of synthesis and absorption markers were evaluated. Pregnant women (n21) were randomised to control and dietary intervention groups, the intervention including advice to follow a balanced diet and to consume spreads enriched with plant stanol esters. Participants were followed during and after pregnancy and their infants up to 1 year of age. A mean 1·1 (sd0·4) g consumption of plant stanols during pregnancy and 1·4 (sd0·9) g 1 month post-partum increased sitostanol and the markers for cholesterol synthesis, lathosterol, lathosterol/campesterol and lathosterol/sitosterol, and reduced a marker for cholesterol absorption, campesterol, in maternal serum. In breast milk, desmosterol was lower in the intervention group, while no differences were detected between the groups in infants' serum. Plant stanol ester spread consumption had no impact on the length of gestation, infants' growth or serum β-carotene concentration at 1 and 6 months of age, but the cholesterol-adjusted serum β-carotene concentration was lowered at 1 month in the intervention group. Plant stanol ester spread consumption appeared safe in the clinical setting, except for potential lowering of infants' serum β-carotene concentration, and was reflected in the markers of cholesterol synthesis and absorption in mothers' serum, encouraging further studies in larger settings.

Sign in / Sign up

Export Citation Format

Share Document