Elastosis Perforans Serpignosa: Treatment with Liquid Nitrogen Cryotherapy and Review of the Literature

2010 ◽  
Vol 14 (1) ◽  
pp. 38-42 ◽  
Author(s):  
Shannon Humphrey ◽  
Iman Hemmati ◽  
Roop Randhawa ◽  
Richard I. Crawford ◽  
Chih-ho Hong
Keyword(s):  
Side Effects ◽  
Connective Tissue ◽  
Liquid Nitrogen ◽  
Outpatient Clinic ◽  
Skin Disease ◽  
Elastic Tissue ◽  
Review Of The Literature ◽  
Therapeutic Challenge ◽  
Cellular Debris ◽  
History Of

Background: Elastosis perforans serpiginosa (EPS) is a rare skin disease in which abnormal elastic tissue fibers, other connective tissue elements, and cellular debris are expelled from the papillary dermis via transepithelial elimination. It is characterized by an eruption of small grouped hyperkeratotic papules in a serpiginous arrangement. This condition presents a therapeutic challenge as many treatments have been reported with inconsistent efficacy. Methods: This article reports a case of a 13-year-old male who presented to our outpatient clinic with a 1-year history of facial lesions showing multiple annular keratotic plaques with slight central atrophy. Conclusion: We report a case of EPS treated successfully with liquid nitrogen cryotherapy. Liquid nitrogen cryotherapy is well tolerated, with few side effects, and can be considered in the management of EPS.

scholarly journals Gemcitabine-induced pseudocellulitis: a case report and review of the literature

2019 ◽  
Vol 26 (5) ◽  
Author(s):  
H. Bami ◽  
C. Goodman ◽  
G. Boldt ◽  
M. Vincent
Keyword(s):  
Emergency Department ◽  
Case Report ◽  
Side Effects ◽  
Chemotherapeutic Agent ◽  
Whipple Procedure ◽  
Venous Stasis ◽  
Past Medical History ◽  
Review Of The Literature ◽  
Peripheral Vascular ◽  
History Of

Gemcitabine is a chemotherapeutic agent used in a wide variety of solid tumours. Known side effects include a dose-limiting myelosuppressive toxicity, mild rash, and radiation-dependent dermatitis. Rarely, localized inflammation in the form of pseudocellulitis has also been observed. We present the case of a 77-year-old woman with a history of a Whipple procedure for pancreatic adenocarcinoma who presented to the emergency department after the start of gemcitabine therapy with increased erythema, swelling, and tenderness in her lower legs. Relevant past medical history included peripheral vascular disease, dyslipidemia, and hypertension. A diagnosis of gemcitabine-induced pseudocellulitis aggravated by venous stasis was confirmed after an extensive workup. This case report and the literature review describe this rare reaction, highlighting the need for increased recognition to avoid unnecessary therapeutic intervention.

Fascial distortion model (FDM-therapy). Principles of diagnosis and treatment (literature review)

2020 ◽  
pp. 121-129
Author(s):  
A. V. Boldin ◽  
S. B. Sokolin ◽  
M. V. Tardov ◽  
E. I. Haimov
Keyword(s):  
Clinical Trials ◽  
Connective Tissue ◽  
Literature Review ◽  
Diagnostic Criteria ◽  
Review Of The Literature ◽  
Distortion Model ◽  
Sufficient Detail ◽  
History Of ◽  
Functional Features

This article provides a review of the literature regarding the original Fascial Distortion Model (FDM). Model was proposed by the American osteopathic doctor S. Typaldos. The article gives brief data on his biography, provides information about the history of the method discovery. Information on the properties and physiology of connective tissue and fascia is presented in sufficient detail. The classification of fascial structures proposed by S. Typaldos with regard to their anatomical and functional features is given. The diagnostic criteria of the six variants of fascial distortions described by S. Typaldos are represented in detail. The principles of FDM treatment are described. Contraindications and possible undesirable reactions that may occur during treatment or after FDM therapy are given. Data on clinical trials conducted in this area are presented.

Erythema Annulare Centrifugum in a Patient with Crohn Disease

2012 ◽  
Vol 16 (6) ◽  
pp. 442-444 ◽  
Author(s):  
Michael Samycia ◽  
Thomas G. Salopek
Keyword(s):  
Connective Tissue ◽  
Hypersensitivity Reaction ◽  
Clinical Examination ◽  
Crohn Disease ◽  
Maladie De Crohn ◽  
Review Of The Literature ◽  
Connective Tissue Disorders ◽  
Erythema Annulare Centrifugum ◽  
Tumeurs Malignes ◽  
History Of

Background: Erythema annulare centrifugum (EAC) represents a hypersensitivity reaction to a variety of conditions, many of which have been reported in the literature. Methods and Results: We report on a 38-year-old woman with a 5-year history of recurrent polycylic, arcuate, scaly, erythematous patches with central clearing on her thighs and trunk. Clinical examination and biopsy were both consistent with a diagnosis of EAC. Two years after the initial presentation, she was diagnosed with mild Crohn disease. Conclusions: The prolonged nature of EAC in our patient and our inability to identify known associations of malignancies, including medications, connective tissue disorders, systemic disorders, and infections, led us to postulate that her EAC was related to her Crohn disease. A thorough review of the literature failed to detect any previous reports linking Crohn disease and EAC. Renseignements de base: L'érythème centrifuge (EAC) représente une réaction d'hypersensibilité à une variété de conditions dont beaucoup ont été signalées dans la littérature. Méthodes et résultats: Nous présentons un rapport sur le cas d'une femme de 38 ans présentant 5 ans d'antécédents de taches érythémateuses squameuses, arquées, polycycliques récurrentes avec guérison centrale sur les cuisses et le tronc. L'examen clinique et la biopsie étaient tous les deux compatibles avec un diagnostic d'EAC. Deux ans après la présentation initiale, elle a été diagnostiquée avec une forme bénigne de la maladie de Crohn. Conclusions: La nature prolongée de l'EAC chez notre patiente, et notre incapacité à identifier les associations connues, y compris les médicaments, les maladies du tissu conjonctif, les troubles systémiques, et des infections, des tumeurs malignes, nous a conduit à postuler que son EAC était lié à sa maladie de Crohn. Un examen approfondi de la littérature ne nous a pas permis de trouver des rapports antérieurs qui établissent un lien entre la maladie de Crohn et l'EAC.

Long-term side effects following pneumonectomy: A case report and review of the literature

2019 ◽  
Author(s):  
BA Högerle ◽  
EL Bulut ◽  
L Klotz ◽  
F Eichhorn ◽  
M Eichhorn ◽  
...  
Keyword(s):  
Case Report ◽  
Side Effects ◽  
Review Of The Literature

Pneumomediastinum: A Rare Presentation of Inflicted Injuries in Infants

2020 ◽  
Author(s):  
Adam Lee ◽  
Adam Bajinting ◽  
Abby Lunneen ◽  
Colleen M. Fitzpatrick ◽  
Gustavo A. Villalona
Keyword(s):  
Literature Review ◽  
Retrospective Review ◽  
Review Of The Literature ◽  
Rare Presentation ◽  
Spontaneous Pneumomediastinum ◽  
Nonaccidental Trauma ◽  
Comprehensive Literature Review ◽  
Healthy Infants ◽  
History Of

AbstractReports of incidental pneumomediastinum in infants secondary to inflicted trauma are limited. A retrospective review of infants with pneumomediastinum and history of inflicted trauma was performed. A comprehensive literature review was performed. Three infants presented with pneumomediastinum associated with inflicted trauma. Mean age was 4.6 weeks. All patients underwent diagnostic studies, as well as a standardized evaluation for nonaccidental trauma. All patients with pneumomediastinum were resolved at follow-up. Review of the literature identified other cases with similar presentations with related oropharyngeal injuries. Spontaneous pneumomediastinum in previously healthy infants may be associated with inflicted injuries. Clinicians should be aware of the possibility of an oropharyngeal perforation related to this presentation.

Probiotics in gastroenterology – from a different angle

2013 ◽  
Vol 154 (8) ◽  
pp. 294-304 ◽  
Author(s):  
György Miklós Buzás
Keyword(s):  
Side Effects ◽  
Beneficial Effect ◽  
Analytical Data ◽  
Well Being ◽  
Gastrointestinal Diseases ◽  
Convincing Evidence ◽  
Probiotic Treatment ◽  
History Of ◽  
Irritable Bowel

After a short overview of the history of probiotics, the author presents the development of human intestinal microflora based on the newest genetic data and the microbiological features of main probiotics. The indications of probiotic administration have been defined and extended in recent years. The author reviews significant results of probiotic treatment in some gastrointestinal diseases based on meta-analytical data. Probiotics are useful in preventing and treating diarrhoea caused by antibiotics and Clostridium difficile caused diarrhoea. In the treatment of Helicobacter pylori infection, preparations containing certain Lactobacillus,Bifidobacterium strains or Saccaromyces boulardii could enhance by 5–10% the rate of successful eradication and reduce the incidence and severity of the side effects. Some symptoms of irritable bowel syndrome and thus the quality of life can be improved by probiotics. Their beneficial effect in ulcerative colitis was proven, while in Crohn’s disease has not yet been defined. The use of probiotics is not included in guidelines, with the exception of the Maastricht IV/Florence consensus. For each disease it is advisable to use probiotics containing strains only with proven beneficial effect. The efficiency of preparations containing mixed strains has not yet been properly investigated. The author reviews the rare but potentially serious side effects of probiotics. In Hungary, there are many probiotic preparations available which can be purchased in pharmacies without prescription: their use is more empirical than evidence-based. The European Food Safety Authority has recently rejected claims for probiotics to be classed as medicines given the lack of convincing evidence on the effects of probiotics on human health and well-being. Clearly, further research is needed to collect evidence which could be incorporated into the international guidelines. Orv. Hetil., 2013, 154, 294–304.

Adenoid cystic carcinoma of the labium oris with rare metastasis to the pleural cavity

2021 ◽  
Vol 14 (1) ◽  
pp. e237622
Author(s):  
Osama Mosalem ◽  
Anas Alsara ◽  
Fawzi Abu Rous ◽  
Borys Hrinczenko
Keyword(s):  
Side Effects ◽  
Adenoid Cystic Carcinoma ◽  
Pleural Cavity ◽  
Epigastric Pain ◽  
Asian Woman ◽  
Upper Lip ◽  
Adenoid Cystic ◽  
History Of ◽  
The Right

A 57-year-old Southeast Asian woman with a remote history of adenoid cystic carcinoma (ACC) of the right labium superius oris (upper lip) presented to the hospital with vague epigastric pain. On workup, she was found to have multiple pleural nodules. Histopathology confirmed the diagnosis of metastatic ACC. After 8 months of active surveillance, evidence of disease progression was found and the patient was started on pembrolizumab. Follow-up after starting pembrolizumab showed stable disease with no significant side effects.

scholarly journals History of Extensive Disease Small Cell Lung Cancer Treatment: Time to Raise the Bar? A Review of the Literature

Cancers ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 998
Author(s):  
Chiara Lazzari ◽  
Aurora Mirabile ◽  
Alessandra Bulotta ◽  
Maria Grazia Viganó ◽  
Francesca Rita Ogliari ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Treatment Time ◽  
Small Cell ◽  
Review Of The Literature ◽  
Small Cell Lung ◽  
Extensive Disease ◽  
History Of ◽  
Line Standard

Several trials have tried for decades to improve the outcome of extensive disease small cell lung cancer (ED-SCLC) through attempts to modify the standard treatments. Nevertheless, platinum/etoposide combination and topotecan have remained respectively the first and the second line standard treatments for the last 40 years. With the advent of immunotherapy, this scenario has finally changed. Our review aims to provide an overview of the primary studies on the actual therapeutic strategies available for ED-SCLC patients, and to highlight emerging evidence supporting the use of immunotherapy in SCLC patients.

scholarly journals Lung adenocarcinoma concomitant with xeroderma pigmentosum: a case report

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Masataka Matsumoto ◽  
Kazumi Kaneshiro ◽  
Kiyonobu Takatsuki
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Side Effects ◽  
Epidermal Growth Factor ◽  
Lung Adenocarcinoma ◽  
Xeroderma Pigmentosum ◽  
Growth Factor Receptor ◽  
Consanguineous Marriage ◽  
History Of ◽  
Epidermal Growth

Abstract Background Xeroderma pigmentosum is a rare, autosomal-recessive photosensitive dermatosis. Patients with xeroderma pigmentosum have an impaired ability to repair deoxyribonucleic acid damage caused by ultraviolet rays, resulting in skin cancer. Patients with xeroderma pigmentosum are more susceptible to some cancers. We herein report a case of xeroderma pigmentosum accompanied by lung cancer. Case presentation The patient was a Japanese woman in her 70s with a family history of consanguineous marriage. Her medical history included squamous cell carcinoma and basal cell carcinoma, in addition to xeroderma pigmentosum. She presented with dry skin with small, pigmented spots, which were particularly focused around the areas exposed to sunlight. Chest computed tomography was conducted to assess for any evidence of metastatic skin carcinoma, and revealed a tumor in the left upper subpleural lobe of the lung. Consequently, she was referred to our department. Finally, we diagnosed lung adenocarcinoma (pT2aN0M1b: stage IVA). She had an epidermal growth factor receptor (EGFR) mutation (p.L858R). Treatment with an epidermal growth factor receptor tyrosine kinase inhibitor (gefitinib) was initiated, and the tumor gradually regressed. No side effects were observed. However, she later died from aspiration pneumonia. Conclusions Although xeroderma pigmentosum is rare, a history of consanguineous marriage should be verified. Because of the severe side effects of cisplatin and radiotherapy in xeroderma pigmentosum patients, the risks and benefits of treatment should be considered thoroughly.

scholarly journals Chronic interstitial pneumonia with features of organizing pneumonia in an adult horse

2020 ◽  
Vol 32 (4) ◽  
pp. 621-625
Author(s):  
Miguel F. Carrillo ◽  
Deborah Kemper ◽  
Leslie W. Woods ◽  
Francisco R. Carvallo
Keyword(s):  
Connective Tissue ◽  
Interstitial Pneumonia ◽  
Bacterial Pneumonia ◽  
Organizing Pneumonia ◽  
Respiratory Problems ◽  
Nodular Pattern ◽  
Quarter Horse ◽  
History Of ◽  
Alveolar Septa ◽  
Formalin Fixed

A 22-y-old American Quarter Horse gelding was presented with a history of chronic progressive respiratory problems and a diffuse pulmonary nodular pattern in thoracic radiographs. The horse was euthanized, and 4 formalin-fixed samples of lung were submitted for histopathology. There were multifocal areas of marked thickening of alveolar septa as a result of proliferation of myofibroblasts embedded in fibromyxoid matrix (interpreted as “Masson bodies”), focal areas of fibrosis, and numerous papillary projections of connective tissue into bronchioles. A diagnosis of organizing pneumonia was reached. No etiology was found for this lesion. It is important to consider causes of chronic interstitial pneumonia with fibrosis in horses other than equid herpesvirus 5, such as complicated viral or bacterial pneumonia or chronic toxicoses.

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