scholarly journals The End-Organ Impairment in Liver Cirrhosis: Appointments for Critical Care

2012 ◽  
Vol 2012 ◽  
pp. 1-13 ◽  
Author(s):  
Antonio Figueiredo ◽  
Francisco Romero-Bermejo ◽  
Rui Perdigoto ◽  
Paulo Marcelino
Keyword(s):  
Intensive Care Unit ◽  
Liver Cirrhosis ◽  
Liver Failure ◽  
Point Of View ◽  
Clinical State ◽  
Liver Support ◽  
Extended Lifespan ◽  
Advanced Stages ◽  
Liver Support Devices ◽  
Support Devices

Liver cirrhosis (LC) can lead to a clinical state of liver failure, which can exacerbate through the course of the disease. New therapies aimed to control the diverse etiologies are now more effective, although the disease may result in advanced stages of liver failure, where liver transplantation (LT) remains the most effective treatment. The extended lifespan of these patients and the extended possibilities of liver support devices make their admission to an intensive care unit (ICU) more probable. In this paper the LC is approached from the point of view of the pathophysiological alterations present in LC patients previous to ICU admission, particularly cardiovascular, but also renal, coagulopathic, and encephalopathic. Infections and available liver detoxifications devices also deserve mentioning. We intend to contribute towards ICU physician readiness to the care for this particular type of patients, possibly in dedicated ICUs.

scholarly journals Review of Extracorporeal Membrane Oxygenation and Dialysis-Based Liver Support Devices for the Use of Nephrologists

2017 ◽  
Vol 46 (2) ◽  
pp. 139-149 ◽  
Author(s):  
Tamim Hamdi ◽  
Biff F. Palmer
Keyword(s):  
Intensive Care Unit ◽  
Acute Kidney Injury ◽  
Clinical Evidence ◽  
Kidney Injury ◽  
Severe Illness ◽  
Liver Support ◽  
Technical Aspects ◽  
Organ Systems ◽  
Liver Support Devices ◽  
Support Devices

Acute kidney injury in the intensive care unit (ICU) is a manifestation of an underlying severe illness that commonly involves other organ systems. Pulmonary, cardiac, and hepatic failures are the most prevalent. This article provides a simplified review of the technical aspects of extracorporeal cardiopulmonary and liver support devices used in the adult ICU patient, as well as a summary of the most relevant and up-to-date clinical evidence that supports their use.

scholarly journals Extracorporeal liver support devices in the ICU

2016 ◽  
Author(s):  
Rajiv Jalan ◽  
Banwari Agarwal
Keyword(s):  
Liver Failure ◽  
Definitive Treatment ◽  
Current Evidence ◽  
High Morbidity ◽  
Liver Support ◽  
Transporter Protein ◽  
Extracorporeal Liver Support ◽  
Mechanical Devices ◽  
Liver Support Devices ◽  
Support Devices

Liver failure is common and carries high morbidity and mortality. Liver transplantation (LT) is the only definitive treatment available performed as an emergency in acute liver failure and electively for chronic liver disease. In the last 50 years, a number of extracorporeal liver support devices and modifications have emerged , some of them purely mechanical in nature aimed at detoxification, while others are cell based systems possessing bio-transformational capability. Mechanical devices are mainly based on albumin dialysis, albumin being a key transporter protein that is severely deficient and irreversibly destroyed in liver diseases. Despite a sound scientific rationale and good safety profile, none of the currently available devices have shown enough promise to be incorporated in routine clinical practice, their use being limited to specific clinical situations. This chapter describes currently available devices, their operational characteristics, current evidence of their utility and limitation, and the future developments in the field of extracorporeal liver support.

ARTIFICIAL LIVER SUPPORT DEVICES FOR FULMINANT LIVER FAILURE

2001 ◽  
Vol 5 (2) ◽  
pp. 415-430 ◽  
Author(s):  
Anna Sechser ◽  
Joseph Osorio ◽  
Chris Freise ◽  
Robert W. Osorio
Keyword(s):  
Liver Failure ◽  
Artificial Liver ◽  
Fulminant Liver Failure ◽  
Liver Support ◽  
Artificial Liver Support ◽  
Liver Support Devices ◽  
Support Devices

Bioartificial liver support devices: historical perspectives

2003 ◽  
Vol 73 (9) ◽  
pp. 739-748 ◽  
Author(s):  
Fiona G. Court ◽  
Simon A. Wemyss-Holden ◽  
Ashley R. Dennison ◽  
Guy J. Maddern
Keyword(s):  
Bioartificial Liver ◽  
Liver Support ◽  
Historical Perspectives ◽  
Bioartificial Liver Support ◽  
Liver Support Devices ◽  
Support Devices
Sign in / Sign up

Export Citation Format

Share Document