scholarly journals Drug-Carrying Magnetic Nanocomposite Particles for Potential Drug Delivery Systems

2009 ◽  
Vol 2009 ◽  
pp. 1-6 ◽  
Author(s):  
R. Asmatulu ◽  
A. Fakhari ◽  
H. L. Wamocha ◽  
H. Y. Chu ◽  
Y. Y. Chen ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Quantum Interference ◽  
Ammonium Hydroxide ◽  
Magnetic Nanocomposite ◽  
Blocking Temperature ◽  
Basic Solution ◽  
Ferrous Chloride ◽  
Oil Emulsion

Drug-carrying magnetic nanocomposite spheres were synthesized using magnetite nanoparticles and poly (D,L-lactide-co-glycolide) (PLGA) for the purpose of magnetic targeted drug delivery. Magnetic nanoparticles (∼13 nm on average) of magnetite were prepared by a chemical coprecipitation of ferric and ferrous chloride salts in the presence of a strong basic solution (ammonium hydroxide). An oil-in-oil emulsion/solvent evaporation technique was conducted at 7000 rpm and 1.5–2 hours agitation for the synthesis of nanocomposite spheres. Specifically, PLGA and drug were first dissolved in acetonitrile (oily phase I) and combined with magnetic nanoparticles, then added dropwise into viscous paraffin oil combined with Span 80 (oily phase II). With different contents (0%, 10%, 20%, and 25%) of magnetite, the nanocomposite spheres were evaluated in terms of particle size, morphology, and magnetic properties by using dynamic laser light scattering (DLLS), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and a superconducting quantum interference device (SQUID). The results indicate that nanocomposite spheres (200 nm to 1.1 μm in diameter) are superparamagnetic above the blocking temperature near 40 K and their magnetization saturates above 5 000 Oe at room temperature.

Fabrication of Magnetic Nanocomposite Spheres for Targeted Drug Delivery

2008 ◽  
Author(s):  
R. Asmatulu ◽  
A. Fakhari ◽  
H. L. Wamocha ◽  
H. H. Hamdeh ◽  
J. C. Ho
Keyword(s):  
Electron Microscopy ◽  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Ammonium Hydroxide ◽  
Magnetic Nanocomposite ◽  
Basic Solution ◽  
Ferrous Chloride ◽  
Oil Emulsion ◽  
Targeted Drug ◽  
Co Precipitation

Biodegradable magnetic nanocomposite spheres were synthesized using magnetite nanoparticles and poly (D,L-lactide-co-glycolide) (PLGA) for the purpose of magnetic targeted drug delivery. Magnetic nanoparticles (∼10 nm) were prepared by a chemical co-precipitation of ferric and ferrous chloride salts in the presence of a strong basic solution (ammonium hydroxide). An oil-in-oil emulsion/solvent evaporation technique was conducted at 7000 rpm and 1.5–2 hrs agitation for the synthesis of nanocomposite spheres. Prior to the experiment, PLGA was dissolved in acetonitrile (phase I), and then added drop-wise into the viscous paraffin oil combined with Span 80 (phase II). The effect of magnetic particle concentrations (0%, 5%, 10%, 20% and 30%) on nanocomposite particles, the particle distribution and morphology were investigated using dynamic laser light scattering (DLLS), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The test results proved that the magnetic nanocomposite spheres were in the range of 200 nm to 1.03 μm.

Synthesizing Magnetic Nanocomposite Fibers by Electrospinning Method

2008 ◽  
Author(s):  
R. Asmatulu ◽  
W. Khan ◽  
K. D. Nguyen ◽  
M. B. Yildirim
Keyword(s):  
Magnetic Nanoparticles ◽  
Ammonium Hydroxide ◽  
Magnetic Nanocomposite ◽  
Ferrous Chloride ◽  
Inorganic Particles ◽  
Electrospinning Method ◽  
Nanocomposite Fibers ◽  
Co Precipitation ◽  
Chloride Salts ◽  
Poly Acrylonitrile

Flexible magnetic nanocomposite fibers were produced by electrospinning method using a polymeric solution containing poly(acrylonitrile) and magnetite nanoparticles. Magnetic nanoparticles (∼10 nm) were prepared by a chemical co-precipitation of ferric and ferrous chloride salts in the presence of an ammonium hydroxide solution. The effect of magnetic particle concentrations (e.g., 0%, 1%, 5%, 10%, 20% and 30%) on nanocomposite fibers, distribution and morphology were studied using scanning electron microscopy (SEM). The experimental study indicated that the average diameters of the magnetic nanocomposite fibers were between 400 nm and 1.08 μm. The magnetic responds were also found to increase linearly with increasing percent loading of the magnetic nanoparticles. It is concluded that this study provides promising results for various applications, such as filtration and separation of micron and nanosize organic and inorganic particles, HF antenna fabrication and biomedical.

scholarly journals Biodegradable Magnetic Nanocomposite Spheres Fabrication by O∕O Emulsion∕Solvent Evaporation Technique for Drug Delivery Purposes

2008 ◽  
Vol 2 (2) ◽  
Author(s):  
R. Asmatulu ◽  
A. Fakhari
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Uv Light ◽  
Solvent Evaporation ◽  
Ferrous Chloride ◽  
Strong Base ◽  
Nanocomposite Particles ◽  
Pump Speed ◽  
Evaporation Technique

Drug targeting systems are important research areas for many diseases treatments (e.g., cancer, nerve damage, heart and artery, diabetic, eye and other medical treatments). Currently, magnetic field, electric field, ultrasound, temperature, UV light and∕or mechanical force systems are considered more for research and development. Magnetic targeted drug delivery system is usually preferred because targeted systems improve the therapeutic index of drug molecules by minimizing the toxic side effects on healthy cells and tissues. In this study, magnetic nanoparticles (∼10nm) were prepared by a chemical coprecipitation of ferric and ferrous chloride salts in the presence of a strong base (ammonium hydroxide) and used for a drug delivery purposes. An oil-in-oil emulsion∕solvent evaporation technique was chosen for the synthesis of nanocomposite spheres. Percentages of magnetic nanoparticles (%5, %10, %20 and%30) and poly(D,L-lactide-co-glycolide) were combined together to produce nanocomposite particles with diameters of 500nmto1.2micronmeter. The effect of particle concentrations on nanocomposite particle size and distribution and morphology were investigated by using scanning electron microscopy (SEM) and laser light scattering (LLS). Additionally, external magnetic fields with various magnet distance, magnetic field, pump speed and solid contents were applied to the nanocomposite particles in a liquid media to find out the effect of variables for the targeting of drug carrying nanocomposite spheres.

scholarly journals Characterization of glycidyl methacrylate based magnetic nanocomposites

2019 ◽  
Vol 73 (1) ◽  
pp. 25-35
Author(s):  
Bojana Markovic ◽  
Vojislav Spasojevic ◽  
Aleksandra Dapcevic ◽  
Zorica Vukovic ◽  
Vladimir Pavlovic ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Magnetic Nanoparticles ◽  
Glycidyl Methacrylate ◽  
Mercury Porosimetry ◽  
Magnetic Nanocomposite ◽  
Magnetic Nanocomposites ◽  
Tem Analysis ◽  
X Ray ◽  
Force Microscopy ◽  
Transmission Electron

Magnetic and non-magnetic macroporous crosslinked copolymers of glycidyl methacrylate and trimethylolpropane trimethacrylate were prepared by suspension copolymerization and functionalized with diethylenetriamine. The samples were characterized by mercury porosimetry, scanning electron microscopy with energy-dispersive X-ray spectroscopy (SEM-EDS), Fourier transform infrared spectroscopy analysis (FTIR-ATR), thermogravimetric analysis (TGA), X-ray diffractometry (XRD), atomic force microscopy (AFM), transmission electron microscopy (TEM) and SQUID magnetometry. The FTIR-ATR analysis of synthesized magnetic nanocomposites confirmed the presence of magnetite and successful amino- functionalization. Non-functionalized and amino-functionalized nanocomposites exhibited superparamagnetic behavior at 300 K, with a saturation magnetization of 5.0 emu/g and 2.9 emu/g, respectively. TEM analysis of the magnetic nanocomposite has shown that magnetic nanoparticles were homogeneously dispersed in the polymer matrix. It was demonstrated that incorporation of magnetic nanoparticles enhanced the thermal stability of the magnetic nanocomposite in comparison to the initial non-magnetic macroporous copolymer.

Detection of endogenous magnetic nanoparticles with a tunnelling magneto resistance sensor

2010 ◽  
Vol 368 (1927) ◽  
pp. 4371-4387 ◽  
Author(s):  
A. Ionescu ◽  
N. J. Darton ◽  
K. Vyas ◽  
J. Llandro
Keyword(s):  
Magnetic Nanoparticles ◽  
Magnetite Nanoparticles ◽  
Quantum Interference ◽  
Blocking Temperature ◽  
Superconducting Quantum Interference Device ◽  
Electron Microscopic ◽  
Freeze Dried ◽  
Shell Forming ◽  
Magneto Resistance ◽  
Good Agreement

The magnetotactic bacterium Magnetospirillum sp. has been cultured and the properties of its endogenous magnetic nanoparticles characterized. Electron-microscopic analyses indicate that the endogenous magnetite nanoparticles in Magnetospirillum sp. are coated with a 3–4 nm thick transparent shell, forming a magnetosome. These magnetite nanoparticles had diameters of 50.9±13.3 nm, in good agreement with the diameter of 40.6±1.2 nm extracted from magnetometry. Each Magnetospirillum sp. bacterium contained chains of 5–25 magnetosomes. Superconducting quantum interference device magnetometry results indicate that the extrinsic superparamagnetic response of the bacterial solution at room temperature can be attributed to the reversal of the magnetization by physical rotation of the nanoparticles. The intrinsic blocking temperature of a sample of freeze-dried bacteria was estimated to be 282±13 K. A tunnelling magneto resistance sensor was used to detect the stray fields of endogenous magnetic nanoparticles in static and quasi-dynamic modes. Based on the tunnelling magneto resistance sensor results, the magnetic moment per bacterium was estimated to be approximately 2.6×10 −13  emu. The feasibility of this detection method either as a mass-coverage device or as part of an integrated microfluidic circuit for detection and sorting of magnetosome-containing cells was demonstrated.

Methotrexate Loaded Magnetic Nanoparticles as a Targeted Drug Delivery Device

2015 ◽  
Author(s):  
L. Saeednia ◽  
R. Asmatulu
Keyword(s):  
Electron Microscopy ◽  
Drug Delivery ◽  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Targeted Drug Delivery ◽  
Surface Coating ◽  
Cancer Drug ◽  
Hydroxyl Groups ◽  
Promising Alternative ◽  
Targeted Drug

Targeted drug delivery systems have been shown to be promising alternative for the conventional drug delivery methods. Among numerous nanocarriers developed for therapeutic applications, iron oxide magnetic nanoparticles have attracted considerable attention. Fe3O4 (magnetite) is one of the most commonly used iron oxide in biomedical applications due to its biocompatibility and can be easily produced in research and industrial laboratories. The core/shell structure of magnetic nanoparticles allows the surface coating to avoid their agglomeration. Moreover, coating of Fe3O4 nanoparticles provide functional groups and consequently make the bioconjugation to the therapeutic agents. Coating magnetic nanoparticles with a biopolymer will also increase biocompatibility. Coating magnetic nanoparticles with a biopolymer will also increase biocompatibility. Chitosan can easily conjugate to the surface of magnetic nanoparticles and provide amine and hydroxyl groups for the further conjugation of the therapeutic drug. In this study, Fe3O4 magnetic nanoparticles were fabricated and were coated with chitosan via in-situ method. Prepared chitosan coated magnetic nanoparticles then were loaded with methotrexate (anti-cancer drug) through adsorption. The size and morphology of synthesized magnetic nanoparticles were evaluated using Transmission Electron Microscopy (TEM) and Scanning Electron Microscopy (SEM). The chemical structure of bare and chitosan coated magnetic nanoparticles was analyzed by Fourier Transforms Infrared (FTIR). Methotrexate loading efficiency of chitosan coated nanoparticles was also evaluated. Cytotoxicity of nanoparticles was also studied in-vitro. The results confirmed the surface coating with chitosan and methotrexate loading. The synthesize chitosan coated magnetic nanoparticles showed promising application for cancer treatment.

Blocking Temperature of Magnetite Nanoparticles Fe3O4 Encapsulated Silicon Dioxide SiO2

2020 ◽  
Vol 855 ◽  
pp. 172-176 ◽  
Author(s):  
Togar Saragi ◽  
Hotmas D. Sinaga ◽  
Feni Rahmi ◽  
Gustiani A. Pramesti ◽  
Adi Sugiarto ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Silicon Dioxide ◽  
Temperature Dependence ◽  
Magnetite Nanoparticles ◽  
Quantum Interference ◽  
Blocking Temperature ◽  
Precipitation Method ◽  
Magnetic Characteristics ◽  
Superconducting Quantum Interference Device ◽  
Co Precipitation

One of the important characteristics of magnetic materials is the measurement of magnetic characteristics through Superconducting Quantum Interference Device (SQUID) especially magnetization temperature dependence M(T)ZFC and MTFC measurement. In this work, we reported magnetization temperature dependence measurements of magnetite nanoparticles without SiO2 encapsulation (Fe3O4) and magnetite nanoparticles with SiO2 encapsulation (Fe3O4.SiO2) at the application of magnetic fields of 100 Oe. The nanoparticles magnetite was synthesized by co-precipitation method. It was calculated that the blocking temperature of magnetite nanoparticles Fe3O4 without and with SiO2 encapsulation is 118.38 K and 209.03 K, respectively. The blocking temperatures of magnetic nanoparticles increase by SiO2 encapsulation.

scholarly journals In Vitro Enzymatic Digestibility of Glutaraldehyde-Crosslinked Chitosan Nanoparticles in Lysozyme Solution and Their Applicability in Pulmonary Drug Delivery

Molecules ◽  
2019 ◽  
Vol 24 (7) ◽  
pp. 1271 ◽  
Author(s):  
Nazrul Islam ◽  
Hui Wang ◽  
Faheem Maqbool ◽  
Vito Ferro
Keyword(s):  
Electron Microscopy ◽  
Drug Delivery ◽  
Structural Integrity ◽  
Chitosan Nanoparticles ◽  
Morphological Characterization ◽  
Pulmonary Drug Delivery ◽  
Oil Emulsion ◽  
Vis Spectroscopy ◽  
Before And After

Herein, the degradation of low molecular weight chitosan (CS), with 92% degree of deacetylation (DD), and its nanoparticles (NP) has been investigated in 0.2 mg/mL lysozyme solution at 37 °C. The CS nanoparticles were prepared using glutaraldehyde crosslinking of chitosan in a water-in-oil emulsion system. The morphological characterization of CS particles was carried out using scanning electron microscopy (SEM) and Transmission Electron Microscopy (TEM) techniques. Using attenuated total reflectance Fourier transform infrared (ATR-FTIR) and UV-VIS spectroscopy, the structural integrity of CS and its NPs in lysozyme solution were monitored. The CS powder showed characteristic FTIR bands around 1150 cm−1 associated with the glycosidic bridges (C-O-C bonds) before and after lysozyme treatment for 10 weeks, which indicated no CS degradation. The glutaraldehyde crosslinked CS NPs showed very weak bands associated with the glycosidic bonds in lysozyme solution. Interestingly, the UV-VIS spectroscopic data showed some degradation of CS NPs in lysozyme solution. The results of this study indicate that CS with a high DD and its NPs crosslinked with glutaraldehyde were not degradable in lysozyme solution and thus unsuitable for pulmonary drug delivery. Further studies are warranted to understand the complete degradation of CS and its NPs to ensure their application in pulmonary drug delivery.

scholarly journals Magnetic nanocomposite derived from Nopal cactus biopolymer and magnetic nanoparticles used for the microalgae flocculation of aqueous solution

BioResources ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. 3469-3493
Author(s):  
Lan Huong Nguyen ◽  
Huu Tap Van ◽  
Duong Hong Quan ◽  
Phuong Thuy Thi Pham
Keyword(s):  
Electron Microscopy ◽  
Magnetic Nanoparticles ◽  
High Efficiency ◽  
Low Cost ◽  
Ultrasonic Waves ◽  
Magnetic Nanocomposite ◽  
Magnetic Nanomaterials ◽  
Scanning Calorimetry ◽  
Transmission Electron ◽  
Modified Magnetic Nanoparticles

A magnetic nanocomposite, using a Nopal cactus-derived biopolymer in combination with NH4OH-modified cobalt superparamagnetic (CoFe2O4) nanoparticles, was developed as a green flocculant system for recovery of microalgae from aqueous solutions. The obtained magnetic nanomaterials were subsequently dispersed in the biopolymer matrix with the support of ultrasonic waves. The effects of various factors on pectin extraction, fabrication of nanocomposites, and the flocculation process of microalgae were also studied. The characteristics of the obtained materials (pectin, modified magnetic nanoparticles, and nanocomposites) were evaluated via X-ray powder diffraction, scanning electron microscopy, transmission electron microscopy, vibrating sample magnetometry, thermogravimetric-differential scanning calorimetry, Fourier transform infrared spectroscopy, and zeta potential analysis. The optimal conditions for pectin extraction from Nopal cactus, as well as the fabrication of magnetic nanoparticles, modified magnetic nanoparticles, and nanocomposite were reported. The characteristic data of the fabricated materials showed heat resistance and abundant surface functional groups with high magnetization. The observed flocculation was attributed to the aggregation of unstable and small particles through surface charge neutralization, electrostatic patching, and/or bridging after addition of flocculants. The results showed that the nanocomposites could be a potential green flocculant for recovering microalgae with low cost and high efficiency.

Formation of gold-coated magnetic nanoparticles using TiO2 as a bridging material

2006 ◽  
Vol 21 (5) ◽  
pp. 1312-1316 ◽  
Author(s):  
Brittany L. Oliva ◽  
Anindya Pradhan ◽  
Daniela Caruntu ◽  
Charles J. O'Connor ◽  
Matthew A. Tarr
Keyword(s):  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Contrast Agents ◽  
Surface Properties ◽  
Blocking Temperature ◽  
Gold Coating ◽  
Magnetic Imaging ◽  
Potential Applications ◽  
Superparamagnetic Properties ◽  
Unique Surface

TiO2 nanoparticles with embedded magnetite were suspended in aqueous HAuCl4 and ultraviolet irradiated to photodeposit gold on the surface. The degree of gold coating and the wavelength of absorbance could be controlled by adjusting [HAuCl4]. Absorbance maxima were between 540-590 nm. Particles exhibited superparamagnetic properties (blocking temperature ∼170 K) whether or not coated with gold. These particles have potential applications as drug delivery agents, magnetic imaging contrast agents, and magnetically separatable photocatalysts with unique surface properties.

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