scholarly journals Aberrant Expression of N-Methylpurine-DNA Glycosylase Influences Patient Survival in Malignant Gliomas

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Ce Liu ◽  
Yanyang Tu ◽  
Jun Yuan ◽  
Xinggang Mao ◽  
Shiming He ◽  
...  
Keyword(s):  
Patient Survival ◽  
Malignant Gliomas ◽  
Dna Glycosylase ◽  
Aberrant Expression ◽  
Methylpurine Dna Glycosylase

TAMI-66. FUNCTIONAL ALTERATIONS IN CORTICAL PROCESSING OF SPEECH IN GLIOMA-INFILTRATED CORTEX

2021 ◽  
Vol 23 (Supplement_6) ◽  
pp. vi212-vi212
Author(s):  
alexander Aabedi ◽  
Benjamin Lipkin ◽  
Jasleen Kaur ◽  
Sofia Kakaizada ◽  
Jacob Young ◽  
...  
Keyword(s):  
Cognitive Processing ◽  
Patient Survival ◽  
Malignant Gliomas ◽  
Paracrine Signaling ◽  
Wild Type ◽  
Information Encoding ◽  
Neural Computations ◽  
Recent Developments ◽  
Invasive Electrophysiologic ◽  
Lower Capacity

Abstract INTRODUCTION Recent developments in the biology of malignant gliomas have demonstrated that glioma cells interact with neurons through both paracrine signaling and electrochemical synapses. Glioma-neuron interactions consequently modulate the excitability of local neuronal circuits, and it is unclear the extent to which glioma-infiltrated cortex can meaningfully participate in neural computations. For example, gliomas may result in a local disorganization of activity that impedes the transient synchronization of neural oscillations. Alternatively, glioma-infiltrated cortex may retain the ability to engage in synchronized activity, in a manner similar to normal-appearing cortex, but exhibit other altered spatiotemporal patterns of activity with subsequent impact on cognitive processing. METHODS Here, we acquired invasive electrophysiologic recordings to sample both normal-appearing and glioma-infiltrated cortex during speech initiation in order to measure language task-related circuit dynamics of IDH-wild-type glioblastoma patients. We then applied an information theoretical framework to directly compare the encoding capacity and decodability of signals arising from these regions. RESULTS We find that glioma-infiltrated cortex engages in synchronous activity during task performance in a manner similar to normal-appearing cortex, but recruits a diffuse spatial network. On a temporal scale, we show that glioma-infiltrated cortex has lower capacity for information encoding when performing nuanced tasks such as speech production of monosyllabic versus polysyllabic words. As a result, temporal decoding strategies for distinguishing monosyllabic from polysyllabic words were feasible for signals arising from normal-appearing cortex, but not from glioma-infiltrated cortex. CONCLUSION These findings inform our understanding of cognitive processing in patients with malignant gliomas and have implications for patient survival, neuromodulation, and prosthetics in patients with malignant gliomas.

Methylpurine DNA Glycosylase of the Hyperthermophilic ArchaeonArchaeoglobus fulgidus†

Biochemistry ◽  
2002 ◽  
Vol 41 (42) ◽  
pp. 12697-12705 ◽  
Author(s):  
Nils-Kåre Birkeland ◽  
Hilde Ånensen ◽  
Wenche Kristoffersen ◽  
Magnar Bjørås ◽  
Frank T. Robb ◽  
...  
Keyword(s):  
Dna Glycosylase ◽  
Methylpurine Dna Glycosylase

scholarly journals N-methylpurine DNA glycosylase inhibits p53-mediated cell cycle arrest and coordinates with p53 to determine sensitivity to alkylating agents

Cell Research ◽  
2012 ◽  
Vol 22 (8) ◽  
pp. 1285-1303 ◽  
Author(s):  
Shanshan Song ◽  
Guichun Xing ◽  
Lin Yuan ◽  
Jian Wang ◽  
Shan Wang ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Alkylating Agents ◽  
Dna Glycosylase ◽  
Cycle Arrest ◽  
Methylpurine Dna Glycosylase

scholarly journals Specific Interaction of Wild-Type and Truncated MouseN-Methylpurine-DNA Glycosylase with Ethenoadenine-Containing DNA, by

Biochemistry ◽  
1999 ◽  
Vol 38 (31) ◽  
pp. 10216-10216
Author(s):  
Rabindra Roy ◽  
Tapan Biswas ◽  
Tapas K. Hazra ◽  
Gargi Roy ◽  
David T. Grabowski ◽  
...  
Keyword(s):  
Specific Interaction ◽  
Dna Glycosylase ◽  
Wild Type ◽  
Methylpurine Dna Glycosylase

Aberrant expression of the sox2 gene in malignant gliomas

2014 ◽  
Vol 8 (5) ◽  
pp. 368-373 ◽  
Author(s):  
A. V. Volnitskiy ◽  
E. V. Semenova ◽  
T. A. Shtam ◽  
R. A. Kovalev ◽  
M. V. Filatov
Keyword(s):  
Malignant Gliomas ◽  
Aberrant Expression ◽  
Sox2 Gene

scholarly journals Aberrant Expression of Interleukin-1β and Inflammasome Activation in Human Malignant Gliomas

PLoS ONE ◽  
2014 ◽  
Vol 9 (7) ◽  
pp. e103432 ◽  
Author(s):  
Leonid Tarassishin ◽  
Diana Casper ◽  
Sunhee C. Lee
Keyword(s):  
Malignant Gliomas ◽  
Interleukin 1Β ◽  
Inflammasome Activation ◽  
Aberrant Expression
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