scholarly journals Verrucous Carcinoma of the Foot with Bone Invasion: A Case Report

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
C. Pempinello ◽  
A. Bova ◽  
R. Pempinello ◽  
R. Luise ◽  
G. Iannaci
Keyword(s):  
Early Stage ◽  
Verrucous Carcinoma ◽  
Focal Lesion ◽  
Multiple Biopsies ◽  
Pathological Evaluation ◽  
Delays In Diagnosis ◽  
Leg Amputation ◽  
Time Of Operation ◽  
Topical Medications ◽  
Chronic Course

Verrucous carcinoma of the foot often affects deep structures such as tendons, muscles, or bones. A 74-year-old man presented with a foot lesion that had been diagnosed as a skin infection 7 years earlier. He was treated with multiple excisions and superficial biopsies associated with antibiotic therapy without success. In our department he underwent an aggressive and accurate debridement with marginal excision harvesting multiple biopsies. Pathological evaluation of tissue at the time of operation confirmed the diagnosis of verrucous carcinoma of the foot. Therefore, the patient underwent an amputation below knee, and there were no postoperative complications; the patient was able to walk with the aid of a prosthesis with no signs of recurrence. The lesion follows a chronic course evolving from a discrete focal lesion to a large fungating deeply penetrating mass often compromised by local infection. The slow growth and confusing early-stage appearances can lead to delays in diagnosis of 8 to 15 years causing the extracutaneous involvement that requires a leg amputation. Many patients are initially treated with many topical medications without success, and most tumors have been treated as recalcitrant warts or corns for some time, whereas the basic approach is surgical.

Rôle du mésoderme somitique dans le développement du plumage dorsal chez l'embryon de Poulet

Development ◽  
1972 ◽  
Vol 28 (2) ◽  
pp. 343-366
Author(s):  
Par Annick Mauger
Keyword(s):  
Early Stage ◽  
Cervical Region ◽  
Lumbar Region ◽  
Chick Embryos ◽  
A Chain ◽  
Normal Differentiation ◽  
Time Of Operation ◽  
Somitic Mesoderm ◽  
Axial Organs

The role of somitic mesoderm in the development of dorsal plumage in chick embryos. II. Regionalisation. Transplantation and inversion experiments were performed on the somitic mesoderm of 2- to 2·5-day chick embryos in order to study the role of regional and axial determinations in the development of the dorsal plumage. The transposition of a piece of somitic mesoderm from the posterior cervical region (where the spinal pteryla is narrow) to the thoraco-lumbar region (where it is wide) leads to a local and unilateral narrowing of the spinal pteryla at the operation site. Conversely, the transposition of somitic mesoderm from the thoraco-lumbar region to the posterior cervical region results in a local and unilateral widening of the spinal pteryla. Consequently at the time of operation the segmented or not yet segmented somitic mesoderm is already determined to give rise to a definite transverse level of the spinal pteryla. The inversion of the cephalo-caudal polarity of a piece of somitic mesoderm without the ectodermal covering, or of a portion of the axial organs deprived of the overlying ectoderm has no effect on the orientation of feather filaments and feather rows. In contrast, the inversion of the cephalo-caudal polarity of a portion of the axial organs together with the overlying ectoderm results in the development of feathers growing in a cephalad direction and feather chevrons opening towards the head of the embryo. The inversion of the dorso-ventral polarity of a piece of somitic mesoderm does not prevent the normal differentiation of feathers in the operated region. The inversion of the medio-lateral polarity of a piece of unsegmented somitic mesoderm has little effect on the development of the spinal pteryla. On the contrary, the medio-lateral inversion of a chain of somites precludes the formation of the feathers at the level of operation. The somitic mesoderm, even when segmented, is endowed with extensive regulative capacity of its axes, except for the medio-lateral polarity, which is fixed irreversibly at the time of segmentation. The regional determination of the feather-forming somitic mesoderm is acquired at an early stage, at any rate before segmentation. However, at a given transverse level of the cephalo-caudal axis, the somitic cells remain totipotent as concerns their histo-genetic destiny (dermatome, myotome, or sclerotome) until after the onset of segmentation.

Verrucous Carcinoma of a Leg Amputation Stump

Dermatology ◽  
1991 ◽  
Vol 182 (3) ◽  
pp. 193-195 ◽  
Author(s):  
R.A. Schwartz ◽  
M.P. Bagley ◽  
C.K. Janniger ◽  
W.C. Lambert
Keyword(s):  
Verrucous Carcinoma ◽  
Amputation Stump ◽  
Leg Amputation

scholarly journals Graphene-based biosensors

2018 ◽  
Vol 8 (3) ◽  
pp. 20160132 ◽  
Author(s):  
Sabine Szunerits ◽  
Rabah Boukherroub
Keyword(s):  
Biological Samples ◽  
Early Stage ◽  
Point Of Care ◽  
High Surface ◽  
Volume Ratio ◽  
Wide Range ◽  
The Status ◽  
Delays In Diagnosis ◽  
Short Time ◽  
Sensor Interfaces

Reliable data obtained from analysis of DNA, proteins, bacteria and other disease-related molecules or organisms in biological samples have become a fundamental and crucial part of human health diagnostics and therapy. The development of non-invasive tests that are rapid, sensitive, specific and simple would allow patient discomfort to be prevented, delays in diagnosis to be avoided and the status of a disease to be followed up. Bioanalysis is thus a progressive discipline for which the future holds many exciting opportunities. The use of biosensors for the early diagnosis of diseases has become widely accepted as a point-of-care diagnosis with appropriate specificity in a short time. To allow a reliable diagnosis of a disease at an early stage, highly sensitive biosensors are required as the corresponding biomarkers are generally expressed at very low concentrations. In the past 50 years, various biosensors have been researched and developed encompassing a wide range of applications. This contrasts the limited number of commercially available biosensors. When it comes to sensing of biomarkers with the required picomolar (pM) sensitivity for real-time sensing of biological samples, only a handful of sensing systems have been proposed, and these are often rather complex and costly. Lately, graphene-based materials have been considered as superior over other nanomaterials for the development of sensitive biosensors. The advantages of graphene-based sensor interfaces are numerous, including enhanced surface loading of the desired ligand due to the high surface-to-volume ratio, excellent conductivity and a small band gap that is beneficial for sensitive electrical and electrochemical read-outs, as well as tunable optical properties for optical read-outs such as fluorescence and plasmonics. In this paper, we review the advances made in recent years on graphene-based biosensors in the field of medical diagnosis.

Properties of the primary organization field in the embryo of Xenopus laevis

Development ◽  
1972 ◽  
Vol 28 (1) ◽  
pp. 27-46
Author(s):  
J. Cooke
Keyword(s):  
Early Stage ◽  
Organizer Region ◽  
Positional Information ◽  
Bilateral Symmetry ◽  
Angular Distance ◽  
Organ Differentiation ◽  
Primary Organization ◽  
Cell Commitment ◽  
Time Of Operation ◽  
Field Formation

The results are reported of a series of experiments, the exact geometry of which has been presented in a previous paper. Late blastulae and early stage-10 gastrulae are supplied with a second head organizer region at varying angular distances, in the marginal zone, from the presumptive site of their own organizer. The configuration of positional information existing in the mesodermal mantle of the late gastrula or earliest neurula, as a final result of such operations, was recorded by observing the pattern of axial organ differentiation obtained by tailbud stages (26–28). The operational differences between various current theories as to the nature of embryonic differentiation fields are briefly discussed, as a framework within which to consider the results of experiments such as those reported here. It is suggested that in the future, and using the present results as a basis, experiments may be possible that are more critical in distinguishing between the various theoretical suppositions involved. Evidence is presented that the final configuration of positional information, achieved as a result of the implantation of a second head organizer at or before the onset of host gastrulation, becomes stable some time before it is irreversibly expressed in terms of a pattern of cell commitment in the mesodermal/endodermal mantle. It is insensitive both to relative ages of host and graft at the time of operation, over the range employed and, probably, to the ambient temperature of development between operation and the time of cell differentiation, being dependent only on the angular distance originally existing between graft and presumptive host organizer sites. In the discussion, a model is given for the visualization of positional information in partially double fields, produced in a two-dimensional sheet of cells where the normal end-point of field formation is a bilateral symmetry of differentiation zones.

scholarly journals Failure of multiple surgical procedures and adjuvant chemotherapy in early-stage steroid-cell ovarian tumor treatment: a case report and literature review

2021 ◽  
Vol 49 (1) ◽  
pp. 030006052098319
Author(s):  
Danuta Vasilevska ◽  
Vilius Rudaitis ◽  
Dominika Vasilevska ◽  
Ugnius Mickys ◽  
Sara Wawrysiuk ◽  
...  
Keyword(s):  
Adjuvant Chemotherapy ◽  
Early Stage ◽  
Surgical Techniques ◽  
Metastatic Tumor ◽  
Primary Treatment ◽  
Clinical Findings ◽  
Ovarian Tumors ◽  
Pathological Evaluation ◽  
Low Incidence ◽  
Effective Treatment Regimen

Ovarian steroid-cell tumors (SCTs) are a rare subgroup of sex-cord tumors of the ovary, accounting for less than 0.1% of all ovarian tumors. Not otherwise specified (NOS) tumors are the most common subtype. More than half of patients with SCTs-NOS show hyperandrogenic symptoms. The primary treatment for SCTs is surgery, as most cases are early-staged and benign. Because of the low incidence of metastatic disease, there is insufficient reliable information on the role of adjuvant therapy and the most effective treatment regimen. In this report, a rare case of a recurrent SCT-NOS in a 36-year-old female patient without endocrine symptoms is presented, highlighting the significance of appropriate pathological evaluation and immunohistochemical testing for the accurate diagnosis of this malignancy, particularly in the case of hormonally “silent” tumors. The metastatic tumor described here showed no response to four courses of adjuvant chemotherapy after several debulking surgeries. Based on the clinical findings, the neoplastic etiology should always be considered during the resection of ovarian tumors to prevent possible disease dissemination due to inappropriate surgical techniques.

scholarly journals Early detection of T-cell lymphoma with T follicular helper phenotype by RHOA mutation analysis

Haematologica ◽  
2021 ◽  
Author(s):  
Rachel Dobson ◽  
Peter Y Du ◽  
Lívia Rásó-Barnett ◽  
Wen-Qing Yao ◽  
Zi Chen ◽  
...  
Keyword(s):  
T Cell ◽  
Early Detection ◽  
Mutation Analysis ◽  
Cell Lymphoma ◽  
Early Stage ◽  
T Cell Lymphoma ◽  
Locked Nucleic Acid ◽  
Follicular Helper ◽  
Multiple Biopsies

Angioimmunoblastic T-cell lymphoma (AITL) and peripheral T-cell lymphoma with T follicular helper phenotype (PTCL-TFH) are a group of complex clinicopathological entities that originate from TFH cells and share a similar mutation profile. Their diagnosis is often a challenge, particularly at an early stage, due to a lack of specific histological and immunophenotypic features, paucity of neoplastic T cells and prominent polymorphous infiltrate. We investigated whether the lymphoma associated RHOA Gly17Val (c.50G>T) mutation, occurring in 60% of cases, is present in the early ‘reactive’ lesions, and whether mutation analysis can help advance early lymphoma diagnosis. The RHOA mutation was detected by quantitative PCR with a locked nucleic acid (LNA) probe specific to the mutation, and a further PNA clamp oligonucleotide to suppress the amplification of the wild-type allele. The qPCR assay was highly sensitive and specific, detecting RHOA Gly17Val at an allele frequency of 0.03%, but not other changes in Gly17, nor in 61 controls. Among the 37 cases of AITL and PTCL-TFH investigated, RHOA Gly17Val was detected in 62.2% (23/37) of which 19 had multiple biopsies including preceding biopsies in 10 and follow up biopsies in 11 cases. RHOA Gly17Val was present in each of these preceding or follow up biopsies including 18 specimens that showed no evidence of lymphoma by combined histological, immunophenotypic and clonality analyses. The mutation was seen in biopsies 0-26.5 months (mean=7.87 months) prior to lymphoma diagnosis. Our results show that RHOA Gly17Val mutation analysis is valuable in the early detection of AITL and PTCL-TFH.

Cutaneous Eccrine Adenolipoma with a Spindle Cell Component

2020 ◽  
Vol 154 (Supplement_1) ◽  
pp. S21-S22
Author(s):  
S S Karimi ◽  
M Braniecki ◽  
M Bain ◽  
N Jetter ◽  
T Murray
Keyword(s):  
Spindle Cell ◽  
Early Stage ◽  
Punch Biopsy ◽  
Sweat Glands ◽  
Cell Component ◽  
Spindle Cell Component ◽  
Eccrine Glands ◽  
Stromal Component ◽  
Pathological Evaluation ◽  
The Right

Abstract Introduction/Objective Cutaneous adenolipoma is a rare, benign variant of solitary lipoma characterized by a mature adipocytic proliferation with entrapped eccrine or apocrine sweat glands. It is found predominately in middle-aged females, with a predilection for lower extremities including the thigh and gluteal regions. Cutaneous adenolipoma is presumed to be a hamartomatous process. Herein, we report a unique case of a cutaneous eccrine adenolipoma with a spindle cell component, namely, an early evolving spindle cell adenolipoma. Methods A 43-year-old female with a recurrent history of hidradenitis presented with a 2.7 cm x 1.5 cm x 0.7 cm soft, mobile nodule on the right posterior thigh. It had been present for at least four months and clinically resembled a lipoma. An excisional punch biopsy was performed for pathological evaluation. A concurrent nevus lipomatosus superficialis was diagnosed from the right perineum. Results Gross examination of the thigh nodule revealed fragments of a tan-yellow, lobulated, fatty lesion. Microscopic examination demonstrated a benign lipomatous proliferation with entrapped eccrine glands associated with a surrounding spindle cell stroma. Initial differential diagnosis included a cutaneous eccrine adenolipoma variant and a cutaneous mixed solitary hamartoma composed of admixed neural, eccrine and lipomatous components. Immunohistochemical staining showed uptake for CD34 and CD10 in the spindle cell stromal component, but negative for desmin and S100. Based on our histopathological findings, our diagnosis of an eccrine cutaneous adenolipoma with a spindle cell component was rendered. This unique lesion displayed features of an evolving spindle cell lipoma with entrapped sweat glands, which may be viewed as an early stage of a dermal spindle cell adenolipoma. Conclusion Cutaneous eccrine adenolipoma is a rare, benign lipomatous neoplasm with entrapped sweat glands that can also show a spindle cell component. We share this rare lesion exemplifying the histomorphological spectrum of a lipomatous hamartoma and to highlight the recognition of a cutaneous adenolipoma.

scholarly journals Gastric stump mucosa: is there a risk for carcinoma?

2001 ◽  
Vol 38 (4) ◽  
pp. 227-231 ◽  
Author(s):  
Adriana Vaz SAFATLE-RIBEIRO ◽  
Ulysses RIBEIRO Jr. ◽  
Paulo SAKAI ◽  
Kyoshi IRIYA ◽  
Shinichi ISHIOKA ◽  
...  
Keyword(s):  
Early Stage ◽  
Cost Benefit ◽  
Pathological Examination ◽  
Severe Dysplasia ◽  
Gastric Stump ◽  
Ulcer Disease ◽  
Pathologic Evaluation ◽  
Multiple Biopsies ◽  
Increased Risk ◽  
Cost Benefit Ratio

Background - Patients who underwent partial gastric resections are at an increased risk for the development of cancer in the gastric remnant. Aim - To assess the long-term patients who underwent surgical treatment for peptic ulcer disease through endoscopic and pathologic evaluation of the gastric stump mucosal alterations. Patients and Methods - Between 1987 and 1990, 154 patients (mean = 20.4 years after gastrectomy) were evaluated by upper digestive endoscopy with multiple biopsies and pathological examination. Results - Endoscopic alterations were present in 111 patients (72.1%). The commonest pathologic alterations were foveolar hyperplasia, intestinal metaplasia and cystic dilation. Severe dysplasia was noted in two (1.25%) and carcinoma in 13 (8.4%) of the cases. In four patients (3.8%) the endoscopic findings did not show any evidence of tumors, however they were detected due to multiple biopsies and histologic studies. Conclusions - Surveillance of these patients with endoscopy and multiple biopsies may provide the means to diagnose tumors at an early stage, but the cost benefit ratio of surveillance requires further study.

scholarly journals Study on incidence of oesophageal carcinoma in patients undergoing upper gastrointestinal endoscopy for upper gastrointestinal symptoms in a secondary care hospital

2019 ◽  
Vol 7 (1) ◽  
pp. 222
Author(s):  
Shashidhara Puttaraju ◽  
Deva Keerthana Yesudian Gnanakumar
Keyword(s):  
Early Stage ◽  
Gastrointestinal Symptoms ◽  
Oesophageal Carcinoma ◽  
Upper Gastrointestinal Endoscopy ◽  
High Morbidity ◽  
Care Hospital ◽  
Multiple Biopsies ◽  
Upper Gastrointestinal Symptoms ◽  
Upper Gastrointestinal ◽  
Suspicious Lesions

Background: Oesophageal carcinoma is one of the leading causes of cancer related deaths worldwide and is also associated with high morbidity. Hence early diagnosis and treatment are the only effective way to improve survival and quality of life in oesophageal carcinoma patients. Early-stage oesophageal carcinoma are often asymptomatic and may also present with common upper gastrointestinal symptoms hence diagnosis of early oesophageal carcinoma is only based on detection of suspicious lesions through endoscopy and histopathological evaluation of biopsies from these suspicious lesions. The study is designed to see whether using alarming upper gastrointestinal symptoms, risk of oesophageal carcinoma in patients can be predicted.Methods: Present study comprises of 200 patients presenting with upper gastrointestinal symptoms at JSS Hospital, Chamarajanagar (both out patients and referred patients) during the period of October 2018 to December 2019, who underwent upper gastrointestinal endoscopy.Results: Out of 200 patients, 135 patients were males and 65 patients were females. According to the study, dysphagia was found to be a significant predictive factor and in contrary to the global statistics this study showed females aged more than 60 years were significantly at higher risk of developing oesophageal carcinoma.Conclusions: We recommend to do an early endoscopy for any patient presenting with upper gastrointestinal symptoms and to take multiple biopsies from any suspicious lesion especially for male gender older than 50 years and female gender older than 60 years presenting with dysphagia.

A Comprehensive Review: Development of Biosensors Based on Graphene-Mesoporous Combined Materials

2019 ◽  
pp. 24-33 ◽  
Author(s):  
Kamrun Nahar Fatema ◽  
Won-Chun Oh
Keyword(s):  
Early Stage ◽  
Point Of Care ◽  
High Surface ◽  
Volume Ratio ◽  
Ordered Mesoporous Materials ◽  
Wide Range ◽  
The Status ◽  
Delays In Diagnosis ◽  
Short Time ◽  
Sensor Interfaces

Reliable data obtained from analysis of DNA, proteins, bacteria and other disease-related molecules or organisms in biological samples have become a fundamental and crucial part of human health diagnostics and therapy. After a brief summary of the implication of template based ordered mesoporous materials in electrochemical science, the various types of inorganic and organic-inorganic hybrid mesostructured used to date in electroanalysis and the corresponding electrode configurations are described. The development of non-invasive tests that are rapid, sensitive, specific and simple would allow patient discomfort to be prevented, delays in diagnosis to be avoided and the status of a disease to be followed up. The use of biosensors for the early diagnosis of diseases has become widely accepted as a point-of-care diagnosis with appropriate specificity in a short time. To allow a reliable diagnosis of a disease at an early stage, highly sensitive biosensors are required as the corresponding biomarkers are generally expressed at very low concentrations. In past 50 years, various biosensors have been researched and developed encompassing a wide range of applications. This contrasts the limited number of commercially available biosensors. Lately, graphene-based materials have been considered as superior over other nanomaterials for the development of sensitive biosensors. The advantages of graphenebased sensor interfaces are numerous, including enhanced surface loading of desired ligand due to the high surface-to-volume ratio, excellent conductivity and a small band gap that is beneficial for sensitive electrical and electrochemical read-outs, as well as tunable optical properties for optical read-outs such as fluorescence and plasmonics. In this paper, we review the advances made in recent years on graphenebased biosensors in the field of medical diagnosis.

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