scholarly journals Lipoprotein lipase activity and serum lipoproteins in untreated Type 2 (insulin-independent) diabetes associated with obesity

Diabetologia ◽  
1982 ◽  
Vol 22 (1) ◽  
pp. 46-50 ◽  
Author(s):  
M. -R. Taskinen ◽  
E. A. Nikkil� ◽  
T. Kuusi ◽  
K. Harno
2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Albert Van de Wiel

Alcohol has a significant additive effect on the postprandial triglyceride peak when it accompanies a meal containing fat, especially saturated fat. This results from a decrease in the breakdown of chylomicrons and VLDL remnants due to an acute inhibitory effect of alcohol on lipoprotein lipase activity. Furthermore, alcohol increases the synthesis of large VLDL particles in the liver, which is the main source of triglycerides in the hypertriglyceridemia associated with chronic excessive alcohol intake. In case of chronic consumption, lipoprotein lipase activity seems to adapt itself. The effect of alcohol on adipose tissues is less clear. Sometimes, a severe hypertriglyceridemia induced by alcohol (SHIBA) can be observed, especially in patients with type 2 diabetes mellitus and/or obesity increasing the risk of pancreatitis.


Metabolism ◽  
1978 ◽  
Vol 27 (11) ◽  
pp. 1661-1671 ◽  
Author(s):  
Esko A. Nikkilä ◽  
Marja-Riitta Taskinen ◽  
Seppo Rehunen ◽  
Matti Härkönen

2004 ◽  
Vol 45 (5) ◽  
pp. 859-865 ◽  
Author(s):  
Valérie Pruneta-Deloche ◽  
Agnès Sassolas ◽  
Geesje M. Dallinga-Thie ◽  
François Berthezène ◽  
Gabriel Ponsin ◽  
...  

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