scholarly journals Review on Analytical and Biological Applications of Hydrazones and their Metal Complexes

2012 ◽  
Vol 9 (3) ◽  
pp. 1288-1304 ◽  
Author(s):  
Lakshmi Narayana Suvarapu ◽  
Young Kyo Seo ◽  
Sung-Ok Baek ◽  
Varada Reddy Ammireddy
Keyword(s):  
Metal Ions ◽  
Metal Complexes ◽  
Chemical Nature ◽  
Biological Activities ◽  
Analytical Techniques ◽  
Biological Applications ◽  
Important Group ◽  
Analytical Applications

Hydrazones are very important group of analytical regents for the determination of various metal ions by using various analytical techniques. Besides this use of hydrazones are also having biological activities also. In this paper we first discussed about the chemical nature of hydrazones and their biological activities. We mainly focused on the papers which were published during 1980-2011 on analytical applications (spectrophotometric and spectrofluorimetric) of hydrazones. We gave the total established conditions for the determination of various metal ions with hydrazones.

scholarly journals Nano-Azo Ligand and Its Superhydrophobic Complexes: Synthesis, Characterization, DFT, Contact Angle, Molecular Docking, and Antimicrobial Studies

2020 ◽  
Vol 2020 ◽  
pp. 1-19
Author(s):  
Gehad G. Mohamed ◽  
Walaa H. Mahmoud ◽  
Ahmed M. Refaat
Keyword(s):  
Crystal Structure ◽  
Contact Angle ◽  
Molecular Docking ◽  
Metal Ions ◽  
Metal Complexes ◽  
Biological Activities ◽  
Thermal Studies ◽  
Free Ligand ◽  
Aminobenzoic Acid ◽  
Azo Ligand

Metal complexes of the 2,2'-(1,3-phenylenebis(diazene-2,1-diyl))bis(4-aminobenzoic acid) diazo ligand (H2L) derived from m-phenylenediamine and p-aminobenzoic acid were synthesized and characterized by different spectral, thermal, and analytical tools. The H2L ligand reacted with the metal ions Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), and Cd(II) as 1 : 1 stoichiometry. All complexes displayed an octahedral geometry according to the electronic and magnetic moment measurements. The IR spectra revealed the binding of the azo ligand to the metal ions via two azo nitrogen atoms and protonated carboxylate O in a neutral tetradentate manner. Both IR and 1H NMR spectra documented the involvement of the carboxylate group without proton displacement. The thermal studies pointed out that the complexes had higher thermal stability comparable with that of the free ligand. SEM images revealed the presence of the diazo ligand and its Cd(II) complex in a nanostructure form. The contact angle measurements proved that the Cd(II) complex can be considered as a superhydrophobic material. The molecular and electronic structure of H2L and [Cd(H2L)Cl2].H2O were optimized theoretically, and the quantum chemical parameters were calculated. The biological activities of the ligand, as well as its metal complexes, have been tested in vitro against some bacteria and fungi species. The results showed that all the tested compounds have significant biological activities with different sensitivity levels. The binding between H2L and its Cd(II) complex with receptors of the crystal structure of S. aureus (PDB ID: 3Q8U), crystal structure of protein phosphatase (PPZ1) of Candida albicans (PDB ID: 5JPE), receptors of breast cancer mutant oxidoreductase (PDB ID: 3HB5), and crystal structure of Escherichia coli (PDB ID: 3T88) was predicted and given in detail using molecular docking.

Varying structural motifs in the salen based metal complexes of Co(ii), Ni(ii) and Cu(ii): synthesis, crystal structures, molecular dynamics and biological activities

2016 ◽  
Vol 45 (47) ◽  
pp. 19096-19108 ◽  
Author(s):  
Anoop Kumar Saini ◽  
Pratibha Kumari ◽  
Vinay Sharma ◽  
Pradeep Mathur ◽  
Shaikh M. Mobin
Keyword(s):  
Molecular Dynamics ◽  
Metal Complexes ◽  
Crystal Structures ◽  
Biological Activities ◽  
Biological Applications ◽  
Reaction Conditions ◽  
Structural Motifs

Four new metal complexes which demonstrates varying structural motifs from monomeric to dimeric to tetrameric complexes by slightly altering the reaction conditions and their biological applications.

scholarly journals Synthesis and Spectral Studies of 4,4′-(Hydrazine-1,2-diylidenedimethylylidene)-bis-(2- methoxyphenol) and Its Transition Metal Complexes with Promising Biological Activities

2020 ◽  
Vol 32 (7) ◽  
pp. 1768-1772
Author(s):  
Anita Rani ◽  
Manoj Kumar ◽  
Hardeep Singh Tuli ◽  
Zahoor Abbas ◽  
Vinit Prakash
Keyword(s):  
Schiff Base ◽  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Schiff Base Ligand ◽  
Biological Activities ◽  
Condensation Reaction ◽  
Analytical Techniques ◽  
Spectral Studies

The study describes the synthesis, characterization and biological activity of a novel Schiff base ligand and its transition metal complexes. The Schiff base ligand was obtained by a condensation reaction between 4-hydroxy-3-methoxybenzaldehyde (p-vanillin) and hydrazine hydrate using ethanol as solvent. A new series of Ni(II) and Fe(III) complexes were also derived by reaction of prepared Schiff base ligand with NiCl2 and FeCl3. Both the ligand and its metal complexes were characterized by solubility, melting point and elemental analysis. These compounds were further identified by analytical techniques, FTIR, NMR and mass spectrometry. The ligand and its transition metal complexes were also subjected to in vitro biological activities i.e. antimicrobial, antiangiogenic and DNA photo cleavage. For antimicrobial activity compounds were tested against two strains of bacteria and two strains of fungi. Different concentrations of prepared compounds were treated with fertilized chicken eggs and plasmid DNA to find out antiangiogenic and DNA photocleavage activity, respectively.

Some analytical applications of aromatic sulfonyl haloamines: Determination of thiosemicarbazide alone and in its metal complexes with bromamine-B and dichloramine-B

1982 ◽  
Vol 27 (2) ◽  
pp. 254-264 ◽  
Author(s):  
Dandinasivara S. Mahadevappa ◽  
K.S. Rangappa ◽  
B.Thimme Gowda ◽  
Netkal M.Made Gowda
Keyword(s):  
Metal Complexes ◽  
Analytical Applications

scholarly journals Diagnosis of Biological Activities by Mass Spectrometry

Proceedings ◽  
2019 ◽  
Vol 11 (1) ◽  
pp. 36
Author(s):  
Vincent Carré ◽  
Pierre Leroy ◽  
Patrick Chaimbault
Keyword(s):  
Mass Spectrometry ◽  
Food Intake ◽  
Secondary Metabolites ◽  
Structural Information ◽  
Biological Activities ◽  
Analytical Techniques ◽  
Active Metabolites ◽  
Cell Defense ◽  
Oxidative Reactions

Oxidative reactions are vital but also cause important stresses and cellular damages resulting in cancers, cardiovascular or neurodegenerative diseases. Antioxidant secondary metabolites from plant can be mobilized for the cell defense and their main source is precisely the food intake such as vegetables, fruits or beverages. Screening natural active metabolites in plants requires different analytical techniques among which mass spectrometry became one of the most popular, not just because of its ability to provide structural information on involved molecules but also because this technique belongs to the arsenal of diagnostic tool for the determination of biological activities.

scholarly journals Verification of the analytical signal additivity for the spectrophotometric determination of the total content of Cu(II), Co(II), Ni(II), Pb(II), Zn(II) using indicator films

2018 ◽  
Keyword(s):  
Metal Ions ◽  
Metal Complexes ◽  
Wavelength Range ◽  
Entire Range ◽  
Total Content ◽  
Analytical Signal ◽  
Metal Salts ◽  
Total Signal ◽  
Metal Contents

Statistical 3s- and t-criteria are used for the verification of the absorbance additivity of the immobilized in gelatin films complexes of 4-(2-pyridylazo)-resorcinol (PAR) with metal ions Co(II), Ni(II), Cu(II), Zn(II), Pb(II), both in equal concentrations, and in different ratios of their molar concentrations over the entire range of metal contents. An Agfa photographic film for offset printing is used as a transparent polymeric sorbent. Silver halides are previously removed from the gelatin layer. The extraction of the reagent into the gelatin film layer is carried out from an aqueous solution of PAR (1 mmol/l) for 45 minutes; the films with the reagent are kept in a solution of metal salts during 15 minutes. The light absorption of the films with red metal complexes is measured versus to the yellow film with the reagent on the Hitachi U-2000 spectrophotometer and the KFK-3 photocolorimeter. Two types of solutions are prepared in the concentration range (0.25–6.5)·10-5 mol/l — solutions of individual metal salts and solutions containing five metal ions simultaneously. Method I: the concentration of metal ions in individual solutions (c) is set equal to the total metal concentration in their mixture (сΣ); the metal concentrations in the mixture are equal (сΣ/5). Method II: the concentrations of metal ions in individual solutions are set to the same as in their mixtures; the ratio of the concentrations of metals in the solutions of their mixture is varied. 3-5 samples of the modified films are immersed in the solutions, air dried and obtained the value of absorbance in the wavelength range 480-580 nm in 5 nm steps. The results of the measurements are averaged and the dispersions are calculated for the individual and summary signals. The analytical signal from the sum of metal complexes(АΣ) and the sum of analytical signals from individual metal complexes (ΣА) are compared. In the case of application of the 3s-criterion, the deviation from the additivity of the total signal is assumed to be statistically insignificant if the calculated differences (| AΣ – ΣА/n | or | AΣ – ΣА |), doesn’t exceed the tripled standard deviation of the total signal. In the case of Student's-test, the critical value (tcrit=t0.01,f) and the calculated on the basis of the experimental data criterion value are compared. It is found, that the analytical signal from the sum of metals, both in equal concentrations, and in different ratios of their molar concentrations, doesn’t have significant deviations from additivity in the entire range of the metal contents and wavelength range. The indicator films are used for spectrophotometric and visual-test determination of the total content of Cu (II), Co (II), Ni (II), Pb (II), Zn (II) in samples of natural water. The accuracy of the determinations is proved by atomic absorption spectroscopy.

Transition metal complexes of 1-substituted tetrazoline-5-thiones

1967 ◽  
Vol 45 (10) ◽  
pp. 1057-1062 ◽  
Author(s):  
Umesh Agarwala ◽  
V. A. Narayan ◽  
S. K. Dikshit
Keyword(s):  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Infrared Spectra ◽  
Gravimetric Determination ◽  
Analytical Applications

Transition metal complexes of a number of 1-substituted tetrazoline-5-thiones have been prepared and their infrared spectra examined in the 3 600 – 500 cm−1 region. The analytical applications of 1-substituted tetrazoline-5-thiones for the gravimetric determination of cadmium and palladium have been studied.

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