scholarly journals Chlamydia trachomatisInfection Control Programs: Lessons Learned and Implications for Vaccine Development

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Jean M. Chavez ◽  
Rodolfo D. Vicetti Miguel ◽  
Thomas L. Cherpes
Keyword(s):  
Tract Infection ◽  
Immune Responses ◽  
Genital Tract ◽  
Vaccine Development ◽  
Lessons Learned ◽  
Prophylactic Vaccine ◽  
Genital Tract Infection ◽  
Control Programs ◽  
Surveillance Programs ◽  
Tract Damage

Chlamydia trachomatiscontrol efforts that enhance detection and treatment of infected women may paradoxically increase susceptibility of the population to infection. Conversely, these surveillance programs lower incidences of adverse sequelae elicited by genital tract infection (e.g., pelvic inflammatory disease and ectopic pregnancy), suggesting enhanced identification and eradication ofC. trachomatissimultaneously reduces pathogen-induced upper genital tract damage and abrogates formation of protective immune responses. In this paper, we detail findings fromC. trachomatisinfection control programs that increase our understanding of chlamydial immunoepidemiology and discuss their implications for prophylactic vaccine design.

scholarly journals CD43−, but not CD43+, IL-10-producing CD1dhiCD5+ B cells suppress type 1 immune responses during Chlamydia muridarum genital tract infection

2014 ◽  
Vol 8 (1) ◽  
pp. 94-106 ◽  
Author(s):  
J M Moore-Connors ◽  
H S Kim ◽  
J S Marshall ◽  
A W Stadnyk ◽  
S A Halperin ◽  
...  
Keyword(s):  
B Cells ◽  
Tract Infection ◽  
Immune Responses ◽  
Genital Tract ◽  
Genital Tract Infection ◽  
Chlamydia Muridarum

scholarly journals Histopathologic Changes Related to Fibrotic Oviduct Occlusion After Genital Tract Infection of Mice With Chlamydia muridarum

2005 ◽  
Vol 32 (1) ◽  
pp. 49-56 ◽  
Author(s):  
Anita A. Shah ◽  
Justin H. Schripsema ◽  
Mohammad T. Imtiaz ◽  
Ira M. Sigar ◽  
John Kasimos ◽  
...  
Keyword(s):  
Tract Infection ◽  
Genital Tract ◽  
Genital Tract Infection ◽  
Chlamydia Muridarum ◽  
Histopathologic Changes

scholarly journals Association of Lower Genital Tract Inflammation With Objective Evidence of Endometritis

2000 ◽  
Vol 8 (2) ◽  
pp. 83-87 ◽  
Author(s):  
Jeffrey F. Peipert ◽  
Roberta B. Ness ◽  
David E. Soper ◽  
Debra Bass
Keyword(s):  
Tract Infection ◽  
Blood Cells ◽  
Genital Tract ◽  
White Blood Cells ◽  
Genital Tract Infection ◽  
Lower Genital Tract ◽  
Objective Evidence ◽  
Group 2 ◽  
Upper Genital Tract Infection ◽  
Group 1

The purpose of this report is to evaluate the association between lower genital tract inflammation and objectively diagnosed endometritis. We analyzed the first 157 patients enrolled in the PEACH study, a multicenter randomized clinical trial designed to compare the effectiveness of outpatient and inpatient therapy for PID. Women less than 38 years of age, who presented with a history of pelvic discomfort for 30 days or less and who were found to have pelvic organ tenderness (uterine or adnexal tenderness) on bimanual examination, were initially invited to participate. After recruitment of the first 58 patients (group 1) we added the presence of leukorrhea, mucopurulent cervicitis, or untreated positive test forN. gonorrhoeaeorC. trachomatisto the inclusion criteria (group 2, N = 99). We compared rates of endometritis in the two groups and calculated the sensitivity, specificity, and predicted values of the presence of white blood cells in the vaginal wet preparation. The rate of upper genital tract infection in group 1 was 46.5% (27/58) compared to 49.5% (49/99) in group 2. Microbiologic evidence of eitherN. gonorrhoeaeorC. trachomatisincreased from 22.4% in group 1 to 38.3% in group 2. The presence of Vaginal white blood cells or mueopus has a high sensitivity (88.9%), but a low specificity (19.4%) for the diagnosis of upper genital-tract infection. Assessment of the lower genital tract for evidence of infection or inflammation is a valuable component of the diagnostic evaluation of pelvic inflammatory disease. The presence of either mucopus or vaginal white blood cells is a highly sensitive test for endometritis in patients with pelvic pain and tenderness. Infect. Dis. Obstet. Gynecol. 8:83–87, 2000.

A novel guinea pig model of Chlamydia trachomatis genital tract infection

Vaccine ◽  
2011 ◽  
Vol 29 (35) ◽  
pp. 5994-6001 ◽  
Author(s):  
Marien I. de Jonge ◽  
Sander A.S. Keizer ◽  
Hicham M. el Moussaoui ◽  
Lieke van Dorsten ◽  
Rima Azzawi ◽  
...  
Keyword(s):  
Chlamydia Trachomatis ◽  
Tract Infection ◽  
Guinea Pig ◽  
Genital Tract ◽  
Pig Model ◽  
Genital Tract Infection ◽  
Guinea Pig Model

Value of detecting leukocytospermia in the diagnosis of genital tract infection in subfertile men

1998 ◽  
Vol 70 (2) ◽  
pp. 315-319 ◽  
Author(s):  
Johannes W. Trum ◽  
Ben W.J. Mol ◽  
Yvonne Pannekoek ◽  
Lodewijk Spanjaard ◽  
Paulien Wertheim ◽  
...  
Keyword(s):  
Tract Infection ◽  
Genital Tract ◽  
Genital Tract Infection

scholarly journals Efficacy of an Immune Modulator in ExperimentalChlamydia trachomatisInfection of the Female Genital Tract

2006 ◽  
Vol 2006 ◽  
pp. 1-6
Author(s):  
Joseph M. Lyons ◽  
James I. Ito ◽  
Servaas A. Morré
Keyword(s):  
Tract Infection ◽  
Murine Model ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Response Modifier ◽  
Genital Tract Infection ◽  
Prophylactic Dose ◽  
Duration Of Infection ◽  
Immune Response Modifier ◽  
Female Genital

Objective.The aim of this study was to determine if vaginal application of the immune response modifier imiquimod (Aldara cream, 3M Pharmaceuticals, St Paul, Minn) would alter the course and/or outcome of female genital tract infection with a human isolate ofChlamydia trachomatisin a murine model.Methods.Groups of CF-1 mice were treated with Aldara on three different schedules: (1) ongoing beginning 5 days prior to and continuing through day 5 of infection; (2) a single prophylactic dose 2 hours prior to infection; and (3) therapeutic from day 4 to day 14 of infection. Mice were infected vaginally with a serovar D strain ofC trachomatis, and monitored by culture to determine the level of shedding and duration of infection.Results.We observed a significant reduction in both duration of infection and the level of shedding during the acute phase in mice treated on an ongoing basis commencing 5 days prior to infection. There was no effect with respect to the other regimens.Conclusion.These results demonstrate that ongoing Aldara treatment has efficacy and may enhance local innate immunity which reduces the duration of subsequent infection with human isolates ofC trachomatisin a murine model of female genital tract infection.

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