scholarly journals Antiobesity and Hypoglycaemic Effects of Aqueous Extract ofIbervillea sonoraein Mice Fed a High-Fat Diet with Fructose

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Fabiola Rivera-Ramírez ◽  
Gerardo N. Escalona-Cardoso ◽  
Leticia Garduño-Siciliano ◽  
Carlos Galaviz-Hernández ◽  
Norma Paniagua-Castro
Keyword(s):  
Aqueous Extract ◽  
High Fat Diet ◽  
Diabetic Rats ◽  
Dependent Manner ◽  
High Fat ◽  
Simultaneous Treatment ◽  
Glucose Levels ◽  
Hepatic Oxidation ◽  
Calorie Diet ◽  
High Doses

Obesity, type II diabetes, and hyperlipidaemia, which frequently coexist and are strongly associated with oxidative stress, increase the risk of cardiovascular disease. An increase in carbohydrate intake, especially of fructose, and a high-fat diet are both factors that contribute to the development of these metabolic disorders. In recent studies carried out in diabetic rats, authors reported thatIbervillea sonoraehad hypoglycaemic activity; saponins and monoglycerides present in the plant could be responsible for the effects observed. In the present study, we determined the effects of an aqueousI. sonoraeextract on a murine model of obesity and hyperglycaemia, induced by a high-calorie diet, and the relationship of these effects with hepatic oxidation. A high-fat diet over a period of 8 weeks induced weight gain in the mice and increased triglycerides and blood glucose levels. Simultaneous treatment withI. sonoraeaqueous extracts, at doses of 100, 200, and 400 mg/kg, decreased triglycerides and glycaemia levels, prevented an increase in body weight in a dose-dependent manner, and decreased hepatic lipid oxidation at a dose of 200 mg/kg. These data suggest that the aqueous extract fromI. sonoraeroot prevents obesity, dyslipidaemia, and hyperglycaemia induced by a hypercaloric diet; however, high doses may induce toxicity.

scholarly journals STUDY OF ANTIOBESITY ACTIVITY OF POLYHERBAL FORMULATION IN CORRELATION WITH ANTIDIABETIC ACTIVITY

2018 ◽  
Vol 11 (8) ◽  
pp. 486
Author(s):  
Jain Deepak ◽  
Jain Anurekha
Keyword(s):  
Blood Glucose ◽  
Aqueous Extract ◽  
High Fat Diet ◽  
Research Work ◽  
Density Lipoprotein ◽  
Diabetic Rats ◽  
Ziziphus Mauritiana ◽  
Dependent Manner ◽  
High Fat ◽  
Polyherbal Formulation

Objective: The objective of this research was to develop a polyherbal formulation using four different herbs using obese diabetic rat’s model. Methods: Rats received high-fat diet and alloxan was injected intraperitoneal to rats for induction of diabetes. In the preventive experiment, diabetic rats received Momordica charantia Linn. (200 and 400 mg/kg/day p.o), Eugenia jambolana Linn. (200 and 400 mg/kg/day p.o), Ziziphus mauritiana (200 and 400 mg/kg/day p.o), Acacia catechu (AC) (200 and 400 mg/kg/day p.o), and aqueous extract of all extracts (100 and 200 mg/kg/day p.o). Diabetic rats were also treated with glibenclamide (5 mg/kg p.o.) and orlistat (60 mg/kg/day p.o.) as reference standards. Results: The results showed that the extract of M. charantia Linn., E. jambolana Linn., Z. mauritiana, and AC significantly (p<0.05) inhibited body weight gain, blood glucose, triglyceride, total cholesterol, low-density lipoprotein (LDL), very LDL, high-density lipoprotein cholesterol, serum glutamic pyruvic transaminase, serum glutamic oxaloacetic transaminase, and fasting blood glucose in a dose-dependent manner. Extracts treated rats at doses of 200 and 400 mg/kg improved dyslipidemia in high-fat diet (HFD)-induced obese rats by enhancing their lipid metabolism when compared to the HFD control. Conclusion: The results obtained in this research work clearly showed that taken together the extract of M. charantia Linn., E. jambolana Linn., Z. mauritiana Lam. AC Willd., and aqueous extract of all extracts has potential as a preventive agent for type 2 diabetes mellitus (and possibly obesity) and deserves clinical trial in the near future.

Effects of Maternal Flaxseed Supplementation on Female Offspring of Diabetic Rats in Serum Concentration of Glucose, Insulin, and Thyroid Hormones

2019 ◽  
Vol 89 (1-2) ◽  
pp. 45-54
Author(s):  
Akemi Suzuki ◽  
André Manoel Correia-Santos ◽  
Gabriela Câmara Vicente ◽  
Luiz Guillermo Coca Velarde ◽  
Gilson Teles Boaventura
Keyword(s):  
Thyroid Hormones ◽  
High Fat Diet ◽  
Female Offspring ◽  
Flaxseed Oil ◽  
Diabetic Rats ◽  
High Fat ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Flaxseed Flour ◽  
Maternal Consumption

Abstract. Objective: This study aimed to evaluate the effect of maternal consumption of flaxseed flour and oil on serum concentrations of glucose, insulin, and thyroid hormones of the adult female offspring of diabetic rats. Methods: Wistar rats were induced to diabetes by a high-fat diet (60%) and streptozotocin (35 mg/kg). Rats were mated and once pregnancy was confirmed, were divided into the following groups: Control Group (CG): casein-based diet; High-fat Group (HG): high-fat diet (49%); High-fat Flaxseed Group (HFG): high-fat diet supplemented with 25% flaxseed flour; High-fat Flaxseed Oil group (HOG): high-fat diet, where soya oil was replaced with flaxseed oil. After weaning, female pups (n = 6) from each group were separated, received a commercial rat diet and were sacrificed after 180 days. Serum insulin concentrations were determined by ELISA, the levels of triiodothyronine (T3), thyroxine (T4) and thyroid-stimulating hormone (TSH) were determined by chemiluminescence. Results: There was a significant reduction in body weight at weaning in HG (−31%), HFG (−33%) and HOG (44%) compared to CG (p = 0.002), which became similar by the end of 180 days. Blood glucose levels were reduced in HFG (−10%, p = 0.044) when compared to CG, and there was no significant difference between groups in relation to insulin, T3, T4, and TSH after 180 days. Conclusions: Maternal severe hyperglycemia during pregnancy and lactation resulted in a microsomal offspring. Maternal consumption of flaxseed reduces blood glucose levels in adult offspring without significant effects on insulin levels and thyroid hormones.

The effects of the aqueous extract and residue of Matcha on the antioxidant status and lipid and glucose levels in mice fed a high-fat diet

2016 ◽  
Vol 7 (1) ◽  
pp. 294-300 ◽  
Author(s):  
Ping Xu ◽  
Le Ying ◽  
Gaojie Hong ◽  
Yuefei Wang
Keyword(s):  
Green Tea ◽  
Aqueous Extract ◽  
High Fat Diet ◽  
Antioxidant Status ◽  
High Fat ◽  
Glucose Levels

Matcha is a kind of powdered green tea produced by grinding with a stone mill.

Programmed metabolic syndrome: prenatal undernutrition and postweaning overnutrition

2007 ◽  
Vol 293 (6) ◽  
pp. R2306-R2314 ◽  
Author(s):  
Mina Desai ◽  
Jooby Babu ◽  
Michael G. Ross
Keyword(s):  
Metabolic Syndrome ◽  
High Fat Diet ◽  
Fat Body ◽  
Female Offspring ◽  
High Fat ◽  
Pregnant Rats ◽  
Glucose Levels ◽  
Thrifty Phenotype ◽  
Calorie Diet ◽  
Plasma Leptin

Maternal nutrient restriction results in intrauterine growth restriction (IUGR) newborns that develop obesity despite normal postweaning diet. The epidemic of metabolic syndrome is attributed to programmed “thrifty phenotype” and exposure to Western diets. We hypothesized that programmed IUGR newborns would demonstrate greater susceptibility to obesity and metabolic abnormalities in response to high-fat diet. From day 10 to term gestation and lactation, control pregnant rats received ad libitum (AdLib) food, whereas study rats were 50% food restricted (FR). Cross-fostering techniques resulted in three offspring groups: control (AdLib/AdLib), FR during pregnancy (FR/AdLib), and FR during lactation (AdLib/FR). At 3 weeks, offspring were weaned to laboratory chow or high-fat calorie diet (9% vs. 17% calorie as fat). Body composition, appetite hormones, and glucose and lipid profiles were determined in 9-mo-old male and female offspring. High-fat diet had no effect on body weight of AdLib/AdLib, but significantly increased weights of FR/AdLib and AdLib/FR offspring. High-fat diet significantly increased body fat, reduced lean body mass, and accentuated plasma leptin but not ghrelin levels in both sexes in all groups. In males, high-fat diet caused a significant increase in glucose levels in all three groups with increased insulin levels in AdLib/AdLib and AdLib/FR, but not in FR/AdLib. In females, high-fat diet had no effect on glucose but significantly increased basal insulin among all three groups. High-fat diet caused hypertriglyceridemia in all three groups although only food-restricted females exhibited hypercholesterolemia. Sex and offspring phenotype-associated effects of high-fat diet indicate differing pathophysiologic mechanisms that require specific therapeutic approaches.

scholarly journals Antidiabetic Effect of Fresh Nopal (Opuntia ficus-indica) in Low-Dose Streptozotocin-Induced Diabetic Rats Fed a High-Fat Diet

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Seung Hwan Hwang ◽  
Il-Jun Kang ◽  
Soon Sung Lim
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
High Fat Diet ◽  
Low Dose ◽  
Water Extract ◽  
Diabetic Rats ◽  
Control Group ◽  
High Fat ◽  
Glucose Levels ◽  
Blood Glucose Levels

The objective of the present study was to evaluateα-glucosidase inhibitory and antidiabetic effects of Nopal water extract (NPWE) and Nopal dry power (NADP) in low-dose streptozotocin- (STZ-) induced diabetic rats fed a high-fat diet (HFD). The type 2 diabetic rat model was induced by HFD and low-dose STZ. The rats were divided into four groups as follows: (1) nondiabetic rats fed a regular diet (RD-Control); (2) low-dose STZ-induced diabetic rats fed HFD (HF-STZ-Control); (3) low-dose STZ-induced diabetic rats fed HFD and supplemented with NPWE (100 mg/kg body weight, HF-STZ-NPWE); and (4) low-dose STZ-induced diabetic rats fed HFD and supplemented with comparison medication (rosiglitazone, 10 mg/kg, body weight, HF-STZ-Rosiglitazone). In results, NPWE and NADP had IC50values of 67.33 and 86.68 μg/mL, both of which exhibit inhibitory activities but lower than that of acarbose (38.05 μg/mL) while NPWE group significantly decreased blood glucose levels compared to control and NPDP group on glucose tolerance in the high-fat diet fed rats model (P<0.05). Also, the blood glucose levels of HR-STZ-NPWE group were significantly lower (P<0.05) than HR-STZ-Control group on low-dose STZ-induced diabetic rats fed HFD. Based on these findings, we suggested that NPWE could be considered for the prevention and/or treatment of blood glucose and a potential use as a dietary supplement.

scholarly journals Extracts from the Leaves of Cissus verticillata Ameliorate High-Fat Diet-Induced Memory Deficits in Mice

Plants ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 1814
Author(s):  
Woosuk Kim ◽  
Hyun Jung Kwon ◽  
Hyo Young Jung ◽  
Soon-Sung Lim ◽  
Beom-Goo Kang ◽  
...  
Keyword(s):  
Group Treatment ◽  
High Fat Diet ◽  
Density Lipoprotein ◽  
Memory Deficits ◽  
Feeding Time ◽  
Dependent Manner ◽  
High Fat ◽  
Proliferating Cells ◽  
Glucose Levels ◽  
Lower Body Weight

We investigated the effects of Cissus verticillata leaf extract (CVE) on a high-fat diet (HFD)-induced obesity and memory deficits. Male mice (5 weeks of age) were fed vehicle (distilled water), or 30, 100, or 300 mg/kg of CVE once a day for 8 weeks with an HFD. Treatment with CVE resulted in lower body weight and glucose levels in a concentration- and feeding time-dependent manner. LDL cholesterol and triglyceride levels were significantly lower in the CVE-treated HFD group than in the vehicle-treated HFD group. In contrast, high-density lipoprotein cholesterol levels did not show any significant changes. Lipid droplets and ballooning were reduced depending on the concentration of CVE treatment compared to the HFD group. Treatment with CVE ameliorated the increase in glucagon and immunoreactivities in the pancreas, and novel object recognition memory was improved by 300 mg/kg CVE treatment compared to the HFD group. More proliferating cells and differentiated neuroblasts were higher in mice treated with CVE than in vehicle-treated HFD-fed mice. Brain-derived neurotrophic factor (BDNF) levels were significantly decreased in the HFD group, which was facilitated by treatment with 300 mg/kg CVE in hippocampal homogenates. These results suggest that CVE ameliorates HFD-induced obesity and memory deficits in mice, associated with increased BDNF levels in the hippocampus.

Antihyperglycemic Activity of Micromeria Graeca Aqueous Extract in Streptozotocin-Induced Diabetic Rats

2020 ◽  
Vol 20 ◽  
Author(s):  
Mourad Akdad ◽  
Amine Azzane ◽  
Fadwa El Ouady ◽  
Abdelhadi Moujani ◽  
Farid El Khallouki ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Oral Administration ◽  
Antioxidant Capacity ◽  
Aqueous Extract ◽  
Diabetic Rats ◽  
Phytochemical Analysis ◽  
Dependent Manner ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Dpph Method

Aims: This study aimed to investigate the effect of Micromeria graeca on blood glucose levels and lipid parameters in an experimental model of diabetes. Objective: This study aimed to evaluate the antihyperglycemic and antihyperlipidemic effects of the aqueous extract of Micromeria graeca (M. graeca) aerial parts (AEMG) under physiological (normal rats) and pathological (STZ-induced diabetic rats) conditions. Additionally, we analyzed the phytochemical composition and antioxidant capacity. Methods: The effects of the acute and sub-chronic administration of AEMG (20 mg/kg) on blood glucose levels and lipid profiles were evaluated in normal and streptozotocin-induced diabetic rats. Moreover, the phytochemical analysis was carried with standard tests and estimation of total phenolics compounds by Folin–Ciocalteu reagent. The antioxidant activity was realized by the DPPH method. Results: Single oral administration of M. greaca aqueous extract decreased blood glucose levels 4 and 6 hours (p<0.01) after treatment in diabetic rats. In accordance, the repeated oral administration of M. graeca showed a significant reduction in blood glucose levels in diabetic rats since the second day to the end of the period experiment (p<0.0001). In addition, two weeks of treatment with M. graeca reduced total cholesterol levels (p<0.05) with a significant increase of HDL-c level (p<0.01) in diabetic rats. Moreover, M. graeca scavenged DPPH radical in a dose-dependent manner (IC50=0.48 mg/ml), whereas IC50 was 0.55 mg/ml for BHT. Phytochemical analysis showed the richness of Micromeria graeca on polyphenols (281.94±4.61 mg GAE/1 g), flavonoids, tannins, glycosides, saponins, sterols, sesquiterpenes, and terpenoids. Conclusion: AEMG exhibits antihyperglycemic and antihyperlipidemic activities in STZ-induced diabetic rats and a potent antioxidant capacity.

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