scholarly journals Plasmacytoid Urothelial Carcinoma of the Bladder Metastatic to the Stomach: A Case Report

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Philippe Nabbout ◽  
James Furr ◽  
Murugan Paari ◽  
Gennady Slobodov
Keyword(s):  
Case Report ◽  
Urothelial Carcinoma ◽  
Urothelial Cancer ◽  
Undifferentiated Carcinoma ◽  
Treatment Delays ◽  
Cancer Of The Bladder ◽  
Histological Variant ◽  
History Of ◽  
Carcinoma Of The Bladder ◽  
High Index Of Suspicion

Introduction. Plasmacytoid urothelial carcinoma (PUC) of the bladder is a rare histological variant of urothelial carcinoma that was recently identified. Available data on this histological variant is limited.Case Report. We report the case of a 75-year-old man with presumed history of high-grade urothelial cancer of the bladder, treated with transurethral resection and Bacille Calmette-Guérin (BCG) in 2004. Six years after treatment of the bladder cancer, the patient underwent gastrectomy for an undifferentiated carcinoma of the stomach. On followup, patient developed right ureterohydronephrosis and peritoneal carcinomatosis. Biopsy of the bladder during stent placement revealed a plasmacytoid urothelial carcinoma of the bladder. Rereadings revealed that the initial bladder and gastric malignancies were also plasmacytoid carcinoma, indicating that, the patient had since 2004, a PUC of the bladder that spread to the stomach and peritoneal cavity.Conclusion. Plasmacytoid urothelial carcinoma of the bladder is an aggressive variant of urothelial carcinoma. Based on our case and the literature review, this tumor can be misdiagnosed because of its rarity, leading to treatment delays. Both the urologist and the pathologist need to have a high index of suspicion for PUC whenever they encounter unusual clinical and/or pathological findings.

scholarly journals Plasmacytoid Urothelial Carcinoma of the Bladder: Case Report and Review of the Literature

2019 ◽  
Vol 28 (04) ◽  
pp. 333-337
Author(s):  
Ángela Molina Barrera ◽  
Andrea Vásquez Franco ◽  
Andrés Felipe Aristizábal ◽  
David Correa Galeano ◽  
Manuel Cabrales Hessen
Keyword(s):  
Case Report ◽  
Urothelial Carcinoma ◽  
Case Series ◽  
Pelvic Lymphadenectomy ◽  
Ultrasound Finding ◽  
Invasive Potential ◽  
Aggressive Approach ◽  
Urothelial Carcinomas ◽  
Histological Variant ◽  
Carcinoma Of The Bladder

Introduction Plasmacytoid urothelial carcinoma (PUC) of the bladder is a rare histological variant, accounting for 1 to 3% of the invasive urothelial carcinomas, and it is typically aggressive. So far, it has not been well characterized, and the literature is based on reports and case series. Case Report A 70-year-old male patient presenting with 4 months of constitutional and urinary symptoms, with an ultrasound finding of bilateral hydronephrosis and diffuse thickening of the bladder walls. In the cystoscopy, trigone of infiltrated appearance, a biopsy wass performed, whose immunohistochemistry revealed a PUC. The abdominopelvic image showed an infiltrative lesion that compromised the muscle of the bladder and extended to the perivesical fat, without adequate plane of cleavage with the prostate and a single hypogastric adenopathy suspected of malignancy. It was classified as cT3b vs cT4aN1M0 (chest computed tomography [CT] negative for malignancy), and the patient was submitted to a radical cystoprostatectomy, extended pelvic lymphadenectomy and non-continent urinary diversion with ileal conduit. The pathology revealed a diffuse PUC with prostatic stromal involvement and 22 of 39 lymph nodes positive for malignancy. Finally, the patient presented a series of postoperative complications and died. Conclusion Plasmacytoid urothelial carcinoma of the bladder is a rare entity, characterized by high aggressiveness, an advanced stage at the time of diagnosis, and a poor prognosis. Currently, an aggressive approach is recommended due to its high invasive potential.

scholarly journals Prolonged survival in a patient with choroidal metastases from urothelial bladder cancer

2013 ◽  
Vol 3 (4) ◽  
pp. 36 ◽  
Author(s):  
Kirsty L. Wiltshire ◽  
Norman Laperriere ◽  
Robert G. Bristow
Keyword(s):  
Bladder Cancer ◽  
Urothelial Carcinoma ◽  
Urothelial Cancer ◽  
Urothelial Bladder Cancer ◽  
Urothelial Bladder ◽  
History Of ◽  
Carcinoma Of The Bladder ◽  
Disease Free ◽  
New Onset

Choroidal metastases secondary to urothelial carcinoma areextremely rare and are usually associated with an extremely poorprognosis. We present a case of an 88-year-old man with newlydiagnosed urothelial carcinoma of the bladder who presented withacute loss of vision before commencing definitive concurrentchemoradiotherapy to the bladder. Ophthalmological examinationdemonstrated bilateral choroidal metastases. He received palliativeradiotherapy to the orbits and completed his planned radiotherapyto the bladder. He remained disease-free at last follow-up 4 yearsafter the completion of treatment. We review the literature particularlywith regard to diagnosis and management of choroidalmetastases. Choroidal metastases should be considered in a patientwith a history of urothelial cancer presenting with new onset ofeye symptoms.

CASE REPORT: RARE FORM OF HIRSCHPRUNG’S DISEASE

2020 ◽  
Vol 30 (5) ◽  
pp. 82-84
Author(s):  
Ilja Skalskis
Keyword(s):  
Down Syndrome ◽  
Case Report ◽  
Clinical Symptoms ◽  
Hirschsprung Disease ◽  
Distal Colon ◽  
Total Colonic Aganglionosis ◽  
Sphincter Function ◽  
Anal Sphincter Function ◽  
History Of ◽  
High Index Of Suspicion

Hirschsprung disease (HD) is a developmental disorder characterized by the absence of ganglia in the distal colon, resulting in a functional obstruction. Incidence of total colonic aganglionosis (TCA) is 1 in 500 000 and it accounts for 5-10% of all cases of HD. HD should be suspected in patients with typical clinical symptoms and a high index of suspicion is appropriate for infants with a predisposing condition such as Down Syndrome (DS), or for those with a family history of HD. The treatment of choice for HD is surgical, such as Swenson, Soave, and Duhamel procedures. The goals are to resect the affected segment of the colon, bring the normal ganglionic bowel down close to the anus, and preserve internal anal sphincter function. We present a clinical case report of TCA in a child with Down syndrome (DS) and review of literature.

scholarly journals Disseminated Histoplasmosis in an Elderly Man Presented with Fever, Weight loss, Abdominal Pain and Haemoptysis - A Case Report with Literature Review

2011 ◽  
Vol 12 (1) ◽  
pp. 81-85
Author(s):  
Mohammad Robed Amin ◽  
Farzana Shumi ◽  
Hasibuddin Khan ◽  
Syed Ahmed Abdullah ◽  
Shafiul Alam ◽  
...  
Keyword(s):  
Elderly Patient ◽  
Weight Loss ◽  
Abdominal Pain ◽  
Case Report ◽  
Literature Review ◽  
Disseminated Histoplasmosis ◽  
History Of ◽  
Background History ◽  
Recurrent Haemoptysis ◽  
High Index Of Suspicion

An elderly patient presented with prolonged fever, gross weight loss, recurrent haemoptysis and abdominal pain. He had a background history of adrenal tuberculosis with completion of treatment without any obvious improvement. Clinically he was diagnosed as a case of adrenocotical insufficiency. Evaluation including histopathology revealed the diagnosis as disseminated histoplasmosis involving adrenal gland and lungs. The disease is a rarity without any underneath immunosuppression and hence high index of suspicion with appropriate steps for investigation is the key to achieve a diagnosis of disseminated histoplasmosis in Bangladesh. Keyword: . DOI: 10.3329/jom.v12i1.6936J Medicine 2011; 12 : 81-85

scholarly journals SLC14A1 (UT-B) gene rearrangement in urothelial carcinoma of the bladder: a case report

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Zhongying Guo ◽  
Xiaobing Niu ◽  
Guangbo Fu ◽  
Baoxue Yang ◽  
Guangping Chen ◽  
...  
Keyword(s):  
Case Report ◽  
Urothelial Carcinoma ◽  
Gene Rearrangement ◽  
Carcinoma Of The Bladder

Rupture of sinus of Valsalva aneurysm: case report and review of contemporary literature

Perfusion ◽  
2020 ◽  
pp. 026765912096691
Author(s):  
Jean-Luc Duval ◽  
Richard AE Ramsingh ◽  
Natasha C Rahaman ◽  
Risshi D Rampersad ◽  
Gianni D Angelini ◽  
...  
Keyword(s):  
Case Report ◽  
Cardiac Failure ◽  
Congenital Heart ◽  
Contemporary Literature ◽  
Rare Condition ◽  
Aneurysm Rupture ◽  
Sinus Of Valsalva ◽  
Sinus Of Valsalva Aneurysm ◽  
History Of ◽  
High Index Of Suspicion

Sinus of Valsalva aneurysm rupture is a rare condition with a great potential for morbidity and mortality if not promptly diagnosed and managed. We present an unusual non-infected sinus of Valsalva aneurysm rupture in a 47-year-old female. This case report, a likely presentation of a late congenital heart defect, highlights the need for a high index of suspicion in a patient with atypical history of congestive cardiac failure.

Cycloid Psychosis: A Case Report

2016 ◽  
Vol 33 (S1) ◽  
pp. S532-S532
Author(s):  
G. Martinez-Ales ◽  
I. Louzao ◽  
A. Irimia ◽  
M.F. Bravo ◽  
J. Marin
Keyword(s):  
Case Report ◽  
Psychotic Disorders ◽  
Clinical History ◽  
Diagnostic Systems ◽  
Cycloid Psychosis ◽  
History Of ◽  
Competing Interest ◽  
High Index Of Suspicion ◽  
Clinical Pictures ◽  
Restitutio Ad Integrum

IntroductionEpisodes of time-limited acute psychosis, with full recovery in between, are categorized as acute polymorphic psychotic or brief psychotic disorders. Leonhard described the three forms of cycloid psychosis (CP). Perry considers it a separate entity.Case reportWe report the case of a 54-year-old male, with a 9-year history of brief psychotic disorders. He was admitted to an inpatient unit after a 4-day episode of persecutory delusion, leading to high emotional repercussions and isolation at home. Euthymia was present. Previous admissions, 9 and 5 years before, presented similar clinical pictures. Treatment with low dose paliperidone during 6-month periods had led to the complete resolution of the episodes (restitutio ad integrum: no psychotic manifestations and the ability to run his business). In this episode, 8 days after the reintroduction of 12 mg of paliperidone per day, cessation of the symptoms took place. Careful reconstruction of the clinical history showed no stressors or drug consumption. And immediately previous 5-day phase of insomnia, hyperactivity and expenditure was described by the patient's wife.DiscussionThree inpatient admissions, a careful clinical history and a thorough review of the evidence regarding Perris criteria led to a diagnosis of CP.ConclusionCP, a classical nosological approach, is helpful in a clinical setting, as it might imply different prognosis and treatment. Recognition of CP, not included as an entity by the major diagnostic systems, requires a high index of suspicion.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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