scholarly journals Body Weight Control by a High-Carbohydrate/Low-Fat Diet Slows the Progression of Diabetic Kidney Damage in an Obese, Hypertensive, Type 2 Diabetic Rat Model

2010 ◽  
Vol 2010 ◽  
pp. 1-11 ◽  
Author(s):  
Shuichi Ohtomo ◽  
Yuko Izuhara ◽  
Masaomi Nangaku ◽  
Takashi Dan ◽  
Sadayoshi Ito ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Control ◽  
Advanced Glycation ◽  
Low Fat ◽  
High Carbohydrate ◽  
Low Fat Diet ◽  
Body Weight Control ◽  
And Oxidative Stress ◽  
Type 2 Diabetic

Obesity is one of several factors implicated in the genesis of diabetic nephropathy (DN). Obese, hypertensive, type 2 diabetic rats SHR/NDmcr-cp were given, for 12 weeks, either a normal, middle-carbohydrate/middle-fat diet (MC/MF group) or a high-carbohydrate/low-fat diet (HC/LF group). Daily caloric intake was the same in both groups. Nevertheless, the HC/LF group gained less weight. Despite equivalent degrees of hypertension, hyperglycemia, hyperlipidemia, hyperinsulinemia, and even a poorer glycemic control, the HC/LF group had less severe renal histological abnormalities and a reduced intrarenal advanced glycation and oxidative stress. Mediators of the renoprotection, specifically linked to obesity and body weight control, include a reduced renal inflammation and TGF-beta expression, together with an enhanced level of adiponectin. Altogether, these data identify a specific role of body weight control by a high-carbohydrate/low-fat diet in the progression of DN. Body weight control thus impacts on local intrarenal advanced glycation and oxidative stress through inflammation and adiponectin levels.

723-P: Effect of Low-Carbohydrate High-Fat vs. High-Carbohydrate Low-Fat Diet on HbA1c Control in Chinese Patients with Type 2 Diabetes

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 723-P
Author(s):  
LINGWANG AN ◽  
DANDAN WANG ◽  
XIAORONG SHI ◽  
CHENHUI LIU ◽  
KUEICHUN YEH ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Chinese Patients ◽  
High Fat ◽  
Low Fat ◽  
High Carbohydrate ◽  
Low Fat Diet ◽  
Low Carbohydrate ◽  
Hba1c Control

scholarly journals A Retrospective Database Study of Liraglutide Persistence Associated with Glycemic and Body Weight Control in Patients with Type 2 Diabetes

2019 ◽  
Vol 10 (2) ◽  
pp. 683-696
Author(s):  
Cheli Melzer-Cohen ◽  
Gabriel Chodick ◽  
Lise Lotte N. Husemoen ◽  
Nicolai Rhee ◽  
Varda Shalev ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Body Weight ◽  
Weight Control ◽  
Database Study ◽  
Body Weight Control ◽  
Retrospective Database

scholarly journals A High-Carbohydrate, High-Fiber, Low-Fat Diet Results in Weight Loss among Adults at High Risk of Type 2 Diabetes

2017 ◽  
pp. jn252395 ◽  
Author(s):  
Allison C Sylvetsky ◽  
Sharon L Edelstein ◽  
Geoffrey Walford ◽  
Edward J Boyko ◽  
Edward S Horton ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Weight Loss ◽  
High Risk ◽  
Low Fat ◽  
High Fiber ◽  
High Carbohydrate ◽  
Low Fat Diet

scholarly journals The Synthesis and Evaluation of RGD−Conjugated Chitosan Gel as Daily Supplement for Body Weight Control

Materials ◽  
2021 ◽  
Vol 14 (16) ◽  
pp. 4467
Author(s):  
Wei-Yao Chen ◽  
Yu-Ting Chen ◽  
Cherng-Jyh Ke ◽  
Ching-Yun Chen ◽  
Feng-Huei Lin
Keyword(s):  
Type 2 Diabetes ◽  
Body Weight ◽  
Chronic Diseases ◽  
Weight Control ◽  
Rgd Peptide ◽  
Health Food ◽  
Short Term ◽  
Body Weight Control

(1) Background: Obesity is one of the most widespread chronic diseases and increases the risk of several other chronic diseases, especially type 2 diabetes. (2) Methods: Endobarrier is a new medical device what is worn in the small intestines for the treatment of type 2 diabetes and obesity. However, given the invasive and other adverse effects of the Endobarrier, we propose the use of RGD peptide conjugated with chitosan (RC) as an alternative. (3) Results: The FTIR and NMR spectrum showed RGD peptide was successfully conjugated on chitosan and RGD−CT is retained in the small intestine even after digestion. In vitro of wst-1 and live and dead staining studies show that the RGD−CT gel is highly biocompatible and non-toxic. Rats treated with the RGD−CT gel for a short term showed significant decrease change more than 30% in body weight, while the blood and hematic biometrics were within normal values. (4) Conclusions: The RGD−CT gel is safe, suitable for the short-term, reducing visceral fat rate health food to control weight. In the future, it is expected to develop a safe, long-term effective, flexibility of use and low-side-effect anti-obesity therapy in the era of precision medicine by further modification.

scholarly journals A randomised-controlled trial of the effects of very low-carbohydrate and high-carbohydrate diets on cognitive performance in patients with type 2 diabetes

2016 ◽  
Vol 116 (10) ◽  
pp. 1745-1753 ◽  
Author(s):  
Jeannie Tay ◽  
Ian T. Zajac ◽  
Campbell H. Thompson ◽  
Natalie D. Luscombe-Marsh ◽  
Vanessa Danthiir ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Body Weight ◽  
Cognitive Function ◽  
Cognitive Performance ◽  
Perceptual Speed ◽  
Low Fat ◽  
Obese Adults ◽  
High Carbohydrate ◽  
Low Carbohydrate

AbstractThis study compared the longer-term effects of a very low-carbohydrate, high-fat diet with a high-carbohydrate, low-fat diet on cognitive performance in individuals with type 2 diabetes (T2D). In total, 115 obese adults with T2D (sixty-six males, BMI: 34·6 (sd 4·3) kg/m2, age: 58 (sd 7) years, HbA1c: 7·3 (sd 1·1) %, diabetes duration: 8 (sd 6) years) were randomised to consume either an energy-restricted, very low-carbohydrate, low-saturated-fat (LC) diet or an energy-matched high unrefined carbohydrate, low-fat (HC) diet with supervised aerobic/resistance exercise (60 min, 3 d/week) for 52 weeks. Body weight, HbA1c and cognitive performance assessing perceptual speed, reasoning speed, reasoning ability, working memory, verbal fluency, processing speed, short-term memory, inhibition and memory scanning speed were assessed before and after intervention. No differences in the changes in cognitive test performance scores between the diet groups were observed for any of the cognitive function outcomes assessed (P≥0·24 time×diet). Percentage reduction in body weight correlated with improvements with perceptual speed performance. In obese adults with T2D, both LC and HC weight-loss diets combined with exercise training had similar effects on cognitive performance. This suggests that an LC diet integrated within a lifestyle modification programme can be used as a strategy for weight and diabetes management without the concern of negatively affecting cognitive function.

Dietary Carbohydrate as an Ergogenic Aid for Prolonged and Brief Competitions in Sport

1995 ◽  
Vol 5 (s1) ◽  
pp. S13-S28 ◽  
Author(s):  
Janet Walberg-Rankin
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Weight Control ◽  
Moderate Intensity ◽  
Dietary Carbohydrate ◽  
High Quality ◽  
Quality Performance ◽  
High Carbohydrate ◽  
Carbohydrate Depletion ◽  
Body Weight Control

Reduction of body stores of carbohydrate and blood glucose is related to the perception of fatigue and the inability to maintain high-quality performance. This has been clearly shown with aerobic, endurance events of moderate intensity of over 90 min duration. Carbohydrate intake may also have relevance for athletes involved in short, high-intensity events, especially if body weight control is an issue. Prevention of carbohydrate depletion begins with a high-carbohydrate training diet of about 60-70% carbohydrate. If possible, carbohydrate beverages should be consumed during the event at the rate of 30-70 g/hr to reduce the chance of body carbohydrate depletion. Finally, replacement of body carbohydrate stores can be achieved most rapidly if 40-60 g of carbohydrate is consumed as soon as possible after the exercise and at repeating 1-hr intervals for at least 5 hr after the event.

scholarly journals Nuts, body weight and insulin resistance

2006 ◽  
Vol 96 (S2) ◽  
pp. S79-S86 ◽  
Author(s):  
Sujatha Rajaram ◽  
Joan Sabaté
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Insulin Sensitivity ◽  
Weight Control ◽  
High Energy ◽  
Sufficient Evidence ◽  
Free Living ◽  
Frequent Consumption ◽  
Body Weight Control

Traditionally, nuts have been considered a staple food, but because of their high energy and fat content are not considered good for body weight control or insulin sensitivity. Frequent consumption of nuts reduces the risk of coronary artery disease and type-2 diabetes and nut-enriched diets favourably alter blood lipids in normal and hypercholesterolemic individuals under controlled and free-living dietary conditions. However, whether or not frequent consumption of nuts can cause weight gain and impair insulin sensitivity is not fully understood. Review of the available data to date suggests that adding nuts to habitual diets of free-living individuals does not cause weight gain. In fact, nuts have a tendency to lower body weight and fat mass. In the context of calorie-restricted diets, adding nuts produces a more lasting and greater magnitude of weight loss among obese subjects while improving insulin sensitivity. Further studies are needed to clarify the effect of long-term (≥ year) consumption of nuts on body weight and their role in altering insulin sensitivity both in normal and type-2 diabetics. In the meantime, there is sufficient evidence to promote the inclusion of nuts as part of healthy diets.

scholarly journals Efficacy and Safety of Semaglutide in Glycemic Control and Body Weight Management Among Obese Type 2 Diabetes Patients Initiated or Switched to Semaglutide From Other GLP-1 Receptor Agonists

2021 ◽  
Author(s):  
Aki Okamoto ◽  
Hirohide Yokokawa ◽  
Tomoko Nagamine ◽  
Hiroshi Fukuda ◽  
Teruhiko Hisaoka ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Body Weight ◽  
Uric Acid ◽  
Serum Creatinine ◽  
Serum Uric Acid ◽  
Weight Control ◽  
Efficacy And Safety ◽  
Albumin Creatinine Ratio ◽  
Body Weight Control

Abstract Background: Evidence of the efficacy and safety of semaglutide among patients with type 2 diabetes who were initiated on or were switched to semaglutide from other GLP-1 RAs remains limited. The objective of this study was to investigate the short-term effects of switching to semaglutide from other GLP-1 RAs.Methods: This retrospective cohort study evaluated patients with type 2 diabetes who were initiated on or were switched to semaglutide due to poor diabetes control with other GLP-1 RAs or other medications, or obesity. HbA1c, body weight, serum creatinine, serum uric acid, parameters of lipid metabolism, and parameters of liver function were measured before and 6 months after administration of semaglutide.Results: A total of 50 patients were registered: 21 men and 29 women, aged 51.3 years. Mean body mass index was 32.2 kg/m2, and serum C-peptide was 2.7mg/mL. After switching to semaglutide (n=43), HbA1c and body weight significantly decreased from 6.72 % to 6.22 % and from 86.5 kg to 82.7 kg, respectively. The same findings were observed in semaglutide-naïve patients (n=7). Serum uric acid, total cholesterol, triglycerides, and urinary albumin-creatinine ratio decreased significantly as well, whereas serum creatinine did not change significantly. Conclusion: Semaglutide showed excellent efficacy, even in patients switched from other GLP-1 RAs. Semaglutide appears to be a promising agent for blood glucose and body weight control in obese type 2 diabetes mellitus patients and could be more potent in treating type 2 diabetes than existing GLP-1 RAs.

Persistence to Liraglutide Therapy Is Associated with Good Glycemic and Body Weight Control in Patients with Type 2 Diabetes

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 2295-PUB
Author(s):  
CHELI MELZER COHEN ◽  
GABRIEL CHODICK ◽  
LISE LOTTE N. HUSEMOEN ◽  
NICOLAI RHEE ◽  
VARDA SHALEV ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Body Weight ◽  
Weight Control ◽  
Body Weight Control
Sign in / Sign up

Export Citation Format

Share Document