scholarly journals Liposomal Tumor Targeting in Drug Delivery Utilizing MMP-2- and MMP-9-Binding Ligands

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Oula Penate Medina ◽  
Merja Haikola ◽  
Marja Tahtinen ◽  
Ilkka Simpura ◽  
Sami Kaukinen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Phage Display ◽  
Targeted Drug Delivery ◽  
Tumor Targeting ◽  
Treatment Options ◽  
Delivery Vehicle ◽  
High Affinity ◽  
Binding Peptides ◽  
Delivery Strategies ◽  
Targeted Drug

Nanotechnology offers an alternative to conventional treatment options by enabling different drug delivery and controlled-release delivery strategies. Liposomes being especially biodegradable and in most cases essentially nontoxic offer a versatile platform for several different delivery approaches that can potentially enhance the delivery and targeting of therapies to tumors. Liposomes penetrate tumors spontaneously as a result of fenestrated blood vessels within tumors, leading to known enhanced permeability and subsequent drug retention effects. In addition, liposomes can be used to carry radioactive moieties, such as radiotracers, which can be bound at multiple locations within liposomes, making them attractive carriers for molecular imaging applications. Phage display is a technique that can deliver various high-affinity and selectivity peptides to different targets. In this study, gelatinase-binding peptides, found by phage display, were attached to liposomes by covalent peptide-PEG-PE anchor creating a targeted drug delivery vehicle. Gelatinases as extracellular targets for tumor targeting offer a viable alternative for tumor targeting. Our findings show that targeted drug delivery is more efficient than non-targeted drug delivery.

Exosomes separated based on the “STOP” criteria for tumor-targeted drug delivery

2018 ◽  
Vol 6 (18) ◽  
pp. 2758-2768 ◽  
Author(s):  
Hongzhao Qi ◽  
Lijun Yang ◽  
Xueping Li ◽  
Qi Zhan ◽  
Donglin Han ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Clinical Translation ◽  
Delivery Vehicle ◽  
Drug Delivery Vehicle ◽  
Related Drug ◽  
Targeted Drug

A new exosome-related drug delivery vehicle was explored based on the “STOP” criteria, dramatically promoting the clinical translation of exosomes.

Rhein-PEG-nHA conjugate as a bone targeted drug delivery vehicle for enhanced cancer chemoradiotherapy

2020 ◽  
Vol 27 ◽  
pp. 102196
Author(s):  
Xiuying Yang ◽  
Dongliang Zhai ◽  
Jia Song ◽  
Rui Qing ◽  
Bochu Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Delivery Vehicle ◽  
Drug Delivery Vehicle ◽  
Targeted Drug

scholarly journals Emerging skin-targeted drug delivery strategies to engineer immunity: A focus on infectious diseases

2020 ◽  
pp. 1-17
Author(s):  
Emrullah Korkmaz ◽  
Stephen C. Balmert ◽  
Cara Donahue Carey ◽  
Geza Erdos ◽  
Louis D. Falo
Keyword(s):  
Drug Delivery ◽  
Infectious Diseases ◽  
Targeted Drug Delivery ◽  
Delivery Strategies ◽  
Targeted Drug

Redox stimuli-responsive hollow mesoporous silica nanocarriers for targeted drug delivery in cancer therapy

2016 ◽  
Vol 1 (6) ◽  
pp. 480-487 ◽  
Author(s):  
Ye Tian ◽  
Ranran Guo ◽  
Yunfeng Jiao ◽  
Yangfei Sun ◽  
Shun Shen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Targeted Drug Delivery ◽  
Tumor Targeting ◽  
Mesoporous Silica Nanoparticles ◽  
Stimuli Responsive ◽  
Disulfide Linkages ◽  
Targeting Delivery ◽  
Targeted Drug ◽  
Hollow Mesoporous Silica

Transferrin-capped hollow mesoporous silica nanoparticles through disulfide linkages realize tumor-targeting delivery and glutathione-induced drug release.

Diselenium-containing ultrathin polymer nanocapsules for highly efficient targeted drug delivery and combined anticancer effect

2019 ◽  
Vol 7 (32) ◽  
pp. 4927-4932 ◽  
Author(s):  
Shuang Fu ◽  
Fei Li ◽  
Mingsong Zang ◽  
Zherui Zhang ◽  
Yuancheng Ji ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Anticancer Effect ◽  
Delivery Vehicle ◽  
Drug Delivery Vehicle ◽  
Highly Efficient ◽  
Targeted Drug

A new highly efficient targeting drug delivery vehicle based on diselenium-containing ultrathin polymer nanocapsules was designed and prepared.

Biomimetic matrix mediated room temperature synthesis and characterization of nano-hydroxyapatite towards targeted drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (67) ◽  
pp. 62556-62571 ◽  
Author(s):  
Lubna Sheikh ◽  
Sucheta Tripathy ◽  
Suprabha Nayar
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Room Temperature ◽  
Nucleation And Growth ◽  
Hydroxyapatite Nanoparticles ◽  
Delivery Vehicle ◽  
Temperature Synthesis ◽  
Targeted Drug ◽  
Potent Drug

Nucleation and growth of hydroxyapatite nanoparticles in the presence of different matrices acting as a potent drug delivery vehicle.

scholarly journals Antituberculosis Targeted Drug Delivery as a Potential Future Treatment Approach

Antibiotics ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 908
Author(s):  
Mohd Khairul Nizam Mazlan ◽  
Mohammad Hafizie Dianel Mohd Tazizi ◽  
Rosliza Ahmad ◽  
Muhammad Amirul Asyraf Noh ◽  
Athirah Bakhtiar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mycobacterium Tuberculosis ◽  
Targeted Drug Delivery ◽  
Treatment Options ◽  
Extrapulmonary Tuberculosis ◽  
Inorganic Materials ◽  
Treatment Modalities ◽  
Antituberculosis Drugs ◽  
Passive Targeting ◽  
Targeted Drug

Mycobacterium tuberculosis (Mtb) is the microorganism that causes tuberculosis. This infectious disease has been around for centuries, with the earliest record of Mtb around three million years ago. The discovery of the antituberculosis agents in the 20th century has managed to improve the recovery rate and reduce the death rate tremendously. However, the conventional antituberculosis therapy is complicated by the development of resistant strains and adverse drug reactions experienced by the patients. Research has been conducted continuously to discover new, safe, and effective antituberculosis drugs. In the last 50 years, only two molecules were approved despite laborious work and costly research. The repurposing of drugs is also being done with few drugs; antibiotics, particularly, were found to have antituberculosis activity. Besides the discovery work, enhancing the delivery of currently available antituberculosis drugs is also being researched. Targeted drug delivery may be a potentially useful approach to be developed into clinically accepted treatment modalities. Active targeting utilizes a specifically designed targeting agent to deliver a chemically conjugated drug(s) towards Mtb. Passive targeting is very widely explored, with the development of multiple types of nanoparticles from organic and inorganic materials. The nanoparticles will be engulfed by macrophages and this will eliminate the Mtb that is present in the macrophages, or the encapsulated drug may be released at the sites of infections that may be in the form of intra- and extrapulmonary tuberculosis. This article provided an overview on the history of tuberculosis and the currently available treatment options, followed by discussions on the discovery of new antituberculosis drugs and active and passive targeting approaches against Mycobacterium tuberculosis.

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