scholarly journals Severe Hypothyroidism Causing Pre-Eclampsia-Like Syndrome

2012 ◽  
Vol 2012 ◽  
pp. 1-2 ◽  
Author(s):  
Annalisa Inversetti ◽  
Audrey Serafini ◽  
Marco F. Manzoni ◽  
Anna Dolcetta Capuzzo ◽  
Luca Valsecchi ◽  
...  
Keyword(s):  
Gestational Age ◽  
Early Onset ◽  
Overt Hypothyroidism ◽  
Pregnancy Induced Hypertension ◽  
Correct Treatment ◽  
Induced Hypertension ◽  
Early Onset Preeclampsia

Objective.Analyzing and managing pre-eclampsia-like syndrome due to severe hypothyroidism.Methods.Presentation of a case of severe hypothyroidism due to Hashimoto’s syndrome, associated with a severe early-onset preeclampsia-like syndrome, managed in our Gynecology Department.Results.Severe pre-eclampsia led to miscarriage at 24 weeks of gestational age in a 42-year-old woman, although we attempted to correct hypothyroidism with increasing doses of levothyroxine and liothyronine sodium.Conclusion.Recognizing pre-eclampsia-like syndrome caused by overt hypothyroidism from other forms of pregnancy-induced hypertension is essential for choosing the correct treatment.

scholarly journals Risk of small for gestational age babies in preterm delivery due to pregnancy-induced hypertension

2019 ◽  
Vol 28 (1) ◽  
pp. 57-62 ◽  
Author(s):  
Rima Irwinda ◽  
Budi Iman Santoso ◽  
Raymond Surya ◽  
Lidia Firmiaty Nembo
Keyword(s):  
Birth Weight ◽  
Gestational Age ◽  
Preterm Births ◽  
Secondary Data ◽  
Large For Gestational Age ◽  
Fisher Exact Test ◽  
Pregnancy Induced Hypertension ◽  
Exact Test ◽  
Induced Hypertension ◽  
The Impact

BACKGROUND Pregnancy-induced hypertension (PIH) causes high maternal morbidity and mortality worldwide. This study aims to assess the impact of PIH on fetal growth according to gestational age in preterm deliveries.METHODS A prospective cohort study using secondary data was undertaken in Ende District, East Nusa Tenggara, Indonesia from September 2014 to August 2015. The t-test was performed to compare mean birth weight based on gestational week between normotensive and PIH women, continued by linear regression. The chi-square or Fisher exact test was also conducted to determine the probability of birthing small for the gestational age (SGA) and large for gestational age (LGA) babies between normotensive and PIH women.RESULTS A total of 1,673 deliveries were recorded in Ende Hospital over the 1-year study period, among which 182 cases involved preterm births. The PIH group had lower birth weight than normotensive women at each gestational age starting from 32–35 weeks (p=0.004; 95% CI 150.84–771.36). Normotensive women at gestational ages of 32 (p=0.05; 95% CI 0.01–0.83), 34 (p=0.37; 95% CI 0.01–4.12), and 36 (p=0.31; 95% CI 0.02–2.95) weeks had a lower risk of birthing SGA babies than PIH women; LGA babies were recorded at gestational ages of 33 (p=1.00; 95% CI 0.07–37.73) and 35 (p=0.31; 95% CI 0.34–63.07) weeks.CONCLUSIONS Poor perfusion of the uteroplacental is one of the reasons behind intrauterine growth restriction, which results in SGA babies born to PIH women.

scholarly journals Maternofetal outcomes in early versus late onset pre-eclampsia: a comparative study

2019 ◽  
Vol 8 (2) ◽  
pp. 548
Author(s):  
Poornima Shankar ◽  
Kavitha Karthikeyan ◽  
Amrita Priscilla Nalini ◽  
Sindhura M. ◽  
Gowtham Kim
Keyword(s):  
Risk Factors ◽  
Gestational Age ◽  
Early Onset ◽  
Age Of Onset ◽  
Late Onset ◽  
Fetal Outcomes ◽  
Chi Square ◽  
Onset Type ◽  
Significant Difference ◽  
Early Onset Preeclampsia

Background: Preeclampsia is being increasingly recognized as two different entities: early-onset preeclampsia occurring at less than 34 weeks of gestation, and late-onset disease occurring at 34 or more weeks of gestation. Early-onset and late-onset pre-eclampsia are found to have different implications for the mother and neonate. The aim of this study is to compare the risk factors, maternal and fetal outcomes in early (<34 weeks) versus late (≥34weeks) onset preeclampsia.Methods: 208 patients diagnosed with pre-eclampsia in Chettinad Academy of Research and Education over a period of three years (From January 2014 to December 2016) were retrospectively studied. Patients were classified as early onset and late onset pre-eclampsia based on the gestational age of onset. Data on risk factors, maternal and fetal outcomes were collected and analyzed using Chi Square and Fisher’s test and compared.Results: The overall preeclampsia rate was 6.3%. Early onset and late onset were 34.6% and 65.3% respectively and the rate increased with increasing gestational age.35.3% of patients with late onset preeclampsia and 55.6% patients of early onset type required more than one drug which is a statistically significant difference. Proteinuria more than 3gm/l/day was significantly more in late onset preeclampsia than in early onset preeclampsia. 55.5% of patients with early onset pre-eclampsia required MgSO4 when compared to 17.4%. There was no statistically significant difference in the rate of caesarean section (61.1% vs 73.5%). Altered coagulation profile was significantly more in early onset preeclampsia (11.1%). The incidence of oligohydramnios, SGA and low APGAR at 5 minutes of birth were significantly high in early onset pre-eclampsia when compared to late onset type.Conclusions: Patients with early onset pre-eclampsia are found to have significantly higher rates of specific maternal and fetal morbidity when compared to the late onset type.

scholarly journals Outcome of expectant line of management in early onset (24-32weeks) pregnancy induced hypertension

2017 ◽  
Vol 6 (5) ◽  
pp. 1932
Author(s):  
Krishna Mandade ◽  
Kashika Singh ◽  
D. P. Bhavthankar
Keyword(s):  
Early Onset ◽  
Perinatal Outcome ◽  
Tertiary Care ◽  
Successful Outcome ◽  
Minimal Risk ◽  
Pregnancy Induced Hypertension ◽  
Fetal Survival ◽  
Organ Systems ◽  
Increased Risk ◽  
Induced Hypertension

Background: Preeclampsia is a disease of multiple organ systems that is unique to pregnancy and is often associated with increased risk of maternal-perinatal adverse outcome, especially when it is severe and occurs well before term.The objective of the study was to study expectant line of management in early onset pregnancy induced hypertension (24-32 weeks) and its maternal and perinatal outcome in relation to preterm delivery, IUD/ Still birth, and early neonatal deaths.Methods: Total 100 patients presented with early onset pregnancy induced hypertension admitted in Pravara Medical College and Hospital. 50 patient’s pregnancy terminated (Aggressive Group) depending on patients clinical profile and other 50 patients given expectant line of management and pregnancy was prolonged (Expectant Group). Maternal and perinatal outcome was compared between the two groups.Results: No maternal mortality was seen in both groups.Perinatal mortality in aggressive line of management was 54% while in expectant line of management perinatal mortality was 30%. Neonatal deaths account for 24% in aggressive group and 10% in expectant group. Fetal survival rate in expectant group was 70% and in aggressive group it was 46%.Conclusions: Expectant management of severe preeclampsia at 24 to 32 weeks in a tertiary care center is associated with good perinatal outcome with a minimal risk for the mother.The early use of antihypertensive drugs, optimum timing of delivery and strict fluid balance will help to achieve successful outcome.

scholarly journals PREGNANCY INDUCED HYPERTENSION AND NEONATAL GROWTH

2019 ◽  
Vol 34 (4) ◽  
pp. 915-919
Author(s):  
Elizabeta Zisovska ◽  
Lidija Madzovska ◽  
Marija Dimitrovska Ivanova
Keyword(s):  
Birth Weight ◽  
Fetal Growth ◽  
Gestational Age ◽  
White Blood Cells ◽  
Infant Growth ◽  
Late Preterm ◽  
Control Group ◽  
Pregnancy Induced Hypertension ◽  
Gynecology And Obstetrics ◽  
Induced Hypertension

Pregnancy-induced hypertension (PIH), especially preeclampsia, is a major cause of maternal and perinatal morbidity and mortality worldwide. The impact of PIH on birth outcomes has not been extensively studied. PIH has been confirmed to increase significantly the risk of low birth weight by both increasing preterm birth as well as reducing fetal growth. Low birth weight or IUGR babies have been associated with the occurrence of several chronic diseases in later life. However, to date, there have been few studies on the effects of PIH on infant growth and neonatal wellbeing. The purpose of this study was to evaluate the fetal growth and wellbeing of newborns born of mothers with confirmed pregnancy induced hypertension.Material and methods: This was prospective opservational study during the period of the last year, 1st of July 2018 up to the end of June 2019 conducted at the University Clinic for Gynecology and Obstetrics in Skopje. As pregnancy induced hypertension is defined the condition of blood pressure equal to or greater than 130/90 mmHg on more than two occasions greater than six hours apart without proteinuria after 21 weeks of gestation. All other more severe conditions are defined as pre-eclampsia or eclampsia. As outcome was considered the birth weight, gestational age and white blood cells count. IUGR was defined as birth weight below the tenth percentile of expected weight for gestational age. Also maternal age and BMI were considered as conjoined risk factor for the birth weight. Results: In this study, 4726 newborns were born at the University Clinic for Gynecology and Obstetrics, and for analysis were considered 4273 newborns who were late preterm (35 and 36 gestational weeks) or term newborns. Two groups were evaluated: control group of 200 consecutively born newborns (late preterm and term) of healthy mothers and 100 newborns (late preterm and term) consecutively born of mothers with confirmed diagnosis of PIH, which constituted the study group. Within the control group, the proportion of Small for Gestational Age-SGA was 6,3%, and in the group of mothers with PIH was 9,5% (p<0,05). The maternal mean age of the hypertensive mothers was (32.8±5.0) years while that of normotensive mothers was (26.6±3.7) years, and there was not statistical significance (p>0.05). The Body Mass Index was higher in hypertensive mothers, compared to the healthy mothers (31,3±2.02 vs. 27.8±2.8). The mean gestational age of the study group was (35.8±1.8) weeks compared to that in control group (37.4±1.2) weeks. The number of White Blood Cells (WBC) count in newborns of hypertensive mothers was 21.4±5.3x109/L compared with the control group, 18.5±3.12x109/L (p=0.005). Neonatal thrombocytopenia was found in 32% of neonates of preeclamptic mothers while it's found only in 9.5% of neonates in control group p<0,002. Discussion: The limitation of this study was the lack of data about maternal smoking, life style, etc. There is limited number of studies examining the correlation between fetal growth and PIH, and every information is of great value. The fact is that this condition can progress in more severe degree of hypertension and deleterious effects on the mother itself and on her child, if not treated on time. Conclusion: A change in infant growth of the IUGR baby itself (e.g. catch-up growth) such as in the critical early infant period may also have long-term effects on health later in life, and this change of postpartum growth may be influenced by PIH. Therefore, it is important to study postpartum infant growth patterns of babies born to mothers with PIH, and to determine if there are differences in infant growth between babies with and those without IUGR. And, the most important action is to monitor and treat pregnancy induced hypertension and prevent more severe condition of pre-eclampsia.

The impact of pregnancy-induced hypertension on birth weight by gestational age

2001 ◽  
Vol 15 (4) ◽  
pp. A37-A37
Author(s):  
X Xiong ◽  
Nn Demianczuk ◽  
Ld Saunders ◽  
Fl Wang ◽  
Wd Fraser
Keyword(s):  
Birth Weight ◽  
Gestational Age ◽  
Pregnancy Induced Hypertension ◽  
Induced Hypertension ◽  
The Impact
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