scholarly journals Tanycytic Ependymoma: A Challenging Histological Diagnosis

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Khaled M. Krisht ◽  
Meic H. Schmidt
Keyword(s):  
Immunohistochemical Staining ◽  
Accurate Diagnosis ◽  
Rare Form ◽  
Tanycytic Ependymoma ◽  
Spindle Cells ◽  
S 100 ◽  
Strong Immunoreactivity ◽  
Hemosiderin Deposits ◽  
Other Neoplasms ◽  
Histology Section

Tanycytic ependymoma is a rare form of ependymoma that usually arises in the intramedullary spine. It has a unique histology emphasized by the inconspicuous ependymal pattern of cells and close resemblance to schwannoma and astrocytoma. The authors report a 50-year-old man with a cervical tanycytic ependymoma that was initially thought to be a schwannoma. The frozen histology section showed spindle cells with oval and elongated nuclei with occasional hemosiderin deposits present suggesting a preliminary diagnosis of schwannoma. Immunohistochemical staining of the permanent section revealed strong immunoreactivity for glial fibrillary acidic protein with intermittent S-100 positivity, confirming that the tumor was a tanycytic ependymoma. This underlines the challenges involved in making an accurate diagnosis and demonstrates that careful and detailed histological inspection with immunohistochemical stains and ultrastructural microscopy may be necessary to distinguish tanycytic ependymoma from other neoplasms.

Primary Prostatic Leiomyosarcoma With Pulmonary Metastases in a Dog

2010 ◽  
Vol 46 (2) ◽  
pp. 103-106 ◽  
Author(s):  
Barbara Bacci ◽  
Massimo Vignoli ◽  
Federica Rossi ◽  
Francesco Gallorini ◽  
Rossella Terragni ◽  
...  
Keyword(s):  
Immunohistochemical Staining ◽  
Pulmonary Metastases ◽  
Smooth Muscle Actin ◽  
Muscle Actin ◽  
Computed Tomography Scan ◽  
Intact Male ◽  
Spindle Cells ◽  
S 100 ◽  
Total Body ◽  
Tomography Scan

A 6-year-old, intact male Jack Russell terrier was diagnosed with a mass in the caudal abdomen, and ultrasound revealed a large prostatic mass. A total-body computed tomography scan was performed for staging, and lung nodules were detected. Histological examination showed a proliferation of spindle cells arranged in interlacing fascicles. Immunohistochemical staining revealed cells were cytokeratin negative and immunoreactive for vimentin and α-smooth muscle actin; cells stained with desmin and S-100 were negative. A diagnosis of primary prostatic leiomyosarcoma with pulmonary metastases was made. This is one of the rare cases of primary prostatic mesenchymal tumor in the canine species.

Gangliocytic Paraganglioma of the Duodenum: Case Report

1987 ◽  
Vol 73 (4) ◽  
pp. 425-429 ◽  
Author(s):  
Stefania Dante ◽  
Giuseppe Viale ◽  
Paolo Dalla Palma
Keyword(s):  
Case Report ◽  
Ganglion Cells ◽  
Neuron Specific Enolase ◽  
Gangliocytic Paraganglioma ◽  
Spindle Cells ◽  
S 100 ◽  
Neurofilament 200

A case of gangliocytic paraganglioma of the second portion of the duodenal loop is presented. The tumor was polypoid and, histologically, composed of mature ganglion cells, spindle cells and epithelial-like cells. Immunocytochemical examination demonstrated the presence of neurofilament 200 K and S-100 protein only in the first two types of cells; all the cells were positive for neuron-specific enolase. The reaction for cytokeratin was negative in all neoplastic components. According to morphologic and immunocytochemical findings, we suggest a hamartomatous nature of this entity.

scholarly journals Glial Fibrillary Acidic Protein (GFAP) in Oligodendrogliomas: A Reflection of Transient GFAP Expression by Immature Oligodendroglia

1986 ◽  
Vol 13 (4) ◽  
pp. 307-311 ◽  
Author(s):  
V. Jagadha ◽  
W.C. Halliday ◽  
L.E. Becker
Keyword(s):  
White Matter ◽  
Glial Fibrillary Acidic Protein ◽  
Tumor Cells ◽  
Intermediate Filaments ◽  
Intermediate Filament ◽  
Immunohistochemical Staining ◽  
Neuron Specific Enolase ◽  
Acidic Protein ◽  
Gfap Expression ◽  
S 100

ABSTRACT:Fourteen pure oligodendrogliomas were studied by light- and electronmicroscopy and immunohistochemistry to examine glial fibrillary acidic protein (GFAP) positivity in the tumors. To compare the immunohistochemical staining patterns of neoplastic oligodendroglia and immature oligodendroglia, myelination glia in the white matter of eight normal brains from children under 6 months of age were studied. The tumors possessed light microscopic and ultrastructural features characteristic of oligodendrogliomas. Microtubules were found in the cytoplasm of nine tumors on electronmicroscopy. In one, intermediate filaments and microtubules were observed in occasional tumor cells with polygonal crystalline structures in the cytoplasm. Using the peroxidase-antiperoxidase technique, all specimens were stained for GFAP, vimentin, S-100 and neuron-specific enolase (NSE). In nine tumors, variable numbers of cells with an oligodendroglial morphology reacted positively for GFAP. All tumors were positive for S-100 and negative for vimentin and NSE. The myelination glia in the eight normal brains stained positively for GFAP but not for vimentin. Vimentin is expressed by developing, reactive and neoplastic astrocytes. Thus, GFAP positivity combined with vimentin negativity in both neoplastic and immature oligodendroglia suggests that GFAP positivity in oligodendrogliomas may reflect the transient expression of this intermediate filament by immature oligodendroglia.

scholarly journals Immunohistochemical study of a canine neurofibroma

2012 ◽  
Vol 83 (1) ◽  
Author(s):  
Hamidreza Fattahian ◽  
Pejman Mortazavi ◽  
Hamidreza Moosavian ◽  
Hamid Mohyeddin ◽  
Roozbeh Moridpour
Keyword(s):  
Case Report ◽  
Diagnostic Imaging ◽  
Peripheral Nerve ◽  
Schwann Cells ◽  
Immunohistochemical Study ◽  
Collagen Fibres ◽  
Spindle Cells ◽  
Left Mandible ◽  
S 100 ◽  
Diagnostic Approaches

Accurate diagnostic approaches to differentiate peripheral nerve sheet tumours from others have not been firmly established. The aim of this case report was to diagnose neurofibroma using a combination of diagnostic imaging, histopathology and immunohistochemistry, which were applied to a canine neurofibroma arising in the left mandible. The tumour was surgically excised and examined histologically. Round or spindle cells, with elongated, dense and homogenous chromatin and pale cytoplasm typical of Schwann cells in an abundant fibromyxomatous stroma, with ruby collagen fibres were seen. Immunohistochemistry demonstrated that S-100 and vimentin were more than 70% positive. Neurofibroma may therefore be recognisable using markers such as S-100 and vimentin.

scholarly journals Rare Lipomatous Tumors with Osseous and/or Chondroid Differentiation in the Oral Cavity Report of Two Cases and Review of the Literature

2009 ◽  
Vol 2009 ◽  
pp. 1-6 ◽  
Author(s):  
Kayo Kuyama ◽  
Sisilia Fusi Fifita ◽  
Masamichi Komiya ◽  
Yan Sun ◽  
Yoshiaki Akimoto ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Immunohistochemical Study ◽  
Fat Cells ◽  
Fatty Tissue ◽  
Review Of The Literature ◽  
Woven Bone ◽  
Osteoid Tissue ◽  
Spindle Cells ◽  
S 100 ◽  
Lipomatous Tumors

The purpose of this study was to determine the clinicopathological and immunohistochemical features of lipoma/fibrolipoma with rare occasions as osseous and/or chondroid differentiation in the oral cavity. Two cases of the tumors, who presented with a painless, relatively hard mass on the oral mucosa, were studied. These were consisted of a well-circumscribed mass of fatty tissue with chondroid and significant fibrous component intermixed with the lobules of fat cells with chondroid and woven bone component, respectively. Immunohistochemical study revealed that peripheral spindle cells around chondroid tissue stained diffusely for S-100 & and Sox-9, though peripheral spindle cells around osteoid tissue only stained for RUNX-2. According to review of the literature, lipoma/fibrolipoma with osseous and/or chondroid differentiation was 18 cases. Also fibrolipoma with osseous and chondroid differentiation is the first to be reported here. These results indicated that the cartilage/bone is produced by differentiation of undifferentiated mesenchymal cells of stroma.

Recurrent Solitary Fibrous Tumor of the Pleura With Malignant Transformation

2004 ◽  
Vol 128 (4) ◽  
pp. 460-462
Author(s):  
Rani Kanthan ◽  
Bahman Torkian
Keyword(s):  
Malignant Transformation ◽  
Solitary Fibrous Tumor ◽  
Immunohistochemical Staining ◽  
White Woman ◽  
Accurate Diagnosis ◽  
Malignant Progression ◽  
Biological Behavior ◽  
Fibrous Tumor

Abstract Recurrent solitary fibrous tumor of the pleura with malignant progression occurs rarely. We report a case of solitary fibrous tumor of the pleura in an 85-year-old white woman that recurred 4 times during a span of 10 years and subsequently underwent malignant transformation. The accurate diagnosis of solitary fibrous tumor is aided by ancillary techniques, such as immunohistochemical staining; however, with malignant transformation, such tools may be of limited value. Long-term clinical follow-up is recommended for all patients with solitary fibrous tumor because of the potential adverse biological behavior of this tumor, which may lead to repeated recurrences and/or malignant transformation.

scholarly journals A Rare Primary Tumor of the Thyroid Gland: A New Case of Leiomyoma and Literature Review

2018 ◽  
Vol 12 ◽  
pp. 117955491881353
Author(s):  
Yanling Zhang ◽  
Heng Tang ◽  
Huaiyuan Hu ◽  
Xiang Yong
Keyword(s):  
Thyroid Gland ◽  
Tumor Cells ◽  
Immunohistochemical Staining ◽  
Smooth Muscle Actin ◽  
Frozen Sections ◽  
Ki 67 ◽  
Eosinophilic Cytoplasm ◽  
S 100 ◽  
Painless Mass ◽  
The Right

Primary leiomyomas of the thyroid are very rare. We here report a case of a 53-year-old woman with a painless mass at the right thyroid, revealed by physical examination. The patient underwent a lobectomy. Frozen sections showed a spindle cell tumor of the thyroid gland. The nuclei of some of the tumor cells were obviously enlarged and deeply stained. Pseudocapsule invasion was observed in small foci. Samples showed neither mitosis nor necrosis and the nature of the tumor was difficult to determine. Paraffin sections showed a well-circumscribed nodular composed of intersecting fascicles of spindled to slightly epithelioid cells with eosinophilic cytoplasm and blunt-ended, cigar-shaped nuclei. We observed no significant nuclear atypia, mitotsis, or necrosis. Immunohistochemical staining showed the tumor cells to be positive for α-smooth muscle actin and h-caldesmon but negative for TG, TTF1, PAX8, S-100, CT, CK, and CD34. The ki-67 index was very low (<1%). Primary thyroid leiomyoma is rare and difficult to diagnose using frozen sections. Diagnosis requires immunohistochemical staining. Leiomyoma may be mistaken for other thyroid tumors also characterized by spindle cells.

scholarly journals A rare case of plexiform schwannoma of the lower lip: Treatment and management

2015 ◽  
Vol 48 (02) ◽  
pp. 208-211 ◽  
Author(s):  
Subha Dhua
Keyword(s):  
Immunohistochemical Staining ◽  
Rare Case ◽  
Protein A ◽  
Complete Recovery ◽  
Cystic Degeneration ◽  
Lower Lip ◽  
Plexiform Schwannoma ◽  
S 100 ◽  
Mitotic Figures ◽  
Immunohistochemical Studies

ABSTRACTAn 18-year-old female presented with a swelling on the lower lip, which was insidious in onset and gradually progressive. The mass was completely excised under local anaesthesia. Complete histopathologic and immunohistochemical studies were conducted. The Antoni A areas were found along with typical verocay bodies composed of palisading nuclei and surrounding spaces filled with eosinophilic filaments. No necrosis was noted and there were no atypical mitotic figures. In the Antoni B region, a closely textured matrix with areas of edema, myxomatous changes, cystic degeneration and dilated vessels were noted. On the basis of the histopathologic and immunohistochemical staining with S-100 protein, a diagnosis of plexiform schwannoma was made and has been reported in this study. The post-operative view confirmed complete recovery after 6 weeks of surgery. This is a rare case with the tumour located in the lower lip, as very few cases have been reported in literature and it may be the first one reported from India.

Leiomyomatous hamartoma of the incisive papilla

2002 ◽  
Vol 25 (2) ◽  
pp. 157-159 ◽  
Author(s):  
Luciana Corrêa ◽  
Mônica Lotufo ◽  
Marília Trierveiler Martins ◽  
Norberto Sugaya ◽  
Suzana Cantanhede Orsini Machado de Sousa
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Immunohistochemical Staining ◽  
Smooth Muscle Actin ◽  
Muscle Cells ◽  
Histological Diagnosis ◽  
Muscle Actin ◽  
Histological Findings ◽  
Spindle Cells ◽  
Congenital Epulis

A case of unusual hamartoma in a six-year-old otherwise healthy Brazilian girl is reported, with emphasis on histological and immunohistochemical features. A mass observed in the incisive papilla was detected whose appearance was similar to congenital epulis or fibroma. Histological findings showed interlacing fascicles of large spindle cells resembling smooth muscle cells. Immunohistochemical staining for desmin and for smooth-muscle actin was positive. The histological diagnosis was leiomyomatous hamartoma, based on clinical and microscopic observations.

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