scholarly journals CD43−, but not CD43+, IL-10-producing CD1dhiCD5+ B cells suppress type 1 immune responses during Chlamydia muridarum genital tract infection

2014 ◽  
Vol 8 (1) ◽  
pp. 94-106 ◽  
Author(s):  
J M Moore-Connors ◽  
H S Kim ◽  
J S Marshall ◽  
A W Stadnyk ◽  
S A Halperin ◽  
...  
Keyword(s):  
B Cells ◽  
Tract Infection ◽  
Immune Responses ◽  
Genital Tract ◽  
Genital Tract Infection ◽  
Chlamydia Muridarum

scholarly journals Histopathologic Changes Related to Fibrotic Oviduct Occlusion After Genital Tract Infection of Mice With Chlamydia muridarum

2005 ◽  
Vol 32 (1) ◽  
pp. 49-56 ◽  
Author(s):  
Anita A. Shah ◽  
Justin H. Schripsema ◽  
Mohammad T. Imtiaz ◽  
Ira M. Sigar ◽  
John Kasimos ◽  
...  
Keyword(s):  
Tract Infection ◽  
Genital Tract ◽  
Genital Tract Infection ◽  
Chlamydia Muridarum ◽  
Histopathologic Changes

scholarly journals Toll-like receptor 3 (TLR3) promotes the resolution of Chlamydia muridarum genital tract infection in congenic C57BL/6N mice

PLoS ONE ◽  
2018 ◽  
Vol 13 (4) ◽  
pp. e0195165 ◽  
Author(s):  
Sebastian E. Carrasco ◽  
Sishun Hu ◽  
Denise M. Imai ◽  
Ramesh Kumar ◽  
George E. Sandusky ◽  
...  
Keyword(s):  
Tract Infection ◽  
Genital Tract ◽  
Toll Like Receptor ◽  
Genital Tract Infection ◽  
Chlamydia Muridarum

The role of an enzymatically inactive CPAF mutant vaccination in Chlamydia muridarum genital tract infection

2021 ◽  
pp. 105137
Author(s):  
Hui Chen ◽  
Bo Peng ◽  
Chunfen Yang ◽  
Lijuan Xie ◽  
Shufang Zhong ◽  
...  
Keyword(s):  
Tract Infection ◽  
Genital Tract ◽  
Genital Tract Infection ◽  
Chlamydia Muridarum

Male Rat Genital Tract Infection With Chlamydia Muridarum has No Significant Consequence on Male Fertility

2012 ◽  
Vol 187 (5) ◽  
pp. 1911-1917 ◽  
Author(s):  
Ruben Darío Motrich ◽  
Leonardo Sanchez ◽  
Mariana Maccioni ◽  
Juan Pablo Mackern-Oberti ◽  
Virginia Elena Rivero
Keyword(s):  
Tract Infection ◽  
Genital Tract ◽  
Male Fertility ◽  
Male Rat ◽  
Genital Tract Infection ◽  
Chlamydia Muridarum

Male Rodent Genital Tract Infection With Chlamydia Muridarum: Persistence in the Prostate Gland That Triggers Self-Immune Reactions in Genetically Susceptible Hosts

2011 ◽  
Vol 186 (3) ◽  
pp. 1100-1106 ◽  
Author(s):  
Juan Pablo Mackern-Oberti ◽  
Ruben Dario Motrich ◽  
Maria Laura Breser ◽  
Hugo Cejas ◽  
Cecilia Cuffini ◽  
...  
Keyword(s):  
Tract Infection ◽  
Genital Tract ◽  
Prostate Gland ◽  
Genital Tract Infection ◽  
Immune Reactions ◽  
Chlamydia Muridarum

scholarly journals In Situ Analysis of the Evolution of the Primary Immune Response in Murine Chlamydia trachomatis Genital Tract Infection

2000 ◽  
Vol 68 (5) ◽  
pp. 2870-2879 ◽  
Author(s):  
Sandra G. Morrison ◽  
Richard P. Morrison
Keyword(s):  
T Cells ◽  
T Cell ◽  
B Cells ◽  
Chlamydia Trachomatis ◽  
Tract Infection ◽  
Inflammatory Response ◽  
Genital Tract ◽  
Genital Tract Infection ◽  
Tnf Α

ABSTRACT Adaptive immune responses contribute to the resolution ofChlamydia trachomatis genital tract infection and protect against reinfection, but our understanding of the mechanisms of those protective responses is incomplete. In this study, we analyzed by in situ immunohistochemistry the progression of the inflammatory and cytokine responses in the genital tracts of mice vaginally infected with C. trachomatis strain mouse pneumonitis. The cellular inflammatory response was characterized by an initial elevation in myeloid cells in the vagina (day 3) and uterine horns (day 7), followed by a marked rise in the number of T cells, predominantly CD4+ cells. CD8+ T cells and CD45R+B cells were also detected but were much less numerous. Perivascular clusters of CD4+ T cells, which resembled clusters of T cells seen in delayed-type hypersensitivity responses, were evident by 2 weeks postinfection. Following the resolution of infection, few CD8+ T cells and CD45R+ B cells remained, whereas numerous CD4+ T cells and perivascular clusters of CD4+ T cells persisted in genital tract tissues. Interleukin-12 (IL-12)- and tumor necrosis factor alpha (TNF-α)-producing cells were observed in vaginal tissue by day 3 of infection and in uterine tissues by day 7. Cells producing IL-4 or IL-10 were absent from vaginal tissues at day 3 of infection but were present in uterine tissues by day 7 and were consistently more numerous than IL-12- and TNF-α-producing cells. Thus, the evolution of the local inflammatory response was characterized by the accumulation of CD4+ T cells into perivascular clusters and the presence of cells secreting both Th1- and Th2-type cytokines. The persistence of CD4+-T-cell clusters long after infection had resolved (day 70) may provide for a readily mobilizable T-cell response by which previously infected animals can quickly respond to and control a secondary infectious challenge.

scholarly journals Chlamydia trachomatisInfection Control Programs: Lessons Learned and Implications for Vaccine Development

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Jean M. Chavez ◽  
Rodolfo D. Vicetti Miguel ◽  
Thomas L. Cherpes
Keyword(s):  
Tract Infection ◽  
Immune Responses ◽  
Genital Tract ◽  
Vaccine Development ◽  
Lessons Learned ◽  
Prophylactic Vaccine ◽  
Genital Tract Infection ◽  
Control Programs ◽  
Surveillance Programs ◽  
Tract Damage

Chlamydia trachomatiscontrol efforts that enhance detection and treatment of infected women may paradoxically increase susceptibility of the population to infection. Conversely, these surveillance programs lower incidences of adverse sequelae elicited by genital tract infection (e.g., pelvic inflammatory disease and ectopic pregnancy), suggesting enhanced identification and eradication ofC. trachomatissimultaneously reduces pathogen-induced upper genital tract damage and abrogates formation of protective immune responses. In this paper, we detail findings fromC. trachomatisinfection control programs that increase our understanding of chlamydial immunoepidemiology and discuss their implications for prophylactic vaccine design.

Sign in / Sign up

Export Citation Format

Share Document