scholarly journals A Comparative Study of the Inclusion Complexes of 2-[5'-benzylidene-2'-phenyl-4'-oxo-1', 3'-thiazolidine]-1, 3-benzothiazole and 2-[5'-(p-N,N-dimethylamino- benzylidene)-2'-phenyl-4'-oxo-1', 3'-thiazolidine]-1, 3-benzothiazole withβ-Cyclodextrin

2011 ◽  
Vol 8 (3) ◽  
pp. 1030-1037
Author(s):  
S. Panda ◽  
S. K. Dash
Keyword(s):  
Complex Formation ◽  
Inclusion Complex ◽  
Inclusion Complexes ◽  
Inclusion Complex Formation ◽  
Polar Medium ◽  
Antibacterial And Antifungal Activities ◽  
Before And After ◽  
The Stability ◽  
Antibacterial And Antifungal

The compounds 2-[5'-benzylidene-2'-phenyl-4'-oxo-1', 3'-thiazolidine]-1, 3-benzothiazole and 2-[5'-(p-N,N-dimethylamino- benzylidene)-2'-phenyl-4'-oxo-1', 3'-thiazolidine]-1, 3-benzothiazole have been synthesized in their purest forms starting from 2-aminobenzothiazole. The inclusion complexes of the above compounds have been prepared with β-cyclodextrin to increase their solubility and bioaccessibility in polar medium. The formation of inclusion complexes have been ascertained by study of spectral characteristic before and after inclusion complex formation. The stability of inclusion complexes and nature of interaction between the host and guest are known from the determination of thermodynamic parameters. Further the antibacterial and antifungal activities of the compounds are determined which is found to increase significantly after inclusion complex formation

Fluorescent Sensor and Application in Determination of Carbaryl Residues

2014 ◽  
Vol 955-959 ◽  
pp. 1220-1223
Author(s):  
Ji Cheng Xu ◽  
Xin Shan Rong ◽  
Ting Tian ◽  
Feng Xian Qiu
Keyword(s):  
Detection Limit ◽  
Complex Formation ◽  
Fluorescence Intensity ◽  
Fluorescent Sensor ◽  
Inclusion Complex Formation ◽  
Cyclodextrin Derivative ◽  
Vegetable Samples ◽  
The Stability ◽  
Sensitive Method

The inclusion complex formation between fluorescent sensor 3, 3’-benzidine/β-cyclodextrin derivative (BDCD) and pesticide carbaryl was studied and characterized by TEM, XRD and fluorescence spectroscopy. The stability constant and the stoichiometry of complex were determined. Based on the enhancement of the fluorescence intensity of carbaryl produced through complex formation, a new sensitive method for the determination of carbaryl was established. The linear relationship between the fluorescence intensity and carbaryl concentration was obtained in the range of 0.60-3.00 μmol/L with a correlation coefficient of 0.9946. The detection limit was 5.12 nmol/L. This method has been successfully applied to the determination of carbaryl pesticide residue in water, fruit and vegetable samples with satisfactory results, recoveries in the range of 94.12 % to 105.88 % were obtained. The method is rapid, simple, direct, economical, sensitive and useful for carbaryl analysis.

scholarly journals Preparation and characterization of artemether inclusion complexes with hydroxypropyl-β-cyclodextrin

2017 ◽  
Vol 16 (10) ◽  
pp. 2359-2364
Author(s):  
Zwanden Sule Yahaya ◽  
Kenneth C. Ofokansi ◽  
Suzane T. Allagh ◽  
Pat G. Bhatia
Keyword(s):  
Complex Formation ◽  
Inclusion Complex ◽  
Dissolution Rate ◽  
Inclusion Complexes ◽  
In Vitro Dissolution ◽  
Phase Solubility ◽  
Inclusion Complex Formation ◽  
Scanning Calorimetry ◽  
Ft Ir

Purpose: To investigate experimentally the inclusion of artemether into the cavity of  hydroxypropyl-β-cyclodextrin and examine its effect on the solubility and dissolution rate of the drug.Methods: Inclusion complexes of artemether with hydroxypropyl-β-cyclodextrin of molar ratios 1:1, 1:2 and 1:3 were prepared using the kneading method. Phase solubility analysis and in vitro dissolution studies were utilized in evaluating the influence of inclusion complex formation on the solubility and dissolution rate of the drug. The complexes were characterized using differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FT-IR). The inclusion complex containing equimolar concentrations of artemether and hydroxypropyl-β-cyclodextrin was then formulated into tablets via direct compression and  evaluated for various pharmaceutical characteristics including hardness, friability, absolute drug content and comparative in vitro dissolution profiles with some  commercially available brands of artemether.Results: The phase solubility diagram for the formed complexes in water at 37 oC indicated a linear curve soluble complex system (referred to as the AL system), and a stability constant (KC) value of 143 M-1. Evidence consistent with inclusion complex formation was obtained using FT-IR and DSC. The formulated inclusion complex tablets exhibited a higher rate of dissolution than the pure drug and commercial brands, showing 3.9-, 1.8- and 1.6-fold increases, respectively, over a period of 15 min.Conclusion: Inclusion complexation of artemether with hydroxypropyl-β-cyclodextrin is a promising approach to enhance the solubility and dissolution rate of the drug.Keywords: Artemether, 2-Hydroxypropyl-β-cyclodextrin, Dissolution, Solubility enhancement, Inclusion complex

Hollow circular compound-based inclusion complexes of an ionic liquid

RSC Advances ◽  
2016 ◽  
Vol 6 (80) ◽  
pp. 76381-76389 ◽  
Author(s):  
Siti Barman ◽  
Mahendra Nath Roy
Keyword(s):  
Ionic Liquid ◽  
Complex Formation ◽  
Inclusion Complex ◽  
Inclusion Complexes ◽  
Crown Ethers ◽  
Nmr Spectra ◽  
Conductivity Measurements ◽  
Inclusion Complex Formation ◽  
Ir And Nmr Spectra ◽  
Circular Compound

Inclusion complex formation between hollow circular compounds, e.g. crown ethers, and an ionic liquid, 1-methyl-3-octylimidazolium tetrafluoroborate, in acetonitrile solvent is studied by means of conductivity measurements, IR and NMR spectra.

Past, present and futute of cyclodextrin research

2004 ◽  
Vol 76 (10) ◽  
pp. 1825-1845 ◽  
Author(s):  
J. Szejtli
Keyword(s):  
Complex Formation ◽  
Inclusion Complex ◽  
Inclusion Complexes ◽  
Outer Surface ◽  
Inclusion Complex Formation ◽  
Molecular Encapsulation ◽  
Hydrophobic Character ◽  
Chemical Derivatives ◽  
Alpha Beta ◽  
Geometric Compatibility

The macrocyclic cyclodextrins (enzymic conversion products of starch) were discovered in 1891, and the structures were elucidated in the mid-1930s. Their industrial significance become obvious in the 1970s, and by now thousand of tons of the three cyclodextrins (alpha-, beta-, and gamma-CD) and of their chemical derivatives and inclusion complexes are produced industrially. The outer surface of these doughnut-shaped molecules is hydrophilic, but they possess an axial open cavity, which is of hydrophobic character and capable of including other apolar molecules (or their moiety) in case of geometric compatibility. This is the essence of molecular encapsulation by inclusion complex formation.

scholarly journals A Comparative Study of Inclusion Complexes of Orthosubstituted [Arylidenamino]-1,3,4- thiadiazino[6,5b] Indole Derivatives

2012 ◽  
Vol 9 (3) ◽  
pp. 1213-1222 ◽  
Author(s):  
Sunakar Panda ◽  
Jagat Krushna Tripathy
Keyword(s):  
Antibacterial Activity ◽  
Complex Formation ◽  
Inclusion Complex ◽  
Inclusion Complexes ◽  
Antioxidant Activities ◽  
Aromatic Aldehydes ◽  
Enthalpy Change ◽  
Indole Derivatives ◽  
Activity Change ◽  
Inclusion Complex Formation

Some[Arylidenamino]-1,3,4-thiadiazino[6,5b] indoles have been synthesized starting from indole-2,3-dione, thiosemicarbazide and aromatic aldehydes with activating and deactivating groups. Inclusion complexes of these compounds have been prepared with β-cyclodextrin so as increase the solubility and bioaccessibility. Thermodynamic properties like change in free energy, change in enthalpy, change in entropy and stability constant of the inclusion complexes have been determined to know whether the inclusion complex formation is thermodynamically allowed or not. The compounds and their inclusion complexes are also screened againt S.aureus and E.coli.to know the antibacterial activity change after inclusion complex formation The antioxidant activities are also studied.

Study on the Determination of Carbendazim in Water and Vegetable Samples

2014 ◽  
Vol 955-959 ◽  
pp. 1351-1354 ◽  
Author(s):  
Ji Cheng Xu ◽  
Xin Shan Rong ◽  
Ting Tian ◽  
Feng Xian Qiu
Keyword(s):  
Complex Formation ◽  
Inclusion Complex ◽  
Fluorescence Intensity ◽  
Limit Of Detection ◽  
Sensitivity Factor ◽  
Inclusion Complex Formation ◽  
Cyclodextrin Derivative ◽  
Vegetable Samples ◽  
Fruit Samples

The host-guest inclusion complex formation between 3, 3’-benzidine/β-cyclodextrin derivative (BDCD) and pesticide carbendazim was studied and characterized by TEM and XRD. The result showed that inclusion complex had hydrophobic small-molecule fluorophores. The fluorescence titration was performed to calculate binding constant, sensitivity factor and limit of detection of the resulting complex. Based on the enhancement of the fluorescence intensity of carbendazim produced throught complex formation, a new sensitive method for the determination of carbendazim was established. A linear relationship was obtained between the fluorescence intensity and carbendazim concentration in the range of 3.57 and 17.83 μmol/L. The correlation coefficient, the lowest limit of detection and RSD were 0.9916, 15.51 nmol/L and 2.13%, respectively. This method has better anti-interference ability and stability. The proposed method have been successfully applied to the determination of carbendazim pesticide residues in water, vegetable and fruit samples with satisfactory results, recoveries in the range of 87.56 % to 104.04 % were obtained.

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