Factors Influencing Intention to Obtain a Genetic Test for Colon Cancer Risk: A Population-Based Study

2002 ◽  
Vol 34 (6) ◽  
pp. 567-577 ◽  
Author(s):  
Janice Yanushka Bunn ◽  
Kwadwo Bosompra ◽  
Takamaru Ashikaga ◽  
Brian S. Flynn ◽  
John K. Worden
Keyword(s):  
Colon Cancer ◽  
Cancer Risk ◽  
Genetic Test ◽  
Population Based ◽  
Population Based Study ◽  
Colon Cancer Risk ◽  
Factors Influencing

scholarly journals Adult BMI Change and Risk of Colon Cancer in Postmenopausal Women

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Lyla Blake-Gumbs ◽  
Zhengyi Chen ◽  
Cheryl L. Thompson ◽  
Nathan A. Berger ◽  
Thomas C. Tucker ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Weight Gain ◽  
Cancer Risk ◽  
Postmenopausal Women ◽  
Early Adulthood ◽  
Population Based ◽  
Colon Cancer Risk ◽  
Increased Risk ◽  
Study Population ◽  
Control Study

Purpose. We recently reported an association of adult BMI change with colon cancer risk. Here, we sought to further explore this association with respect to postmenopausal HRT use in a larger study population.Methods. We included 1,457 postmenopausal women participating in an ongoing population-based case-control study of colon cancer.Results. We confirmed a previously reported association of adulthood weight gain and increased risk of colon cancer: compared to those with <5 kg/m2change of BMI, women who reported moderate (5–10 kg/m2) and large (>10 kg/m2) BMI changes since their 20s had OR estimates of 1.54 (95% CI = 1.09–2.19) and 1.45 (95% CI = 0.90–2.33), respectively (Pfor trend = 0.05). Stratified analyses showed that this association was limited to HRT nonusers: ORs were 1.77 (95% CI = 1.02–3.05) and 2.21 (95% CI = 1.09–4.45), respectively (Pfor trend = 0.03), for BMI changes occurring between the 20s decade and time of recruitment among non-users. Similar associations were observed for BMI changes since the 30s decade. There was no association among HRT users.Conclusion. Our results suggest early adulthood weight gain increases colon cancer risk in postmenopausal women who do not use HRT.

scholarly journals High plasma levels of pro-NT are associated with increased colon cancer risk

2020 ◽  
Vol 27 (11) ◽  
pp. 641-646
Author(s):  
Li Li ◽  
Heidi L Weiss ◽  
Jing Li ◽  
Zhengyi Chen ◽  
Leslie Donato ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Risk ◽  
Plasma Levels ◽  
Significant Risk ◽  
High Plasma ◽  
Population Based ◽  
Continuous Measure ◽  
Logistic Regression Models ◽  
Colon Cancer Risk ◽  
History Of

Emerging data supports a potential role of neurotensin (NT) in the development of obesity, obesity-associated comorbidities, and certain cancers. The association of NT with colon cancer risk has not been explicitly explored. We determined plasma levels of pro-NT, a stable NT precursor fragment, in 223 incident colon cancer patients and 223 age-, gender-, BMI-matched population controls participating in a population-based case–control study of colon cancer. On average, the cases have significantly higher levels of pro-NT than the controls (median = 205.6 pmol/L vs 183.1 pmol/L, respectively; P = 0.02). Multivariate logistic regression models, adjusted for age, gender, BMI, family history of colorectal cancer, smoking, diabetes mellitus, alcohol, and non-steroidal anti-inflammatory drugs use, show statistically significant risk associations: for continuous measure of pro-NT, the OR estimate was 1.30 (95% CI =1.03–1.64; P = 0.026) for each increment of 175 pmol/L; for dichotomized measure of pro-NT, the OR estimate was 1.75 (95% CI = 1.12–2.74; P = 0.025) for those in the top quartile comparing to the other participants. Our results support circulating levels of pro-NT as a novel risk biomarker for colon cancer.

Factors influencing birth weight in newborns of diabetic and non-diabetic women a population based study

1990 ◽  
Vol 6 (4) ◽  
pp. 427-431 ◽  
Author(s):  
D. Fraser ◽  
S. Weitzman ◽  
J. R. Leiberman ◽  
E. Eschwege
Keyword(s):  
Birth Weight ◽  
Population Based ◽  
Population Based Study ◽  
Factors Influencing

Oncological outcomes after complete mesocolic excision in right‐sided colon cancer: a population‐based study

2021 ◽  
Author(s):  
Richard Bernhoff ◽  
Annika Sjövall ◽  
Fredrik Granath ◽  
Torbjörn Holm ◽  
Anna Martling ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Complete Mesocolic Excision ◽  
Population Based ◽  
Population Based Study ◽  
Oncological Outcomes ◽  
Mesocolic Excision

scholarly journals Familial colorectal cancer risk by subsite of primary cancer: a population-based study in Utah

2015 ◽  
Vol 41 (6) ◽  
pp. 573-580 ◽  
Author(s):  
N. J. Samadder ◽  
K. R. Smith ◽  
G. P. Mineau ◽  
R. Pimentel ◽  
J. Wong ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Population Based ◽  
Colorectal Cancer Risk ◽  
Primary Cancer ◽  
Familial Colorectal Cancer ◽  
Population Based Study

Prevalence of the E318K and V320I MITF germline mutations in Polish cancer patients and multiorgan cancer risk-a population-based study

2014 ◽  
Vol 207 (4) ◽  
pp. 128-132 ◽  
Author(s):  
Tomasz Gromowski ◽  
Bartłomiej Masojć ◽  
Rodney J. Scott ◽  
Cezary Cybulski ◽  
Bohdan Górski ◽  
...  
Keyword(s):  
Cancer Risk ◽  
Cancer Patients ◽  
Germline Mutations ◽  
Population Based ◽  
Population Based Study
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