scholarly journals The Effect of Alcohol on Postprandial and Fasting Triglycerides

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Albert Van de Wiel
Keyword(s):  
Lipoprotein Lipase ◽  
Lipase Activity ◽  
Saturated Fat ◽  
Inhibitory Effect ◽  
Lipoprotein Lipase Activity ◽  
Severe Hypertriglyceridemia ◽  
Postprandial Triglyceride ◽  
Excessive Alcohol ◽  
Significant Additive Effect

Alcohol has a significant additive effect on the postprandial triglyceride peak when it accompanies a meal containing fat, especially saturated fat. This results from a decrease in the breakdown of chylomicrons and VLDL remnants due to an acute inhibitory effect of alcohol on lipoprotein lipase activity. Furthermore, alcohol increases the synthesis of large VLDL particles in the liver, which is the main source of triglycerides in the hypertriglyceridemia associated with chronic excessive alcohol intake. In case of chronic consumption, lipoprotein lipase activity seems to adapt itself. The effect of alcohol on adipose tissues is less clear. Sometimes, a severe hypertriglyceridemia induced by alcohol (SHIBA) can be observed, especially in patients with type 2 diabetes mellitus and/or obesity increasing the risk of pancreatitis.

scholarly journals Preserved Endothelial Function in Patients With Severe Hypertriglyceridemia and Low Functional Lipoprotein Lipase Activity

1997 ◽  
Vol 29 (5) ◽  
pp. 964-968 ◽  
Author(s):  
Philip J Chowienczyk ◽  
Gerald F Watts ◽  
Anthony S Wierzbicki ◽  
John R Cockcroft ◽  
Sally E Brett ◽  
...  
Keyword(s):  
Endothelial Function ◽  
Lipoprotein Lipase ◽  
Lipase Activity ◽  
Lipoprotein Lipase Activity ◽  
Severe Hypertriglyceridemia

Regulation of lipoprotein lipase activity in cardiac myocytes from control and diabetic rat hearts by plasma lipids

1992 ◽  
Vol 70 (9) ◽  
pp. 1271-1279 ◽  
Author(s):  
Brian Rodrigues ◽  
Janice E. A. Braun ◽  
Michael Spooner ◽  
David L. Severson
Keyword(s):  
Lipoprotein Lipase ◽  
Cardiac Myocytes ◽  
Lipase Activity ◽  
Plasma Lipids ◽  
Inhibitory Effect ◽  
Diabetic Rats ◽  
Diabetic Rat ◽  
Lipoprotein Lipase Activity ◽  
Triton Wr 1339 ◽  
Plasma Triacylglycerol

The objective of this investigation was to test the hypothesis that the diabetes-induced reduction in lipoprotein lipase activity in cardiac myocytes may be due to hypertriglyceridemia. Administration of 4-aminopyrazolopyrimidine (50 mg/kg) to control rats for 24 h reduced plasma triacylglycerol levels and increased the heparin-induced release of lipoprotein lipase into the incubation medium of cardiac myocytes. The acute (3–5 days) induction of diabetes by streptozotocin (100 mg/kg) produced hypertriglyceridemia and reduced heparin-releasable lipoprotein lipase activity in cardiac myocytes. Treatment of diabetic rats with 4-aminopyrazolopyrimidine resulted in a fall in plasma triacylglycerol content and increased heparin-releasable lipoprotein lipase activity. Administration of Triton WR-1339 also resulted in hypertriglyceridemia, but the heparin-induced release of lipoprotein lipase from control cardiac myocytes was not reduced in the absence of lipolysis of triacylglycerol-rich lipoproteins. Treatment with Triton WR-1339 did, however, increase the heparin-induced release of lipoprotein lipase from diabetic cardiac myocytes. Preparation of cardiac myocytes with 0.9 mM oleic acid resulted in a decrease in both total cellular and heparin-releasable lipoprotein lipase activities. These results suggest that the diabetes-induced reduction in heart lipoprotein lipase activity may, at least in part, be due to an inhibitory effect of free fatty acids, derived either from lipoprotein degradation or from adipose tissue lipolysis, on lipoprotein lipase activity in (and (or) release from) cardiac myocytes.Key words: diabetes, plasma triacylglycerols, cardiac myocytes, lipoprotein lipase.

Inhibitory Effect ofMorinda CitrifoliaL. on Lipoprotein Lipase Activity

2008 ◽  
Vol 73 (8) ◽  
pp. C595-C598 ◽  
Author(s):  
M.S. Pak-Dek ◽  
A. Abdul-Hamid ◽  
A. Osman ◽  
C.S. Soh
Keyword(s):  
Lipoprotein Lipase ◽  
Lipase Activity ◽  
Inhibitory Effect ◽  
Lipoprotein Lipase Activity

scholarly journals Alteration in lipoprotein lipase activity bound to triglyceride-rich lipoproteins in the postprandial state in type 2 diabetes

2004 ◽  
Vol 45 (5) ◽  
pp. 859-865 ◽  
Author(s):  
Valérie Pruneta-Deloche ◽  
Agnès Sassolas ◽  
Geesje M. Dallinga-Thie ◽  
François Berthezène ◽  
Gabriel Ponsin ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Lipoprotein Lipase ◽  
Lipase Activity ◽  
Lipoprotein Lipase Activity ◽  
Postprandial State

scholarly journals Severe acquired hypertriglyceridemia following COVID-19

2021 ◽  
Vol 14 (11) ◽  
pp. e246698
Author(s):  
Lauré M Fijen ◽  
Aldo Grefhorst ◽  
Johannes H M Levels ◽  
Danny M Cohn
Keyword(s):  
Acute Pancreatitis ◽  
Risk Factor ◽  
Autoimmune Diseases ◽  
Lipoprotein Lipase ◽  
Western Blotting ◽  
Lipase Activity ◽  
Lipoprotein Lipase Activity ◽  
Severe Hypertriglyceridemia ◽  
Healthy Control

Severe hypertriglyceridemia is a major risk factor for acute pancreatitis. In exceptional cases, it is caused by plasma components inhibiting lipoprotein lipase activity. This phenomenon is predominantly associated with autoimmune diseases. Here, we report a case of severe hypertriglyceridemia due to a transient reduction in lipoprotein lipase activity following an episode of COVID-19 in an otherwise healthy 45-year-old woman. The lipoprotein lipase activity of the patient was markedly reduced compared with a healthy control and did recover to 20% of the healthy control’s lipoprotein lipase activity 5 months after the COVID-19 episode. Mixing tests substantiated reduced lipolytic capacity in the presence of the patient’s plasma at presentation compared with a homozygous lipoprotein lipase-deficient control, which was no longer present at follow-up. Western blotting confirmed that the quantity of lipoprotein lipase was not aberrant. Fibrate treatment and a strict hypolipidemic diet improved the patient’s symptoms and triglyceride levels.

Severe hypertriglyceridemia with plasma inhibitory factor(s) on lipoprotein lipase activity in a patient with a common Ser447–Ter LPL mutation

2001 ◽  
Vol 308 (1-2) ◽  
pp. 139-146 ◽  
Author(s):  
Yanjuan Zhu ◽  
Hideaki Bujo ◽  
Kazuo Takahashi ◽  
Koichi Taira ◽  
Junji Kobayashi ◽  
...  
Keyword(s):  
Lipoprotein Lipase ◽  
Lipase Activity ◽  
Inhibitory Factor ◽  
Lipoprotein Lipase Activity ◽  
Severe Hypertriglyceridemia
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