scholarly journals Adult BMI Change and Risk of Colon Cancer in Postmenopausal Women

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Lyla Blake-Gumbs ◽  
Zhengyi Chen ◽  
Cheryl L. Thompson ◽  
Nathan A. Berger ◽  
Thomas C. Tucker ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Weight Gain ◽  
Cancer Risk ◽  
Postmenopausal Women ◽  
Early Adulthood ◽  
Population Based ◽  
Colon Cancer Risk ◽  
Increased Risk ◽  
Study Population ◽  
Control Study

Purpose. We recently reported an association of adult BMI change with colon cancer risk. Here, we sought to further explore this association with respect to postmenopausal HRT use in a larger study population.Methods. We included 1,457 postmenopausal women participating in an ongoing population-based case-control study of colon cancer.Results. We confirmed a previously reported association of adulthood weight gain and increased risk of colon cancer: compared to those with <5 kg/m2change of BMI, women who reported moderate (5–10 kg/m2) and large (>10 kg/m2) BMI changes since their 20s had OR estimates of 1.54 (95% CI = 1.09–2.19) and 1.45 (95% CI = 0.90–2.33), respectively (Pfor trend = 0.05). Stratified analyses showed that this association was limited to HRT nonusers: ORs were 1.77 (95% CI = 1.02–3.05) and 2.21 (95% CI = 1.09–4.45), respectively (Pfor trend = 0.03), for BMI changes occurring between the 20s decade and time of recruitment among non-users. Similar associations were observed for BMI changes since the 30s decade. There was no association among HRT users.Conclusion. Our results suggest early adulthood weight gain increases colon cancer risk in postmenopausal women who do not use HRT.

scholarly journals Serum Lipids and the Risk of Gastrointestinal Malignancies in the Swedish AMORIS Study

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Wahyu Wulaningsih ◽  
Hans Garmo ◽  
Lars Holmberg ◽  
Niklas Hammar ◽  
Ingmar Jungner ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Colon Cancer ◽  
Cancer Risk ◽  
Proportional Hazards ◽  
Cox Proportional Hazards ◽  
Gastrointestinal Malignancies ◽  
Colon Cancer Risk ◽  
Colon And Rectal Cancer ◽  
Increased Risk ◽  
Lipid Components

Background. Metabolic syndrome has been linked to an increased cancer risk, but the role of dyslipidaemia in gastrointestinal malignancies is unclear. We aimed to assess the risk of oesophageal, stomach, colon, and rectal cancers using serum levels of lipid components.Methods. From the Swedish Apolipoprotein Mortality Risk (AMORIS) study, we selected 540,309 participants (> 20 years old) with baseline measurements of total cholesterol (TC), triglycerides (TG), and glucose of whom 84,774 had baseline LDL cholesterol (LDL), HDL cholesterol (HDL), apolipoprotein B (apoB), and apolipoprotein A-I (apoA-I). Multivariate Cox proportional hazards regression was used to assess glucose and lipid components in relation to oesophageal, stomach, colon, and rectal cancer risk.Results. An increased risk of oesophageal cancer was observed in persons with high TG (e.g. HR: 2.29 (95% CI: 1.42–3.68) for the 4th quartile compared to the 1st) and low LDL, LDL/HDL ratio, TC/HDL ratio, log (TG/HDL), and apoB/apoA-I ratio. High glucose and TG were linked with an increased colon cancer risk, while high TC levels were associated with an increased rectal cancer risk.Conclusion. The persistent link between TC and rectal cancer risk as well as between TG and oesophageal and colon cancer risk in normoglycaemic individuals may imply their substantiality in gastrointestinal carcinogenesis.

scholarly journals Association between shiftwork and the risk of colorectal cancer in females: a population-based case–control study

2018 ◽  
Vol 75 (5) ◽  
pp. 344-350 ◽  
Author(s):  
Wa Mwenga Walasa ◽  
Renee N Carey ◽  
Si Si ◽  
Lin Fritschi ◽  
Jane S Heyworth ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Case Control Study ◽  
Early Morning ◽  
Population Based ◽  
Case Control ◽  
Colorectal Cancer Risk ◽  
Adverse Health Outcomes ◽  
Increased Risk ◽  
Control Study

ObjectiveResearch indicates that shiftwork may be associated with increased risks of adverse health outcomes, including some cancers. However, the evidence of an association between shiftwork and colorectal cancer risk is limited and inconclusive. Further, while several possible pathways through which shiftwork might result in cancer have been proposed, few studies have taken these factors into account. We investigated the association between two types of shiftwork (graveyard shiftwork and early-morning shiftwork) and six mechanistic shiftwork variables (including light at night and phase shift) and the risk of colorectal cancer among females in an Australian population-based case–control study. Graveyard shiftwork was the primary exposure of interest.MethodsParticipants (350 cases and 410 controls) completed a lifetime occupational history, and exposure to each of the eight shiftwork variables was assigned to participants through a job exposure matrix. We used logistic regression to calculate odds ratios (OR) and corresponding 95% confidence intervals (CI) for the association between different shiftwork variables and the risk of colorectal cancer, adjusting for potential demographic, lifestyle and medical confounders.ResultsWorking in an occupation involving long-term exposure (>7.5 years) to graveyard shiftwork was not associated with colorectal cancer risk (adjusted OR 0.95, 95% CI 0.57 to 1.58). Similarly, no increased risks of colorectal cancer were seen for any of the other seven shiftwork variables examined.ConclusionsNo evidence of an increased risk of colorectal cancer among females who had worked in occupations involving shiftwork was observed in this study.

scholarly journals Colon cancer risk and different HRT formulations: a case-control study

BMC Cancer ◽  
2007 ◽  
Vol 7 (1) ◽  
Author(s):  
Jürgen C Dinger ◽  
Lothar AJ Heinemann ◽  
Sabine Möhner ◽  
Do Minh Thai ◽  
Anita Assmann
Keyword(s):  
Colon Cancer ◽  
Cancer Risk ◽  
Case Control Study ◽  
Case Control ◽  
Colon Cancer Risk ◽  
Control Study

scholarly journals Exposure to passive smoking and rheumatoid arthritis risk: results from the Swedish EIRA study

2018 ◽  
Vol 77 (7) ◽  
pp. 970-972 ◽  
Author(s):  
Anna Karin Hedström ◽  
Lars Klareskog ◽  
Lars Alfredsson
Keyword(s):  
Rheumatoid Arthritis ◽  
Passive Smoking ◽  
Population Based ◽  
Rheumatoid Arthritis Risk ◽  
Increased Risk ◽  
Study Population ◽  
Never Smokers ◽  
Incident Cases ◽  
Citrullinated Peptide ◽  
Control Study

IntroductionSmoking has consistently been associated with increased risk of developing rheumatoid arthritis (RA). The aim of this study was to estimate the influence of passive smoking on the risk of developing anti-cyclic citrullinated peptide antibodies (ACPA)-positive and ACPA-negative RA.MethodsA population-based case–control study using incident cases of RA was performed in Sweden, and the study population in this report was restricted to include never-smokers (589 cases, 1764 controls). The incidence of RA among never-smokers who had been exposed to passive smoking was compared with that of never-smokers who had never been exposed, by calculating the OR with a 95% CI employing logistic regression.ResultsNo association was observed between exposure to passive smoking and RA risk (OR 1.0, 95% CI 0.8 to 1.2 for ACPA-positive RA, and OR 0.9, 95% CI 0.7 to 1.2, for ACPA-negative RA). No suggestion of a trend between duration of passive smoking and RA risk was observed.DiscussionsNo association was observed between exposure to passive smoking and RA risk, which may be explained by a threshold below which no association between smoke exposure and RA occurs.

Factors Influencing Intention to Obtain a Genetic Test for Colon Cancer Risk: A Population-Based Study

2002 ◽  
Vol 34 (6) ◽  
pp. 567-577 ◽  
Author(s):  
Janice Yanushka Bunn ◽  
Kwadwo Bosompra ◽  
Takamaru Ashikaga ◽  
Brian S. Flynn ◽  
John K. Worden
Keyword(s):  
Colon Cancer ◽  
Cancer Risk ◽  
Genetic Test ◽  
Population Based ◽  
Population Based Study ◽  
Colon Cancer Risk ◽  
Factors Influencing

scholarly journals 2845. Oral Antibiotic Use and Risk of Colorectal Cancer in the UK, 1989–2012: A Matched Case–Control Study

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S68-S69
Author(s):  
Jiajia Zhang ◽  
Charles Haines ◽  
Alastair Watson ◽  
Andrew Hart ◽  
Mary Jane Platt ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Risk ◽  
Antibiotic Use ◽  
Tumor Location ◽  
Oral Antibiotic ◽  
Antibiotic Exposure ◽  
Colon Cancer Risk ◽  
Increased Risk ◽  
Matched Case ◽  
The Right

Abstract Background Microbiome dysbiosis predisposes to colorectal cancer (CRC), but a population-based study of oral antibiotic exposure and CRC risk is lacking. Methods A matched case–control study (incident CRC cases and up to 5 matched controls) was conducted in the Clinical Practice Research Datalink (CPRD; 1989–2012). The CRPD is validated as 92% and 99% sensitive and specific for CRC detection (98% PPV). Antibiotic exposure [categorical and continuous terms (spline)] was investigated for risk pattern, stratified by tumor location, using conditional logistic regression and adjusting for known confounders. Results In total, 28,980 CRC cases and 137,077 controls were identified. Oral antibiotic use increased risk of colon cancer in a dose-dependent fashion (Ptrend < 0.001), but effects differed by anatomic location. Colon cancer risk was greatest in the proximal colon and with antibiotics with anti-anaerobic activity (Figure 1). In contrast, an inverse association was detected between antibiotic use and rectal cancers (Ptrend = 0.003), particularly with length of antibiotic exposure >60 days (adjusted odds ratio [AOR], 0.85, 95% CI 0.79–0.93) when compared with no antibiotic exposure. Nonlinearity models showed significantly increased colon cancer risk after minimal antibiotic use, but decreased rectum cancer risk with cumulative use of over 30 days (Figure 2). Penicillins, particularly ampicillin/amoxicillin, increased risk of colon cancer (AOR,1.09, [1.05–1.13]) whereas tetracyclines reduced risk for rectal cancer (AOR, 0.90, [0.84–0.97]). Significant interactions were detected between antibiotic use and tumor location (colon vs. rectum, Pinteraction < 0.001). The antibiotic-cancer association was found for antibiotic exposure occurring >10 years before diagnosis (AOR, 1.17, [1.06–1.31]). Conclusion We conclude that oral antibiotic use associates with increased colon cancer risk, particularly in the right colon, but a reduced risk for rectal cancer. This effect heterogeneity suggests unabsorbed antibiotics impact gut microbiota in the right colon to enhance carcinogenesis whereas antibiotic anti-inflammatory or anti-proliferative actions may yield an inverse effect on carcinogenesis in the rectum. Disclosures Sara E. Cosgrove, MD, MS, Basilea: Consultant; Theravance: Consultant.

Association of vitamin D receptor and toll like receptor genetic variants and haplotypes with colon cancer risk: A case control study in Egypt

Meta Gene ◽  
2017 ◽  
Vol 11 ◽  
pp. 209-216
Author(s):  
Ragaa A. Ramadan ◽  
Lubna M. Desouky ◽  
Mai Moaaz ◽  
Mostafa A. Elnaggar ◽  
Mohamed Selima ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Vitamin D ◽  
Cancer Risk ◽  
Vitamin D Receptor ◽  
Genetic Variants ◽  
Case Control Study ◽  
Case Control ◽  
Toll Like Receptor ◽  
Colon Cancer Risk ◽  
Control Study

scholarly journals High plasma levels of pro-NT are associated with increased colon cancer risk

2020 ◽  
Vol 27 (11) ◽  
pp. 641-646
Author(s):  
Li Li ◽  
Heidi L Weiss ◽  
Jing Li ◽  
Zhengyi Chen ◽  
Leslie Donato ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Risk ◽  
Plasma Levels ◽  
Significant Risk ◽  
High Plasma ◽  
Population Based ◽  
Continuous Measure ◽  
Logistic Regression Models ◽  
Colon Cancer Risk ◽  
History Of

Emerging data supports a potential role of neurotensin (NT) in the development of obesity, obesity-associated comorbidities, and certain cancers. The association of NT with colon cancer risk has not been explicitly explored. We determined plasma levels of pro-NT, a stable NT precursor fragment, in 223 incident colon cancer patients and 223 age-, gender-, BMI-matched population controls participating in a population-based case–control study of colon cancer. On average, the cases have significantly higher levels of pro-NT than the controls (median = 205.6 pmol/L vs 183.1 pmol/L, respectively; P = 0.02). Multivariate logistic regression models, adjusted for age, gender, BMI, family history of colorectal cancer, smoking, diabetes mellitus, alcohol, and non-steroidal anti-inflammatory drugs use, show statistically significant risk associations: for continuous measure of pro-NT, the OR estimate was 1.30 (95% CI =1.03–1.64; P = 0.026) for each increment of 175 pmol/L; for dichotomized measure of pro-NT, the OR estimate was 1.75 (95% CI = 1.12–2.74; P = 0.025) for those in the top quartile comparing to the other participants. Our results support circulating levels of pro-NT as a novel risk biomarker for colon cancer.

scholarly journals Endogenous Circulating Sex Hormone Concentrations and Colon Cancer Risk in Postmenopausal Women: A Prospective Study and Meta-Analysis

2021 ◽  
Author(s):  
Nagisa Mori ◽  
Pekka Keski-Rahkonen ◽  
Audrey Gicquiau ◽  
Sabina Rinaldi ◽  
Niki Dimou ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Colon Cancer ◽  
Cancer Risk ◽  
Postmenopausal Women ◽  
Dose Response ◽  
Meta Analysis ◽  
Free Testosterone ◽  
Colon Cancer Risk ◽  
Colon And Rectal Cancer ◽  
Free Estradiol

Abstract Background Observational studies have consistently reported that postmenopausal hormone therapy use is associated with lower colon cancer risk. However, epidemiological studies examining the associations between circulating concentrations of endogenous estrogens and colorectal cancer have reported inconsistent results. Methods We investigated the associations between circulating concentrations of estrone, estradiol, free estradiol, testosterone, free testosterone, androstenedione, dehydroepiandrosterone (DHEA), progesterone, and sex hormone binding globulin (SHBG) with colon cancer risk in a nested case–control study of 1,028 postmenopausal European women (512 colon cancer cases, 516 matched controls) who were non-current users of exogenous hormones at blood collection. Multivariable conditional logistic regression models were used to compute odds ratios (ORs) and 95% confidence intervals (CIs) to evaluate the association between circulating sex hormones and colon cancer risk. We also conducted a dose-response meta-analysis of prospective studies of circulating estrone and estradiol with colorectal, colon, and rectal cancer risk in postmenopausal women. All statistical tests were 2-sided. Results In the multivariable model, a non-statistically significant positive relationship was found between circulating estrone and colon cancer risk (OR per log2-1 unit increment = 1.17, 95%CI = 1.00–1.38; ORquartile4-quartile1 = 1.33, 95%CI = 0.89–1.97, Ptrend = 0.20). Circulating concentrations of estradiol, free estradiol, testosterone, free testosterone, androstenedione, DHEA, progesterone, and SHBG were not associated with colon cancer risk. In the dose-response meta-analysis, no clear evidence of associations were found between circulating estradiol, and estrone concentrations with colorectal, colon, and rectal cancer risk. Conclusion Our observational and meta-analysis results do not support an association between circulating concentrations of endogenous sex hormones and colon or rectal cancer in postmenopausal women.

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