scholarly journals Nuts, body weight and insulin resistance

2006 ◽  
Vol 96 (S2) ◽  
pp. S79-S86 ◽  
Author(s):  
Sujatha Rajaram ◽  
Joan Sabaté

Traditionally, nuts have been considered a staple food, but because of their high energy and fat content are not considered good for body weight control or insulin sensitivity. Frequent consumption of nuts reduces the risk of coronary artery disease and type-2 diabetes and nut-enriched diets favourably alter blood lipids in normal and hypercholesterolemic individuals under controlled and free-living dietary conditions. However, whether or not frequent consumption of nuts can cause weight gain and impair insulin sensitivity is not fully understood. Review of the available data to date suggests that adding nuts to habitual diets of free-living individuals does not cause weight gain. In fact, nuts have a tendency to lower body weight and fat mass. In the context of calorie-restricted diets, adding nuts produces a more lasting and greater magnitude of weight loss among obese subjects while improving insulin sensitivity. Further studies are needed to clarify the effect of long-term (≥ year) consumption of nuts on body weight and their role in altering insulin sensitivity both in normal and type-2 diabetics. In the meantime, there is sufficient evidence to promote the inclusion of nuts as part of healthy diets.

2010 ◽  
Vol 2010 ◽  
pp. 1-11 ◽  
Author(s):  
Shuichi Ohtomo ◽  
Yuko Izuhara ◽  
Masaomi Nangaku ◽  
Takashi Dan ◽  
Sadayoshi Ito ◽  
...  

Obesity is one of several factors implicated in the genesis of diabetic nephropathy (DN). Obese, hypertensive, type 2 diabetic rats SHR/NDmcr-cp were given, for 12 weeks, either a normal, middle-carbohydrate/middle-fat diet (MC/MF group) or a high-carbohydrate/low-fat diet (HC/LF group). Daily caloric intake was the same in both groups. Nevertheless, the HC/LF group gained less weight. Despite equivalent degrees of hypertension, hyperglycemia, hyperlipidemia, hyperinsulinemia, and even a poorer glycemic control, the HC/LF group had less severe renal histological abnormalities and a reduced intrarenal advanced glycation and oxidative stress. Mediators of the renoprotection, specifically linked to obesity and body weight control, include a reduced renal inflammation and TGF-beta expression, together with an enhanced level of adiponectin. Altogether, these data identify a specific role of body weight control by a high-carbohydrate/low-fat diet in the progression of DN. Body weight control thus impacts on local intrarenal advanced glycation and oxidative stress through inflammation and adiponectin levels.


2019 ◽  
Vol 10 (2) ◽  
pp. 683-696
Author(s):  
Cheli Melzer-Cohen ◽  
Gabriel Chodick ◽  
Lise Lotte N. Husemoen ◽  
Nicolai Rhee ◽  
Varda Shalev ◽  
...  

Diabetes Care ◽  
2006 ◽  
Vol 29 (8) ◽  
pp. 1826-1832 ◽  
Author(s):  
J. Martin ◽  
Z. Q. Wang ◽  
X. H. Zhang ◽  
D. Wachtel ◽  
J. Volaufova ◽  
...  

Metabolism ◽  
2005 ◽  
Vol 54 (11) ◽  
pp. 1480-1489 ◽  
Author(s):  
Moon K. Song ◽  
Mark J. Rosenthal ◽  
Albert M. Song ◽  
Hong Yang ◽  
Yan Ao ◽  
...  

Materials ◽  
2021 ◽  
Vol 14 (16) ◽  
pp. 4467
Author(s):  
Wei-Yao Chen ◽  
Yu-Ting Chen ◽  
Cherng-Jyh Ke ◽  
Ching-Yun Chen ◽  
Feng-Huei Lin

(1) Background: Obesity is one of the most widespread chronic diseases and increases the risk of several other chronic diseases, especially type 2 diabetes. (2) Methods: Endobarrier is a new medical device what is worn in the small intestines for the treatment of type 2 diabetes and obesity. However, given the invasive and other adverse effects of the Endobarrier, we propose the use of RGD peptide conjugated with chitosan (RC) as an alternative. (3) Results: The FTIR and NMR spectrum showed RGD peptide was successfully conjugated on chitosan and RGD−CT is retained in the small intestine even after digestion. In vitro of wst-1 and live and dead staining studies show that the RGD−CT gel is highly biocompatible and non-toxic. Rats treated with the RGD−CT gel for a short term showed significant decrease change more than 30% in body weight, while the blood and hematic biometrics were within normal values. (4) Conclusions: The RGD−CT gel is safe, suitable for the short-term, reducing visceral fat rate health food to control weight. In the future, it is expected to develop a safe, long-term effective, flexibility of use and low-side-effect anti-obesity therapy in the era of precision medicine by further modification.


2021 ◽  
Author(s):  
Aki Okamoto ◽  
Hirohide Yokokawa ◽  
Tomoko Nagamine ◽  
Hiroshi Fukuda ◽  
Teruhiko Hisaoka ◽  
...  

Abstract Background: Evidence of the efficacy and safety of semaglutide among patients with type 2 diabetes who were initiated on or were switched to semaglutide from other GLP-1 RAs remains limited. The objective of this study was to investigate the short-term effects of switching to semaglutide from other GLP-1 RAs.Methods: This retrospective cohort study evaluated patients with type 2 diabetes who were initiated on or were switched to semaglutide due to poor diabetes control with other GLP-1 RAs or other medications, or obesity. HbA1c, body weight, serum creatinine, serum uric acid, parameters of lipid metabolism, and parameters of liver function were measured before and 6 months after administration of semaglutide.Results: A total of 50 patients were registered: 21 men and 29 women, aged 51.3 years. Mean body mass index was 32.2 kg/m2, and serum C-peptide was 2.7mg/mL. After switching to semaglutide (n=43), HbA1c and body weight significantly decreased from 6.72 % to 6.22 % and from 86.5 kg to 82.7 kg, respectively. The same findings were observed in semaglutide-naïve patients (n=7). Serum uric acid, total cholesterol, triglycerides, and urinary albumin-creatinine ratio decreased significantly as well, whereas serum creatinine did not change significantly. Conclusion: Semaglutide showed excellent efficacy, even in patients switched from other GLP-1 RAs. Semaglutide appears to be a promising agent for blood glucose and body weight control in obese type 2 diabetes mellitus patients and could be more potent in treating type 2 diabetes than existing GLP-1 RAs.


2005 ◽  
Vol 289 (2) ◽  
pp. E212-E217 ◽  
Author(s):  
Ling-Ling Tsai ◽  
Yu-Che Tsai ◽  
Kai Hwang ◽  
Yu-Wen Huang ◽  
Jeh-En Tzeng

This study is aimed at verifying the causal relationship of chronic circadian desynchronization and changes in body weight control. Eight male albino F344 rats aged between 12–15 wk were subjected to twice weekly 12-h shifts of the daily light-dark (LD) cycle for 13 wk (3 mo). Continuous circadian phase shifts consisting of intermittent phase delay and advance and reduced circadian amplitudes were consistently displayed in all five experimental rats implanted intraperitoneally with heart rate, body temperature, and activity transponders. The experimental rat maintained a greater body weight during LD shifts and even after 10 days of recovery than that of the age-matched control rat, which was maintained on a regular LD cycle. Body weight gain was greater in the first 2 mo of LD shifts in the experimental rat than in the control rat. Relative to the baseline, food intake and activity percentages were increased and reduced, respectively, for the experimental rats. Features of these results, such as increased body weight gain and food intake, and reduced activity, suggest a causal relationship of chronic circadian desynchronization and changes in body weight control in male albino F344 rats.


2019 ◽  
Vol 44 (5) ◽  
pp. 528-532
Author(s):  
Kimi Sawada ◽  
Yukari Takemi ◽  
Nobuko Murayama ◽  
Hiromi Ishida

Increasing obesity rates have driven research into dietary support for body weight control, but previous studies have only assessed changes in body weight of ±3 kg. We investigated the relationships between white or brown/multi-grain rice consumption and 1-year body weight gain ≥3 kg in Japanese factory workers (n = 437). Routine medical check-up data from a 1-year nutrition and lifestyle cohort study were analysed. Participants were divided into white rice and brown/multi-grain rice consumption groups and further classified by tertile of rice consumption. Multiple logistic regression analyses were performed by tertile. At 1 year, high white rice consumption was significantly associated with increased risk of body weight gain ≥3 kg compared with low white rice consumption, maintained after adjustment for age, sex, and consumption of other obesogenic foods (p = 0.034). In the brown/multi-grain rice consumption group, however, there was no significant difference in risk between high and low consumption, even after multi-variate adjustment (p = 0.387). The consumption of white rice, but not brown rice/multi-grain rice, was positively correlated with the risk of a 1-year body weight gain of 3 kg or more. This suggests that brown rice/multi-grain rice consumption is useful for body weight control among Japanese workers.


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