scholarly journals Polymorphism and Balancing Selection of MHC Class II DAB Gene in 7 Selective Flounder (Paralichthys olivaceus) Families

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Min Du ◽  
Song-lin Chen ◽  
You Liang ◽  
Lei Wang ◽  
Feng-tao Gao ◽  
...  
Keyword(s):  
Mhc Class Ii ◽  
Balancing Selection ◽  
Direct Sequencing ◽  
Paralichthys Olivaceus ◽  
Nonsynonymous Substitution ◽  
Class Ii ◽  
Sequencing Method ◽  
Mhc Class Iib ◽  
Class Iib ◽  
Selection Of

In order to determine the genetic variation of the MHC class IIB exon2 allele in the offspring, 700 fry from seven families of Japanese flounder challenged withV. anguillarumwere studied, and different mortality rates were found in those families. Five to ten surviving and dead fry from each of the seven families were selected to study the MHC class II B exon2 gene with PCR and a direct sequencing method. One hundred and sixteen different exon2 sequences were found and 116 different alleles were identified, while a minimum of four loci were revealed in the MHC class II B exon2 gene. The ratio (dN/dS) of nonsynonymous substitution (dN) to synonymous substitutions (dS) in the peptide-binding region (PBR) of the MHC class IIB gene was 6.234, which indicated that balancing selection is acting on the MHC class IIB genes. The MHC IIB alleles were thus being passed on to their progeny. Some alleles were significantly more frequent in surviving than dead individuals. All together our data suggested that the allelesPaol-DAB*4301,Paol-DAB*4601,Paol-DAB*4302,Paol-DAB*3803, andPaol-DAB*4101were associated with resistance toV. anguillarumin flounder.

Mhc class II diversity and balancing selection in greater prairie-chickens

Genetica ◽  
2009 ◽  
Vol 138 (2) ◽  
pp. 265-271 ◽  
Author(s):  
John A. Eimes ◽  
Jennifer L. Bollmer ◽  
Peter O. Dunn ◽  
Linda A. Whittingham ◽  
Charles Wimpee
Keyword(s):  
Mhc Class Ii ◽  
Balancing Selection ◽  
Class Ii

Selection of Unrelated Bone Marrow Donors: Does the Current Procedure Warrant Complete MHC Class II Identity?

1992 ◽  
Vol 19 (3) ◽  
pp. 127-129
Author(s):  
T.H. Eiermann ◽  
M. Ballas ◽  
J. Fakler ◽  
C. Müller ◽  
A. Wölpl ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Mhc Class Ii ◽  
Class Ii ◽  
Selection Of ◽  
Current Procedure

Positive selection of CD4+ thymocytes controlled by MHC class II gene products

Nature ◽  
1988 ◽  
Vol 336 (6198) ◽  
pp. 471-473 ◽  
Author(s):  
H. Robson MacDonald ◽  
Rosemary K. Lees ◽  
Reto Schneider ◽  
Rolf M. Zinkernagel ◽  
Hans Hengartner
Keyword(s):  
Positive Selection ◽  
Mhc Class Ii ◽  
Class Ii ◽  
Gene Products ◽  
Selection Of

scholarly journals Comparison of peptides bound to spleen and thymus class II.

1993 ◽  
Vol 178 (6) ◽  
pp. 2173-2183 ◽  
Author(s):  
P Marrack ◽  
L Ignatowicz ◽  
J W Kappler ◽  
J Boymel ◽  
J H Freed
Keyword(s):  
Positive Selection ◽  
Mhc Class Ii ◽  
Class Ii ◽  
The Past ◽  
Histocompatibility Complex ◽  
Specific Distribution ◽  
Class Ii Mhc ◽  
Beta Receptors ◽  
Self Peptides ◽  
Selection Of

In the past we and others have suggested that positive selection of developing thymocytes may depend upon interaction between the alpha beta receptors on these cells and major histocompatibility complex (MHC) proteins bound to peptides found uniquely in the selecting tissue, thymus cortical epithelium. To test this hypothesis, peptides were isolated from MHC class II proteins of spleen, thymus cortical plus medullary epithelium, or thymus cortical epithelium alone. The results showed that the major peptides bound to class II on thymus cortical epithelium were also associated with spleen class II. Some peptides could only be detected in isolates from spleen, probably because of differences in the distribution or uptake of the donor proteins between spleen and thymus. Thus, although we found some tissue-specific distribution of self-peptides, our data suggest that there are no fundamental differences among these tissues in the occupancy of class II MHC by self-peptides. These results limit hypotheses which depend on a specialized mechanism of peptide generation and/or MHC class II loading to account for the positive selection of T cells on thymic cortical epithelium.

The role of HLA-DM for loading and selection of the peptide repertoire of MHC class-II molecules

1997 ◽  
Vol 56 ◽  
pp. 236
Author(s):  
H. Kropshofer ◽  
A.B. Vogt ◽  
G. Moldenhauer ◽  
O. Arndt ◽  
G.J. Hämmerling
Keyword(s):  
Mhc Class Ii ◽  
Class Ii ◽  
Mhc Class Ii Molecules ◽  
Selection Of

scholarly journals Immunohistochemistry for Detection of MHC Class II-Expressing Cells in Japanese Flounder Paralichthys olivaceus

2021 ◽  
Vol 55 (4) ◽  
pp. 151-161
Author(s):  
Osamu Kurata ◽  
Suyu Miyashita ◽  
Shusei Toda ◽  
Shinpei Wada ◽  
Takamitsu Sakai
Keyword(s):  
Mhc Class Ii ◽  
Paralichthys Olivaceus ◽  
Class Ii ◽  
Japanese Flounder
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