scholarly journals Kaposi Sarcoma of the Adrenal Gland Resembling Epithelioid Angiosarcoma: A Case Report

Sarcoma ◽  
2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Hassan Huwait ◽  
Adam Meneghetti ◽  
Torsten O. Nielsen
Keyword(s):  
Human Immunodeficiency Virus ◽  
Virus Infection ◽  
Adrenal Gland ◽  
Human Immunodeficiency Virus Infection ◽  
Kaposi Sarcoma ◽  
Metastatic Potential ◽  
Epithelioid Angiosarcoma ◽  
Human Herpes Virus 8 ◽  
Increased Risk ◽  
Immunodeficiency Virus

Patients with human immunodeficiency virus infection are known to have increased risk of various neoplasms, including Kaposi sarcoma, which classically involves the skin and mucosal locations. The anaplastic variant of Kaposi sarcoma is rare and poorly documented in the literature. It is characterised clinically by a more aggressive behaviour and increased metastatic potential, and histologically by increased cellularity, mitotic rate, and rarely by epithelioid angiosarcoma-like morphology. We report herein a 64-year-old man with a long-standing history of human immunodeficiency virus infection who developed a right adrenal tumor with a high-grade anaplastic angiosarcoma-like morphology. Immunohistochemistry for human herpes virus-8 was strongly positive in the tumor cells. To the best of our knowledge, this is the first report of an anaplastic Kaposi sarcoma in the adrenal gland.

scholarly journals Kaposi sarcoma in a non-immunocompromised patient - a potential diagnostic pitfall

2019 ◽  
Vol 72 (5-6) ◽  
pp. 180-183
Author(s):  
Jelena Nikolic ◽  
Nada Vuckovic ◽  
Marija Marinkovic ◽  
Ivana Mijatov ◽  
Dragana Lekovic ◽  
...  
Keyword(s):  
Risk Factors ◽  
Human Immunodeficiency Virus ◽  
Virus Infection ◽  
Human Immunodeficiency Virus Infection ◽  
Immunohistochemical Staining ◽  
Kaposi Sarcoma ◽  
Human Herpes ◽  
Human Herpes Virus 8 ◽  
Human Herpes Virus ◽  
Immunodeficiency Virus

Introduction. Kaposi sarcoma is a rare soft tissue tumor that may form masses in the skin, lymph nodes, mucosa and many other organs. It has a strong male predilection and is usually seen in the older population. It is caused by human herpes virus 8. Risk factors include compromised immune system, typically seen in patients with human immunodeficiency virus infection or organ transplant recipients. Case Report. We report a 66-year-old Caucasian woman with no previous history of human immunodeficiency virus infection, immunosuppressive therapy or organ transplantation. She was referred to a plastic surgeon by a dermatologist due to a suspected dermatofibroma presenting with one solitary, firm nodule on the dorsal aspect of the foot that she reported to have occurred a year before. A surgery was scheduled in 6 months, as the tumor was assessed as benign. After excisional biopsy and histological evaluation without immunohistochemical staining, that was not available, a diagnosis of benign myofibroblastic tumor was made. Later on, a new similar tumor on the hand appeared and the diagnosis was changed into a malignant tumor. Further pathological examination, using immunohistochemical staining, confirmed Kaposi sarcoma. The malignant cells showed positive immunostaining for CD34, CD31, D2-40, WT1, bcl-2, and human herpes virus 8, but they were CD99 negative. Conclusion. Nonspecific clinical presentation and absence of risk factors may mislead the doctors, delay the biopsy and thus delay adequate treatment. In the same time, histological similarities with other disorders and tumors may be challenging for pathologists and lead to wrong diagnosis.

Kaposi Sarcoma Associated with Human Immunodeficiency Virus Infection

1991 ◽  
Vol 30 (2) ◽  
pp. 109-113 ◽  
Author(s):  
Dimas E. Hernández ◽  
José Ricardo Pérez ◽  
Jaime Wilder ◽  
Rafael Muci
Keyword(s):  
Human Immunodeficiency Virus ◽  
Virus Infection ◽  
Human Immunodeficiency Virus Infection ◽  
Kaposi Sarcoma ◽  
Immunodeficiency Virus

scholarly journals Human Immunodeficiency Virus Infection Is Associated With Preterm Delivery Independent of Vaginal Microbiota in Pregnant African Women

2019 ◽  
Vol 221 (7) ◽  
pp. 1194-1203 ◽  
Author(s):  
Muchaneta Gudza-Mugabe ◽  
Enock Havyarimana ◽  
Shameem Jaumdally ◽  
Kirsty Lee Garson ◽  
Katie Lennard ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Virus Infection ◽  
Human Immunodeficiency Virus Infection ◽  
Pregnant Women ◽  
Vaginal Microbiota ◽  
African Women ◽  
Hiv Status ◽  
Age Assessment ◽  
Increased Risk ◽  
Immunodeficiency Virus

Abstract Background During pregnancy, the vaginal microbiota is relatively stable. However, African women have more diverse vaginal microbiota than their European counterparts, in addition to high human immunodeficiency virus (HIV) prevalence and risk of adverse birth outcomes. Although HIV is associated with alterations in vaginal microbiota and inflammation in nonpregnant women, these relationships are underexplored in pregnant women. Methods In this study, we characterize the vaginal microbiota and immune factors in pregnant African women who were HIV-uninfected (n = 314) versus HIV-infected (n = 42). Mucosal samples were collected once at the enrollment visit (between 15 and 35 weeks of gestation) and women were followed until delivery. Results Vaginal microbial communities of pregnant women with HIV were significantly more diverse than women without HIV (P = .004), with community structure also differing by HIV status (P = .002, R2 = 0.02). Human immunodeficiency virus infection was also associated with increased risk of preterm birth (PTB) (31% versus 15.3%; P = .066). In a multivariate analysis, HIV infection was independently associated with diverse vaginal community state type (CST)-IVA (P = .005) and CST-IVB (P = .018) as well as PTB (P = .049). No association between HIV status and cytokine concentrations was found. Conclusions Longitudinal studies with accurate gestational age assessment would be important to confirm these relationships.

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