Comparison of Post-Lyme Borreliosis Symptoms in Erythema Migrans Patients with Positive and Negative Borrelia burgdorferi Sensu Lato Skin Culture

2011 ◽  
Vol 11 (7) ◽  
pp. 883-889 ◽  
Author(s):  
Daša Stupica ◽  
Lara Lusa ◽  
Tjaša Cerar ◽  
Eva Ružić-Sabljić ◽  
Franc Strle
Keyword(s):  
Borrelia Burgdorferi ◽  
Lyme Borreliosis ◽  
Erythema Migrans ◽  
Borrelia Burgdorferi Sensu Lato ◽  
Skin Culture

scholarly journals Geographical and genospecies distribution of Borrelia burgdorferi sensu lato DNA detected in humans in the USA

2014 ◽  
Vol 63 (5) ◽  
pp. 674-684 ◽  
Author(s):  
Kerry L. Clark ◽  
Brian F. Leydet ◽  
Clifford Threlkeld
Keyword(s):  
Lyme Disease ◽  
Borrelia Burgdorferi ◽  
Skin Biopsy ◽  
Lyme Borreliosis ◽  
Erythema Migrans ◽  
Skin Lesions ◽  
Sensu Stricto ◽  
Borrelia Burgdorferi Sensu Lato ◽  
Southern States ◽  
The Usa

The present study investigated the cause of illness in human patients primarily in the southern USA with suspected Lyme disease based on erythema migrans-like skin lesions and/or symptoms consistent with early localized or late disseminated Lyme borreliosis. The study also included some patients from other states throughout the USA. Several PCR assays specific for either members of the genus Borrelia or only for Lyme group Borrelia spp. (Borrelia burgdorferi sensu lato), and DNA sequence analysis, were used to identify Borrelia spp. DNA in blood and skin biopsy samples from human patients. B. burgdorferi sensu lato DNA was found in both blood and skin biopsy samples from patients residing in the southern states and elsewhere in the USA, but no evidence of DNA from other Borrelia spp. was detected. Based on phylogenetic analysis of partial flagellin (flaB) gene sequences, strains that clustered separately with B. burgdorferi sensu stricto, Borrelia americana or Borrelia andersonii were associated with Lyme disease-like signs and symptoms in patients from the southern states, as well as from some other areas of the country. Strains most similar to B. burgdorferi sensu stricto and B. americana were found most commonly and appeared to be widely distributed among patients residing throughout the USA. The study findings suggest that human cases of Lyme disease in the southern USA may be more common than previously recognized and may also be caused by more than one species of B. burgdorferi sensu lato. This study provides further evidence that B. burgdorferi sensu stricto is not the only species associated with signs and/or symptoms consistent with Lyme borreliosis in the USA.

scholarly journals Clinical Features of 705Borrelia burgdorferiSeropositive Patients in an Endemic Area of Northern Italy

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Giuseppe Stinco ◽  
Maurizio Ruscio ◽  
Serena Bergamo ◽  
Davide Trotter ◽  
Pasquale Patrone
Keyword(s):  
Borrelia Burgdorferi ◽  
Clinical Features ◽  
Lyme Borreliosis ◽  
Erythema Migrans ◽  
Geographic Area ◽  
Borrelia Burgdorferi Sensu Lato ◽  
Neurological Involvement ◽  
Clinical Feature ◽  
Cutaneous Manifestations ◽  
Acrodermatitis Chronica Atrophicans

Background. Lyme Borreliosis is a multisystemic infection caused by spirochetes ofBorrelia burgdorferi sensu latocomplex. The features of Lyme Borreliosis may differ in the various geographical areas, primarily between the manifestations found in America and those found in Europe and Asia.Objective. to describe the clinical features of Lyme Borreliosis in an endemic geographic area such as Friuli-Venezia Giulia in the Northeastern part of Italy.Methods. The medical records of patients resulted seropositive forBorrelia burgdorferihave been retrospectively recorded and analyzed.Results. Seven hundred and five patients met the inclusion criteria, 363 males and 342 females. Erythema migrans was the most common manifestation, detected in 437 patients. Other classical cutaneous manifestations included 58 cases of multiple erythema migrans, 7 lymphadenosis benigna cutis, and 18 acrodermatitis chronica atrophicans. The musculoskeletal system was involved in 511 patients. Four hundred and sixty patients presented a neurological involvement. Flu-like symptoms preceded or accompanied or were the only clinical feature in 119 patients.Comments. The manifestations of Lyme borreliosis recorded in this study are similar to the ones of other endemic areas in Europe, even if there are some peculiar features which are different from those reported in Northern Europe and in the USA.

scholarly journals Clinical Characteristics Associated with Borrelia burgdorferi Sensu Lato Skin Culture Results in Patients with Erythema Migrans

PLoS ONE ◽  
2013 ◽  
Vol 8 (12) ◽  
pp. e82132 ◽  
Author(s):  
Franc Strle ◽  
Lara Lusa ◽  
Eva Ružić-Sabljić ◽  
Vera Maraspin ◽  
Stanka Lotrič Furlan ◽  
...  
Keyword(s):  
Borrelia Burgdorferi ◽  
Clinical Characteristics ◽  
Erythema Migrans ◽  
Borrelia Burgdorferi Sensu Lato ◽  
Skin Culture

scholarly journals Study of a Cohort of 1,886 Persons To Determine Changes in Antibody Reactivity to Borrelia burgdorferi 3 Months after a Tick Bite

2015 ◽  
Vol 22 (7) ◽  
pp. 823-827 ◽  
Author(s):  
Ram B. Dessau ◽  
Linda Fryland ◽  
Peter Wilhelmsson ◽  
Christina Ekerfelt ◽  
Dag Nyman ◽  
...  
Keyword(s):  
Borrelia Burgdorferi ◽  
Lyme Borreliosis ◽  
Erythema Migrans ◽  
Significant Rise ◽  
Tick Bite ◽  
Content Type ◽  
Paired Samples ◽  
Antibody Reactivity ◽  
Flagellar Antigen ◽  
Relative Change

ABSTRACTLyme borreliosis is a tick-borne disease caused by the bacteriumBorrelia burgdorferi. The most frequent clinical manifestation is a rash called erythema migrans. Changes in antibody reactivity toB. burgdorferi3 months after a tick bite are measured using enzyme-linked immunosorbent assays (ELISAs). One assay is based on native purified flagellum antigen (IgG), and the other assay is based on a recombinant antigen called C6 (IgG or IgM). Paired samples were taken at the time of a tick bite and 3 months later from 1,886 persons in Sweden and the Åland Islands, Finland. The seroconversion or relative change is defined by dividing the measurement units from the second sample by those from the first sample. The threshold for the minimum level of significant change was defined at the 2.5% level to represent the random error level. The thresholds were a 2.7-fold rise for the flagellar IgG assay and a 1.8-fold rise for the C6 assay. Of 1,886 persons, 102/101 (5.4%) had a significant rise in antibody reactivity in the flagellar assay or the C6 assay. Among 40 cases with a diagnosis of Lyme borreliosis, the sensitivities corresponding to a rise in antibodies were 33% and 50% for the flagellar antigen and the C6 antigen, respectively. Graphical methods to display the antibody response and to choose thresholds for a rise in relative antibody reactivity are shown and discussed. In conclusion, 5.4% of people with tick bites showed a rise inBorrelia-specific antibodies above the 2.5% threshold in either ELISA but only 40 (2.1%) developed clinical Lyme borreliosis.

scholarly journals Differential Transmission of the Genospecies of Borrelia burgdorferi Sensu Lato by Game Birds and Small Rodents in England

1998 ◽  
Vol 64 (4) ◽  
pp. 1169-1174 ◽  
Author(s):  
Klaus Kurtenbach ◽  
Mick Peacey ◽  
Sjoerd G. T. Rijpkema ◽  
Andrew N. Hoodless ◽  
Patricia A. Nuttall ◽  
...  
Keyword(s):  
Borrelia Burgdorferi ◽  
Lyme Borreliosis ◽  
Sensu Stricto ◽  
Rrna Genes ◽  
Borrelia Burgdorferi Sensu Lato ◽  
Internal Organs ◽  
Borrelia Garinii ◽  
Game Birds ◽  
5S Rrna Genes ◽  
Pcr Targeting

ABSTRACT The genetic diversity of Borrelia burgdorferi sensu lato was assessed in a focus of Lyme borreliosis in southern Britain dominated by game birds. Ticks, rodents, and pheasants were analyzed for spirochete infections by PCR targeting the 23S-5S rRNA genes, followed by genotyping by the reverse line blot method. In questingIxodes ricinus ticks, three genospecies of B. burgdorferi sensu lato were detected, with the highest prevalences found for Borrelia garinii and Borrelia valaisiana. B. burgdorferi sensu stricto was rare (<1%) in all tick stages. Borrelia afzelii was not detected in any of the samples. More than 50% of engorged nymphs collected from pheasants were infected with borreliae, mainly B. garinii and/orB. valaisiana. Although 19% of the rodents harboredB. burgdorferi sensu stricto and/or B. gariniiin internal organs, only B. burgdorferi sensu stricto was transmitted to xenodiagnostic tick larvae (it was transmitted to 1% of the larvae). The data indicate that different genospecies of B. burgdorferi sensu lato can be maintained in nature by distinct transmission cycles involving the same vector tick species but different vertebrate host species. Wildlife management may have an influence on the relative risk of different clinical forms of Lyme borreliosis.

Lyme borreliosis

2011 ◽  
Author(s):  
Sue O’Connell
Keyword(s):  
Lyme Borreliosis ◽  
Erythema Migrans ◽  
The United States ◽  
Borrelia Burgdorferi Sensu Lato ◽  
Protection Measures ◽  
Stage Disease ◽  
Control And Prevention ◽  
Ixodes Ticks ◽  
Musculoskeletal Systems ◽  
Specific Symptoms

Lyme borreliosis is the most common vector-borne bacterial infection in the temperate northern hemisphere. In the United States of America over 35,000 confirmed or probable cases were reported by state health departments to the Centers for Disease Control and Prevention (CDC) in 2008. It is likely that well over 100,000 cases occur in Europe each year. Lyme borreliosis is caused by several genospecies of Borrelia burgdorferi sensu lato, which are transmitted by ticks of the Ixodes ricinus complex. The infection occurs most commonly in forested, woodland and heathland habitats that support the lifecycles of Ixodes ticks and the small mammals and birds that are reservoir-competent hosts for B burgorferi. The most common presenting feature of Lyme borreliosis is erythema migrans, a slowly spreading rash. The spirochaetes can disseminate through the bloodstream and lymphatics to other organs and tissues and cause later manifestations, most commonly affecting the nervous and musculoskeletal systems. The infection responds to appropriate antibiotic treatment at any stage of disease, with excellent outcomes in most cases, but patients with severe tissue damage from previously untreated late stage disease may recover incompletely. A small proportion of patients can have persistent non-specific symptoms following treatment, without evidence of continuing active infection. This has been termed “post-Lyme syndrome” and appears to be similar to other post-infection syndromes. Prevention relies mainly on personal protection measures against tick bites.

Sign in / Sign up

Export Citation Format

Share Document