scholarly journals Cardiac Epithelioid PEComa: Report of Two Cases and Review of the Literature

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Huilin Niu ◽  
F. W. Wang ◽  
Paul J. Zhang ◽  
Zhanyong Bing
Keyword(s):  
Clear Cell ◽  
Coagulation Necrosis ◽  
Review Of The Literature ◽  
Epithelioid Cells ◽  
Adult Case ◽  
Pediatric Case ◽  
High Mitotic Activity ◽  
Atypical Mitosis ◽  
Malignant Behavior ◽  
Hmb 45

Cardiac PEComa is very rare. We reported two cases of epithelioid PEComas, one in an adult and one in a 2-year-old child. Both tumors were composed of sheets of epithelioid cells with coagulation necrosis. In addition, the adult case showed marked nuclear atypia and high mitotic activity with atypical mitosis and the pediatric case showed unusual clear cell features. Immunohistochemically, both tumors were positive for HMB-45 and SMA and negative for S100 and cytokeratin. Electron microscopy was performed in the pediatric case and showed premelanosomes. The adult patient developed extensive metastasis indicating malignant behavior. Prior to the two cases, only 5 other cases of cardiac PEComa were reported and the literatures are reviewed.

Clear Cell Ductal Adenocarcinoma of Pancreas: A Case Report and Review of the Literature

2004 ◽  
Vol 128 (6) ◽  
pp. 693-696 ◽  
Author(s):  
Sourav Ray ◽  
Zhengbin Lu ◽  
Swaminathan Rajendiran
Keyword(s):  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Ductal Adenocarcinoma ◽  
Molecular Evidence ◽  
Cytokeratin 20 ◽  
Ras Oncogene ◽  
Cytokeratin 7 ◽  
Review Of The Literature ◽  
Hyaline Globules ◽  
Hmb 45

Abstract We present a unique carcinoma of the pancreas with predominantly clear cell morphology (>95% clear cells). Mucicarmine stain revealed abundant intraluminal and intracytoplasmic mucin. Immunohistochemically, the cells were positive for the epithelial markers cytokeratin 7 and CAM 5.2, and were focally positive for cytokeratin 20. These cells also expressed monoclonal carcinoembryonic antigen. Stains for the neuroendocrine markers synaptophysin and chromogranin were negative, as were stains for vimentin, p53, HMB-45, and CD10. An additional outstanding feature was the presence of dense intraluminal and intracytoplasmic hyaline globules, which were immunohistochemically positive for α1-antitrypsin. Sequencing of the K-ras oncogene revealed a point mutation in codon 12, providing molecular evidence of ductal origin. In the proper morphologic context supported by immunohistochemistry, clear cell carcinoma can be regarded as a rare variant of ductal adenocarcinoma.

scholarly journals Clear Cell Tumor of the Lung Could Be Aggressive: a case report and review of the literature

2020 ◽  
Author(s):  
leilei shen ◽  
Jixing LIN ◽  
Zhipeng REN ◽  
Bailin WANG ◽  
You Liu ◽  
...  
Keyword(s):  
Fine Needle Aspiration Biopsy ◽  
Clear Cell ◽  
Mediastinal Lymph Node ◽  
Lower Lobe ◽  
Needle Aspiration ◽  
Exact Nature ◽  
Review Of The Literature ◽  
Epithelioid Cells ◽  
Case Presentation ◽  
Clear Cell Tumor

Abstract Background: Clear cell tumors of the lung (CCTLs) are rare and mostly benign pulmonary neoplasms arising from perivascular epithelioid cells. Only approximately 100 cases have been reported, and half of them were in China. Limited details about CCTLs often cause diagnostic or therapeutic problems. Case presentation: We describe a case of a 28-year-old woman with multiple gradually replicating and enlarging nodules in the left lower lobe. The patient underwent fine-needle aspiration biopsy and was diagnosed with CCTL. A left lower lobectomy and mediastinal lymph node dissection were performed. The gradual changes in size (1.4 cm to 2.8 cm) and quantity (10 to 49) of the CCTLs in this case were the biggest differences from previously reported cases. Conclusions: CCTLs are very uncommon and mostly benign PEComatous tumors with no specific morphologic features. We present a case of CCTL with multiplicity and rapid growth, which may indicate its aggressive nature. The accumulation of similar cases will help clarify the exact nature and improve our understanding of the disease.

scholarly journals Cutaneous Melanocytic Tumor with CRTC1::TRIM11 Fusion: Review of the Literature of a Potentially Novel Entity

Biology ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 1286
Author(s):  
Ourania Parra ◽  
Konstantinos Linos
Keyword(s):  
S100 Protein ◽  
Review Of The Literature ◽  
Epithelioid Cells ◽  
Melanocytic Tumor ◽  
Comprehensive Literature Review ◽  
The Family ◽  
Initial Resection ◽  
Melanocytic Differentiation ◽  
Hmb 45

“Cutaneous melanocytic tumor with CRTC1::TRIM11 fusion” (CMTCT) is a recently described entity belonging to the family of superficial tumors displaying melanocytic differentiation. Thirteen cases have been reported so far, on the head and neck, extremities, and trunk of adults of all ages (12 cases) and one in an 11-year-old child. Histopathologically, it is a nodular or multilobulated tumor composed of spindle and epithelioid cells arranged in nests, fascicles, or bundles that are surrounded by thin collagenous septa. By immunohistochemistry, the tumor shows variable immunoreactivity for S100-protein, SOX10, and MITF, as well as specific melanocytic markers such as MelanA and HMB-45. The neoplasm’s biologic behavior remains uncertain since the reported cases are limited and the follow-up is short (median 12 months). However, local recurrence and synchronous distant metastasis after 13 years of initial resection has been described in one case. Herein, we present a comprehensive literature review of CMTCT hoping to raise awareness among the dermatopathologists of this potentially novel entity.

Clear cell carcinoma of the ovary: A review of the literature

2012 ◽  
Vol 126 (3) ◽  
pp. 481-490 ◽  
Author(s):  
Marcela G. del Carmen ◽  
Michael Birrer ◽  
John O. Schorge
Keyword(s):  
Cell Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Review Of The Literature ◽  
Carcinoma Of The Ovary

scholarly journals Von hippel-lindaus disease: Report of three cases and review of the literature

1995 ◽  
Vol 53 (4) ◽  
pp. 782-788 ◽  
Author(s):  
Luiz F. Bleggi-Torres ◽  
Lúcia de Noranha ◽  
J. Fillus Neto ◽  
José E. Queiroz Telles ◽  
Luiz E. Madalozzo
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Review Of The Literature ◽  
The Third ◽  
The Family ◽  
Cerebellar Haemangioblastoma ◽  
Atypical Meningiomas ◽  
Cns Lesions

The authors present the autopsy findings of two related patients and the biopsy findings of a thrid member of the family. The oldest member was 34 years old at death and on postmortem examination he had haemangioblastomas in the retina, cerebellum, medulla and spinal cord. Other findings were renal cell carcinoma, phaechromocytoma, cysts of kidney and pancreas, hydromyelia and atypical meningiomas. His brother died when 30 years old. The autopsy revealed haemangioblastomas of cerebellum, renal cell carcinoma and a clear cell cystadenoma of epididymus. The third patient was the daughter of the first and presented with headache and dizziness. CT-scan showed a cerebellar haemangioblastoma. Epidemiological considerations on the commonest visceral and CNS lesions and a review of current diagnostic criteria are discussed.

Clear cell variant of calcifying epithelial odontogenic tumor: Case report and review of the literature

Head & Neck ◽  
1994 ◽  
Vol 16 (3) ◽  
pp. 272-277 ◽  
Author(s):  
M. John Hicks ◽  
Catherine M. Flaitz ◽  
Mark E. K. Wong ◽  
R. Keith McDaniel ◽  
Philip T. Cagle
Keyword(s):  
Case Report ◽  
Clear Cell ◽  
Odontogenic Tumor ◽  
Review Of The Literature ◽  
Calcifying Epithelial Odontogenic Tumor ◽  
Cell Variant ◽  
Clear Cell Variant ◽  
Epithelial Odontogenic Tumor

scholarly journals Blastic Plasmacytoid Dendritic Cell Neoplasm: A Pediatric Case Report With Review of the Literature

2013 ◽  
Vol 140 (suppl 1) ◽  
pp. A135-A135
Author(s):  
Yanli Ding ◽  
Weiwei Chen ◽  
Zachary O'Neill ◽  
Maurice Barcos ◽  
Amy Sands ◽  
...  
Keyword(s):  
Case Report ◽  
Dendritic Cell ◽  
Plasmacytoid Dendritic Cell ◽  
Review Of The Literature ◽  
Pediatric Case ◽  
Cell Neoplasm
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