scholarly journals Herpes Zoster and Postherpetic Neuralgia: Past, Present and Future

2009 ◽  
Vol 14 (4) ◽  
pp. 275-282 ◽  
Author(s):  
Gary J Bennett ◽  
C Peter N Watson
Keyword(s):  
Herpes Zoster ◽  
Varicella Zoster Virus ◽  
Recent Work ◽  
Postherpetic Neuralgia ◽  
Current Understanding ◽  
Varicella Zoster

OBJECTIVES: The history behind the current understanding of the varicella-zoster virus and its relationship to the pain conditions caused by shingles and postherpetic neuralgia are reviewed. The framework for the current conceptualization is Hope-Simpson’s latency hypothesis. Data from recent work in virology, neuroanatomy and epidemiology are reviewed, as is work using varicella-zoster virus-infected animals. The recent data largely confirm Hope-Simpson’s hypothesis and extend it significantly.

scholarly journals Kestabilan Model Matematika Infeksi Primer Penyakit Varicella Dan Infeksi Rekuren Penyakit Herpes Zoster Oleh Virus Varicella Zoster

2020 ◽  
Vol 17 (1) ◽  
pp. 82-91
Author(s):  
Hardiyanti ◽  
R Ratianingsih ◽  
Hajar
Keyword(s):  
Herpes Zoster ◽  
Stability Analysis ◽  
Varicella Zoster Virus ◽  
Critical Point ◽  
Postherpetic Neuralgia ◽  
Primary Infection ◽  
Skin Diseases ◽  
Varicella Zoster ◽  
Stable Conditions ◽  
Disease Free

Varicella and herpes zoster are two infectious skin diseases of human that caused by varicella zoster virus, where varicella disease is a primary infection that often infected younger people while herpes zoster disease is a recurrent disease that often infected older people because of reactivation of latent varicella-zoster virus. If the pain caused by herpes zoster after recurrent phase is a appeared then the condition is known as postherpetic neuralgia. This study builds a mathematical model of primary infection (varicella disease) and recurrent infection (herpes zoster disease) developed from the SIR model (Susceptible, Infected, Recovered). The human population is divided into seven subpopulations, namely susceptible, infection, recovered of varicella, herpes zoster and postherpetic neuralgia subpopulation. Stability analysis at the critical point by linearization method gives a critical point 𝑇1 that guaranted to exist and unstable if 𝛼 𝜇(𝛽1+𝜇) 𝐴 , while the critical point 𝑇1 does not have any reqruitment. Stability analysis at the endemic disease-free critical point is represented 𝑇1 that will be unstable if 𝑇2 exist and stable 𝑇1 if 𝑇2 exist. Numerical simulations by simulated to describe such temporary disease-free conditions and an endemic stable conditions.

Chronic Chest Wall Pain in Postherpetic Neuralgia

2018 ◽  
Author(s):  
Kenneth D. Candido ◽  
Teresa M. Kusper ◽  
Nebojsa Nick Knezevic
Keyword(s):  
Neuropathic Pain ◽  
Herpes Zoster ◽  
Varicella Zoster Virus ◽  
Chest Wall ◽  
Postherpetic Neuralgia ◽  
Early Treatment ◽  
Chemical Compounds ◽  
Skin Lesions ◽  
Varicella Zoster ◽  
Sensory Disturbances

Postherpetic neuralgia (PHN) is a debilitating condition that frequently arises after herpes zoster (HZ) caused by the varicella-zoster virus. It is characterized by severe neuropathic pain and sensory disturbances persisting after the resolution of characteristic vesicular skin lesions. Most commonly affected are the thoracic dermatomes. Trigeminal (V1), cervical, and lumbar nerves are other frequently affected sites. Early treatment shortens the duration of acute HZ and may prevent the onset of PHN. A variety of modalities are utilized to treat PHN, including chemical compounds, interventional pain techniques, and neuromodulation. HZ vaccine is recommended for individuals more than 60 years old, and it is currently the best method of averting HZ and consequent progression to PHN.

scholarly journals Varicella-Zoster Virus-Derived Major Histocompatibility Complex Class I-Restricted Peptide Affinity Is a Determining Factor in the HLA Risk Profile for the Development of Postherpetic Neuralgia

2014 ◽  
Vol 89 (2) ◽  
pp. 962-969 ◽  
Author(s):  
Pieter Meysman ◽  
Benson Ogunjimi ◽  
Stefan Naulaerts ◽  
Philippe Beutels ◽  
Viggo Van Tendeloo ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Herpes Zoster ◽  
Varicella Zoster Virus ◽  
Postherpetic Neuralgia ◽  
Common Complication ◽  
Varicella Zoster ◽  
High Affinity ◽  
Histocompatibility Complex ◽  
Relative Affinity ◽  
Peptide Affinity

ABSTRACTPostherpetic neuralgia (PHN) is the most common complication of herpes zoster and is typified by a lingering pain that can last months or years after the characteristic herpes zoster rash disappears. It is well known that there are risk factors for the development of PHN, such as its association with certain HLA alleles. In this study, previous HLA genotyping results were collected and subjected to a meta-analysis with increased statistical power. This work shows that the alleles HLA-A*33 and HLA-B*44 are significantly enriched in PHN patients, while HLA-A*02 and HLA-B*40 are significantly depleted. Prediction of the varicella-zoster virus (VZV) peptide affinity for these four HLA variants by using one in-house-developed and two existing state-of-the-art major histocompatibility complex (MHC) class I ligand prediction methods reveals that there is a great difference in their absolute and relative peptide binding repertoires. It was observed that HLA-A*02 displays a high affinity for an ∼7-fold-higher number of VZV peptides than HLA-B*44. Furthermore, after correction for HLA allele-specific limitations, the relative affinity of HLA-A*33 and HLA-B*44 for VZV peptides was found to be significantly lower than those of HLA-A*02 and HLA-B*40. In addition, HLA peptide affinity calculations indicate strong trends for VZV to avoid high-affinity peptides in some of its proteins, independent of the studied HLA allele.IMPORTANCEVaricella-zoster virus can cause two distinct diseases: chickenpox (varicella) and shingles (herpes zoster). Varicella is a common disease in young children, while herpes zoster is more frequent in older individuals. A common complication of herpes zoster is postherpetic neuralgia, a persistent and debilitating pain that can remain months up to years after the resolution of the rash. In this study, we show that the relative affinity of HLA variants associated with higher postherpetic neuralgia risk for varicella-zoster virus peptides is lower than that of variants with a lower risk. These results provide new insight into the development of postherpetic neuralgia and strongly support the hypothesis that one of its possible underlying causes is a suboptimal anti-VZV immune response due to weak HLA binding peptide affinity.

Acute pain and postherpetic neuralgia related to Varicella zoster virus reactivation: Comparison between typical herpes zoster and zoster sine herpete

2018 ◽  
Vol 91 (2) ◽  
pp. 287-295 ◽  
Author(s):  
Francesco Drago ◽  
Astrid Herzum ◽  
Giulia Ciccarese ◽  
Francesco Broccolo ◽  
Alfredo Rebora ◽  
...  
Keyword(s):  
Herpes Zoster ◽  
Varicella Zoster Virus ◽  
Acute Pain ◽  
Postherpetic Neuralgia ◽  
Virus Reactivation ◽  
Varicella Zoster ◽  
Zoster Sine Herpete

scholarly journals Effective Natural Drug Remedies against Herpes Zoster: A Review

2020 ◽  
Vol 10 (6-s) ◽  
pp. 112-118
Author(s):  
Pankaj Shahajirao Patil ◽  
Pankaj S Patil ◽  
Rajendra S Bhambar
Keyword(s):  
Herpes Zoster ◽  
Varicella Zoster Virus ◽  
Plant Extracts ◽  
Alternative Treatment ◽  
Postherpetic Neuralgia ◽  
Chemical Nature ◽  
Accurate Data ◽  
Varicella Zoster ◽  
Active Elements ◽  
Vesicular Rash

Herpes zoster (HZ), also known as shingles, is a painful vesicular rash resulting from reactivation of the virus that also causes chickenpox – Varicella zoster virus (VZV). Typically, the rash runs its course in a matter of 4-5 weeks. The pain, however, may persist months, even years, after the skin heals. This phenomenon is known as postherpetic neuralgia (PHN). This review tried to provide more comprehensive and accurate data on the effects of different herbals on the VZV as a probable alternative treatment for VZV. Further clarification of the herbals interactions with VZV is required which could provide valuable information about the chemical nature and mechanism(s) of action of the potential anti-VZV molecule(s) and all the most potential plant extracts must undertake further analysis and purification steps with the aim of identifying the active elements existing in the herbals. Key words: Herpes zoster (HZ), Shingles, Varicella zoster virus (VZV), Post neuralgia, Natural products

Blistering Rash

2018 ◽  
pp. 240-243
Author(s):  
Ashley Sutherland
Keyword(s):  
Older Adults ◽  
Herpes Zoster ◽  
Herpes Simplex ◽  
Varicella Zoster Virus ◽  
Postherpetic Neuralgia ◽  
Skin Lesions ◽  
Stevens Johnson Syndrome ◽  
Previous Exposure ◽  
Varicella Zoster ◽  
Johnson Syndrome

This case reviews an eruption of herpes zoster (shingles) in an inpatient. It examines the clinical presentation, pathophysiology, and treatment of this condition. Herpes zoster is an acute, painful vesiculobullous eruption that is seen most commonly in older adults in the setting of previous exposure to varicella zoster virus. Classic features include painful vesicles on well-defined erythema, typically confined to a single dermatome. Initiation of antiviral therapy within 72 hours of the onset of skin lesions is given to reduce the duration of the eruption and decrease the incidence of postherpetic neuralgia. This case will also review how herpes zoster differs from other cutaneous eruptions that may look similar, such as herpes simplex or Stevens Johnson syndrome.

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