scholarly journals Adaptive and Innate Immune Responsiveness toBorrelia burgdorferi sensu latoin Exposed Asymptomatic Children and Children with Previous Clinical Lyme Borreliosis

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Barbro H. Skogman ◽  
Sandra Hellberg ◽  
Christina Ekerfelt ◽  
Maria C. Jenmalm ◽  
Pia Forsberg ◽  
...  
Keyword(s):  
Borrelia Burgdorferi ◽  
Lyme Borreliosis ◽  
Clinical Manifestations ◽  
Innate Immune ◽  
Borrelia Burgdorferi Sensu Lato ◽  
Immune Responsiveness ◽  
Asymptomatic Children ◽  
Immunological Mechanisms ◽  
Spontaneous Secretion ◽  
Necrosis Factor

Why some individuals develop clinical manifestations in Lyme borreliosis (LB) while others remain asymptomatic is largely unknown. Therefore, we wanted to investigate adaptive and innate immune responsiveness toBorrelia burgdorferi sensu latoin exposedBorrelia-antibody-positive asymptomatic children (n=20), children with previous clinical LB (n=24), and controls (n=20). Blood samples were analyzed forBorrelia-specific interferon (IFN)-γ, interleukin (IL)-4, and IL-17 secretion by ELISPOT andBorrelia-induced IL-1β, IL-6, IL-10, IL-12(p70), and tumor necrosis factor (TNF) secretion by Luminex. We found no significant differences in cytokine secretion between groups, but a tendency towards an increased spontaneous secretion of IL-6 was found among children with previous clinical LB. In conclusion, the adaptive or innate immune responsiveness toBorrelia burgdorferi sensu latowas similar inBorrelia-exposed asymptomatic children and children with previous clinical LB. Thus, the immunological mechanisms of importance for eradicating the spirochete effectively without developing clinical manifestations of LB remain unknown.

scholarly journals Modern condition of the problem of Lime Burreliosis of animals (systematic review)

2021 ◽  
pp. 64-78
Author(s):  
O. Panteleenko ◽  
B. Yarchuk ◽  
T. Tsarenko
Keyword(s):  
Borrelia Burgdorferi ◽  
Lyme Borreliosis ◽  
Clinical Manifestations ◽  
Ecological Factors ◽  
Scientific Data ◽  
Temperate Climate ◽  
Borrelia Burgdorferi Sensu Lato ◽  
Considerable Uncertainty ◽  
Reservoir Hosts

Lyme borreliosis (LB) is the most common tick-borne disease in the temperate climate of the Northern Hemisphere. LB is caused by spirochetes, which are grouped in the complex Borrelia burgdorferi sensu lato, vectors – Ixodidae mites, dozens of species of small mammals and birds actas reservoir hosts, and the role of reservoirs of domestic animals, such as dogs and cats, is not excluded. Although the ecology and epidemiology of the disease have been extensively studied in Europe and North America, there is considerable uncertainty regarding the study of Lyme borreliosis in veterinary medicine. Search, selection andanalysis of scientific data on the research topic were carried out according to acceptable rules for systematic reviews of the literature. The scientometric database Web of Science Core Collection, the database of scientific articles Pub Med and the database Scientific Periodicals of Ukraine were used. Seventy-four scientific articles were used for the article, which contained the necessary set of data and met the set goal. The article highlights the main issues of the etiology of the disease, which describes the characteristics of the pathogen, its properties, genotypic composition of Borrelia, which cause Lyme disease, the spread of pathogenic genotypes of Borrelia in Europe and Ukraine. The connection of Lyme borreliosis spread with ecological factors, climatic changes and anthropogenic impact on biocenoses and biotopes, the role of vectors and reservoir hosts in the spread of LB is described. Data on the prevalence and degree of infection of Ixodes mites with Borrelia, as well as the spread of LB among the population of Europe and Ukraine are presented. The seroprevalence of each of the animal species (dogs, cats, horses, ruminants), clinical manifestations of LB, if documented and indicators of LB prevalence among animals in Europe and Ukraine, as well as currently known treatments, prevention and diagnosis of LB animals are considered. Key words: Borrelia Burgdorferi Sensu Lato, Lyme Diseases Etiology, Ixodidae.

scholarly journals Seroprevalence of antibodies against Borrelia burgdorferi sensu lato in healthy blood donors in Romania: an update

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Zsuzsa Kalmár ◽  
Violeta Briciu ◽  
Mircea Coroian ◽  
Mirela Flonta ◽  
Amanda-Lelia Rădulescu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Borrelia Burgdorferi ◽  
Western Blot ◽  
Lyme Borreliosis ◽  
Blood Donors ◽  
Clinical Manifestations ◽  
Borrelia Burgdorferi Sensu Lato ◽  
Serum Samples ◽  
Igm Antibodies ◽  
Associated Risk Factors

Abstract Background The Borrelia burgdorferi sensu lato (s.l.) genogroup is the causative agent responsible for Lyme borreliosis, a common tick-borne infectious disease in some temperate regions of the Northern Hemisphere. In humans, the clinical manifestations of Lyme borreliosis vary from dermatological infection to severe systemic manifestations. In Romania, data on the seroprevalence of Lyme borreliosis and associated risk factors are scarce and outdated, as the only seroprevalence study with a large dataset was published more than 20 years ago. Therefore, the aim of the present study was to evaluate the seroprevalence for Borrelia burgdorferi s.l. in healthy blood donors from six Romanian counties and identify the associated risk factors. Methods The study was conducted among 1200 healthy blood donors aged between 18 and 65 years during November 2019 and September 2020 from six counties in the northwestern and central parts of Romania. A two-tiered testing strategy was applied. Positive and equivocal immunoenzymatic test results for IgG and IgM antibodies were further confirmed by Western blot. Results Serum samples from 20% of the blood donors had positive or equivocal IgG and IgM ELISA index values. In total, 2.3% of the serum samples for IgG and 1.8% for IgM were positive by Western blot. The seroprevalence for both antibodies varied between 1.5% (Satu-Mare) and 6.5% (Bistrița-Năsăud) in the six counties investigated. The highest seroprevalence was observed in men (4.7%), in blood donors performing their professional activities outdoors (4.2%), and in those aged  ≥ 56 years (8%). Conclusions These findings confirm the presence of specific IgG and IgM antibodies to B. burgdorferi s.l. among healthy blood donors from Romania. Furthermore, potential risk factors, such as gender, age, and behavior, associated with the presence of positive B. burgdorferi s.l. antibodies among healthy blood donors were identified. Graphical Abstract

scholarly journals Imbalanced presence of Borrelia burgdorferi s.l. multilocus sequence types in clinical manifestations of Lyme borreliosis

2016 ◽  
Vol 42 ◽  
pp. 66-76 ◽  
Author(s):  
E. Claudia Coipan ◽  
Setareh Jahfari ◽  
Manoj Fonville ◽  
G. Anneke Oei ◽  
Lodewijk Spanjaard ◽  
...  
Keyword(s):  
Borrelia Burgdorferi ◽  
Lyme Borreliosis ◽  
Clinical Manifestations ◽  
Borrelia Burgdorferi S.L ◽  
Sequence Types

scholarly journals Differential Transmission of the Genospecies of Borrelia burgdorferi Sensu Lato by Game Birds and Small Rodents in England

1998 ◽  
Vol 64 (4) ◽  
pp. 1169-1174 ◽  
Author(s):  
Klaus Kurtenbach ◽  
Mick Peacey ◽  
Sjoerd G. T. Rijpkema ◽  
Andrew N. Hoodless ◽  
Patricia A. Nuttall ◽  
...  
Keyword(s):  
Borrelia Burgdorferi ◽  
Lyme Borreliosis ◽  
Sensu Stricto ◽  
Rrna Genes ◽  
Borrelia Burgdorferi Sensu Lato ◽  
Internal Organs ◽  
Borrelia Garinii ◽  
Game Birds ◽  
5S Rrna Genes ◽  
Pcr Targeting

ABSTRACT The genetic diversity of Borrelia burgdorferi sensu lato was assessed in a focus of Lyme borreliosis in southern Britain dominated by game birds. Ticks, rodents, and pheasants were analyzed for spirochete infections by PCR targeting the 23S-5S rRNA genes, followed by genotyping by the reverse line blot method. In questingIxodes ricinus ticks, three genospecies of B. burgdorferi sensu lato were detected, with the highest prevalences found for Borrelia garinii and Borrelia valaisiana. B. burgdorferi sensu stricto was rare (<1%) in all tick stages. Borrelia afzelii was not detected in any of the samples. More than 50% of engorged nymphs collected from pheasants were infected with borreliae, mainly B. garinii and/orB. valaisiana. Although 19% of the rodents harboredB. burgdorferi sensu stricto and/or B. gariniiin internal organs, only B. burgdorferi sensu stricto was transmitted to xenodiagnostic tick larvae (it was transmitted to 1% of the larvae). The data indicate that different genospecies of B. burgdorferi sensu lato can be maintained in nature by distinct transmission cycles involving the same vector tick species but different vertebrate host species. Wildlife management may have an influence on the relative risk of different clinical forms of Lyme borreliosis.

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