scholarly journals Klossiella equiInfection in an Immunosuppressed Horse: Evidence of Long-Term Infection

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Lora R. Ballweber ◽  
Deanna Dailey ◽  
Gabriele Landolt
Keyword(s):  
Weight Loss ◽  
Pituitary Gland ◽  
Developmental Stages ◽  
Pars Intermedia ◽  
Nasal Discharge ◽  
Coccidian Parasite ◽  
Quarter Horse ◽  
History Of ◽  
Initial Improvement

A 13-year-old quarter horse gelding presented with a history of hematuria of approximately 1-year duration, anemia, weight loss over the previous six months, and bilateral nasal discharge of 2-week duration. It was determined that hematuria was most likely caused by the coccidian parasiteKlossiella equi. Additional case workup suggested a diagnosis of pituitary pars intermedia dysfunction. Confirmatory testing was declined by the owners and the horse was discharged on medical therapy. Despite initial improvement after discharge, the horse developed unresolving sinusitis approximately 1 year later and was euthanized. Necropsy confirmed the presence of an adenoma of the pars intermedia of the pituitary gland, supporting the initial diagnosis. Additional findings included multiple developmental stages ofK. equipresent in the kidneys. This finding demonstrates infections withK. equican be chronic in nature and supports the association of increased severity of klossiellosis and impaired immune function.

scholarly journals Diagnostic Exercise: Equine Rhabdomyolysis

2011 ◽  
Vol 48 (6) ◽  
pp. E52-E59 ◽  
Author(s):  
E. M. Quist ◽  
J. J. Dougherty ◽  
M. K. Chaffin ◽  
B. F. Porter
Keyword(s):  
Skeletal Muscles ◽  
Nasal Discharge ◽  
Muscular Pain ◽  
Immune Mediated ◽  
Muscular Disorders ◽  
Streptococcus Equi ◽  
Quarter Horse ◽  
History Of ◽  
Polymerase Chain ◽  
Muscle Groups

A 1.5-year-old Quarter Horse gelding with a history of chronic nasal discharge and leukocytosis presented with signs of increased lethargy and muscular pain. The horse quickly became recumbent and unable to rise and was euthanized due to a poor prognosis. At necropsy, severe bilateral guttural pouch empyema was observed, as well as numerous well-demarcated areas of pallor within the skeletal muscles of all major muscle groups. Polymerase chain reaction testing of the guttural pouch exudate confirmed an infection with Streptococcus equi subsp. equi, and an S. equi–associated immune-mediated rhabdomyolysis was initially considered to be the most likely diagnosis. This report briefly discusses the various etiologies that should be considered in cases of equine myopathy, and it demonstrates the complexity of these poorly understood muscular disorders.

scholarly journals Changes in Maternal Weight 5–10 Years after a First Delivery

2012 ◽  
Vol 8 (5) ◽  
pp. 513-519 ◽  
Author(s):  
Sarah E Britz ◽  
Kelly C McDermott ◽  
Christopher B Pierce ◽  
Joan L Blomquist ◽  
Victoria L Handa
Keyword(s):  
Weight Loss ◽  
Black Women ◽  
Reproductive Factors ◽  
Education History ◽  
Healthy Weight ◽  
Maternal Weight ◽  
History Of ◽  
The Difference ◽  
Self Administered Questionnaire

Aim: The objective of this study was to identify maternal, obstetrical and reproductive factors associated with long-term changes in maternal weight after delivery. Materials & methods: Participants were enrolled in a longitudinal cohort study of maternal health 5–10 years after childbirth. Data were obtained from obstetrical records and a self-administered questionnaire. Weight at the time of first delivery (5–10 years prior) was obtained retrospectively and each woman's weight at the time of her first delivery was compared with her current weight. Results: Among 948 women, obesity was associated with race, parity, education, history of diabetes and history of cesarean at the time of first delivery. On average, the difference between weight at the time of first delivery and weight 5–10 years later was −11 kg (11 kg weight loss). In a multivariate model, black race and diabetes were associated with significantly less weight loss. Cesarean delivery, parity and breastfeeding were not associated with changes in maternal weight. Conclusion: Black women and those with a history of diabetes may be appropriate targets for interventions that promote a long-term healthy weight after childbirth.

scholarly journals Weight Loss Barriers and Dietary Quality of Intermittent and Continuous Dieters in Women with a History of Gestational Diabetes

2021 ◽  
Vol 18 (19) ◽  
pp. 10243
Author(s):  
Kristy L. Gray ◽  
Peter M. Clifton ◽  
Jennifer B. Keogh
Keyword(s):  
Weight Loss ◽  
Gestational Diabetes ◽  
Secondary Analysis ◽  
Theoretical Domains Framework ◽  
Energy Restriction ◽  
Dietary Quality ◽  
Behavioral Regulation ◽  
History Of ◽  
Regulation Strategies

Weight-loss after gestational diabetes (GDM) lowers the risk of type-2 diabetes (T2DM). Intermittent energy restriction (IER) produces comparable weight-loss to continuous energy restriction (CER), but long-term adherence remains difficult in this population. This exploratory secondary analysis of a 12-month trial comparing IER to CER following GDM examined weight-loss and dietary quality associated with barriers to weight-loss or T2DM risk perception as assessed in a Likert scale questionnaire at baseline. The participants had a median (IQR) BMI of 32.6 (9.4) kg/m2 and 3 (4) years postpartum (n = 121). Forty-five percent (n = 54) of the participants thought they were at a high risk of developing T2DM. Greater affordability of healthy food was related with greater weight-loss at 3 months (p = 0.044, n = 85). At 12 months, there was no significant relationship between weight-loss and the barriers to weight-loss (p > 0.05). CER had superior improvement in dietary quality at 12 months (CER 11 ± 10, IER 6 ± 5.6, n = 42, p = 0.05). Under the Theoretical Domains Framework, the barriers were predominantly related to behavioral regulation (n = 83, 69%; n = 76, 63%) and environmental context and resources (n = 67, 56%). Interventions for diabetes prevention in this population should include behavioral regulation strategies, consider the family home environment, and ensure that the risk of T2DM is conveyed. Women choosing IER may benefit from education to improve their dietary quality.

scholarly journals Experience (Mostly Negative) with the Use of Sympathomimetic Agents for Weight Loss

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Mario A. Inchiosa
Keyword(s):  
Weight Loss ◽  
Cardiac Arrhythmias ◽  
Indirect Effects ◽  
Adrenergic Receptors ◽  
Direct Effects ◽  
Cardiovascular Toxicity ◽  
Sympathomimetic Drug ◽  
History Of ◽  
Treatment Of Obesity

Sympathomimetic agents have a poor history of long-term success in the treatment of obesity. From earlier experiences with amphetamine and its analogs, to more recent drugs with direct effects on adrenergic receptors or indirect effects from release of catecholamines or inhibition of reuptake, cardiovascular toxicity (strokes and cardiac arrhythmias) has been the major concern. These concerns also extended to food supplements containing ephedra alkaloids and may require consideration for current supplements containing the sympathomimetic drug, synephrine.

One More Time: Redo Paraesophageal Hernia Repair Results in Safe, Durable Outcomes Compared with Primary Repairs

2018 ◽  
Vol 84 (7) ◽  
pp. 1138-1145 ◽  
Author(s):  
Angela M. Kao ◽  
Javier Otero ◽  
Kathryn A. Schlosser ◽  
Julia E. Marx ◽  
Tanushree Prasad ◽  
...  
Keyword(s):  
Weight Loss ◽  
Paraesophageal Hernia ◽  
Postoperative Morbidity ◽  
Operative Time ◽  
Hernia Recurrence ◽  
Prior History ◽  
Paraesophageal Hernia Repair ◽  
Conversion Rates ◽  
History Of

The incidence and causes of failed paraesophageal hernia repairs (PEHR) remain poorly understood. Our study aimed to evaluate long-term clinical outcomes after reoperative fundoplication as compared with initial PEHR. A prospectively maintained institutional hernia-specific database was queried for PEHR between 2008 and 2017. Patients with prior history of PEHR were categorized as “redo” paraesophageal hernia (RPEH). Primary outcomes included postoperative morbidity, mortality, symptom resolution, and hernia recurrence. A total of 402 patients underwent minimally invasive PEHR (Initial PEH = 305, RPEH = 97). Redo PEHR had more prevalent preoperative nausea/vomiting (50.6% vs 34.1%, P < 0.007) and weight loss (24.1% vs 13.5%, P < 0.02). RPEH had had longer mean operative time (256.4 ± 91.2 vs 190.3 ± 59.9 minutes, P < 0.0001) and higher rate of conversion to open (10.3% vs 0.67%, P < 0.0001); however, no difference was noted in postoperative complications, hernia recurrence, or mortality between cohorts. Laparoscopic revision of prior PEHR in symptomatic patients can be safely performed with favorable outcomes compared with initial PEHR. Despite redo procedures seeming to be more technically demanding (as noted by longer operative time and higher conversion rates), outcomes are similar and overall resolution of symptoms is achieved in most patients.

scholarly journals Rhinoscleroma with laryngotracheal involvement: a case report

2020 ◽  
Vol 6 (3) ◽  
pp. 595
Author(s):  
Saroo Singh ◽  
Ankur Gupta ◽  
Nishi Sharma
Keyword(s):  
Rural Areas ◽  
Young Male ◽  
Nasal Discharge ◽  
Upper Respiratory Tract ◽  
Long Term Follow Up ◽  
Progression Of Disease ◽  
History Of ◽  
One Year ◽  
High Degree

<p class="abstract">Rhinoscleroma is a chronic, slowly progressive, granulomatous inflammatory disease of the upper respiratory tract. It is more common in developing countries and rural areas and endemic in Asia, Africa and South and Latin America. We report a case of rhinoscleroma in a young male presented to our Outpatient Department with complaint of hoarseness since one and half years. He had history of dyspnoea on exertion. Patient also had history of bilateral nasal discharge and obstruction. A nasal specimen was taken for histological diagnosis which confirmed rhinoscleroma. Patient was put on medical management and was assessed weekly for improvement by nasal endoscopy and laryngeal examination for one year. A high degree of suspicion is required by clinician to diagnose the disease and prompt treatment should be given to avoid the progression of disease and complications. Patient requires long term follow up for proper management.</p>

Rituximab therapy in a patient with steroid-refractory bird fancier’s lung

2020 ◽  
Vol 13 (12) ◽  
pp. e237232
Author(s):  
Etienne Ceci Bonello ◽  
Jonathan Gauci ◽  
Sarah Bonello ◽  
Peter Fsadni ◽  
Stephen Montefort
Keyword(s):  
Pulmonary Function Tests ◽  
Symptomatic Relief ◽  
Good Effect ◽  
History Of ◽  
Initial Improvement ◽  
Bird Fancier’S Lung ◽  
Restrictive Defect ◽  
Oral Glucocorticoids ◽  
Long Term Oxygen Therapy

A 62-year-old woman presented with a 3-month history of shortness of breath on exertion and dry cough. On examination, she was noted to have fine end-inspiratory crepitations over the upper zone of the lungs. Pulmonary function tests (PFTs) showed a restrictive defect. Initial chest radiography revealed diffuse reticular interstitial shadowing while high-resolution CT scan of the thorax showed fibrotic changes. Avian precipitins were also highly positive for pigeons, parrots and budgerigars. Taking into account these results, the patient was diagnosed with hypersensitivity pneumonitis. Antigen avoidance, oral glucocorticoids and azathioprine achieved an initial improvement in PFTs and symptoms; however, the patient still deteriorated, requiring long-term oxygen therapy. While working the patient up for lung transplantation, rituximab was given to good effect (acting as a bridging therapy) as it achieved symptomatic relief and stabilisation of her PFTs.

Profound diarrhoea and weight loss in an immunocompromised patient

2021 ◽  
Vol 14 (1) ◽  
pp. e236913
Author(s):  
George Ashton ◽  
Alan Shand ◽  
Ian Arnott ◽  
Shahida Din
Keyword(s):  
Weight Loss ◽  
Complete Resolution ◽  
Immunocompromised Patient ◽  
Acute Illness ◽  
Chronic Diarrhoea ◽  
Infectious Gastroenteritis ◽  
Immunosuppressed Patients ◽  
History Of ◽  
Stool Samples

A 75-year-old man was admitted with a 3-month history of worsening diarrhoea and weight loss. He was on long-term immunosuppression following cardiac transplantation. Investigations revealed herpes simplex oesophagitis and stool samples were positive for norovirus. Treatment with acyclovir and nitazoxanide resulted in a complete resolution of symptoms. Norovirus is a common cause of infectious gastroenteritis, but immunosuppressed patients may present with chronic diarrhoea rather than an acute illness. This case highlights the importance of a low clinical threshold for testing for norovirus infection in immunocompromised patients.

Abstract #240 Weight Loss Trajectory Following Randomization to Bariatric Surgery on Long-Term Diabetes Outcomes

2018 ◽  
Vol 24 ◽  
pp. 49
Author(s):  
Keren Zhou ◽  
Kathy Wolski ◽  
Ali Aminian ◽  
Steven Malin ◽  
Philip Schauer ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Weight Loss ◽  
Diabetes Outcomes ◽  
Trajectory Following

Behavioral Mediators of Long-Term Weight Loss Maintenance

2013 ◽  
Author(s):  
J. W. Coughlin ◽  
C. M. Gullion ◽  
P. J. Brantley ◽  
V. J. Stevens ◽  
A. Bauck ◽  
...  
Keyword(s):  
Weight Loss ◽  
Weight Loss Maintenance
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