scholarly journals Intraoperative Pontine Infarction: A Hidden Challenge

2012 ◽  
Vol 2012 ◽  
pp. 1-2
Author(s):  
Nicholas Marcanthony ◽  
Ehab Farag
Keyword(s):  
Breathing Pattern ◽  
Postanesthesia Care Unit ◽  
The Core ◽  
Neurological Intensive Care ◽  
Abnormal Breathing ◽  
Gag Reflex ◽  
Pneumotaxic Center ◽  
Clinical Changes ◽  
The Brain ◽  
Pontine Infarct

Apneusis, or apneustic respirations, is characterized by an abnormal breathing pattern involving gasping and the inability to fully expire. A loss of gag reflex and other cranial nerve deficits are also often accompanied with these respiratory changes. In neurological intensive care units (NICUs), these respiratory and airway changes are not uncommon and have been well documented (Lee et al. 1976). These clinical changes are often associated with pontine trauma as it is the core pneumotaxic center in the brain stem. We describe the airway management of a patient with an acute, occult pontine infarct status post craniectomy and cervical laminectomy for decompression of known Chiari malformation in the postanesthesia care unit (PACU).

The Core of What the Brain Does

PsycCRITIQUES ◽  
2017 ◽  
Vol 62 (44) ◽  
Author(s):  
David S. Kreiner
Keyword(s):  
The Core ◽  
The Brain

scholarly journals The Skull’s Girder: A Brief Review of the Cranial Base

2021 ◽  
Vol 9 (1) ◽  
pp. 3
Author(s):  
Shankar Rengasamy Venugopalan ◽  
Eric Van Otterloo
Keyword(s):  
Birth Defects ◽  
Vertebral Column ◽  
Endochondral Ossification ◽  
Cranial Base ◽  
Facial Skeleton ◽  
The Core ◽  
Skull Vault ◽  
Congenital Birth Defects ◽  
Intimate Association ◽  
The Brain

The cranial base is a multifunctional bony platform within the core of the cranium, spanning rostral to caudal ends. This structure provides support for the brain and skull vault above, serves as a link between the head and the vertebral column below, and seamlessly integrates with the facial skeleton at its rostral end. Unique from the majority of the cranial skeleton, the cranial base develops from a cartilage intermediate—the chondrocranium—through the process of endochondral ossification. Owing to the intimate association of the cranial base with nearly all aspects of the head, congenital birth defects impacting these structures often coincide with anomalies of the cranial base. Despite this critical importance, studies investigating the genetic control of cranial base development and associated disorders lags in comparison to other craniofacial structures. Here, we highlight and review developmental and genetic aspects of the cranial base, including its transition from cartilage to bone, dual embryological origins, and vignettes of transcription factors controlling its formation.

scholarly journals What is special about L3 processing?

2013 ◽  
Vol 18 (2) ◽  
pp. 130-144 ◽  
Author(s):  
KEES DE BOT ◽  
CAROL JAENSCH
Keyword(s):  
Second Language ◽  
Language Processing ◽  
Language Use ◽  
Fundamental Question ◽  
Third Language ◽  
The Core ◽  
Dynamic Perspective ◽  
Core Issue ◽  
The Brain ◽  
Over Time

While research on third language (L3) and multilingualism has recently shown remarkable growth, the fundamental question of what makes trilingualism special compared to bilingualism, and indeed monolingualism, continues to be evaded. In this contribution we consider whether there is such a thing as a true monolingual, and if there is a difference between dialects, styles, registers and languages. While linguistic and psycholinguistic studies suggest differences in the processing of a third, compared to the first or second language, neurolinguistic research has shown that generally the same areas of the brain are activated during language use in proficient multilinguals. It is concluded that while from traditional linguistic and psycholinguistic perspectives there are grounds to differentiate monolingual, bilingual and multilingual processing, a more dynamic perspective on language processing in which development over time is the core issue, leads to a questioning of the notion of languages as separate entities in the brain.

scholarly journals Tracheal occlusion-evoked respiratory load compensation and inhibitory neurotransmitter expression in rats

2014 ◽  
Vol 116 (8) ◽  
pp. 1006-1016 ◽  
Author(s):  
Hsiu-Wen Tsai ◽  
Paul W. Davenport
Keyword(s):  
Neural Network ◽  
Brain Stem ◽  
Breathing Pattern ◽  
Respiratory Rhythm ◽  
Inhibitory Neurotransmitter ◽  
Load Compensation ◽  
Efferent Projections ◽  
Motor Reflex ◽  
Sensory Pathway ◽  
The Brain

Respiratory load compensation is a sensory-motor reflex generated in the brain stem respiratory neural network. The nucleus of the solitary tract (NTS) is thought to be the primary structure to process the respiratory load-related afferent activity and contribute to the modification of the breathing pattern by sending efferent projections to other structures in the brain stem respiratory neural network. The sensory pathway and motor responses of respiratory load compensation have been studied extensively; however, the mechanism of neurogenesis of load compensation is still unknown. A variety of studies has shown that inhibitory interconnections among the brain stem respiratory groups play critical roles for the genesis of respiratory rhythm and pattern. The purpose of this study was to examine whether inhibitory glycinergic neurons in the NTS were activated by external and transient tracheal occlusions (ETTO) in anesthetized animals. The results showed that ETTO produced load compensation responses with increased inspiratory, expiratory, and total breath time, as well as elevated activation of inhibitory glycinergic neurons in the caudal NTS (cNTS) and intermediate NTS (iNTS). Vagotomized animals receiving transient respiratory loads did not exhibit these load compensation responses. In addition, vagotomy significantly reduced the activation of inhibitory glycinergic neurons in the cNTS and iNTS. The results suggest that these activated inhibitory glycinergic neurons in the NTS might be essential for the neurogenesis of load compensation responses in anesthetized animals.

scholarly journals Situating allostasis and interoception at the core of human brain function

2021 ◽  
Author(s):  
Yuta Katsumi ◽  
Karen Quigley ◽  
Lisa Feldman Barrett
Keyword(s):  
Brain Function ◽  
Brain Evolution ◽  
Human Mind ◽  
Biological Mechanisms ◽  
The Core ◽  
Starting Point ◽  
Basic Functions ◽  
Mental Events ◽  
Physical Phenomena ◽  
The Brain

It is now well known that brain evolution, development, and structure do not respect Western folk categories of mind – that is, the boundaries of those folk categories have never been identified in nature, despite decades of search. Categories for cognitions, emotions, perceptions, and so on, may be useful for describing the mental phenomena that constitute a human mind, but they make a poor starting point for understanding the interplay of mechanisms that create those mental events in the first place. In this paper, we integrate evolutionary, developmental, anatomical, and functional evidence and propose that predictive regulation of the body’s internal systems (allostasis) and modeling the sensory consequences of this regulation (interoception) may be basic functions of the brain that are embedded in coordinated structural and functional gradients. Our approach offers the basis for a coherent, neurobiologically-inspired research program that attempts to explain how a variety of psychological and physical phenomena may emerge from the same biological mechanisms, thus providing an opportunity to unify them under a common explanatory framework that can be used to develop shared vocabulary for theory building and knowledge accumulation.

Chapter 54: Biology, Genetics and Evolution

2021 ◽  
Author(s):  
Antonio Benítez-Burraco ◽  
Koji Fuita ◽  
Koji Hoshi ◽  
Ljiljana Progovac
Keyword(s):  
Language Evolution ◽  
Future Prospects ◽  
Brain Section ◽  
The Core ◽  
Discontinuous Nature ◽  
The Brain

In this Chapter we first look at the core view of the biology of language associated with Minimalism, including the Biolinguistics Program (section 2). Next, we consider research on the brain (section 3) and genetics (section 4), associated with this framework. Finally, we introduce some subsequent views of language evolution which break away from the saltationist, discontinuous nature of the mainstream approach (section 5), and draw some conclusions regarding future prospects (section 6).

Abnormal movements and diaphragmatic flutter in a case of suspected induced illness

2021 ◽  
Vol 14 (4) ◽  
pp. e236962
Author(s):  
Rebecca Arvier ◽  
Thomas Clayton ◽  
Monique Dade ◽  
Rahul S Joshi
Keyword(s):  
Breathing Pattern ◽  
Tertiary Hospital ◽  
Drug Screen ◽  
Urine Drug Screen ◽  
Breathing Patterns ◽  
Abnormal Movements ◽  
Urine Drug ◽  
Conscious Level ◽  
Abnormal Breathing ◽  
Initial Results

A 6-month-old girl presented to hospital via ambulance with a decreased conscious level (initial Glasgow Coma Scale of 3) and an abnormal breathing pattern described as diaphragmatic flutter. She then developed abnormal movements and continued to have episodes of fluctuating conscious levels so was transferred to a tertiary hospital paediatric intensive care unit for further investigation. During her 16-day stay in hospital, she continued to experience discrete episodes of drowsiness, bradycardia, unusual breathing patterns and abnormal movements which were associated with agitation, tachycardia, hypertension and insomnia. The patient underwent extensive investigation for her symptoms and, after some delay in waiting for initial results before considering a urine drug screen, she was ultimately found to have lisdexamfetamine and clonidine in her urine drug screen. Her symptoms subsequently resolved after her mother’s visits were restricted.

The Benefits of Partnership and the Costs of Domination

2019 ◽  
pp. 98-129
Author(s):  
Riane Eisler
Keyword(s):  
Well Being ◽  
The Other ◽  
Growing Up ◽  
Neurological Development ◽  
Family Experiences ◽  
Advanced Level ◽  
The Core ◽  
Core Components ◽  
Early Family ◽  
The Brain

This chapter focuses on the tension between domination systems and partnership systems as two ends of a continuum along which human societies can be organized, regardless of whether they are Eastern or Western, Northern or Southern, religious or secular, rightist or leftist, and so on. It describes the core components of each system, how these interact, and how growing up in societies that orient to one or the other differently affects neurological development and hence our perceptions, cognitions, emotions, and behaviors—which in turn affect human health, happiness, well-being, and the types of societies we create. The chapter provides examples of how domination systems produce high levels of stress—from the artificial creation of economic scarcity to stressful early family experiences—and how this plays out in the neurochemistry of the brain, tending to keep people at a less advanced level of overall human development that interferes with the full flourishing of those very qualities that make people happiest: security, empathy, consciousness, creativity, and love. On the other hand, partnership environments—as illustrated by descriptions of conditions in Nordic nations—enhance the expression of human capacities for health, happiness, well-being, consciousness, and creativity.

7. Into the 21st century

2018 ◽  
pp. 112-124 ◽  
Author(s):  
Tom Burns
Keyword(s):  
Mental Health ◽  
Artificial Intelligence ◽  
Virtual Reality ◽  
21St Century ◽  
Mental Illnesses ◽  
New Science ◽  
The Core ◽  
New Treatment ◽  
The Brain ◽  
Manage Mental

‘Into the 21st century’ explains how there is an increased focus on how our body, and not just the brain, influences our mental health. Rapidly advancing computer technology, including artificial intelligence and virtual reality, is beginning to provide new treatment possibilities, not just support and simplify the old ones. The development of sophisticated imaging has supercharged the area of neurosciences and the increased understanding of genetics and the new science of epigenetics provide psychiatry with greater tools to identify and manage mental illnesses. A paradox with our increasingly technological and scientific advances is that the core dilemmas of psychiatry appear not to be diminishing. Psychiatry will survive the 21st century, but certainly it is changing.

Genesis of rhythmic respiratory activity in pons independent of medulla

1985 ◽  
Vol 59 (3) ◽  
pp. 684-690 ◽  
Author(s):  
W. M. St John ◽  
T. A. Bledsoe
Keyword(s):  
Brain Stem ◽  
Phrenic Nerve ◽  
Respiratory Activity ◽  
Respiratory Rhythm ◽  
Related Activity ◽  
Pharmacological Agents ◽  
Pneumotaxic Center ◽  
Trigeminal Nerves ◽  
The Brain ◽  
Pontomedullary Junction

We hypothesized that rhythmic respiratory-related activity could be generated in pons independent of medullary mechanisms. In decerebrate, cerebellectomized, vagotomized, paralyzed, and ventilated cats, we recorded efferent activities of the phrenic nerve and mylohyoid branch of the trigeminal nerve. Following transections of the brain stem at the pontomedullary junction, the phrenic and trigeminal nerves discharged with independent rhythms. Spontaneous trigeminal discharges eventually ceased but were reestablished after strychnine, doxapram, and/or protriptyline were administered. In some animals having no spontaneous trigeminal discharges after transection, these discharges appeared, with a rhythm different from the phrenic, following administration of these agents. In other cats having no transections between pons and medulla, these pharmacological agents induced trigeminal and phrenic discharges after kainic acid had been injected into the entire dorsal and ventral medullary respiratory nuclei. Phrenic and trigeminal discharges were linked, indicating survival of bulbospinal neurons or presence of pontospinal units. We conclude that rhythms, similar to respiratory rhythm, can occur by mechanisms in isolated pons. Such mechanisms are hypothesized to be within the pneumotaxic center and may underlie the neurogenesis of eupnea.

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