scholarly journals What's in a Name? Can Mullein Weed Beat TB Where Modern Drugs Are Failing?

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Eibhlín McCarthy ◽  
Jim M. O'Mahony
Keyword(s):  
Skin Disease ◽  
Pathogenic Bacteria ◽  
Mycobacterial Disease ◽  
Verbascum Thapsus ◽  
Medicinal Use ◽  
History Of ◽  
Common Mullein

Common mullein weed (Verbascum thapsus) has a large number of synonyms and old local “nick names” which connect the plant with mycobacteria. A strong history of medicinal use has been uncovered for the treatment of tuberculosis, tubercular skin disease, leprosy, and mycobacterial disease in animals. Here, we examine problems encountered in treating such diseases today, the historical and scientific links between mullein and pathogenic bacteria, and the possibility that this common weed could harbour the answer to beating one of the world's biggest infectious killers.

Natural products investigation of Hawaiian samples of Verbascum thapsus – common Mullein

Planta Medica ◽  
2015 ◽  
Vol 81 (11) ◽  
Author(s):  
D Weingärtener Rosa ◽  
K Hagiwara ◽  
AD Wright
Keyword(s):  
Natural Products ◽  
Verbascum Thapsus ◽  
Common Mullein

scholarly journals Topical Tofacitinib: A Janus Kinase Inhibitor for the Treatment of Vitiligo in an Adolescent Patient

2021 ◽  
pp. 190-194
Author(s):  
Sineida Berbert Ferreira ◽  
Rachel Berbert Ferreira ◽  
Afonso Cesar Neves Neto ◽  
Silvana Martins Caparroz Assef ◽  
Morton Scheinberg
Keyword(s):  
Case Report ◽  
Skin Disease ◽  
Kinase Inhibitor ◽  
Effective Therapy ◽  
Janus Kinase ◽  
Jak Inhibitor ◽  
Adolescent Patient ◽  
Jak Inhibitors ◽  
Janus Kinase Inhibitor ◽  
History Of

Vitiligo is an autoimmune skin disease presenting with areas of depigmentation. Recent reports suggest that Janus kinase (JAK) inhibitors may be an effective therapy. In this case report, we show our experience with an adolescent patient with a long history of generalized and refractory vitiligo, for which treatment with topical tofacitinib, a JAK inhibitor, associated with phototherapy for 9 months, resulted in near complete repigmentation.

scholarly journals Prevalence of scabies and its associated factors among school age children in Arba Minch zuria district, Southern Ethiopia, 2018

2020 ◽  
Author(s):  
Abayneh Tunje ◽  
Chuchu Churko ◽  
Desta Haftu ◽  
Amsalu Alagaw ◽  
Eyayou Girma
Keyword(s):  
Bacterial Infection ◽  
Skin Disease ◽  
General Health ◽  
Associated Factors ◽  
School Age Children ◽  
Southern Ethiopia ◽  
School Age ◽  
The World ◽  
History Of ◽  
Considerable Impact

AbstractBackgroundScabies, a common human skin disease with a prevalence range of 0.2% to 71.4% in the world. It can have considerable impact on general health leading to illness and death not only through direct effect of its infestation and as a result of secondary bacterial infection. The aim of this study was to assess the prevalence of scabies and its associated factors among school age children in Arba Minch zuria district, Gamo zone, Southern Ethiopia.MethodsA community based cross sectional study was carried out in 845 school age children from February 20 to March 30, 2018. Multi-stage sampling technique was used to select study populations. Logistic regression an analysis was used to identify factors associated with scabies. Findings were presented using 95% CI of Crude Odds Ratios (COR) and Adjusted Odds Ratios (AOR. To declare statistical significance, p-value less than 0.05 was used.ResultA total of 825 children participated in the study with response rate of 97.6%. The overall prevalence of scabies was 16.4% [95% CI: 13.9%, 18.9%]. overcrowding index, family history of itching in the past two weeks, wealth index, knowledge of scabies, climatic zone, frequency of washing body, frequency of washing clothes, finger nails cutting practice, history of skin contact with scabies patient, washing hair more than once weekly, and sharing of clothes were significantly associated scabies disease.ConclusionIn conclusion, the prevalence of scabies in Arba Minch lies at 16.4% in the global scabies range 0.2% to 71.4%. The prevalence was highest in highlands followed by midland and then lowland. This represents a significant scabies burden which we recommend warrants health service intervention.Authors summaryScabies, a common human skin disease with a prevalence range of 0.2% to 71.4% in the world. It can have considerable impact on general health leading to illness and death not only through direct effect of its infestation and as a result of secondary bacterial infection. Conducting a research on this neglected tropical disease would contribute in designing a policies and strategies on prevention and control measures in the study area. Therefore, the aim of this study was to assess the prevalence of scabies and its associated factors among school age children in Arba Minch zuria district, Gamo zone, Southern Ethiopia.

Taxonomic and nomenclatural notes on the Rhinusa tetra (Fabricius) species complex (Coleoptera: Curculionidae)

Zootaxa ◽  
2012 ◽  
Vol 3329 (1) ◽  
pp. 31 ◽  
Author(s):  
ROBERTO CALDARA ◽  
ROBERTO CASALINI ◽  
COSIMO BAVIERA
Keyword(s):  
Biological Control ◽  
North America ◽  
Species Complex ◽  
Broad Sense ◽  
Valid Species ◽  
Potential Candidate ◽  
Verbascum Thapsus ◽  
New Findings ◽  
Common Mullein

All taxa closely related to or synonymized with Rhinusa tetra (Fabricius, 1792) are studied, including the available type mate-rial. Four species are considered taxonomically valid: Rhinusa tetra, R. comosa (Rosenschoeld, 1838), R. moroderi (Reitter,1906), R. verbasci (Rosenschoeld, 1838). The following four new synonymies are proposed: R. tetra (= Gymnetron eoumRosenschoeld, 1838 syn. n.; = Cleopus uncinatus Dufour, 1843 syn. n.; = Cleopus verbasci Dufour, 1843 syn. n.); R. moroderi(= Gymnetron otini Hustache, 1946 syn. n). Neotypes are designated for Cionus amictus Germar, 1821, Cleopus uncinatus andCleopus verbasci. Lectotypes are designated for Curculio teter, Gymnetron comosum, Gymnetron crassirostre Lucas, 1849,Gymnetron eoum, Gymnetron fuscescens Rosenschoeld, 1838, Gymnetron haemorrhoum Rosenhauer, 1847, Gymnetron moro-deri, Gymnetron plagiellum Gyllenhal, 1838, Gymnetron trigonale Gyllenhal, 1838 and Gymnetron verbasci, all currentlyincluded in Rhinusa. A key separating the four valid species is supported by diagnoses, biological notes, distributional data andillustrations. These new findings are important because R. tetra in the broad sense was proposed as a potential candidate for the biological control of invasive Common Mullein (Verbascum thapsus L.) in North America.

scholarly journals HELICHRYSUM LONGIFOLIUM AND HELICHRYSUM PEDUNCULATUM: A COMPARATIVE ANALYSIS OF THEIR MEDICINAL USES, CHEMISTRY AND BIOLOGICAL ACTIVITIES

2019 ◽  
pp. 41-46
Author(s):  
ALFRED MAROYI
Keyword(s):  
Biological Activities ◽  
Herbal Medicines ◽  
Pharmaceutical Products ◽  
Medicinal Uses ◽  
Additional Information ◽  
Medicinal Use ◽  
Need To Evaluate ◽  
History Of ◽  
Cytotoxicity Activities ◽  
The University

Helichrysum longifolium and Helichrysum pedunculatum have a long history of medicinal use, particularly managing wounds acquired during male circumcision rites in South Africa. There is a need to evaluate the existence of any correlation between the ethnomedicinal applications, the phytochemistry and pharmacological properties of the species. Therefore, in this review, analyses of the botanical, medicinal, and chemical and biological activities of H. longifolium and H. pedunculatum are presented as well as exploring the potential of the two species as important sources of health and pharmaceutical products. Information on the botany, medicinal uses, and phytochemistry and biological activities of H. longifolium and H. pedunculatum was assembled from several internet sources which included Scopus, Google Scholar, Elsevier, Science Direct, Web of Science, PubMed, SciFinder, and BMC. Additional information was sourced from journal articles, scientific reports, theses, books, and book chapters obtained from the University library. This study showed that alkaloids, flavonoids, linoleic acid, oleic acid, phenol, proanthocyanidin, saponins, and tannins have been identified from the leaves of H. longifolium and H. pedunculatum. The pharmacological research showed that H. longifolium and H. pedunculatum extracts and compounds isolated from the species have antibacterial, antifungal, anti-inflammatory, antioxidant, antiplasmodial, antiprotozoal, and cytotoxicity activities. For local communities to use H. longifolium and H. pedunculatum extracts with confidence as herbal medicines, there is a need for extensive phytochemical and pharmacological studies. Further research is required to establish the safety profiles of different H. longifolium and H. pedunculatum preparations.

scholarly journals Determination of caffeic acid in root and rhizome of Black cohosh (Cimicifuga racemosa (L.) Nutt.)

2014 ◽  
Vol 27 (2) ◽  
pp. 108-110
Author(s):  
Karolina Zapala ◽  
Grazyna Szymczak ◽  
Magdalena Wojciak-Kosior
Keyword(s):  
Caffeic Acid ◽  
Bioactive Compound ◽  
Reversed Phase ◽  
Hplc Method ◽  
Black Cohosh ◽  
Cimicifuga Racemosa ◽  
Medicinal Use ◽  
Relative Standard ◽  
Validation Parameters ◽  
History Of

Abstract Cimicifuga racemosa, is a plant with a diverse and long history of medicinal use. Caffeic acid, bioactive compound, which often occurs with other polyphenols can influence the biological activity of this plant. The aim of our work was quantitative analysis of caffeic acid in roots and rhizomes of two varieties of C. racemosa. Analysis was performed by HPLC method. The extracts were separated on C18 reversed-phase column using mixture of methanol, water and formic acid (25:75:0.5 v/v/v) as a mobile phase. The flow rate of eluent was 1.0 ml·min-1. The obtained validation parameters such as linearity, linear regression equation and precision expressed as a relative standard deviation were adequate for quantitative determination. Caffeic acid was found in all tested extracts. The highest total amount of caffeic acid was determined in C. racemosa var. racemosa (255.3 μg·g-1) while its concentration in C. racemosa var. cordifolia was significantly lower (213.0 μg·g-1).

scholarly journals Barriers to the wider adoption of medicinal Cannabis

2020 ◽  
Vol 14 (2) ◽  
pp. 122-132
Author(s):  
Stephen PH Alexander
Keyword(s):  
Healthcare Professionals ◽  
Ancient Egypt ◽  
The Public ◽  
Public Media ◽  
Medicinal Use ◽  
History Of ◽  
Medicinal Cannabis

The use of Cannabis-based preparations for medicinal use has waxed and waned in the multi-millennial history of human co-existence with the plant and its cultivation. Recorded use of preparations from Cannabis is effectively as old as recorded history with examples from China, India and Ancient Egypt. Prohibition and restriction of availability allowed a number of alternatives to take the place of Cannabis preparations. However, there has been a worldwide resurgence in medicinal Cannabis advocacy from the public. Media interest has been piqued by particular evocative cases. Altogether, therefore, there is pressure on healthcare professionals to prescribe and dispense Cannabis-based preparations. This review enunciates some of the barriers which are slowing the wider adoption of medicinal Cannabis.

Elastosis Perforans Serpignosa: Treatment with Liquid Nitrogen Cryotherapy and Review of the Literature

2010 ◽  
Vol 14 (1) ◽  
pp. 38-42 ◽  
Author(s):  
Shannon Humphrey ◽  
Iman Hemmati ◽  
Roop Randhawa ◽  
Richard I. Crawford ◽  
Chih-ho Hong
Keyword(s):  
Side Effects ◽  
Connective Tissue ◽  
Liquid Nitrogen ◽  
Outpatient Clinic ◽  
Skin Disease ◽  
Elastic Tissue ◽  
Review Of The Literature ◽  
Therapeutic Challenge ◽  
Cellular Debris ◽  
History Of

Background: Elastosis perforans serpiginosa (EPS) is a rare skin disease in which abnormal elastic tissue fibers, other connective tissue elements, and cellular debris are expelled from the papillary dermis via transepithelial elimination. It is characterized by an eruption of small grouped hyperkeratotic papules in a serpiginous arrangement. This condition presents a therapeutic challenge as many treatments have been reported with inconsistent efficacy. Methods: This article reports a case of a 13-year-old male who presented to our outpatient clinic with a 1-year history of facial lesions showing multiple annular keratotic plaques with slight central atrophy. Conclusion: We report a case of EPS treated successfully with liquid nitrogen cryotherapy. Liquid nitrogen cryotherapy is well tolerated, with few side effects, and can be considered in the management of EPS.

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