Positive selection of CD4+ thymocytes controlled by MHC class II gene products

Nature ◽  
1988 ◽  
Vol 336 (6198) ◽  
pp. 471-473 ◽  
Author(s):  
H. Robson MacDonald ◽  
Rosemary K. Lees ◽  
Reto Schneider ◽  
Rolf M. Zinkernagel ◽  
Hans Hengartner
Keyword(s):  
Positive Selection ◽  
Mhc Class Ii ◽  
Class Ii ◽  
Gene Products ◽  
Selection Of

scholarly journals Comparison of peptides bound to spleen and thymus class II.

1993 ◽  
Vol 178 (6) ◽  
pp. 2173-2183 ◽  
Author(s):  
P Marrack ◽  
L Ignatowicz ◽  
J W Kappler ◽  
J Boymel ◽  
J H Freed
Keyword(s):  
Positive Selection ◽  
Mhc Class Ii ◽  
Class Ii ◽  
The Past ◽  
Histocompatibility Complex ◽  
Specific Distribution ◽  
Class Ii Mhc ◽  
Beta Receptors ◽  
Self Peptides ◽  
Selection Of

In the past we and others have suggested that positive selection of developing thymocytes may depend upon interaction between the alpha beta receptors on these cells and major histocompatibility complex (MHC) proteins bound to peptides found uniquely in the selecting tissue, thymus cortical epithelium. To test this hypothesis, peptides were isolated from MHC class II proteins of spleen, thymus cortical plus medullary epithelium, or thymus cortical epithelium alone. The results showed that the major peptides bound to class II on thymus cortical epithelium were also associated with spleen class II. Some peptides could only be detected in isolates from spleen, probably because of differences in the distribution or uptake of the donor proteins between spleen and thymus. Thus, although we found some tissue-specific distribution of self-peptides, our data suggest that there are no fundamental differences among these tissues in the occupancy of class II MHC by self-peptides. These results limit hypotheses which depend on a specialized mechanism of peptide generation and/or MHC class II loading to account for the positive selection of T cells on thymic cortical epithelium.

scholarly journals Positive selection of thymocytes induced by gene transfer: MHC class II-mediated selection of CD8 lineage cells

1999 ◽  
Vol 11 (10) ◽  
pp. 1595-1600 ◽  
Author(s):  
Ronald Rooke ◽  
Caroline Waltzinger ◽  
Christophe Benoist ◽  
Diane Mathis
Keyword(s):  
Gene Transfer ◽  
Positive Selection ◽  
Mhc Class Ii ◽  
Class Ii ◽  
Selection Of

scholarly journals Deficient Positive Selection of CD4 T Cells in Mice Displaying Altered Repertoires of MHC Class II–Bound Self-Peptides

Immunity ◽  
1997 ◽  
Vol 7 (2) ◽  
pp. 197-208 ◽  
Author(s):  
Catherine E Grubin ◽  
Susan Kovats ◽  
Paul deRoos ◽  
Alexander Y Rudensky
Keyword(s):  
T Cells ◽  
Positive Selection ◽  
Mhc Class Ii ◽  
Cd4 T Cells ◽  
Class Ii ◽  
Self Peptides ◽  
Selection Of

scholarly journals Positive selection of self-MHC-reactive T cells by individual peptide-MHC class II complexes

2002 ◽  
Vol 99 (10) ◽  
pp. 6937-6942 ◽  
Author(s):  
G. M. Barton ◽  
C. Beers ◽  
P. deRoos ◽  
S. R. Eastman ◽  
M. E. Gomez ◽  
...  
Keyword(s):  
T Cells ◽  
Positive Selection ◽  
Mhc Class Ii ◽  
Class Ii ◽  
Individual Peptide ◽  
Selection Of

scholarly journals Targeted Expression of Major Histocompatibility Complex (MHC) Class II Molecules Demonstrates that Dendritic Cells Can Induce Negative but Not Positive Selection of Thymocytes In Vivo

1997 ◽  
Vol 185 (3) ◽  
pp. 541-550 ◽  
Author(s):  
Thomas Brocker ◽  
Mireille Riedinger ◽  
Klaus Karjalainen
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Major Histocompatibility Complex ◽  
Positive Selection ◽  
Mhc Class Ii ◽  
Class Ii ◽  
Major Histocompatibility ◽  
Histocompatibility Complex ◽  
Selection Of

It is well established that lymphoid dendritic cells (DC) play an important role in the immune system. Beside their role as potent inducers of primary T cell responses, DC seem to play a crucial part as major histocompatibility complex (MHC) class II+ “interdigitating cells” in the thymus during thymocyte development. Thymic DC have been implicated in tolerance induction and also by some authors in inducing major histocompatibility complex restriction of thymocytes. Most of our knowledge about thymic DC was obtained using highly invasive and manipulatory experimental protocols such as thymus reaggregation cultures, suspension cultures, thymus grafting, and bone marrow reconstitution experiments. The DC used in those studies had to go through extensive isolation procedures or were cultured with recombinant growth factors. Since the functions of DC after these in vitro manipulations have been reported to be not identical to those of DC in vivo, we intended to establish a system that would allow us to investigate DC function avoiding artificial interferences due to handling. Here we present a transgenic mouse model in which we targeted gene expression specifically to DC. Using the CD11c promoter we expressed MHC class II I-E molecules specifically on DC of all tissues, but not on other cell types. We report that I-E expression on thymic DC is sufficient to negatively select I-E reactive CD4+ T cells, and to a less complete extent, CD8+ T cells. In contrast, if only DC expressed I-E in a class II–deficient background, positive selection of CD4+ T cells could not be observed. Thus negative, but not positive, selection events can be induced by DC in vivo.

Evolution of MHC class II SLA-DRB1 locus in the Croatian wild boar (Sus scrofa ) implies duplication and weak signals of positive selection

2018 ◽  
Vol 50 (1) ◽  
pp. 33-41
Author(s):  
H. Arbanasić ◽  
D. Konjević ◽  
L. Vranković ◽  
M. Bujanić ◽  
S. Stipoljev ◽  
...  
Keyword(s):  
Positive Selection ◽  
Wild Boar ◽  
Mhc Class Ii ◽  
Sus Scrofa ◽  
Class Ii ◽  
Weak Signals ◽  
Drb1 Locus

Selection of Unrelated Bone Marrow Donors: Does the Current Procedure Warrant Complete MHC Class II Identity?

1992 ◽  
Vol 19 (3) ◽  
pp. 127-129
Author(s):  
T.H. Eiermann ◽  
M. Ballas ◽  
J. Fakler ◽  
C. Müller ◽  
A. Wölpl ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Mhc Class Ii ◽  
Class Ii ◽  
Selection Of ◽  
Current Procedure
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