Hollow circular compound-based inclusion complexes of an ionic liquid

RSC Advances ◽  
2016 ◽  
Vol 6 (80) ◽  
pp. 76381-76389 ◽  
Author(s):  
Siti Barman ◽  
Mahendra Nath Roy
Keyword(s):  
Ionic Liquid ◽  
Complex Formation ◽  
Inclusion Complex ◽  
Inclusion Complexes ◽  
Crown Ethers ◽  
Nmr Spectra ◽  
Conductivity Measurements ◽  
Inclusion Complex Formation ◽  
Ir And Nmr Spectra ◽  
Circular Compound

Inclusion complex formation between hollow circular compounds, e.g. crown ethers, and an ionic liquid, 1-methyl-3-octylimidazolium tetrafluoroborate, in acetonitrile solvent is studied by means of conductivity measurements, IR and NMR spectra.

scholarly journals Preparation and characterization of artemether inclusion complexes with hydroxypropyl-β-cyclodextrin

2017 ◽  
Vol 16 (10) ◽  
pp. 2359-2364
Author(s):  
Zwanden Sule Yahaya ◽  
Kenneth C. Ofokansi ◽  
Suzane T. Allagh ◽  
Pat G. Bhatia
Keyword(s):  
Complex Formation ◽  
Inclusion Complex ◽  
Dissolution Rate ◽  
Inclusion Complexes ◽  
In Vitro Dissolution ◽  
Phase Solubility ◽  
Inclusion Complex Formation ◽  
Scanning Calorimetry ◽  
Ft Ir

Purpose: To investigate experimentally the inclusion of artemether into the cavity of  hydroxypropyl-β-cyclodextrin and examine its effect on the solubility and dissolution rate of the drug.Methods: Inclusion complexes of artemether with hydroxypropyl-β-cyclodextrin of molar ratios 1:1, 1:2 and 1:3 were prepared using the kneading method. Phase solubility analysis and in vitro dissolution studies were utilized in evaluating the influence of inclusion complex formation on the solubility and dissolution rate of the drug. The complexes were characterized using differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FT-IR). The inclusion complex containing equimolar concentrations of artemether and hydroxypropyl-β-cyclodextrin was then formulated into tablets via direct compression and  evaluated for various pharmaceutical characteristics including hardness, friability, absolute drug content and comparative in vitro dissolution profiles with some  commercially available brands of artemether.Results: The phase solubility diagram for the formed complexes in water at 37 oC indicated a linear curve soluble complex system (referred to as the AL system), and a stability constant (KC) value of 143 M-1. Evidence consistent with inclusion complex formation was obtained using FT-IR and DSC. The formulated inclusion complex tablets exhibited a higher rate of dissolution than the pure drug and commercial brands, showing 3.9-, 1.8- and 1.6-fold increases, respectively, over a period of 15 min.Conclusion: Inclusion complexation of artemether with hydroxypropyl-β-cyclodextrin is a promising approach to enhance the solubility and dissolution rate of the drug.Keywords: Artemether, 2-Hydroxypropyl-β-cyclodextrin, Dissolution, Solubility enhancement, Inclusion complex

Past, present and futute of cyclodextrin research

2004 ◽  
Vol 76 (10) ◽  
pp. 1825-1845 ◽  
Author(s):  
J. Szejtli
Keyword(s):  
Complex Formation ◽  
Inclusion Complex ◽  
Inclusion Complexes ◽  
Outer Surface ◽  
Inclusion Complex Formation ◽  
Molecular Encapsulation ◽  
Hydrophobic Character ◽  
Chemical Derivatives ◽  
Alpha Beta ◽  
Geometric Compatibility

The macrocyclic cyclodextrins (enzymic conversion products of starch) were discovered in 1891, and the structures were elucidated in the mid-1930s. Their industrial significance become obvious in the 1970s, and by now thousand of tons of the three cyclodextrins (alpha-, beta-, and gamma-CD) and of their chemical derivatives and inclusion complexes are produced industrially. The outer surface of these doughnut-shaped molecules is hydrophilic, but they possess an axial open cavity, which is of hydrophobic character and capable of including other apolar molecules (or their moiety) in case of geometric compatibility. This is the essence of molecular encapsulation by inclusion complex formation.

scholarly journals A Comparative Study of Inclusion Complexes of Orthosubstituted [Arylidenamino]-1,3,4- thiadiazino[6,5b] Indole Derivatives

2012 ◽  
Vol 9 (3) ◽  
pp. 1213-1222 ◽  
Author(s):  
Sunakar Panda ◽  
Jagat Krushna Tripathy
Keyword(s):  
Antibacterial Activity ◽  
Complex Formation ◽  
Inclusion Complex ◽  
Inclusion Complexes ◽  
Antioxidant Activities ◽  
Aromatic Aldehydes ◽  
Enthalpy Change ◽  
Indole Derivatives ◽  
Activity Change ◽  
Inclusion Complex Formation

Some[Arylidenamino]-1,3,4-thiadiazino[6,5b] indoles have been synthesized starting from indole-2,3-dione, thiosemicarbazide and aromatic aldehydes with activating and deactivating groups. Inclusion complexes of these compounds have been prepared with β-cyclodextrin so as increase the solubility and bioaccessibility. Thermodynamic properties like change in free energy, change in enthalpy, change in entropy and stability constant of the inclusion complexes have been determined to know whether the inclusion complex formation is thermodynamically allowed or not. The compounds and their inclusion complexes are also screened againt S.aureus and E.coli.to know the antibacterial activity change after inclusion complex formation The antioxidant activities are also studied.

scholarly journals A Comparative Study of the Inclusion Complexes of 2-[5'-benzylidene-2'-phenyl-4'-oxo-1', 3'-thiazolidine]-1, 3-benzothiazole and 2-[5'-(p-N,N-dimethylamino- benzylidene)-2'-phenyl-4'-oxo-1', 3'-thiazolidine]-1, 3-benzothiazole withβ-Cyclodextrin

2011 ◽  
Vol 8 (3) ◽  
pp. 1030-1037
Author(s):  
S. Panda ◽  
S. K. Dash
Keyword(s):  
Complex Formation ◽  
Inclusion Complex ◽  
Inclusion Complexes ◽  
Inclusion Complex Formation ◽  
Polar Medium ◽  
Antibacterial And Antifungal Activities ◽  
Before And After ◽  
The Stability ◽  
Antibacterial And Antifungal

The compounds 2-[5'-benzylidene-2'-phenyl-4'-oxo-1', 3'-thiazolidine]-1, 3-benzothiazole and 2-[5'-(p-N,N-dimethylamino- benzylidene)-2'-phenyl-4'-oxo-1', 3'-thiazolidine]-1, 3-benzothiazole have been synthesized in their purest forms starting from 2-aminobenzothiazole. The inclusion complexes of the above compounds have been prepared with β-cyclodextrin to increase their solubility and bioaccessibility in polar medium. The formation of inclusion complexes have been ascertained by study of spectral characteristic before and after inclusion complex formation. The stability of inclusion complexes and nature of interaction between the host and guest are known from the determination of thermodynamic parameters. Further the antibacterial and antifungal activities of the compounds are determined which is found to increase significantly after inclusion complex formation

Effect of starch-lipids inclusion complex formation on functional properties of flour in tandoori roti

2000 ◽  
Vol 69 (2) ◽  
pp. 129-133 ◽  
Author(s):  
Narpinder Singh ◽  
Kulwinder Kaur ◽  
Hardeep Singh ◽  
Harmeet Singh
Keyword(s):  
Complex Formation ◽  
Inclusion Complex ◽  
Functional Properties ◽  
Inclusion Complex Formation
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