scholarly journals The Impact of Various Reactive Oxygen Species on the Formation of Neutrophil Extracellular Traps

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Tina Kirchner ◽  
Sonja Möller ◽  
Matthias Klinger ◽  
Werner Solbach ◽  
Tamás Laskay ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Nadph Oxidase ◽  
Reactive Oxygen ◽  
Neutrophil Extracellular Traps ◽  
Oxygen Species ◽  
Extracellular Traps ◽  
Comprehensive Manner ◽  
The Impact ◽  
Net Release

The formation of neutrophil extracellular traps (NETs) depends on the generation of reactive oxygen species (ROS). Previous studies revealed that both NADPH oxidase and myeloperoxidase (MPO) are required for NET release. However, the contribution of various ROS as well as the role of mitochondria-derived ROS has not been addressed so far. In the present study we aimed to investigate in a systematic and comprehensive manner the contribution of various ROS and ROS-generating pathways to the PMA-induced NET release. By using specific inhibitors, the role of both NADPH oxidase- and mitochondria-derived ROS as well as the contribution of superoxide dismutase (SOD) and MPO on the NET release was assessed. We could demonstrate that NADPH oxidase function is crucial for the formation of NETs. In addition, we could clearly show the involvement of MPO-derived ROS in NET release. Our results, however, did not provide evidence for the role of SOD- or mitochondria-derived ROS in NET formation.

scholarly journals NADPH Oxidase as a Therapeutic Target for Oxalate Induced Injury in Kidneys

2013 ◽  
Vol 2013 ◽  
pp. 1-18 ◽  
Author(s):  
Sunil Joshi ◽  
Ammon B. Peck ◽  
Saeed R. Khan
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Nadph Oxidase ◽  
Tissue Injury ◽  
Nicotinamide Adenine Dinucleotide Phosphate ◽  
Reactive Oxygen ◽  
Renal Tissue ◽  
Oxygen Species ◽  
Gene Expressions

A major role of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase family of enzymes is to catalyze the production of superoxides and other reactive oxygen species (ROS). These ROS, in turn, play a key role as messengers in cell signal transduction and cell cycling, but when they are produced in excess they can lead to oxidative stress (OS). Oxidative stress in the kidneys is now considered a major cause of renal injury and inflammation, giving rise to a variety of pathological disorders. In this review, we discuss the putative role of oxalate in producing oxidative stress via the production of reactive oxygen species by isoforms of NADPH oxidases expressed in different cellular locations of the kidneys. Most renal cells produce ROS, and recent data indicate a direct correlation between upregulated gene expressions of NADPH oxidase, ROS, and inflammation. Renal tissue expression of multiple NADPH oxidase isoforms most likely will impact the future use of different antioxidants and NADPH oxidase inhibitors to minimize OS and renal tissue injury in hyperoxaluria-induced kidney stone disease.

scholarly journals Role of reactive oxygen species produced by NADPH oxidase in gibberellin biosynthesis during barley seed germination

2016 ◽  
Vol 11 (5) ◽  
pp. e1180492 ◽  
Author(s):  
Kyohei Kai ◽  
Shinsuke Kasa ◽  
Masatsugu Sakamoto ◽  
Nozomi Aoki ◽  
Gaku Watabe ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Seed Germination ◽  
Nadph Oxidase ◽  
Reactive Oxygen ◽  
Barley Seed ◽  
Gibberellin Biosynthesis ◽  
Oxygen Species

Role of reactive oxygen species and NADPH-oxidase in the development of rat cerebellum

2013 ◽  
Vol 62 (7) ◽  
pp. 998-1011 ◽  
Author(s):  
Angélica Coyoy ◽  
Mauricio Olguín-Albuerne ◽  
Patricio Martínez-Briseño ◽  
Julio Morán
Keyword(s):  
Reactive Oxygen Species ◽  
Nadph Oxidase ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Rat Cerebellum

Mo2060 Pathogenic Role of NADPH Oxidase 1 (NOX1)-Derived Reactive Oxygen Species in 5-Fluorouracil-Induced Intestinal Mucositis in Mice

2012 ◽  
Vol 142 (5) ◽  
pp. S-731
Author(s):  
Masashi Yasuda ◽  
Shinichi Kato ◽  
Naoki Yamanaka ◽  
Maho Iimori ◽  
Kazumi Iwata ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Nadph Oxidase ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Pathogenic Role ◽  
Nadph Oxidase 1 ◽  
Intestinal Mucositis

scholarly journals The Role of NADPH Oxidase 1–Derived Reactive Oxygen Species in Paraquat-Mediated Dopaminergic Cell Death

2009 ◽  
Vol 11 (9) ◽  
pp. 2105-2118 ◽  
Author(s):  
Ana Clara Cristóvão ◽  
Dong-Hee Choi ◽  
Graça Baltazar ◽  
M. Flint Beal ◽  
Yoon-Seong Kim
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Death ◽  
Nadph Oxidase ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Dopaminergic Cell ◽  
Nadph Oxidase 1
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