scholarly journals Vitreous Diagnosis in Neoplastic Diseases

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Mónica Asencio-Duran ◽  
José Luis Vallejo-Garcia ◽  
Natalia Pastora-Salvador ◽  
Agustín Fonseca-Sandomingo ◽  
Mario R. Romano
Keyword(s):  
Optic Nerve ◽  
Inflammatory Mediators ◽  
Ciliary Body ◽  
Vitreous Body ◽  
Vitreous Humor ◽  
Inflammatory Reactions ◽  
Primary Vitreoretinal Lymphoma ◽  
Vitreoretinal Lymphoma ◽  
Pathologic Processes ◽  
Masquerade Syndromes

Vitreous body is an intraocular structure, origin of diverse pathologies, but is also the place where cells and inflammatory mediators are released coming from several pathologic processes. These inflammatory reactions can happen in any other ocular location like choroid, retina, optic nerve, or ciliary body and vitreous humor constitutes a stagnant reservoir for these resulting substances and debris. Through the recent techniques of vitreous collecting, handling, and analysis, increasingly more sophisticated and with fewer complications, cellularity and molecules in the vitreous of challenging pathologies for the ophthalmologist can now be studied. The most usefulness for vitreous diagnosis would be the masquerade syndromes, and the best exponent in this group is the primary vitreoretinal lymphoma (PVRL), in which cytology and an IL-10/IL-6 ratio more than 1 is fundamental for the diagnosis.

scholarly journals Eye Tumors in Childhood as First Sign of Tumor Predisposition Syndromes: Insights from an Observational Study Conducted in Germany and Austria

Cancers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1876
Author(s):  
Madlen Reschke ◽  
Eva Biewald ◽  
Leo Bronstein ◽  
Ines B. Brecht ◽  
Sabine Dittner-Moormann ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Observational Study ◽  
Ciliary Body ◽  
Prospective Observational Study ◽  
Genetic Data ◽  
Detailed History ◽  
Cancer Early Detection ◽  
Physical Examinations ◽  
Eye Tumors ◽  
Multicenter Prospective Observational Study

Retinoblastoma and other eye tumors in childhood are rare diseases. Many eye tumors are the first signs of a genetic tumor predisposition syndrome and the affected children carry a higher risk of developing other cancers later in life. Clinical and genetic data of all children with eye tumors diagnosed between 2013–2018 in Germany and Austria were collected in a multicenter prospective observational study. In five years, 300 children were recruited into the study: 287 with retinoblastoma, 7 uveal melanoma, 3 ciliary body medulloepithelioma, 2 retinal astrocytoma, 1 meningioma of the optic nerve extending into the eye. Heritable retinoblastoma was diagnosed in 44% of children with retinoblastoma. One child with meningioma of the optic nerve extending into the eye was diagnosed with neurofibromatosis 2. No pathogenic constitutional variant in DICER1 was detected in a child with medulloepithelioma while two children did not receive genetic analysis. Because of the known association with tumor predisposition syndromes, genetic counseling should be offered to all children with eye tumors. Children with a genetic predisposition to cancer should receive a tailored surveillance including detailed history, physical examinations and, if indicated, imaging to screen for other cancer. Early detection of cancers may reduce mortality.

scholarly journals Primary vitreoretinal lymphoma

2019 ◽  
Vol 33 (1) ◽  
pp. 66-80 ◽  
Author(s):  
Dimitrios Kalogeropoulos ◽  
Georgios Vartholomatos ◽  
Arijit Mitra ◽  
Ibrahim Elaraoud ◽  
Soon Wai Ch'ng ◽  
...  
Keyword(s):  
Primary Vitreoretinal Lymphoma ◽  
Vitreoretinal Lymphoma

En Face Optical Coherence Tomography Angiography of Primary Vitreoretinal Lymphoma

2018 ◽  
Vol 49 (10) ◽  
pp. e173-e174
Author(s):  
Luisa Pierro ◽  
Alessandro Arrigo ◽  
Giuseppe Casalino ◽  
Elisabetta Miserocchi ◽  
Emanuela Aragona ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Optical Coherence ◽  
Primary Vitreoretinal Lymphoma ◽  
Vitreoretinal Lymphoma ◽  
En Face

scholarly journals Primary vitreoretinal lymphoma: prevalence, impact, and management challenges

2019 ◽  
Vol Volume 13 ◽  
pp. 353-364 ◽  
Author(s):  
Ramesh Venkatesh ◽  
Bharathi Bavaharan ◽  
Padmamalini Mahendradas ◽  
Naresh Kumar Yadav
Keyword(s):  
Primary Vitreoretinal Lymphoma ◽  
Vitreoretinal Lymphoma

Branch Retinal Artery Occlusion Following Intravitreal Injection of Methotrexate for the Treatment of Primary Vitreoretinal Lymphoma

2019 ◽  
Vol 3 (6) ◽  
pp. 485-487
Author(s):  
Arthi G. Venkat ◽  
Naveen Karthik ◽  
Ashley Lowe ◽  
Sumit Sharma
Keyword(s):  
Intravitreal Injection ◽  
Retinal Artery Occlusion ◽  
Artery Occlusion ◽  
Branch Retinal Artery Occlusion ◽  
Primary Vitreoretinal Lymphoma ◽  
Case Summary ◽  
Vitreoretinal Lymphoma ◽  
Retinal Artery ◽  
Vitreous Biopsy ◽  
Rule Out

Purpose: This paper reports a case of an older white woman presenting with recalcitrant bilateral vitreoretinal inflammation that was ultimately proven to be primary vitreoretinal lymphoma by vitreous biopsy who subsequently developed a branch retinal artery occlusion (BRAO) following an intravitreal injection of methotrexate. Methods: Case summary. Results: The patient was treated with serial intravitreal methotrexate injections and subsequently developed a BRAO immediately following her seventh injection. Conclusions: A full systemic evaluation to rule out other causes of the BRAO was negative and given the timing of her symptoms after the injection it was determined that the BRAO was most likely realted to the intravitreal methotrexate injection.

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