scholarly journals Human Herpes Virus-8 Infections among Subjects with Human Immunodeficiency Virus Infection and Normal Healthy Individuals in India

Intervirology ◽  
2013 ◽  
Vol 56 (4) ◽  
pp. 253-257 ◽  
Author(s):  
J. Sachithanandham ◽  
R. Kannangai ◽  
A.M. Abraham ◽  
G.J. Fletcher ◽  
O.C. Abraham ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Virus Infection ◽  
Human Immunodeficiency Virus Infection ◽  
Herpes Virus ◽  
Healthy Individuals ◽  
Human Herpes ◽  
Human Herpes Virus 8 ◽  
Human Herpes Virus ◽  
Immunodeficiency Virus ◽  
Herpès Virus

scholarly journals Kaposi sarcoma in a non-immunocompromised patient - a potential diagnostic pitfall

2019 ◽  
Vol 72 (5-6) ◽  
pp. 180-183
Author(s):  
Jelena Nikolic ◽  
Nada Vuckovic ◽  
Marija Marinkovic ◽  
Ivana Mijatov ◽  
Dragana Lekovic ◽  
...  
Keyword(s):  
Risk Factors ◽  
Human Immunodeficiency Virus ◽  
Virus Infection ◽  
Human Immunodeficiency Virus Infection ◽  
Immunohistochemical Staining ◽  
Kaposi Sarcoma ◽  
Human Herpes ◽  
Human Herpes Virus 8 ◽  
Human Herpes Virus ◽  
Immunodeficiency Virus

Introduction. Kaposi sarcoma is a rare soft tissue tumor that may form masses in the skin, lymph nodes, mucosa and many other organs. It has a strong male predilection and is usually seen in the older population. It is caused by human herpes virus 8. Risk factors include compromised immune system, typically seen in patients with human immunodeficiency virus infection or organ transplant recipients. Case Report. We report a 66-year-old Caucasian woman with no previous history of human immunodeficiency virus infection, immunosuppressive therapy or organ transplantation. She was referred to a plastic surgeon by a dermatologist due to a suspected dermatofibroma presenting with one solitary, firm nodule on the dorsal aspect of the foot that she reported to have occurred a year before. A surgery was scheduled in 6 months, as the tumor was assessed as benign. After excisional biopsy and histological evaluation without immunohistochemical staining, that was not available, a diagnosis of benign myofibroblastic tumor was made. Later on, a new similar tumor on the hand appeared and the diagnosis was changed into a malignant tumor. Further pathological examination, using immunohistochemical staining, confirmed Kaposi sarcoma. The malignant cells showed positive immunostaining for CD34, CD31, D2-40, WT1, bcl-2, and human herpes virus 8, but they were CD99 negative. Conclusion. Nonspecific clinical presentation and absence of risk factors may mislead the doctors, delay the biopsy and thus delay adequate treatment. In the same time, histological similarities with other disorders and tumors may be challenging for pathologists and lead to wrong diagnosis.

scholarly journals Profound CD4+ T lymphocytopenia in human immunodeficiency virus negative individuals, improved with anti-human herpes virus treatment

2012 ◽  
pp. 305-311 ◽  
Author(s):  
María Lilia Diaz Betancourth ◽  
Julio Cesar Klinger ◽  
Victoria Eugenia Niño
Keyword(s):  
Human Immunodeficiency Virus ◽  
Epstein Barr Virus ◽  
Herpes Virus ◽  
Viral Infections ◽  
Human Herpes ◽  
Barr Virus ◽  
Human Herpes Virus ◽  
Immunodeficiency Virus ◽  
Epstein Barr ◽  
Herpès Virus

Lymphocytopenia and CD4+ T lymphocytopenia can be associated with many bacterial, fungal, parasite and viral infections. They can also be found in autoimmune and neoplastic diseases, common variable immu­nodeficiency syndrome, physical, psychological and traumatic stress, malnutrition and immunosuppressive therapy. Besides, they can also be brought into relation, without a known cause, with idiopathic CD4+ T lym­phocytopenia. Among viral infections, the Retrovirus, specially the human immunodeficiency virus, is the most frequently cause. However, many acute viral infections, including cytomegalovirus and Epstein Barr virus can be associated with transient lymphocytopenia and CD4+ T lymphocytopenia. As is well known, transient lymphocytopenia and CD4+ T lymphocytopenia are temporary and overcome when the disease improves. Nonetheless, severe CD4+ T Lymphocytopenia associated with chronic infections by human herpes virus has not been reported. We describe 6 cases of human immunodeficiency virus negative patients, with chronic cytomegalovirus and Epstein Barr virus infections and profound lymphocytopenia with clinical symptoms of cellular immunodeficiency. These patients improved rapidly with ganciclovir or valganciclovir treatment. We claim here that it is important to consider the chronic human herpes virus infection in the differential diag­nosis of profoundly CD4+ T lymphocytopenia etiology, when human immunodeficiency virus is absent, in order to start effective treatment and to determine, in future studies, the impact of chronic human herpes virus infection in human beings’ health.

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