The role of morphology, shell composition and protein corona formation in Au/Fe3O4 composite nanoparticle mediated macrophage responses

2021 ◽  
Author(s):  
Lihua He ◽  
Kang Ma ◽  
Xiaonan Liu ◽  
Huixia Li ◽  
Lei Zhang ◽  
...  
Keyword(s):  
Immune System ◽  
Physicochemical Properties ◽  
Biomedical Applications ◽  
Protein Corona ◽  
System P ◽  
Corona Formation ◽  
Composite Nanoparticle ◽  
Shell Composition

The great interest in using nanoparticles (NPs) for biomedical applications is transversal to various materials despite the poorly understood correlation between their physicochemical properties and effects on the immune system....

scholarly journals Nanomaterials and Annelid Immunity: A Comparative Survey to Reveal the Common Stress and Defense Responses of Two Sentinel Species to Nanomaterials in the Environment

Biology ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 307 ◽  
Author(s):  
Kornélia Bodó ◽  
Nicoló Baranzini ◽  
Rossana Girardello ◽  
Bohdana Kokhanyuk ◽  
Péter Németh ◽  
...  
Keyword(s):  
Protein Corona ◽  
Defense Responses ◽  
Freshwater Ecosystems ◽  
Special Focus ◽  
Early Stress ◽  
Corona Formation ◽  
Evolutionarily Conserved ◽  
Stress Signal ◽  
The Common

Earthworms and leeches are sentinel animals that represent the annelid phylum within terrestrial and freshwater ecosystems, respectively. One early stress signal in these organisms is related to innate immunity, but how nanomaterials affect it is poorly characterized. In this survey, we compare the latest literature on earthworm and leeches with examples of their molecular/cellular responses to inorganic (silver nanoparticles) and organic (carbon nanotubes) nanomaterials. A special focus is placed on the role of annelid immunocytes in the evolutionarily conserved antioxidant and immune mechanisms and protein corona formation and probable endocytosis pathways involved in nanomaterial uptake. Our summary helps to realize why these environmental sentinels are beneficial to study the potential detrimental effects of nanomaterials.

scholarly journals Hemocompatibility of Carbon Nanostructures

2020 ◽  
Vol 6 (1) ◽  
pp. 12 ◽  
Author(s):  
Mariangela Fedel
Keyword(s):  
Carbon Nanostructures ◽  
Biomedical Applications ◽  
Size Structure ◽  
Blood Compatibility ◽  
Protein Corona ◽  
Blood Components ◽  
Critical Aspect ◽  
Improved Performance ◽  
New Generation

Carbon nanostructures (CNs), such as carbon nanotubes, fullerenes, carbon dots, nanodiamonds as well as graphene and its derivatives present a tremendous potential for various biomedical applications, ranging from sensing to drug delivery and gene therapy, biomedical imaging and tissue engineering. Since most of these applications encompass blood contact or intravenous injection, hemocompatibility is a critical aspect that must be carefully considered to take advantage of CN exceptional characteristics while allowing their safe use. This review discusses the hemocompatibility of different classes of CNs with the purpose of providing biomaterial scientists with a comprehensive vision of the interactions between CNs and blood components. The various complex mechanisms involved in blood compatibility, including coagulation, hemolysis, as well as the activation of complement, platelets, and leukocytes will be considered. Special attention will be paid to the role of CN size, structure, and surface properties in the formation of the protein corona and in the processes that drive blood response. The aim of this review is to emphasize the importance of hemocompatibility for CNs intended for biomedical applications and to provide some valuable insights for the development of new generation particles with improved performance and safety in the physiological environment.

scholarly journals Machine learning provides predictive analysis into silver nanoparticle protein corona formation from physicochemical properties

2018 ◽  
Vol 5 (1) ◽  
pp. 64-71 ◽  
Author(s):  
Matthew R. Findlay ◽  
Daniel N. Freitas ◽  
Maryam Mobed-Miremadi ◽  
Korin E. Wheeler
Keyword(s):  
Machine Learning ◽  
Surface Chemistry ◽  
Physicochemical Properties ◽  
Silver Nanoparticle ◽  
Protein Corona ◽  
Engineered Nanomaterials ◽  
Predictive Analysis ◽  
Environmental Systems ◽  
Corona Formation ◽  
P Proteins

Proteins encountered in biological and environmental systems bind to engineered nanomaterials (ENMs) to form a protein corona (PC) that alters the surface chemistry, reactivity, and fate of the ENMs.

scholarly journals Protein Corona Hinders N-CQDs Oxidative Potential and Favors Their Application as Nanobiocatalytic System

2021 ◽  
Vol 22 (15) ◽  
pp. 8136
Author(s):  
Joanna Czarnecka ◽  
Mateusz Kwiatkowski ◽  
Marek Wiśniewski ◽  
Katarzyna Roszek
Keyword(s):  
Biomedical Applications ◽  
Catalytic Efficiency ◽  
Protein Corona ◽  
Immobilized Enzymes ◽  
Oxidative Capacity ◽  
Carbon Quantum Dots ◽  
Oxidative Potential ◽  
Corona Formation ◽  
High Concentrations ◽  
Enzyme Application

The oxidative properties of nanomaterials arouse legitimate concerns about oxidative damage in biological systems. On the other hand, the undisputable benefits of nanomaterials promote them for biomedical applications; thus, the strategies to reduce oxidative potential are urgently needed. We aimed at analysis of nitrogen-containing carbon quantum dots (N-CQDs) in terms of their biocompatibility and internalization by different cells. Surprisingly, N-CQD uptake does not contribute to the increased oxidative stress inside cells and lacks cytotoxic influence even at high concentrations, primarily through protein corona formation. We proved experimentally that the protein coating effectively limits the oxidative capacity of N-CQDs. Thus, N-CQDs served as an immobilization support for three different enzymes with the potential to be used as therapeutics. Various kinetic parameters of immobilized enzymes were analyzed. Regardless of the enzyme structure and type of reaction catalyzed, adsorption on the nanocarrier resulted in increased catalytic efficiency. The enzymatic-protein-to-nanomaterial ratio is the pivotal factor determining the course of kinetic parameter changes that can be tailored for enzyme application. We conclude that the above properties of N-CQDs make them an ideal support for enzymatic drugs required for multiple biomedical applications, including personalized medical therapies.

Promising insights into the kosmotropic effect of magnetic nanoparticles on proteins: The pivotal role of protein corona formation

2020 ◽  
Vol 36 (6) ◽  
Author(s):  
Reza Fattah ◽  
Hamid Rashedi ◽  
Fatemeh Yazdian ◽  
Seyed Babak Mousavi ◽  
Ahmad Fazeli
Keyword(s):  
Magnetic Nanoparticles ◽  
Protein Corona ◽  
Pivotal Role ◽  
Corona Formation

scholarly journals Functionalized branched polymers: promising immunomodulatory tools for the treatment of cancer and immune disorders

2019 ◽  
Vol 6 (10) ◽  
pp. 1956-1973 ◽  
Author(s):  
Liane I. F. Moura ◽  
Alessio Malfanti ◽  
Carina Peres ◽  
Ana I. Matos ◽  
Elise Guegain ◽  
...  
Keyword(s):  
Immune System ◽  
Infectious Diseases ◽  
Physicochemical Properties ◽  
Delivery Systems ◽  
Branched Polymers ◽  
Immune Disorders ◽  
System P ◽  
Immunomodulatory Properties

The review focus on branched polymers as promising delivery systems with immunomodulatory properties against cancer and infectious diseases. It covers their physicochemical properties and on how those can be tailored to modulate the immune system.

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