scholarly journals Antibody-Conjugated Nanoparticles for Biomedical Applications

2009 ◽  
Vol 2009 ◽  
pp. 1-24 ◽  
Author(s):  
Manuel Arruebo ◽  
Mónica Valladares ◽  
África González-Fernández
Keyword(s):  
Immune System ◽  
Physicochemical Properties ◽  
Thermal Imaging ◽  
Biomedical Applications ◽  
Drug Carrier ◽  
Diagnostic Procedures ◽  
Selective Recognition ◽  
Magnetic Characteristics ◽  
Recent Developments ◽  
Hybrid Product

Nanoscience and Nanotechnology have found their way into the fields of Biotechnology and Medicine. Nanoparticles by themselves offer specific physicochemical properties that they do not exhibit in bulk form, where materials show constant physical properties regardless of size. Antibodies are nanosize biological products that are part of the specific immune system. In addition to their own properties as pathogens or toxin neutralizers, as well as in the recruitment of immune elements (complement, improving phagocytosis, cytotoxicity antibody dependent by natural killer cells, etc.), they could carry several elements (toxins, drugs, fluorochroms, or even nanoparticles, etc.) and be used in several diagnostic procedures, or even in therapy to destroy a specific target. The conjugation of antibodies to nanoparticles can generate a product that combines the properties of both. For example, they can combine the small size of nanoparticles and their special thermal, imaging, drug carrier, or magnetic characteristics with the abilities of antibodies, such as specific and selective recognition. The hybrid product will show versatility and specificity. In this review, we analyse both antibodies and nanoparticles, focusing especially on the recent developments for antibody-conjugated nanoparticles, offering the researcher an overview of the different applications and possibilities of these hybrid carriers.

scholarly journals Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Huan Cao ◽  
Lixia Duan ◽  
Yan Zhang ◽  
Jun Cao ◽  
Kun Zhang
Keyword(s):  
Physicochemical Properties ◽  
Cell Biology ◽  
Biomedical Applications ◽  
Biomedical Application ◽  
Drug Carrier ◽  
Biological Response ◽  
Hydrogel Matrix ◽  
Underlying Mechanisms

AbstractHydrogel is a type of versatile platform with various biomedical applications after rational structure and functional design that leverages on material engineering to modulate its physicochemical properties (e.g., stiffness, pore size, viscoelasticity, microarchitecture, degradability, ligand presentation, stimulus-responsive properties, etc.) and influence cell signaling cascades and fate. In the past few decades, a plethora of pioneering studies have been implemented to explore the cell–hydrogel matrix interactions and figure out the underlying mechanisms, paving the way to the lab-to-clinic translation of hydrogel-based therapies. In this review, we first introduced the physicochemical properties of hydrogels and their fabrication approaches concisely. Subsequently, the comprehensive description and deep discussion were elucidated, wherein the influences of different hydrogels properties on cell behaviors and cellular signaling events were highlighted. These behaviors or events included integrin clustering, focal adhesion (FA) complex accumulation and activation, cytoskeleton rearrangement, protein cyto-nuclei shuttling and activation (e.g., Yes-associated protein (YAP), catenin, etc.), cellular compartment reorganization, gene expression, and further cell biology modulation (e.g., spreading, migration, proliferation, lineage commitment, etc.). Based on them, current in vitro and in vivo hydrogel applications that mainly covered diseases models, various cell delivery protocols for tissue regeneration and disease therapy, smart drug carrier, bioimaging, biosensor, and conductive wearable/implantable biodevices, etc. were further summarized and discussed. More significantly, the clinical translation potential and trials of hydrogels were presented, accompanied with which the remaining challenges and future perspectives in this field were emphasized. Collectively, the comprehensive and deep insights in this review will shed light on the design principles of new biomedical hydrogels to understand and modulate cellular processes, which are available for providing significant indications for future hydrogel design and serving for a broad range of biomedical applications.

The role of morphology, shell composition and protein corona formation in Au/Fe3O4 composite nanoparticle mediated macrophage responses

2021 ◽  
Author(s):  
Lihua He ◽  
Kang Ma ◽  
Xiaonan Liu ◽  
Huixia Li ◽  
Lei Zhang ◽  
...  
Keyword(s):  
Immune System ◽  
Physicochemical Properties ◽  
Biomedical Applications ◽  
Protein Corona ◽  
System P ◽  
Corona Formation ◽  
Composite Nanoparticle ◽  
Shell Composition

The great interest in using nanoparticles (NPs) for biomedical applications is transversal to various materials despite the poorly understood correlation between their physicochemical properties and effects on the immune system....

scholarly journals Stereocomplex Polylactide for Drug Delivery and Biomedical Applications: A Review

Molecules ◽  
2021 ◽  
Vol 26 (10) ◽  
pp. 2846
Author(s):  
Seung Hyuk Im ◽  
Dam Hyeok Im ◽  
Su Jeong Park ◽  
Justin Jihong Chung ◽  
Youngmee Jung ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Self Assembly ◽  
Biomedical Applications ◽  
Drug Carrier ◽  
Micelle Formation ◽  
Weak Stability ◽  
Critical Fields ◽  
Physical Strength ◽  
Anti Cancer

Polylactide (PLA) is among the most common biodegradable polymers, with applications in various fields, such as renewable and biomedical industries. PLA features poly(D-lactic acid) (PDLA) and poly(L-lactic acid) (PLLA) enantiomers, which form stereocomplex crystals through racemic blending. PLA emerged as a promising material owing to its sustainable, eco-friendly, and fully biodegradable properties. Nevertheless, PLA still has a low applicability for drug delivery as a carrier and scaffold. Stereocomplex PLA (sc-PLA) exhibits substantially improved mechanical and physical strength compared to the homopolymer, overcoming these limitations. Recently, numerous studies have reported the use of sc-PLA as a drug carrier through encapsulation of various drugs, proteins, and secondary molecules by various processes including micelle formation, self-assembly, emulsion, and inkjet printing. However, concerns such as low loading capacity, weak stability of hydrophilic contents, and non-sustainable release behavior remain. This review focuses on various strategies to overcome the current challenges of sc-PLA in drug delivery systems and biomedical applications in three critical fields, namely anti-cancer therapy, tissue engineering, and anti-microbial activity. Furthermore, the excellent potential of sc-PLA as a next-generation polymeric material is discussed.

scholarly journals Recent Advances in Zwitterionic Hydrogels: Preparation, Property, and Biomedical Application

Gels ◽  
2022 ◽  
Vol 8 (1) ◽  
pp. 46
Author(s):  
Sihang Liu ◽  
Jingyi Tang ◽  
Fangqin Ji ◽  
Weifeng Lin ◽  
Shengfu Chen
Keyword(s):  
Immune System ◽  
Polyethylene Glycol ◽  
Biomedical Applications ◽  
Biomedical Application ◽  
Synthetic Polymers ◽  
Human Environment ◽  
The Past ◽  
Recent Advances ◽  
Nonspecific Protein Adsorption ◽  
Anionic Groups

Nonspecific protein adsorption impedes the sustainability of materials in biologically related applications. Such adsorption activates the immune system by quick identification of allogeneic materials and triggers a rejection, resulting in the rapid failure of implant materials and drugs. Antifouling materials have been rapidly developed in the past 20 years, from natural polysaccharides (such as dextran) to synthetic polymers (such as polyethylene glycol, PEG). However, recent studies have shown that traditional antifouling materials, including PEG, still fail to overcome the challenges of a complex human environment. Zwitterionic materials are a class of materials that contain both cationic and anionic groups, with their overall charge being neutral. Compared with PEG materials, zwitterionic materials have much stronger hydration, which is considered the most important factor for antifouling. Among zwitterionic materials, zwitterionic hydrogels have excellent structural stability and controllable regulation capabilities for various biomedical scenarios. Here, we first describe the mechanism and structure of zwitterionic materials. Following the preparation and property of zwitterionic hydrogels, recent advances in zwitterionic hydrogels in various biomedical applications are reviewed.

scholarly journals Green Synthesis of Magnetic Iron Oxide Nanoparticle for Antibacterial Activity: A Review

2021 ◽  
Vol 64 (2) ◽  
pp. 202-210
Author(s):  
Muhammad Isa Khan ◽  
Aliza Zahoor ◽  
Tahir Iqbal ◽  
Abdul Majid ◽  
Mohsin Ijaz
Keyword(s):  
Iron Oxide ◽  
Green Synthesis ◽  
Biomedical Applications ◽  
Synthesis Method ◽  
Antibacterial Activities ◽  
Magnetic Characteristics ◽  
Iron Oxide Nanoparticle ◽  
The Past ◽  
Wide Range ◽  
Oxide Nanoparticle

  Recently, different researchers find nanoparticles as an auspicious alternative to antibacterial agents due to their antibacterial behaviour. This antibacterial behaviour contributes in many biomedical applications including; tissue engineering, drug and gene delivery and, imaging. Furthermore, iron oxide nanoparticle gains much importance due to their magnetic characteristics and wide range of application. Iron oxide nanoparticle (IONPs) have exhibits great potential against bacteria. During the past decade, various routes were developed to synthesize iron oxide nanoparticle with suitable size and composition. This article reviews the recent iron oxide nanoparticle obtained by green synthesis with a focus on their response to antibacterial activities. The iron nanoparticles synthesized by green synthesis method has accumulated a vital attention over the last couple of years due to their unique characteristic as it makes sure environmental friendly, nontoxic and safe reagents.

Therapeutic applications of selenium-derived compounds

2018 ◽  
Vol 38 (2) ◽  
pp. 49-76 ◽  
Author(s):  
Amna Kamal ◽  
Muhammad Adnan Iqbal ◽  
Haq Nawaz Bhatti
Keyword(s):  
Human Body ◽  
Biomedical Applications ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Biochemical Reactions ◽  
Therapeutic Applications ◽  
Minimal Toxicity ◽  
Structure Activity ◽  
Recent Developments

AbstractSelenium is a biocompatible element and participates in several biochemical reactions occurring in the human body. Its biocompatibility and minimal toxicity has attracted researchers to develop selenium-based drugs. Hence, recent developments on biomedical applications of selenium-based compounds have been discussed. A structure activity relationship has also been interpreted.

Physicochemical properties of chitosan–magnetite nanocomposites obtained with different pH

2021 ◽  
pp. 096739112110384
Author(s):  
Christian Chapa González ◽  
Javier Ulises Navarro Arriaga ◽  
Perla Elvia García Casillas
Keyword(s):  
Zeta Potential ◽  
Physicochemical Properties ◽  
Biomedical Applications ◽  
Spherical Shape ◽  
Polymeric Coating ◽  
X Ray Diffraction ◽  
X Ray ◽  
Coated Nanoparticles ◽  
Nanoparticle Surface ◽  
Magnetite Phase

The physicochemical properties of the nanoparticle surface determine the performance of nanocomposites in biomedical applications such as their biodistribution and pharmacokinetics. The physicochemical properties of chitosan, such as apparent charge density and solubility, are pH dependent. Similarly, Fe3O4 nanoparticles are susceptible to variations in their physicochemical properties due to changes in pH. In this work, we evaluated the physicochemical properties of chitosan–magnetite nanocomposites that were suspended at pH 7.0, 9.0, and 11.0 to determinate the effect on particle size, zeta potential, and mass percentage of the polymeric coating, in addition to the crystalline phase and magnetic properties of magnetite phase. X-ray diffraction results exposed that the present phase was magnetite with no other phases present and that the crystallite size was between 10.8 and 14.1 nm. Fourier transform infrared verified the chitosan functional groups in treated samples while the percentage of mass determined by TGA found to be nearly 9%. Scanning electron microscopy micrographs corroborated the spherical shape of the bare and chitosan-coated nanoparticles. Dynamic light scattering results showed that chitosan coating modifies the zeta potential, going from a potential of −11.8 mV for bare particles to −3.0 mV (pH 11). Besides, vibrating sample magnetometer measurements showed that coercivity remained very low, which is desirable in biomedical applications.

Recent advancements in lignin valorization and biomedical applications: A patent review

2021 ◽  
Vol 15 ◽  
Author(s):  
Vandana Prasad ◽  
Lubna Siddiqui ◽  
Pawan Kumar Mishra ◽  
Adam Ekielski ◽  
Sushama Talegaonkar
Keyword(s):  
Biomedical Applications ◽  
Drug Carrier ◽  
Industrial Applications ◽  
Future Research ◽  
Lignin Valorization ◽  
New Methods ◽  
Cleaning Agents ◽  
Patent Review ◽  
Commercial Applications ◽  
Made In

Background: Synthetic polymers present disadvantages such as high cost, limited availability, safety concerns, environmental hazards and overtime accumulation in body. Lignin, an aromatic biopolymer, is highly abundant and offers various advantages including cost effectiveness, biocompatibility and biodegradability. It also possesses various pharmacological activities including antioxidant, antibacterial, anticancer and UV protection, thus lignin has become a popular biopolymer in recent years and is no more considered as bio-waste rather an extensive research is been carried out on developing it as drug carrier. Lignin also has non-biomedical applications including dispersing agents, surfactants, detergent/cleaning agents, energy storage, etc. Methods: This review compiles patents granted on production of technical lignin, different lignin therapeutic carriers and its biomedical and non-biomedical applications. The literature is collected from recent years including both articles as well as patents and is carefully analyzed and compiled in an easy to comprehend pattern for guiding future research. Results: The reviewed patents and articles highlighted the advancement made in lignin isolation and valorization. Numerous lignin nanoformulations as drug delivery agents or as standalone entities with various pharmacological actions like antibacterial, antioxidant or UV protectant have been reported. As well as industrial applications of lignin as adhesives, insulators or supercapacitors have also made lignin a biopolymer of choice. Conclusion: Lignin being a bio-inspired polymer has huge potential in commercial applications. New methods of lignin isolation from lignocellulosic biomass including physical pretreatments, solvent fraction, and chemical and biological pretreatment have been widely patented. Several micro/nano lignin formulations with improved and controllable reactivity like nanocontainers, nanocapsules, nanoparticles have also been reported recently. Also various pharmacological properties of lignin have also been explored, thus valorization of lignin is a hot topic of hour.

Recent Advances in the Development of Magnetic Nanoparticles for Biomedical Applications

2021 ◽  
Vol 21 (5) ◽  
pp. 2705-2741
Author(s):  
Maria Monteserín ◽  
Silvia Larumbe ◽  
Alejandro V. Martínez ◽  
Saioa Burgui ◽  
L. Francisco Martín
Keyword(s):  
Magnetic Nanoparticles ◽  
Physicochemical Properties ◽  
Biomedical Applications ◽  
High Surface ◽  
High Surface Area ◽  
Synthetic Methods ◽  
Magnetic Drug Targeting ◽  
Surface Area Ratio ◽  
Biomedical Field

The unique properties of magnetic nanoparticles have led them to be considered materials with significant potential in the biomedical field. Nanometric size, high surface-area ratio, ability to function at molecular level, exceptional magnetic and physicochemical properties, and more importantly, the relatively easy tailoring of all these properties to the specific requirements of the different biomedical applications, are some of the key factors of their success. In this paper, we will provide an overview of the state of the art of different aspects of magnetic nanoparticles, specially focusing on their use in biomedicine. We will explore their magnetic properties, synthetic methods and surface modifications, as well as their most significative physicochemical properties and their impact on the in vivo behaviour of these particles. Furthermore, we will provide a background on different applications of magnetic nanoparticles in biomedicine, such as magnetic drug targeting, magnetic hyperthermia, imaging contrast agents or theranostics. Besides, current limitations and challenges of these materials, as well as their future prospects in the biomedical field will be discussed.

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