scholarly journals Hydrogel Synthesis Directed Toward Tissue Engineering: Impact of Reaction Condition on Structural Parameters and Macroscopic Properties of Xerogels

2011 ◽  
Vol 2011 ◽  
pp. 1-14 ◽  
Author(s):  
Borivoj Adnadjević ◽  
Jelena Jovanović
Keyword(s):  
Tissue Engineering ◽  
Acrylic Acid ◽  
Molar Mass ◽  
Structural Parameters ◽  
Scaling Exponent ◽  
Reaction Conditions ◽  
Average Molar Mass ◽  
Functional Relationships ◽  
Macroscopic Properties ◽  
Poly Acrylic Acid

The existence of correlation and functional relationships between reaction conditions (concentrations of crosslinker, monomer and initiator, and neutralization degree of monomer), primary structural parameters (crosslinking density of network, average molar mass between crosslinks, and distance between macromolecular chains), and macroscopic properties (equilibrium swelling degree and xerogel density) of the synthesized xerogels which are important for application in tissue engineering is investigated. The structurally different xerogels samples of poly(acrylic acid), poly(methacrylic acid), and poly(acrylic acid-g-gelatin) were synthesized by applying different methods of polymerization: crosslinking polymerization, crosslinking polymerization in high concentrated aqueous solution, and crosslinking graft polymerization. The values of primary structural parameters and macroscopic properties were determined for the synthesized xerogels samples. For all of the investigated methods of polymerization, an existence of empirical power function of the dependence of primary structural parameters and macroscopic properties on the reaction conditions was established. The scaling laws between primary structural parameters and macroscopic properties on average molar mass between crosslinks were established. It is shown that scaling exponent is independent from the type of monomer and other reaction conditions within the same polymerization method. The physicochemical model that could be used for xerogel synthesis with predetermined macroscopic properties was suggested.

A Safety Strategy for Producing Poly(Acrylic Acid) of Low Molar Mass

2017 ◽  
Vol 11 (3) ◽  
pp. 1600049 ◽  
Author(s):  
Gerardo Cáceres Montenegro ◽  
Carolina G. Gutierrez ◽  
Santiago E. Vaillard ◽  
Roque J. Minari ◽  
Jorge R. Vega ◽  
...  
Keyword(s):  
Acrylic Acid ◽  
Molar Mass ◽  
Safety Strategy ◽  
Poly Acrylic Acid

scholarly journals The investigations of bioactive copper(II) complexes with reduced low-molar dextran

2008 ◽  
Vol 22 (2-3) ◽  
pp. 177-185 ◽  
Author(s):  
Milorad Cakić ◽  
Žarko Mitić ◽  
Goran S. Nikolić ◽  
Ljubomir Ilić ◽  
Goran M. Nikolić
Keyword(s):  
Fourier Transform ◽  
Complex Formation ◽  
Room Temperature ◽  
Molar Mass ◽  
Reaction Conditions ◽  
Average Molar Mass ◽  
Square Planar ◽  
Physicochemical Methods ◽  
Fourier Transform Ir ◽  
Aqueous Complexes

The optimization of the reaction conditions (pH,T,t) to obtain stable copper(II) ion complexes with dextran derivatives were investigated in this paper. A complete synthesis of stable aqueous complexes can be realized with reduced low-molar polysaccharides, at an average molar mass 5000 g mol–1and pH 7.5–8. Fourier-transform IR spectra of polysaccharide dextran and its compounds with copper(II) ion, recorded at room temperature, were analyzed in order to obtain the information about the structure and the conformation of these polymer compounds. The ESR parameters of the spectra indicate the square-planar coordination of Cu(II) ion with four O atoms. Copper(II) complex formation with dextran and its derivatives were analyzed by physicochemical methods. Synthesized complexes of Cu(II) ion with reduced low-molar dextran in comparison with commercial preparations showed the considerably lower acute toxicity (LD501705).

scholarly journals Synthesis, Characterization, and Osteoblastic Cell Culture of Poly(L-co-D,L-lactide-co-trimethylene carbonate) Scaffolds

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
André Dutra Messias ◽  
Kelly Fernanda Martins ◽  
Adriana Cristina Motta ◽  
Eliana Aparecida de Rezende Duek
Keyword(s):  
Tissue Engineering ◽  
Cell Culture ◽  
Glass Transition ◽  
Bone Tissue Engineering ◽  
Molar Mass ◽  
Bulk Polymerization ◽  
Osteoblastic Cell ◽  
Trimethylene Carbonate ◽  
Average Molar Mass ◽  
Copolymer Poly

Lactide-based polymers have been widely investigated as materials for tissue engineering. However, characteristics such as low flexibility and elongation tend to limit particular applications, although these can be enhanced by adding plasticizers such as trimethylene carbonate (TMC) to the polymer chain of the copolymer poly(L-lactide-co-D,L-lactide) (PLDLA). The aim of this work was to synthesize and characterize a terpolymer of L-lactide, D,L-lactide, and TMC. The polymers were synthesized from 30% TMC by bulk polymerization and resulted in an average molar mass >105 g/mol. Thermal investigation of PLDLA-TMC showed a decrease in the glass transition and onset temperatures compared to PLDLA. PLDLA-TMC scaffolds stimulated the proliferation and normal phenotypic manifestations of cultured osteoblasts. These results show that it was possible to produce a terpolymer from L-lactide, D,L-lactide, and TMC. Scaffolds of this terpolymer had important characteristics that could be useful for applications in bone tissue engineering.

scholarly journals The pH-responsive behaviour of poly(acrylic acid) in aqueous solution is dependent on molar mass

Soft Matter ◽  
2016 ◽  
Vol 12 (9) ◽  
pp. 2542-2549 ◽  
Author(s):  
Thomas Swift ◽  
Linda Swanson ◽  
Mark Geoghegan ◽  
Stephen Rimmer
Keyword(s):  
Aqueous Solution ◽  
Acrylic Acid ◽  
Molar Mass ◽  
Ph Responsive ◽  
Poly Acrylic Acid

scholarly journals Inhibition of homogenous formation of calcium carbonate by poly (acrylic acid). The effect of molar mass and end-group functionality

Desalination ◽  
2014 ◽  
Vol 338 ◽  
pp. 93-105 ◽  
Author(s):  
Ali A. Al-Hamzah ◽  
Christopher P. East ◽  
William O.S. Doherty ◽  
Christopher M. Fellows
Keyword(s):  
Calcium Carbonate ◽  
Acrylic Acid ◽  
Molar Mass ◽  
End Group ◽  
Poly Acrylic Acid
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