scholarly journals Antidiabetic Effect of an Active Components Group fromIlex kudingchaand Its Chemical Composition

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Chengwu Song ◽  
Chao Xie ◽  
Zhiwen Zhou ◽  
Shanggong Yu ◽  
Nianbai Fang
Keyword(s):  
Synergistic Effects ◽  
Fatty Acid Synthetase ◽  
Antidiabetic Activity ◽  
Diabetic Mice ◽  
Active Components ◽  
Triterpenoid Saponins ◽  
Antidiabetic Effect ◽  
First Time ◽  
Type 2 Diabetic

The leaves ofIlex kudingchaare used as an ethnomedicine in the treatment of symptoms related with diabetes mellitus and obesity throughout the centuries in China. The present study investigated the antidiabetic activities of an active components group (ACG) obtained fromIlex kudingchain alloxan-induced type 2 diabetic mice. ACG significantly reduced the elevated levels of serum glycaemic and lipids in type 2 diabetic mice. 3-Hydroxy-3-methylglutaryl coenzyme A reductase and glucokinase were upregulated significantly, while fatty acid synthetase, glucose-6-phosphatase catalytic enzyme was downregulated in diabetic mice after treatment of ACG. These findings clearly provided evidences regarding the antidiabetic potentials of ACG fromIlex kudingcha. Using LC-DAD/HR-ESI-TOF-MS, six major components were identified in ACG. They are three dicaffeoylquinic acids that have been reported previously, and three new triterpenoid saponins, which were the first time to be identified inIlex kudingcha. It is reasonable to assume that antidiabetic activity ofIlex kudingchaagainst hyperglycemia resulted from these six major components. Also, synergistic effects among their compounds may exist in the antidiabetic activity ofIlex kudingcha.

scholarly journals Antidiabetic Activity of Green Tea (Thea sinensis L.) in Genetically Type 2 Diabetic Mice

2005 ◽  
Vol 51 (6) ◽  
pp. 708-710 ◽  
Author(s):  
Toshihiro Miura ◽  
Tomoko Koike ◽  
Torao Ishida
Keyword(s):  
Green Tea ◽  
Antidiabetic Activity ◽  
Diabetic Mice ◽  
Type 2 Diabetic

Antidiabetic Effect of Sargassum wightii and Ulva fasciata in High Fat Diet and Multi Low Dose Streptozotocin Induced Type 2 Diabetic Mice

2016 ◽  
Vol 4 (2) ◽  
pp. 13 ◽  
Author(s):  
Lucy Mohapatra ◽  
Subrat Kumar Bhattamishra ◽  
Ramachandra Panigrahy ◽  
Sambit Parida ◽  
Premalata Pati
Keyword(s):  
High Fat Diet ◽  
Low Dose ◽  
Diabetic Mice ◽  
High Fat ◽  
Antidiabetic Effect ◽  
Ulva Fasciata ◽  
Sargassum Wightii ◽  
Type 2 Diabetic

Orostachys japonicus A. Berger (Crassulaceae) Exerts Antidiabetic Activity by Improving Glucose and Lipid Levels in Type 2 Diabetic Mice

2019 ◽  
Vol 22 (8) ◽  
pp. 797-809 ◽  
Author(s):  
Hyuneui Jeong ◽  
Jong-Won Kim ◽  
Daram Yang ◽  
Tae-Won Jeong ◽  
Jing Zhao ◽  
...  
Keyword(s):  
Antidiabetic Activity ◽  
Diabetic Mice ◽  
Lipid Levels ◽  
Type 2 Diabetic

scholarly journals Role of Green Macroalgae Enteromorpha Prolifera Polyphenols in the Modulation of Gene Expression and Intestinal Microflora Profiles in Type 2 Diabetic Mice

2018 ◽  
Vol 20 (1) ◽  
pp. 25 ◽  
Author(s):  
Guopeng Lin ◽  
Xiaoyan Liu ◽  
Xin Yan ◽  
Dan Liu ◽  
Chengfeng Yang ◽  
...  
Keyword(s):  
Intestinal Microflora ◽  
Fasting Blood Glucose ◽  
Antidiabetic Activity ◽  
Rrna Gene ◽  
Regulation Mechanism ◽  
Diabetic Mice ◽  
Enteromorpha Prolifera ◽  
Green Macroalgae ◽  
Type 2 Diabetic

Effects of green macroalgae 55% ethanolic extract Enteromorpha prolifera through an ultrafiltration membrane of 3 kDa (EPE3k) on antidiabetic activity, gut microbiota, and regulation mechanism were investigated in high-fat/high-sucrose diet and streptozocin-induced diabetic mice. The structural characterizations of its major compounds in EPE3k were determined by ultra-performance liquid chromatography-quadrupole/time of flight mass spectrometry. Furthermore, the intestinal microflora modulation in diabetic mice was also investigated with high-throughput 16S rRNA gene sequencing. The proposed presence of polyphenols in EPE3k was confirmed. EPE3k could significantly decrease the fasting blood glucose and improve fasting glucose tolerance. The hypoglycemic effect of EPE3k was via activation of phosphatidylinositol 3-kinase and suppression of c-Jun N-terminal kinase in liver. EPE3k treatment significantly increased the relative abundance of Akkermansia and decreased the proportion of Alistipes and Turicibacter. The above results indicated that EPE3k could be provided as a new potential therapy for the treatment of type 2 diabetic mellitus.

scholarly journals In Vivo Antidiabetic Activities of Polyherbal Extracts against Streptozotocin- Nicotinamide Induced Type 2 Diabetic Mice Model

2021 ◽  
Vol 47 (3) ◽  
pp. 877-891
Author(s):  
Pradnya Jagtap ◽  
Yashashri Nimbalkar ◽  
Vidya Patil ◽  
Ravindra Y. Patil
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Density Lipoprotein ◽  
Alternative Therapies ◽  
Tinospora Cordifolia ◽  
Antidiabetic Activity ◽  
Oral Glucose ◽  
Diabetic Mice ◽  
Type 2 Diabetic

Diabetes mellitus is a chronic metabolic disorder and rapidly increasing cases of diabetes throughout the world are major concerns in both developed and developing countries. Currently available oral antidiabetic medicines have limitations in efficacy and safety, which in conjunction with the emergence of diabetes mellitus as a global epidemic have aided the popularity of alternative therapies to manage the disease safely and more efficiently. Herbal medicines are accepted as alternative therapies for blood sugar control. Gymnema sylvestre, Boerhavia diffusa, Tinospora cordifolia, and Argyreia nervosa are some potent herbs used for the management of diabetes. Mixing of these plants in different ratios may produce synergistic antidiabetic actions which may have greater antidiabetic activity. Hence, the present study aimed to determine the anti-diabetic activities of polyherbal extracts in streptozotocin-nicotinamide induced type 2 diabetic mice. The administration of polyherbal extract orally at doses of 100, 200 and 400 mg/kg significantly decreased the blood glucose levels compared to the control diabetic mice. The polyherbal extract significantly lowered the elevated total cholesterol, triglycerides and low-density lipoprotein levels, while increased the high-density lipoprotein indicating antihyperlipidemic activity. The present study reveals that polyherbal extract at a dose of 400 mg/kg body weight resulted in a significant decline (p < 0.001) in blood glucose level. Keywords: Polyherbal extracts; diabetes mellitus; Oral glucose tolerance test; Streptozotocin-Nicotinamide

scholarly journals Antidiabetic Activity of Lyophyllum decastes in Genetically Type 2 Diabetic Mice

2002 ◽  
Vol 25 (9) ◽  
pp. 1234-1237 ◽  
Author(s):  
Toshihiro Miura ◽  
Mizue Kubo ◽  
Yasushi Itoh ◽  
Naoki Iwamoto ◽  
Motoshi Kato ◽  
...  
Keyword(s):  
Antidiabetic Activity ◽  
Diabetic Mice ◽  
Type 2 Diabetic ◽  
Lyophyllum Decastes

Antidiabetic Activity of Lessonia nigrescens Extract in Type 2 Diabetic Mice

2017 ◽  
Vol 112 ◽  
pp. 159
Author(s):  
Chao Zhao ◽  
Chengfeng Yang ◽  
Mingjun Chen ◽  
Bin Liu ◽  
Jianbo Xiao
Keyword(s):  
Antidiabetic Activity ◽  
Diabetic Mice ◽  
Lessonia Nigrescens ◽  
Type 2 Diabetic
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