scholarly journals Influence of Dendritic Cells on B-Cell Responses during HIV Infection

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Johanne Poudrier ◽  
Josiane Chagnon-Choquet ◽  
Michel Roger
Keyword(s):  
Dendritic Cells ◽  
Hiv Infection ◽  
B Cell ◽  
B Lymphocyte ◽  
Cell Types ◽  
B Cell Differentiation ◽  
Cell Responses ◽  
Control Versus ◽  
B Cell Responses ◽  
And Function

Dendritic cells (DCs) modulate B-cell differentiation, activation, and survival mainly through production of growth factors such as B lymphocyte stimulator (BLyS/BAFF). DC populations have been reported to be affected in number, phenotype and function during HIV infection and such alterations may contribute to the dysregulation of the B-cell compartment. Herein, we reflect on the potential impact of DC on the pathogenesis of HIV-related B cell disorders, and how DC status may modulate the outcome of mucosal B cell responses against HIV, which are pivotal to the control of disease. A concept that could be extrapolated to the overall outcome of HIV disease, whereby control versus progression may reside in the host’s capacity to maintain DC homeostasis at mucosal sites, where DC populations present an inherent capacity of modulating the balance between tolerance and protection, and are amongst the earliest cell types to be exposed to the virus.

scholarly journals B cell survival, surface BCR and BAFFR expression, CD74 metabolism, and CD8− dendritic cells require the intramembrane endopeptidase SPPL2A

2012 ◽  
Vol 210 (1) ◽  
pp. 31-40 ◽  
Author(s):  
Hannes Bergmann ◽  
Mehmet Yabas ◽  
Alanna Short ◽  
Lisa Miosge ◽  
Nadine Barthel ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
B Cell ◽  
B Lymphocyte ◽  
B Cell Lymphoma ◽  
Cell Types ◽  
Proteolytic Processing ◽  
Mhc Ii ◽  
Humoral Immunodeficiency ◽  
B Cell Subsets ◽  
New Treatments

Druggable proteins required for B lymphocyte survival and immune responses are an emerging source of new treatments for autoimmunity and lymphoid malignancy. In this study, we show that mice with an inactivating mutation in the intramembrane protease signal peptide peptidase–like 2A (SPPL2A) unexpectedly exhibit profound humoral immunodeficiency and lack mature B cell subsets, mirroring deficiency of the cytokine B cell–activating factor (BAFF). Accumulation of Sppl2a-deficient B cells was rescued by overexpression of the BAFF-induced survival protein B cell lymphoma 2 (BCL2) but not BAFF and was distinguished by low surface BAFF receptor and IgM and IgD B cell receptors. CD8-negative dendritic cells were also greatly decreased. SPPL2A deficiency blocked the proteolytic processing of CD74 MHC II invariant chain in both cell types, causing dramatic build-up of the p8 product of Cathepsin S and interfering with earlier steps in CD74 endosomal retention and processing. The findings illuminate an important role for the final step in the CD74–MHC II pathway and a new target for protease inhibitor treatment of B cell diseases.

scholarly journals Clinical Adjuvant Combinations Stimulate Potent B-Cell Responses In Vitro by Activating Dermal Dendritic Cells

PLoS ONE ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. e63785 ◽  
Author(s):  
Katie Matthews ◽  
Nancy P. Y. Chung ◽  
Per Johan Klasse ◽  
Magda Moutaftsi ◽  
Darrick Carter ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
B Cell ◽  
Cell Responses ◽  
B Cell Responses

scholarly journals Differential macrophage requirements for T helper cell and T helper cell-induced B lymphocyte proliferation.

1983 ◽  
Vol 157 (1) ◽  
pp. 312-323 ◽  
Author(s):  
A Bandeira ◽  
G Pobor ◽  
S Petterson ◽  
A Coutinho
Keyword(s):  
T Cell ◽  
B Cell ◽  
B Lymphocyte ◽  
T Helper Cell ◽  
Helper Cell ◽  
T Helper ◽  
Helper T Cell ◽  
Cell Responses ◽  
Macrophage Depletion ◽  
B Cell Responses

Major histocompatibility complex-restricted helper T cell clones against "minor" antigens expressed on B cell and macrophage surfaces, when confronted with appropriate T cell-depleted spleen cells, are induced to proliferation and, in turn, activate "target-responder" B cells to polyclonal growth and maturation. Irradiation of helper cell populations, however, demonstrates that their effector functions (and B lymphocyte responses) are independent of proliferative activity. Adherent cell depletion on Sephadex G10 columns, while completely abrogating helper T cell proliferation, does not abolish helper cell-induced B cell responses, demonstrating a remarkable quantitative difference in macrophage requirements for the growth of these two cell types. Because significant B cell responses are detected upon interaction with primed helper T cells under conditions of extreme macrophage depletion, we conclude that the role of macrophages in T-B cell cooperation is limited to expansion of optimal numbers of helper T lymphocytes. It follows that activated helper cells can autonomously produce all B cell-specific growth and maturation factors mediating cooperative antibody responses. In contrast, the profound reduction of LPS-induced responses upon macrophage depletion suggests accessory cell production of such factors in thymus-independent B cell growth and/or maturation.

scholarly journals Extrafollicular B cell activation by marginal zone dendritic cells drives T cell–dependent antibody responses

2012 ◽  
Vol 209 (10) ◽  
pp. 1825-1840 ◽  
Author(s):  
Craig P. Chappell ◽  
Kevin E. Draves ◽  
Natalia V. Giltiay ◽  
Edward A. Clark
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
B Cells ◽  
B Cell ◽  
Cell Activation ◽  
Marginal Zone ◽  
Receptor Expression ◽  
B Cell Activation ◽  
Cell Responses ◽  
B Cell Responses

Dendritic cells (DCs) are best known for their ability to activate naive T cells, and emerging evidence suggests that distinct DC subsets induce specialized T cell responses. However, little is known concerning the role of DC subsets in the initiation of B cell responses. We report that antigen (Ag) delivery to DC-inhibitory receptor 2 (DCIR2) found on marginal zone (MZ)–associated CD8α− DCs in mice leads to robust class-switched antibody (Ab) responses to a T cell–dependent (TD) Ag. DCIR2+ DCs induced rapid up-regulation of multiple B cell activation markers and changes in chemokine receptor expression, resulting in accumulation of Ag-specific B cells within extrafollicular splenic bridging channels as early as 24 h after immunization. Ag-specific B cells primed by DCIR2+ DCs were remarkably efficient at driving naive CD4 T cell proliferation, yet DCIR2-induced responses failed to form germinal centers or undergo affinity maturation of serum Ab unless toll-like receptor (TLR) 7 or TLR9 agonists were included at the time of immunization. These results demonstrate DCIR2+ DCs have a unique capacity to initiate extrafollicular B cell responses to TD Ag, and thus define a novel division of labor among splenic DC subsets for B cell activation during humoral immune responses.

Antibody and B-cell responses may control circulating lipopolysaccharide in patients with HIV infection

AIDS ◽  
2011 ◽  
Vol 25 (11) ◽  
pp. 1379-1383 ◽  
Author(s):  
Andrew Lim ◽  
Afsana Amini ◽  
Lloyd J. D’Orsogna ◽  
Reena Rajasuriar ◽  
Marit Kramski ◽  
...  
Keyword(s):  
Hiv Infection ◽  
B Cell ◽  
Cell Responses ◽  
B Cell Responses

B cell responses in HIV infection of the central nervous system

2006 ◽  
Vol 33 (S 1) ◽  
Author(s):  
G. von Geldern ◽  
S. Cepok ◽  
T. Nolting ◽  
V. Grummel ◽  
H.P. Hartung ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Hiv Infection ◽  
B Cell ◽  
Cell Responses ◽  
The Central Nervous System ◽  
B Cell Responses

scholarly journals HIV-1 gp120 Impairs the Induction of B Cell Responses by TLR9-Activated Plasmacytoid Dendritic Cells

2012 ◽  
Vol 189 (11) ◽  
pp. 5257-5265 ◽  
Author(s):  
Nancy P. Y. Chung ◽  
Katie Matthews ◽  
Per Johan Klasse ◽  
Rogier W. Sanders ◽  
John P. Moore
Keyword(s):  
Dendritic Cells ◽  
B Cell ◽  
Plasmacytoid Dendritic Cells ◽  
Cell Responses ◽  
B Cell Responses ◽  
Hiv 1
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